Finn Cilius Nielsen
Clinical Professor
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14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif
Andersen, S. D., Keijzers, G., Rampakakis, E., Engels, K., Luhn, P., El-Shemerly, M., Nielsen, Finn Cilius, Du, Y., May, A., Bohr, Vilhelm, Ferrari, S., Zannis-Hadjopoulos, M., Fu, H. & Rasmussen, Lene Juel, Mar 2012, In: D N A Repair. 11, 3, p. 267-77 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Achromobacter spp. genetic adaptation in cystic fibrosis
Gabrielaite, M., Nielsen, Finn Cilius, Johansen, Helle Krogh & Marvig, R. L., 2021, In: Microbial genomics. 7, 7, 13 p., 000582.Research output: Contribution to journal › Journal article › Research › peer-review
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Drosophila Imp iCLIP identifies an RNA assemblage coordinating F-actin formation
Hansen, H. T., Rasmussen, S. H., Adolph, S. K., Plass, M., Krogh, Anders, Sanford, J., Nielsen, Finn Cilius & Christiansen, Jan, 2015, In: Genome Biology (Online Edition). 16, 16 p., 123.Research output: Contribution to journal › Journal article › Research › peer-review
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c-myc and IGF-II mRNA-binding protein (CRD-BP/IMP-1) in benign and malignant mesenchymal tumors
Ioanidis, P., Trangas, T., Dimitriadis, E., Samiotaki, M., Kyriazoglou, I., Tsiapalis, C. M., Kittas, C., Agnantis, N., Nielsen, Finn Cilius, Nielsen, J., Christiansen, Jan & Pandis, N., 2001, In: International Journal of Cancer. 94, p. 480-484Research output: Contribution to journal › Journal article › Research › peer-review
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A BRCA2 mutation incorrectly mapped in the original BRCA2 reference sequence, is a common West Danish founder mutation disrupting mRNA splicing
Thomassen, M., Pedersen, I. S., Vogel, I., Hansen, T. V. O., Brasch-Andersen, C., Brasen, C. L., Crüger, D., Sunde, L. E. M., Nielsen, Finn Cilius, Jensen, U. B., Bisgaard, M. L., Borg, A., Gerdes, Anne-Marie Axø & Kruse, T. A., 1 Jul 2011, In: Breast Cancer Research and Treatment. 128, 1, p. 179-85 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A Transcriptome-Wide Association Study Among 97,898 Women to Identify Candidate Susceptibility Genes for Epithelial Ovarian Cancer Risk
et al., E. A., 15 Sep 2018, In: Cancer Research. 78, 18, p. 5419-5430 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers
GEMO Study Collaborators, G. S. C., EMBRACE Collaborators, E. C., kConFab Investigators, K. I., HEBON Investigators, H. I. & ABCTB Investigators, A. I., Dec 2021, In: Nature Communications. 12, 1, 22 p., 1078.Research output: Contribution to journal › Journal article › Research › peer-review
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A catalog of curated breast cancer genes
Bose, M., Benada, Jan, Thatte, Jayashree Vijay, Kinalis, S., Ejlertsen, Bent Laursen, Nielsen, Finn Cilius, Sørensen, Claus Storgaard & Rossing, Caroline Maria, 2022, In: Breast Cancer Research and Treatment. 191, p. 431-441Research output: Contribution to journal › Journal article › Research › peer-review
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A comparison of tools for copy-number variation detection in germline whole exome and whole genome sequencing data
Gabrielaite, M., Torp, M. H., Rasmussen, Malthe Sebro, Andreu-Sánchez, S., Vieira, Filipe Garrett, Pedersen, C. B., Kinalis, S., Madsen, M. B., Kodama, M., Demircan, G. S., Simonyan, A., Yde, C. W., Olsen, L. R., Marvig, R. L., Østrup, O., Rossing, Caroline Maria, Nielsen, Finn Cilius, Winther, Ole & Bagger, F. O., 2021, In: Cancers. 13, 24, 6283.Research output: Contribution to journal › Journal article › Research › peer-review
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A comparison of tools for copy-number variation detection in germline whole exome and whole genome sequencing data
Gabrielaite, M., Torp, M., Rasmussen, M., Andreu-Sánchez, S., Vieira, Filipe Garrett, Pedersen, C., Kinalis, S., Madsen, M., Yde, C., Rønn, O. L., Marvig, R., Østrup, O., Rossing, Caroline Maria, Nielsen, Finn Cilius, Winther, Ole & Bagger, F. O., 2021, bioRxiv, 29 p.Research output: Working paper › Preprint › Research
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A distal Sp 1-element is necessary for maximal activity of the human gastrin gene promoter
R. Bundgaard, J., Hansen, Thomas van Overeem, Friis-Hansen, Lennart Jan, Rourke, I. J., van Solinge, W. W., Nielsen, Finn Cilius & Rehfeld, Jens Frederik, 7 Aug 1995, In: FEBS Letters. 369, 2-3, p. 225-228 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development
Nielsen, J., Christiansen, Jan, Lykke-Andersen, J., Johnsen, A. H., Wewer, Ulla M. & Nielsen, Finn Cilius, 1999, In: Molecular and Cellular Biology. 19, 2, p. 1262-1270 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A genome-wide scan in affected sib-pairs with idiopathic recurrent miscarriage suggests genetic linkage
Kolte, A. M., Nielsen, Henriette Svarre, Moltke, Ida, Degn, B., Pedersen, B., Sunde, L., Nielsen, Finn Cilius & Christiansen, O. B., 2011, In: Molecular Human Reproduction. 17, 6, p. 379-385 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A high and increasing HPV prevalence in tonsillar cancers in Eastern Denmark, 2000-2010: The largest registry-based study to date
Garnaes, E., Kiss, K., Andersen, L., Therkildsen, M. H., Franzmann, M. B., Filtenborg-Barnkob, B., Høgdall, Estrid Vilma Solyom, Krenk, L., Josiassen, M., Lajer, C. B., Specht, Lena, Frederiksen, K., Friis-Hansen, Lennart Jan, Nielsen, Finn Cilius, Kjær, Susanne Krüger, Norrild, B. & von Buchwald, Christian, 1 May 2015, In: International journal of cancer. Journal international du cancer. 136, 9, p. 2196-203 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated sorting protein (GASP)
Heydorn, A., Søndergaard, B. P., Ersbøll, B., Holst, Birgitte, Nielsen, Finn Cilius, Haft, C. R., Whistler, J. & Schwartz, Thue W., 2004, In: Journal of Biological Chemistry. 279, 52, p. 54291-303 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population
Antoniou, A. C., Wang, X., Fredericksen, Z. S., McGuffog, L., Tarrell, R., Sinilnikova, O. M., Healey, S., Morrison, J., Kartsonaki, C., Lesnick, T., Ghoussaini, M., Barrowdale, D., Peock, S., Cook, M., Oliver, C., Frost, D., Eccles, D., Evans, D. G., Eeles, R., Izatt, L. & 31 others, , 1 Oct 2010, In: Nature Genetics. 42, 10, p. 885-92 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A maternal low protein diet has pronounced effects on mitochondrial gene expression in offspring liver and skeletal muscle; protective effect of taurine
Mortensen, Ole Hartvig, Olsen, H. L., Frandsen, L., Nielsen, Peter E., Nielsen, Finn Cilius, Grunnet, N. & Quistorff, B., 1 Aug 2010, In: Journal of Biomedical Science. 24, 17, p. 1-11Research output: Contribution to journal › Journal article › Research › peer-review
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A method for detecting IBD regions simultaneously in multiple individuals--with applications to disease genetics
Moltke, Ida, Albrechtsen, Anders, Hansen, Thomas van Overeem, Nielsen, Finn Cilius & Nielsen, Rasmus, 2011, In: Genome Research. 21, 7, p. 1168-80 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A new NFIA:RAF1 fusion activating the MAPK pathway in pilocytic astrocytoma
Yde, C. W., Sehested, A., Regué, À. M., Østrup, O., Scheie, David, Nysom, K., Nielsen, Finn Cilius & Rossing, M., Oct 2016, In: Cancer genetics and cytogenetics. 209, 10, p. 440-444 5 p.Research output: Contribution to journal › Letter › Research › peer-review
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A novel DICER1 mutation identified in a female with ovarian Sertoli-Leydig cell tumor and multinodular goiter: a case report
Rossing, M., Gerdes, A., Juul, Anders, Rechnitzer, C., Rudnicki, M., Nielsen, Finn Cilius & Vo Hansen, T., 2014, In: Journal of Medical Case Reports. 8, p. 1-5 5 p., 112.Research output: Contribution to journal › Journal article › Research › peer-review
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A novel mutation in the NOD2 gene associated with Blau syndrome: a Norwegian family with four affected members
Milman, N., Ursin, K., Rødevand, E., Nielsen, Finn Cilius & Hansen, T. V. O., 2009, In: Scandinavian Journal of Rheumatology. 38, 3, p. 190-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A simple procedure for routine RNA extraction and miRNA array analyses from a single thyroid in vivo fine needle aspirate
Rossing, M., Kaczkowski, B., Futoma-Kazmierczak, E., Glud, M., Klausen, M., Faber, Jens, Nygaard, Birte, Kiss, K., Sørensen, C. H., Nielsen, Finn Cilius, Bennedbæk, F. N. & Friis-Hansen, Lennart Jan, 2010, In: Scandinavian Journal of Clinical & Laboratory Investigation. 70, 8, p. 529-534 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A simple, safe and sensitive method for SARS-CoV-2 inactivation and RNA extraction for RT-qPCR
Kalnina, L., Mateu-Regué, À., Oerum, S., Hald, A., Gerstoft, Jan, Oerum, H., Nielsen, Finn Cilius & Iversen, A. K. N., 2021, In: APMIS. 129, 7, p. 393-400 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A transgenic mouse marking live replicating cells reveals in vivo transcriptional program of proliferation
Klochendler, A., Weinberg-Corem, N., Moran, M., Swisa, A., Pochet, N., Savova, V., Vikeså, J., Van de Peer, Y., Brandeis, M., Regev, A., Nielsen, Finn Cilius, Dor, Y. & Eden, A., 2012, In: Developmental Cell. 23, 4, p. 681-90 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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ADAM12 alleviates the skeletal muscle pathology in mdx dystrophic mice
Kronqvist, P., Kawaguchi, N., Albrechtsen, Reidar, Xu, X., Schrøder, H. D., Moghadaszadeh, B., Nielsen, Finn Cilius, Frohlich, C., Engvall, E. & Wewer, Ulla M., 1 Nov 2002, In: American Journal of Pathology. 161, 5, p. 1535-40 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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ADAM12 redistributes and activates MMP-14, resulting in gelatin degradation, reduced apoptosis and increased tumor growth
Albrechtsen, Reidar, Kveiborg, Marie, Hansen, D. S., Vikeså, J., Noer, Julie Boertmann, Kotzsh, A., Nielsen, Finn Cilius, Wewer, Ulla M. & Frohlich, C., 15 Oct 2013, In: Journal of Cell Science. 126, 20, p. 4707-20 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Aberrant expression of fetal RNA-binding protein p62 in liver cancer and liver cirrhosis
Lu, M., Nakamura, R. M., Dent, E. D., Zhang, J., Nielsen, Finn Cilius, Christiansen, Jan, Chan, E. K. L. & Tan, E. M., 2001, In: American Journal of Pathology. 159, p. 945-953Research output: Contribution to journal › Journal article › Research › peer-review
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Actionable targets in recurrent bile duct and pancreatic cancer in a prospective cohort of patients evaluated by whole exome sequencing and SNP array analysis
Tuxen, I. E. V., Mau-Sørensen, M., Yde, C. W., Jønson, L., Oestrup, O., Hasselby, Jane Preuss, Santoni Rugiu, Eric, Lassen, Ulrik Niels & Nielsen, Finn Cilius, 2016, In: Journal of Clinical Oncology. 34, 15, Suppl., 1 p., e23256.Research output: Contribution to journal › Conference abstract in journal › Research
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Amplicon-Based NGS Panels for Actionable Cancer Target Identification in Follicular Cell-Derived Thyroid Neoplasia
Madsen, M. B., Kiss, K., Nielsen, Finn Cilius, Bennedbæk, F. N. & Rossing, M., 2020, In: Frontiers in Endocrinology. 11, 8 p., 146.Research output: Contribution to journal › Journal article › Research › peer-review
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An original phylogenetic approach identified mitochondrial haplogroup T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers
Blein, S., Bardel, C., Danjean, V., McGuffog, L., Healey, S., Barrowdale, D., Lee, A., Dennis, J., Kuchenbaecker, K. B., Soucy, P., Terry, M. B., Chung, W. K., Goldgar, D. E., Buys, S. S., Janavicius, R., Tihomirova, L., Tung, N., Dorfling, C. M., van Rensburg, E. J., Neuhausen, S. L. & 31 others, , 2015, In: Breast cancer research : BCR. 17, 1, p. 1-15 15 p., 61.Research output: Contribution to journal › Journal article › Research › peer-review
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Ancient human genome sequence of an extinct Palaeo-Eskimo
Rasmussen, M., Li, Y., Lindgreen, S., Pedersen, J. S., Albrechtsen, A., Moltke, I., Metspalu, M., Metspalu, E., Kivisild, T., Gupta, R., Bertalan, M., Nielsen, K., Gilbert, T., Wang, Y., Raghavan, M., Campos, P., Kamp, H. L. M., Wilson, A. S., Gledhill, A., Tridico, S. & 32 others, , 11 Feb 2010, In: Nature. 463, 7282, p. 757-762 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Application of cell-free DNA for genomic tumor profiling: a feasibility study
Ahlborn, L. B., Rohrberg, K. S., Gabrielaite, M., Tuxen, I. V., Yde, C. W., Spanggaard, I., Santoni Rugiu, Eric, Nielsen, Finn Cilius, Lassen, Ulrik Niels, Mau-Sorensen, M. & Østrup, O., Feb 2019, In: OncoTarget. 10, 14, p. 1388-1398Research output: Contribution to journal › Journal article › Research › peer-review
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Application of whole-exome sequencing to direct the specific functional testing and diagnosis of rare inherited bleeding disorders in patients from the Öresund Region, Scandinavia
Leinøe, E., Zetterberg, E., Kinalis, S., Østrup, O., Kampmann, P., Norström, E., Andersson, N., Klintman, J., Qvortrup, Klaus, Nielsen, Finn Cilius & Rossing, M., Oct 2017, In: British Journal of Haematology. 179, 2, p. 308-322 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Arachidonic and oleic acid exert distinct effects on the DNA methylome
Silva-Martínez, G. A., Rodríguez-Ríos, D., Alvarado-Caudillo, Y., Vaquero, A., Esteller, M., Carmona, F. J., Moran, S., Nielsen, Finn Cilius, Wickström-Lindholm, M., Wrobel, K., Wrobel, K., Barbosa-Sabanero, G., Zaina, S. & Lund, G., 2016, In: Epigenetics. 11, 5, p. 321-334 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Ascertainment biases in SNP chips affect measures of population divergence
Albrechtsen, Anders, Nielsen, Finn Cilius & Nielsen, R., 1 Nov 2010, In: Molecular Biology and Evolution. 27, 11, p. 2534-47 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness
Patel, V. L., Busch, E. L., Friebel, T. M., Cronin, A., Leslie, G., McGuffog, L., Adlard, J., Agata, S., Agnarsson, B. A., Ahmed, M., Aittomäki, K., Alducci, E., Andrulis, I. L., Arason, A., Arnold, N., Artioli, G., Arver, B., Auber, B., Azzollini, J., Balmaña, J. & 243 others, , 1 Feb 2020, In: Cancer Research. 80, 3, p. 624-638 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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BRCA1 and BRCA2 mutations in Danish families with hereditary breast and/or ovarian cancer.
Thomassen, M., Hansen, T. V. O., Borg, A., Lianee, H. T., Wikman, F., Pedersen, I. S., Bisgaard, M. L., Nielsen, Finn Cilius, Kruse, T. A. & Gerdes, A., 2008, In: Acta Odontologica Scandinavica. 47, 4, p. 772-7 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Benchmarking full-length transcript single cell mRNA sequencing protocols
Probst, V., Simonyan, Arman, Pacheco, F., Guo, Yuliu, Nielsen, Finn Cilius & Bagger, F. O., 2022, In: BMC Genomics. 23, 860.Research output: Contribution to journal › Journal article › Research › peer-review
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Bi-directional routing of DNA mismatch repair protein human exonuclease 1 to replication foci and DNA double strand breaks
Liberti, S. E., Andersen, S. D., Wang, J., May, A., Miron, S., Perderiset, M., Keijzers, G., Nielsen, Finn Cilius, Charbonnier, J., Bohr, Vilhelm & Rasmussen, Lene Juel, 2 Jan 2011, In: DNA Repair. 10, 1, p. 73-86 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Biochemical characterization of MLH3 missense mutations does not reveal an apparent role of MLH3 in Lynch syndrome
Ou, J., Rasmussen, M., Westers, H., Andersen, S. D., Jager, P. O., Kooi, K. A., Niessen, R. C., Eggen, B. J. L., Nielsen, Finn Cilius, Kleibeuker, J. H., Sijmons, R. H., Rasmussen, Lene Juel & Hofstra, R. M. W., 2009, In: Genes, Chromosomes & Cancer. 48, 4, p. 340-50 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Blau syndrome-associated mutations in exon 4 of the caspase activating recruitment domain 15 (CARD 15) gene are not found in ethnic Danes with sarcoidosis
Milman, N., Nielsen, Finn Cilius, Hviid, Thomas Vauvert F. & Hansen, Thomas van Overeem, Dec 2007, In: Clinical Respiratory Journal. 1, 2, p. 74-9 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Brain response to traumatic brain injury in wild-type and interleukin-6 knockout mice: a microarray analysis
Poulsen, C. B., Penkowa, M., Borup, R., Nielsen, Finn Cilius, Cáceres, M., Quintana, A., Molinero, A., Carrasco, J., Giralt, M. & Hidalgo, J., 2005, In: Journal of Neurochemistry. 92, 2, p. 417-32 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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CARD15 status and familial predisposition for Crohn's disease and colonic gene expression
Csillag, C., Nielsen, O. H., Borup, R., Olsen, Jørgen, Bjerrum, Jakob Tveiten & Nielsen, Finn Cilius, 2007, In: Digestive Diseases and Sciences. 52, 8, p. 1783-1789 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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CARD15 status and familial predisposition for Crohn's disease and colonic gene expression
vlz241, vlz241, Nielsen, Ole Haagen, Borup, R., Olsen, J., Bjerrum, Jakob Tveiten & Nielsen, Finn Cilius, 2007, In: Digestive Diseases and Sciences. 52, 8, p. 1783-1789Research output: Contribution to journal › Journal article › Research › peer-review
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Cancers of unknown primary origin (CUP) are characterized by chromosomal instability (CIN) compared to metastasis of know origin
Vikeså, J., Møller, A. K. H., Kaczkowski, B., Helweg-Larsen, R. B., Winther, Ole, Henao Giraldo, R., Krogh, Anders, Perell, K., Jensen, F., Daugaard, G. & Nielsen, Finn Cilius, 2015, In: B M C Cancer. 15, 14 p., 151.Research output: Contribution to journal › Journal article › Research › peer-review
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Cell-free DNA in newly diagnosed patients with glioblastoma - a clinical prospective feasibility study
Nørøxe, D. S., Østrup, O., Yde, C. W., Ahlborn, L. B., Nielsen, Finn Cilius, Michaelsen, Signe Regner, Larsen, V. A., Skjøth-Rasmussen, J., Brennum, J., Hamerlik, P., Poulsen, H. S. & Lassen, Ulrik Niels, 2019, In: OncoTarget. 10, 43, p. 4397-4406 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Characteristics of the Danish families with multiple endocrine neoplasia type 1
Jäger, A. C., Friis-Hansen, Lennart Jan, Hansen, Thomas van Overeem, Eskildsen, P. C., Sølling, K., Knigge, Ulrich, Hansen, C. P., Andersen, P. H., Brixen, K., Feldt-Rasmussen, Ulla, Kroustrup, J. P., Mollerup, C. L., Rehfeld, Jens Frederik, Blichert-Toft, M. & Nielsen, Finn Cilius, 25 Apr 2006, In: Molecular and Cellular Endocrinology. 249, 1-2, p. 123-132 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of MYG1 gene and protein: subcellular distribution and function
Philips, M., Vikeså, J., Luuk, H., Jønson, L., Lilleväli, K., Rehfeld, Jens Frederik, Vasar, E., Kõks, S. & Nielsen, Finn Cilius, 2009, In: Biology of the Cell. 101, 6, p. 361-73 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of basal-like subtype in a Danish consecutive primary breast cancer cohort
Kinalis, S., Nielsen, Finn Cilius, Talman, M. L., Ejlertsen, B. & Rossing, M., 2018, In: Acta Oncologica. 57, 1, p. 51-57Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of miRNA Expression in Human Degenerative Lumbar Disks
Ohrt-Nissen, S., Døssing, K. B. V., Rossing, M., Lajer, C., Vikeså, J., Nielsen, Finn Cilius, Friis-Hansen, Lennart Jan & Dahl, Benny, 2013, In: Connective Tissue Research. 54, 3, p. 197-203 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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IMP3 RNP safe houses prevent miRNA-directed HMGA2 mRNA decay in cancer and development
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RNA assemblages orchestrate complex cellular processes
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Cancers of unknown primary origin (CUP) are characterized by chromosomal instability (CIN) compared to metastasis of know origin
Research output: Contribution to journal › Journal article › Research › peer-review
Published