David Paul Drucker Woldbye
Associate Professor
Neuropharm and Genetics
Blegdamsvej 3, 2200 København N.
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A C-terminal PDZ domain-binding sequence is required for striatal distribution of the dopamine transporter
Rickhag, Karl Mattias, Herborg, Freja, Sørensen, G., Strandfelt, K. N., Andresen, B., Gotfryd, K., Madsen, Kenneth Lindegaard, Vestergaard-Klewe, I., Ammendrup-Johnsen, I., Eriksen, J., Newman, A. H., Füchtbauer, E., Gomeza, J., Woldbye, David Paul Drucker, Wörtwein, Gitta & Gether, Ulrik, 2013, In: Nature Communications. 4, p. 1-13 13 p., 1580.Research output: Contribution to journal › Journal article › Research › peer-review
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A Peptide Antagonist of ErbB Receptors, Inherbin3, Induces Neurite Outgrowth from Rat Cerebellar Granule Neurons Through ErbB1 Inhibition
Xu, R., Pankratova, Stanislava, Christiansen, S. H. O., Woldbye, David Paul Drucker, Højland, A., Bock, E. M. & Berezin, V., 2013, In: Neurochemical Research. 38, 12, p. 2550-8 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A dual-immunocytochemical method to localize c-fos protein in specific neurons based on their content of neuropeptides and connectivity.
Mikkelsen, J. D., Larsen, Jacob, Sørensen, G. G., Woldbye, David Paul Drucker, Bolwig, T. G., Hastings, M. H. & Ebling, F. J., 1994, In: Histochemistry. 101, 4, p. 245-51 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene
Gregersen, N., Dahl, H. A., Buttenschøn, H. N., Nyegaard, M., Hedemand, A., Als, T. D., Wang, August Gabriel, Joensen, S., Woldbye, David Paul Drucker, Koefoed, P., Kristensen, A. S., Kruse, T. A., Børglum, A. & Mors, O., 2012, In: European Journal of Human Genetics. 20, p. 84-90 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A subpopulation of neuronal M4 muscarinic acetylcholine receptors plays a critical role in modulating dopamine-dependent behaviors
Jeon, J., Dencker, D., Wörtwein, G., Woldbye, D. P. D., Cui, Y., Davis, A. A., Levey, A. I., Schütz, G., Sager, T. N., Mørk, A., Li, C., Deng, C-X., Fink-Jensen, A., Wess, J., Jeon, J., Nielsen, D. D., Wörtwein, G., Woldbye, D. P. D., Cui, Y., Davis, A. A. & 8 others, , 10 Feb 2010, In: Journal of Neuroscience. 30, 6, p. 2396-405 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Accumulated increase in neuropeptide Y and somatostatin gene expression of the rat in response to repeated electroconvulsive stimulation
Mikkelsen, J. D. & Woldbye, David Paul Drucker, 2006, In: Journal of Psychiatric Research. 40, 2, p. 153-159 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Activation of Neuropeptide Y Receptors Modulates Retinal Ganglion Cell Physiology and Exerts Neuroprotective Actions In Vitro
Martins, J., Elvas, F., Brudzewsky, D., Martins, T., Kolomiets, B., Tralhão, P., Gøtzsche, C. R., Cavadas, C., Castelo-Branco, M., Woldbye, David Paul Drucker, Picaud, S., Santiago, A. R. & Ambrósio, A. F., 2015, In: A S N Neuro. 7, 4, p. 1-21 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Addiction-Related Effects of DOV 216,303 and Cocaine: A Comparative Study in the Mouse
Sørensen, G., Husum, H., Brennum, L. T., Bundgaard, C., Montezinho, L. C. P., Mørk, A., Wörtwein, Gitta & Woldbye, David Paul Drucker, Jun 2014, In: Basic & Clinical Pharmacology & Toxicology. 114, 6, p. 451-9 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Adeno-associated viral vector-induced overexpression of neuropeptide Y Y2 receptors in the hippocampus suppresses seizures
Woldbye, David Paul Drucker, Ängehagen, M., Gøtzsche, C. R., Elbrønd-Bek, H., Sørensen, Andreas Toft, Christiansen, S. H. O., Olesen, M. V., Nikitidou, L., Hansen, T. V. O., Kanter-Schlifke, I. & Kokaia, M., Sep 2010, In: Brain. 133, 9, p. 2778-88 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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An allosteric enhancer of M4 muscarinic acetylcholine receptor function inhibits behavioral and neurochemical effects of cocaine
Nielsen, D. D., Weikop, Pia, Sørensen, G., Woldbye, David Paul Drucker, Wörtwein, Gitta, Wess, J. & Fink-Jensen, Anders, 2012, In: Psychopharmacology. 224, 2, p. 277-87 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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An intron 1 polymorphism in the cholecystokinin-A receptor gene associated with schizophrenia in males
Koefoed, P., Hansen, T. V. O., Woldbye, D. P. D., Werge, T., Mors, O., Hansen, T., Jakobsen, K. D., Nordentoft, M., Wang, A., Bolwig, T. G., Rehfeld, J. F., Koefoed, P., Hansen, T. V. O., Woldbye, D. P. D., Werge, T., Mors, O., Hansen, T. F., Jakobsen, K. D., Nordentoft, M., Wang, A. & 2 others, , 2009, In: Acta Psychiatrica Scandinavica. 120, 4, p. 281-7 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Antiepileptic effects of NPY on pentylenetetrazole seizures
Woldbye, David Paul Drucker, 1998, In: Regulatory Peptides. 75-76, p. 279-282Research output: Contribution to journal › Journal article › Research › peer-review
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Antipsychotic-induced catalepsy is attenuated in mice lacking the M4 muscarinic acetylcholine receptor.
Fink-Jensen, Anders, Schmidt, L. S., Dencker, D., Schülein, C., Wess, J., Wörtwein, Gitta & Woldbye, David Paul Drucker, 10 Apr 2011, In: European Journal of Pharmacology. 656, 1-3, p. 39-44 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Antisense oligonucleotide to GABAA receptor 2 subunit induces limbic status epilepticus
Karle, J., Woldbye, David Paul Drucker, Elster, L., Diemer, N. H., Bolwig, T. G., Olsen, R. W. & Nielsen, M., 1998, In: Journal of Neuroscience Research. 54, p. 863-869Research output: Contribution to journal › Journal article › Research › peer-review
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Anxiolytic-Like Effects of Increased Ghrelin Receptor Signaling in the Amygdala
Jensen, M., Ratner, C., Rudenko, Olga, Christiansen, S. H., Skov, Louise Julie, Johnsen, Cecilie Hundahl, Woldbye, David Paul Drucker & Holst, Birgitte, 1 May 2016, In: International Journal of Neuropsychopharmacology. 19, 5, 12 p., pyv123.Research output: Contribution to journal › Journal article › Research › peer-review
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Anxiolytic-like effects after vector-mediated overexpression of neuropeptide Y in the amygdala and hippocampus of mice
Christiansen, S. H. O., Olesen, M. V., Gøtzsche, C. R. & Woldbye, David Paul Drucker, 16 Sep 2014, In: Neuropeptides. 48, 6, p. 335-44 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Are TMEM genes potential candidate genes for panic disorder?
NO, G., Buttenschøn, H. N., Hedemand, A., Dahl, H. A., Kristensen, A. S., B, C., Woldbye, David Paul Drucker, Koefoed, P., Erhardt, A., Kruse, T. A., Wang, August Gabriel, Børglum, A. & Mors, O., 2014, In: Psychiatric Genetics. 24, 1, p. 37-41 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Aripiprazole blocks acute self-administration of cocaine and is not self-administered in mice
Sørensen, G., Sager, T. N., Petersen, Jørgen Holm, Brennum, L. T., Thøgersen, P., Hee Bengtsen, C., Thomsen, M., Wörtwein, Gitta, Fink-Jensen, Anders & Woldbye, David Paul Drucker, 2008, In: Psychopharmacology. 199, 1, p. 37-46 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Association between genes on chromosome 19p13.2 and panic disorder
Gregersen, N. O., Buttenschon, H. N., Hedemand, A., Nielsen, M. N., Dahl, H. A., Kristensen, A. S., Johansen, O., Woldbye, David Paul Drucker, Erhardt, A., Krusee, T. A., Wang, August Gabriel, Borglum, A. D. & Mors, O., Dec 2016, In: Psychiatric Genetics. 26, 6, p. 287-292Research output: Contribution to journal › Journal article › Research › peer-review
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Association of the leucine-7 to proline-7 variation in the signal sequence of neuropeptide Y with major depression
Koefoed, P., Woldbye, D. P. D., Hansen, T. V. O., Eplov, L. F., Christiansen, S. H. O., Mors, O., Kessing, L. V., Werge, T., Kaipio, K., Pesonen, U., Fahmy, T., Mellerup, E. T., Jakobsen, K. D., Hansen, E. S., Knudsen, G. M., Bukh, J. D., Bock, C., Lindberg, C., Kristensen, A. S., Dam, H. & 6 others, , 23 Mar 2012, In: Acta Neuropsychiatrica. 24, 2, p. 81-90 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Can gene therapy treat anxiety? Overexpression of Neuropeptide S using adeno-associated viral vectors
Tillmann, S., Elbrond-Bek, H., Gotzsche, C. R., Christiansen, S. H., Mathe, A. A., Woldbye, David Paul Drucker & Wegener, G., Jun 2016, In: International Journal of Neuropsychopharmacology. 19, S1, p. 52-53Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Candidate genes in panic disorder: meta-analyses of 23 common variants in major anxiogenic pathways
Howe, A. S., Buttenschön, H. N., Bani-Fatemi, A., Maron, E., Otowa, T., Erhardt, A., Binder, E. B., Gregersen, N. O., Mors, O., Woldbye, D. P., Domschke, K., Reif, A., Shlik, J., Kks, S., Kawamura, Y., Miyashita, A., Kuwano, R., Tokunaga, K., Tanii, H., Smoller, J. W. & 3 others, , 2016, In: Molecular Psychiatry. 21, 5, p. 665-679 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Chemogenetic Modulation of G Protein-Coupled Receptor Signalling in Visual Attention Research
Jørgensen, Søren Heide, Fitzpatrick, C. M., Gether, Ulrik, Woldbye, David Paul Drucker & Sørensen, Andreas Toft, Nov 2017, In: Basic & Clinical Pharmacology & Toxicology. 121, 5, p. 373-381 9 p.Research output: Contribution to journal › Review › Research › peer-review
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Combinatorial gene therapy for epilepsy: Gene sequence positioning and AAV serotype influence expression and inhibitory effect on seizures
Melin, Esbjörn Aage Anders, Andersson, M., Gøtzsche, C. R., Wickham, J., Huang, Y., Szczygiel, Julia Alicja, Boender, A., Christiansen, S. H., Pinborg, Lars Hageman, Woldbye, David Paul Drucker & Kokaia, M., 2023, In: Gene Therapy. 30, p. 649-658 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Combined gene overexpression of neuropeptide Y and its receptor Y5 in the hippocampus suppresses seizures.
Gøtzsche, C. R., Nikitidou, L., Sørensen, Andreas Toft, Olesen, M. V., Sørensen, G., Christiansen, S. H. O., Ängehagen, M., Woldbye, David Paul Drucker & Kokaia, M., 2012, In: Neurobiology of Disease. 45, p. 288-96 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Complex plastic changes in the neuropeptide Y system during ethanol intoxication and withdrawal in the rat brain
Olling, J. D., Ulrichsen, J., Christensen, D. Z., Woldbye, David Paul Drucker, Olling, J. D., Ulrichsen, J., Christensen, D. Z. & Woldbye, D. P. D., 2009, In: Journal of Neuroscience Research. 87, 10, p. 2386-97 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Current and Future Prospects for Gene Therapy for Rare Genetic Diseases Affecting the Brain and Spinal Cord
Jensen, T. L., Gøtzsche, C. R. & Woldbye, David Paul Drucker, 2021, In: Frontiers in Molecular Neuroscience. 14, 27 p., 695937.Research output: Contribution to journal › Review › Research › peer-review
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DREADDs suppress seizure-like activity in a mouse model of pharmacoresistant epileptic brain tissue
Avaliani, N., Andersson, M., Thomsen, A. H. R., Woldbye, David Paul Drucker & Kokaia, M., Oct 2016, In: Gene Therapy. 23, 10, p. 760-766 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Decreased gene expression of neuropeptide Y and its receptors in hippocampal regions during ethanol withdrawal in rats
Olling, J. D., Ulrichsen, J., Haugbøl, S., Glenthøj, Birte Yding, Hemmingsen, R. & Woldbye, David Paul Drucker, 2007, In: Neuroscience Letters. 424, 3, p. 160-164 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Decreased prepulse inhibition and increased sensitivity to muscarinic, but not dopaminergic drugs in M-5 muscarinic acetylcholine receptor knockout mice
Thomsen, M., Wortwein, G., Fink-Jensen, Anders, Woldbye, David Paul Drucker, Wess, J. & Caine, S. B., 2007, In: Psychopharmacology. 192, 1, p. 97-110 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Decreased spontaneous activity in AMPK alpha 2 muscle specific kinase dead mice is not caused by changes in brain dopamine metabolism
Møller, Lisbeth L V, Sylow, Lykke, Gøtzsche, C. R., Serup, A. K. L., Christiansen, S. H., Weikop, Pia, Kiens, Bente, Woldbye, David Paul Drucker & Richter, Erik A., 2016, In: Physiology & Behavior. 164, Part A, p. 300-305 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Deep-Learning-Based Classification of Rat OCT Images After Intravitreal Injection of ET-1 for Glaucoma Understanding
Fuentes-Hurtado, F., Morales, S., Mossi, J. M., Naranjo, V., Fedulov, V., Woldbye, David Paul Drucker, Klemp, Kristian, Torm, M. & Larsen, M., 2018, Intelligent Data Engineering and Automated Learning – IDEAL 2018 - 19th International Conference, Proceedings. Yin, H., Novais, P., Camacho, D. & Tallón-Ballesteros, A. J. (eds.). Springer, p. 27-34 8 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), Vol. 11314 LNCS).Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review
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Differential Effect of Neuropeptides on Excitatory Synaptic Transmission in Human Epileptic Hippocampus
Ledri, M., Sørensen, Andreas Toft, Madsen, M. G., Christiansen, S. H., Ledri, L. N., Cifra, A., Bengzon, J., Lindberg, E., Pinborg, L. H., Jespersen, B., Gotzsche, C. R., Woldbye, David Paul Drucker, Andersson, M. & Kokaia, M., 1 Jul 2015, In: Journal of Neuroscience. 35, 26, p. 9622-9631 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Differential Expression of the β3 Subunit of Voltage-Gated Ca2+ Channel in Mesial Temporal Lobe Epilepsy
Kjær, C., Palasca, Oana, Barzaghi, G., Bak, Lasse Kristoffer, Durhuus, R. K. J., Jakobsen, Emil, Pedersen, Louise, Bartels, Emil Daniel, Woldbye, David Paul Drucker, Pinborg, Lars Hageman & Jensen, Lars Juhl, 2023, In: Molecular Neurobiology. 60, p. 5755–5769Research output: Contribution to journal › Journal article › Research › peer-review
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Differential effects of chemogenetic inhibition on dopamine and norepinephrine neurons in the mouse 5-choice serial reaction time task
Fitzpatrick, C. M., Runegaard, A. H., Christiansen, S. H., Hansen, Nikolaj Winther, Jørgensen, Søren Heide, McGirr, J. C., de Diego Ajenjo, A., Sørensen, Andreas Toft, Perrier, Jean-Francois Marie, Petersen, A., Gether, Ulrik, Woldbye, David Paul Drucker & Andreasen T., Jesper, 2019, In: Progress in Neuro-Psychopharmacology & Biological Psychiatry. 90, 2, p. 264-276 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Differential plastic changes in synthesis and binding in the mouse somatostatin system after electroconvulsive stimulation
Olesen, M. V., Gøtzsche, C. R., Christiansen, S. H. & Woldbye, David Paul Drucker, 2018, In: Acta Neuropsychiatrica. 30, 4, p. 192-202 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Differential roles for neuropeptide Y Y1 and Y5 receptors in anxiety and sedation
Sørensen, G., Lindberg, C., Wörtwein, Gitta, Bolwig, T. G., Woldbye, David Paul Drucker & Sørensen, G., 1 Sep 2004, In: Journal of Neuroscience Research. 77, 5, p. 723-9 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Differential suppression of seizures via Y2 and Y5 neuropeptide Y receptors
Woldbye, David Paul Drucker, Nanobashvili, A., Sørensen, Andreas Toft, Husum, H., Bolwig, T. G., Sørensen, G., Ernfors, P., Kokaia, M. & Sørensen, G., 1 Dec 2005, In: Neurobiology of Disease. 20, 3, p. 760-72 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Disease Modification by Combinatorial Single Vector Gene Therapy: A Preclinical Translational Study in Epilepsy
Melin, E., Nanobashvili, A., Avdic, U., Gøtzsche, C. R., Andersson, M., Woldbye, David Paul Drucker & Kokaia, M., 2019, In: Molecular Therapy - Methods and Clinical Development. 15, p. 179-193 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Disruption of the PDZ domain-binding motif of the dopamine transporter uniquely alters nanoscale distribution, dopamine homeostasis, and reward motivation
Sørensen, G., Rickhag, Karl Mattias, Leo, D., Lycas, M. D., Ridderstrøm, P. H., Weikop, P., Lilja, J. H., Rifes, P., Herborg, Freja, Woldbye, David Paul Drucker, Wörtwein, Gitta, Gainetdinov, R. R., Fink-Jensen, Anders & Gether, Ulrik, 2021, In: Journal of Biological Chemistry. 297, 6, 101361.Research output: Contribution to journal › Journal article › Research › peer-review
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Editorial: Gene Therapy in the CNS – Progress and Prospects for Novel Therapies
Ledri, M., Sørensen, Andreas Toft, Kokaia, M., Woldbye, David Paul Drucker & Gøtzsche, C. R., 2021, In: Frontiers in Molecular Neuroscience. 14, 778134.Research output: Contribution to journal › Editorial › Research › peer-review
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Effects of acute and chronic aripiprazole treatment on choice between cocaine self-administration and food under a concurrent schedule of reinforcement in rats
Thomsen, M., Fink-Jensen, Anders, Woldbye, David Paul Drucker, Wörtwein, Gitta, Sager, T., Holm, R., Pepe, L. & Barak Caine, S., 2008, In: Psychopharmacology.Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of amphetamine and methylphenidate on attentional performance and impulsivity in the mouse 5-Choice Serial Reaction Time Task
Caballero Puntiverio, M., Fitzpatrick, C. M., Woldbye, David Paul Drucker & Andreasen T., Jesper, 2017, In: Journal of Psychopharmacology. 31, 2, p. 272-283Research output: Contribution to journal › Journal article › Research › peer-review
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Electrical amygdala kindling in alcohol-withdrawal kindled rats
Ulrichsen, J., Woldbye, David Paul Drucker, Madsen, T. M., Clemmesen, L., Haugbøl, S., Olsen, C. H., Laursen, H., Bolwig, T. G. & Hemmingsen, R., 1998, In: Alcohol & Alcoholism. 33, 3, p. 244-254Research output: Contribution to journal › Journal article › Research › peer-review
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Electroconvulsive shock (ECS) does not facilitate the development of kindling
Kragh, J., Bruhn, T., Woldbye, David Paul Drucker & Bolwig, T. G., 1993, In: Progress in Neuro-Psychopharmacology & Biological Psychiatry. 17, p. 985-989Research output: Contribution to journal › Journal article › Research › peer-review
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Electroconvulsive shock and lidocaine-induced seizures in the rat activate astrocytes as measured by glial fibrillary acidic protein
Kragh, J., Bolwig, T. G., Woldbye, David Paul Drucker & Jørgensen, O. S., 1993, In: Biological Psychiatry. 33, p. 794-800Research output: Contribution to journal › Journal article › Research › peer-review
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Electroconvulsive shocks increase the expression of neuropeptide Y (NPY) mRNA in the piriform cortex and the dentate gyrus
Mikkelsen, J. D., Woldbye, David Paul Drucker, Kragh, J., Larsen, P. J. & Bolwig, T. G., 1994, In: Molecular Brain Research. 23, p. 317-322Research output: Contribution to journal › Journal article › Research › peer-review
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Electroconvulsive stimulation reverses anhedonia and cognitive impairments in rats exposed to chronic mild stress.
K, H., Woldbye, David Paul Drucker & Wiborg, O., 2013, In: European Neuropsychopharmacology. 23, 12, p. 1789-94 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Electroconvulsive therapy as an anticonvulsant: A possible role of neuropeptide Y (NPY)
Bolwig, T. G., Woldbye, David Paul Drucker & Mikkelsen, J. D., 1999, In: Journal of ECT. 15, 1, p. 93-101Research output: Contribution to journal › Journal article › Research › peer-review
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Epigenetic regulation of Dnmt3a and Arc gene expression after electroconvulsive stimulation in the rat
Dyrvig, M., Gotzsche, C. R., Woldbye, David Paul Drucker & Lichota, J., Jul 2015, In: Molecular and Cellular Neuroscience. 67, p. 137-143 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Association of the leucine-7 to proline-7 variation in the signal sequence of neuropeptide Y with major depression
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PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance
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Locomotor- and Reward-Enhancing Effects of Cocaine Are Differentially Regulated by Chemogenetic Stimulation of Gi-Signaling in Dopaminergic Neurons
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