Darryl S Pickering
Associate Professor
Molecular and Cellular Pharmacology
Jagtvej 160, København Ø
- 2012
- Published
Pharmacological and structural characterization of conformationally restricted (S)-glutamate analogues at ionotropic glutamate receptors
Juknaite, L., Venskutonyte, R., Assaf, Z., Faure, S., Gefflaut, T., Aitken, D. J., Nielsen, Birgitte, Gajhede, Michael, Kastrup, Jette Sandholm Jensen, Bunch, Lennart, Frydenvang, Karla Andrea & Pickering, Darryl S, 2012, In: Journal of Structural Biology. 180, 1, p. 39-46Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cognitive enhancing effects of an AMPA receptor positive modulator on place learning in mice
Rytter, Hana Malá, Chen, Y., Worm, V. H., Kure, J., Kaae, B. H., Madsen, Ulf, Badolo, L., Pickering, Darryl S & Mogensen, J., 2012, In: Behavioural Brain Research. 226, 1, p. 18-25Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural and pharmacological characterization of phenylalanine-based AMPA receptor antagonists at kainate receptors
Venskutonyte, R., Frydenvang, Karla Andrea, Valadés, E. A., Szymanska, E. M., Johansen, Tommy Nørskov, Kastrup, Jette Sandholm Jensen & Pickering, Darryl S, Oct 2012, In: ChemMedChem. 7, 10, p. 1793-1798 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
UCCB01-125, a dimeric inhibitor of PSD-95, reduces inflammatory pain without disrupting cognitive or motor performance: Comparison with the NMDA receptor antagonist MK-801
Andreasen T., Jesper, Bach, Anders, Gynther, M., Nasser, A., Mogensen, J., Strømgaard, Kristian & Pickering, Darryl S, Apr 2013, In: Neuropharmacology. 67, p. 193-200 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Does increasing the ratio of AMPA-to-NMDA receptor mediated neurotransmission engender antidepressant action? Studies in the mouse forced swim and tail suspension tests
Andreasen T., Jesper, Gynther, M. O. O., Rygaard, A., Bøgelund, T., Nielsen, S. D., Clausen, Rasmus Prætorius, Mogensen, J. & Pickering, Darryl S, 2013, In: Neuroscience Letters. 546, p. 6-10 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chemo-enzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters
Assaf, Z., Larsen, A. P., Venskutonyte, R., Han, L., Abrahamsen, B., Nielsen, Birgitte, Gajhede, Michael, Kastrup, Jette Sandholm Jensen, Jensen, Anders A., Pickering, Darryl S, Frydenvang, Karla Andrea, Gefflaut, T. & Bunch, Lennart, 2013, In: Journal of Medicinal Chemistry. 56, 4, p. 1614-1628Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Erratum: Chemoenzymatic synthesis of new 2,4- syn -functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters (Journal of Medicinal Chemistry (2013) 56 (1614-1628))
Assaf, Z., Larsen, A. P., Venskutonyteì, R., Han, L., Abrahamsen, B., Nielsen, Birgitte, Gajhede, Michael, Kastrup, Jette Sandholm Jensen, Jensen, A. A., Pickering, Darryl S, Frydenvang, Karla Andrea, Gefflaut, T. & Bunch, Lennart, 25 Jul 2013, In: Journal of Medicinal Chemistry. 56, 14, p. 5985 1 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
Studies on an (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) receptor antagonist IKM-159: asymmetric synthesis, neuroactivity, and structural characterization
Juknaite, L., Sugamata, Y., Tokiwa, K., Ishikawa, Y., Takamizawa, S., Eng, A., Sakai, R., Pickering, Darryl S, Frydenvang, Karla Andrea, Swanson, G. T., Kastrup, Jette Sandholm Jensen & Oikawa, M., 2013, In: Journal of Medicinal Chemistry. 56, 6, p. 2283-2293Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain
Krintel, C., Harpsøe, Kasper, Zachariassen, L. G., Peters, D., Frydenvang, Karla Andrea, Pickering, Darryl S, Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 2013, In: Acta Crystallographica Section D: Structural Biology. 69, Pt 9, p. 1645-1652 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site
Kvist, T., Steffensen, T. B., Greenwood, J. R., Mehrzad Tabrizi, F., Hansen, K. B., Gajhede, Michael, Pickering, Darryl S, Traynelis, S. F., Kastrup, Jette Sandholm Jensen & Bräuner, Hans, 2013, In: The Journal of Biological Chemistry. 288, p. 33124-35 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Corrigendum to "Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamate" [J. Struct. Biol. 176 (2011) 307-314]
Venskutonyte, R., Frydenvang, Karla Andrea, Gajhede, Michael, Bunch, Lennart, Pickering, Darryl S & Kastrup, Jette Sandholm Jensen, Nov 2013, In: Journal of Structural Biology. 184, 2, p. 381 1 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- 2014
- Published
Analogues of 3-Hydroxyisoxazole-Containing Glutamate Receptor Ligands Based on the 3-Hydroxypyrazole-Moiety: Design, Synthesis and Pharmacological Characterization
Jørgensen, L., Nielsen, Birgitte, Pickering, Darryl S, Kristensen, Anders Skov, Frydenvang, Karla Andrea, Madsen, Ulf & Clausen, Rasmus Prætorius, 2014, In: Neurochemical Research. 39, 10, p. 1895-1905 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain
Krintel, C., Frydenvang, Karla Andrea, Ceravalls de Rabassa, A., Kaern, A. M., Gajhede, Michael, Pickering, Darryl S & Kastrup, Jette Sandholm Jensen, 27 Mar 2014, In: F E B S Journal. p. 2422–2430 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Design, synthesis and in vitro pharmacology of GluK1 and GluK3 antagonists. Studies towards the design of subtype-selective antagonists through 2-carboxyethyl-phenylalanines with substituents interacting with non-conserved residues in the GluK binding sites
Sköld, N., Nielsen, Birgitte, Olsen, J., Han, L., Olsen, L., Madsen, Ulf, Kristensen, Jesper Langgaard, Pickering, Darryl S & Johansen, Tommy Nørskov, 2 Aug 2014, In: Bioorganic & Medicinal Chemistry. 22, 19, p. 5368-5377 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular recognition of two 2,4-syn-functionalized (S)-glutamate analogues by the kainate receptor GluK3 ligand-binding domain
Venskutonyte, R., Larsen, A. P., Frydenvang, Karla Andrea, Gajhede, Michael, Gefflaut, T., Pickering, Darryl S, Bunch, Lennart & Kastrup, Jette Sandholm Jensen, 2014, In: ChemMedChem. 9, 10, p. 2254-2259 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Forster Resonance Energy Transfer (FRET) Analysis of Dual CFP/YFP Labeled AMPA Receptors Reveals Structural Rearrangement within the C-Terminal Domain during Receptor Activation
Zachariassen, L. G., Katchan, M., Plested, A., Pickering, Darryl S & Kristensen, Anders Skov, 16 Feb 2014. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- 2015
- Published
Differential role of AMPA receptors in mouse tests of antidepressant and anxiolytic action
Andreasen T., Jesper, Fitzpatrick, C. M., Larsen, M., Skovgaard, L., Nielsen, S. D., Clausen, Rasmus Prætorius, Troelsen, K. & Pickering, Darryl S, 19 Mar 2015, In: Brain Research. 1601, p. 117-26 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Binding Mode of an α-Amino Acid-Linked Quinoxaline-2,3-dione Analogue at Glutamate Receptor Subtype GluK1
Demmer, C. S., Møller, C., Brown, P. M. G. E., Han, L., Pickering, Darryl S, Nielsen, Birgitte, Bowie, D., Frydenvang, Karla Andrea, Kastrup, Jette Sandholm Jensen & Bunch, Lennart, 9 Apr 2015, In: A C S Chemical Neuroscience. 6, p. 845-854 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Solid-Phase Peptide Synthesis of Human alfa-Calcitonin Gene-Related Peptide and Two Fluorescent Analogs.
Fuente-Moreno, M., Oddo, A., Sheykhzade, Majid, Pickering, Darryl S & Hansen, Paul Robert, 2015, Proceedings of the 24th American Peptide Symposium . 2 p.Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review
- Published
Blood-brain barrier permeability and brain uptake mechanism of kainic Acid and dihydrokainic Acid
Gynther, M., Petsalo, A., Hansen, S. H., Bunch, Lennart & Pickering, Darryl S, Mar 2015, In: Neurochemical Research. 40, 3, p. 542-549 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure-Activity Relationship Study of Ionotropic Glutamate Receptor Antagonist (2S,3R)-3-(3-Carboxyphenyl)pyrrolidine-2-carboxylic Acid
Krogsgaard-Larsen, N., Storgaard, M., Møller, C., Demmer, C. S., Hansen, J., Han, L., Monrad, R. N., Nielsen, Birgitte, Tapken, D., Pickering, Darryl S, Kastrup, Jette Sandholm Jensen, Frydenvang, Karla Andrea & Bunch, Lennart, 2015, In: Journal of Medicinal Chemistry. 58, 15, p. 6131-50 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
Synthesis and Pharmacological Characterization of the Selective GluK1 Radioligand (S)-2-Amino-3-(6-[3H]-2,4-dioxo-3,4-dihydrothieno[3,2-d]pyrimidin-1(2H)-yl)propanoic acid ([3H]-NF608)
Alcaide, A., Marconi, L., Marek, A., Haym, I., Nielsen, Birgitte, Møllerud, S., Jensen, M., Conti, P., Pickering, Darryl S & Bunch, Lennart, 2016, In: MedChemComm. 7, p. 2136-2144 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of the dimeric PSD-95 inhibitor UCCB01-144 in mouse models of pain, cognition and motor function
Andreasen T., Jesper, Nasser, A., Caballero-Puntiverio, M., Sahlholt, M., Bach, Anders, Gynther, M., Strømgaard, Kristian & Pickering, Darryl S, 5 Jun 2016, In: European Journal of Pharmacology. 780, p. 166-73 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Positive allosteric modulation of AMPA receptors differentially modulates the behavioural effects of citalopram in mouse models of antidepressant and anxiolytic action
Fitzpatrick, C. M., Larsen, M., Madsen, L., Pickering, Darryl S, Clausen, Rasmus Prætorius & Andreasen T., Jesper, 26 Jun 2016, In: Behavioural Pharmacology. 27, 6, p. 549-555 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Systemic and Brain Pharmacokinetics of Perforin Inhibitor Prodrugs
Gynther, M., Pickering, Darryl S, Spicer, J., Denny, W. & Huttunen, K., 2016, In: Molecular Pharmaceutics. 13, 7, p. 2484-2491 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 1299533
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Investigation of the presence and antinociceptive function of muscarinic acetylcholine receptors in the African naked mole-rat (Heterocephalus glaber)
Research output: Contribution to journal › Journal article › Research › peer-review
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Discovery of the First Highly Selective Antagonist of the GluK3 Kainate Receptor Subtype
Research output: Contribution to journal › Journal article › Research › peer-review
Published