Cord Herbert Brakebusch
Department of Biomedical Sciences
Blegdamsvej 3
2200 København N
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90K (MAC-2 BP) gene expression in breast cancer and evidence for the production of 90K by peripheral-blood mononuclear cells.
Fusco, O., Querzoli, P., Nenci, I., Natoli, C., Brakebusch, Cord Herbert, Ullrich, A. & Iacobelli, S., 1998, In: International Journal of Cancer. 79, 1, p. 23-6 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Adgrf5 contributes to patterning of the endothelial deep layer in retina
Niaudet, C., Petkova, M., Jung, B., Lu, S., Laviña, B., Offermanns, S., Brakebusch, Cord Herbert & Betsholtz, C., 2019, In: Angiogenesis. 22, 4, p. 491-505 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis
Dütting, S., Gaits-Iacovoni, F., Stegner, D., Popp, M., Antkowiak, A., Van Eeuwijk, J. M. M., Nurden, P., Stritt, S., Heib, T., Aurbach, K., Angay, O., Cherpokova, D., Heinz, N., Baig, A. A., Gorelashvili, M. G., Gerner, F., Heinze, K. G., Ware, J., Krohne, G., Ruggeri, Z. M. & 6 others, , 15 Jun 2017, In: Nature Communications. 8, 13 p., 15838.Research output: Contribution to journal › Journal article › Research › peer-review
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A RhoA-mediated biomechanical response in Schwann cells modulates peripheral nerve myelination
Seixas, A. I., Morais, M. R. G., Brakebusch, Cord Herbert & Relvas, J. B., 2023, In: Progress in Neurobiology. 227, 13 p., 102481.Research output: Contribution to journal › Journal article › Research › peer-review
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A central role for the small GTPase Rac1 in hippocampal plasticity and spatial learning and memory
Haditsch, U., Leone, D. P., Farinelli, M., Chrostek-Grashoff, A., Brakebusch, Cord Herbert, Mansuy, I. M., McConnell, S. K. & Palmer, T. D., 2009, In: Molecular and Cellular Neuroscience. 41, 4, p. 409-19 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A crucial role of beta 1 integrins for keratinocyte migration in vitro and during cutaneous wound repair.
Grose, R., Hutter, C., Bloch, W., Thorey, I., Watt, F. M., Fässler, R., Brakebusch, Cord Herbert & Werner, S., 2002, In: Development. 129, 9, p. 2303-15 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A function for Rac1 in the terminal differentiation and pigmentation of hair
Behrendt, K., Klatte, J., Pofahl, R., Bloch, W., Smyth, N., Tscharntke, M., Krieg, T., Paus, R., Niessen, C., Niemann, C., Brakebusch, Cord Herbert & Haase, I., 24 Jan 2012, In: Journal of Cell Science. 125, Pt 4, p. 896-905 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A human antithrombin isoform dampens inflammatory responses and protects from organ damage during bacterial infection
Papareddy, P., Rossnagel, M., Doreen Hollwedel, F., Kilic, G., Veerla, S., Naudin, C., Smeds, E., Westman, J., Martinez-Martinez, I., Egesten, A., de la Morena-Barrio, M. E., Corral, J., Linder, A., Artoni, A., Abbattista, M., Novembrino, C., Brakebusch, Cord Herbert, Martinelli, I., Kasetty, G. & Herwald, H., 2019, In: Nature Microbiology. 4, 12, p. 2442-2455 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A new genetic tool to improve immune-compromised mouse models: Derivation and CRISPR/Cas9-mediated targeting of NRG embryonic stem cell lines
Martin Gonzalez, Javier, Baudet, A., Abelechian, Sahar, Bonderup, K., d'Altri, T., Porse, Bo Torben, Brakebusch, Cord Herbert, Juliusson, G. & Cammenga, J., 2018, In: Genesis: The Journal of Genetics and Development (Print). 56, 9, p. 1-7 7 p., e23238.Research output: Contribution to journal › Journal article › Research › peer-review
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A radial glia-specific role of RhoA in double cortex formation
Cappello, S., Böhringer, C. R. J., Bergami, M., Conzelmann, K., Ghanem, A., Tomassy, G. S., Arlotta, P., Mainardi, M., Allegra, M., Caleo, M., van Hengel, J., Brakebusch, Cord Herbert & Götz, M., 8 Mar 2012, In: Neuron. 73, 5, p. 911-24 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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ACK1 is dispensable for development, skin tumor formation, and breast cancer cell proliferation
Brandao, R., Kwa, M. Q., Yarden, Y. & Brakebusch, Cord Herbert, 2021, In: FEBS Open Bio. 11, 6, p. 1579-1592 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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ATF3 downmodulates its new targets IFI6 and IFI27 to suppress the growth and migration of tongue squamous cell carcinoma cells
Xu, L., Zu, T., Li, T., Li, M., Mi, J., Bai, F., Liu, G., Wen, J., Li, H., Brakebusch, Cord Herbert, Wang, X. & Wu, X., 2021, In: PLOS Genetics. 17, 2, p. 1-25 e1009283.Research output: Contribution to journal › Journal article › Research › peer-review
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Adult murine hematopoiesis can proceed without beta1 and beta7 integrins.
Bungartz, G., Stiller, S., Bauer, M., Müller, W., Schippers, A., Wagner, N., Fässler, R. & Brakebusch, Cord Herbert, 2006, In: Blood. 108, 6, p. 1857-64 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Analyzing skin tumor development in mice by the DMBA/TPA model
Li, H. & Brakebusch, Cord Herbert, 2021, Carcinogen-driven mouse models of oncogenesis. Galluzzi, L. & Buqué, A. (eds.). Elsevier, Vol. 163. p. 113-121 9 p. (Methods in Cell Biology).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
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Antibodies to a soluble form of a tumor necrosis factor (TNF) receptor have TNF-like activity.
Engelmann, H., Holtmann, H., Brakebusch, Cord Herbert, Avni, Y. S., Sarov, I., Nophar, Y., Hadas, E., Leitner, O. & Wallach, D., 1990, In: Journal of Biological Chemistry. 265, 24, p. 14497-504 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Author Correction: FMNL2 and -3 regulate Golgi architecture and anterograde transport downstream of Cdc42
Kage, F., Steffen, A., Ellinger, A., Ranftler, C., Gehre, C., Brakebusch, Cord Herbert, Pavelka, M., Stradal, T. & Rottner, K., 26 Nov 2019, In: Scientific Reports. 9, 1, p. 18008 1 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
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Beta 1 integrin is essential for teratoma growth and angiogenesis.
Bloch, W., Forsberg, E., Lentini, S., Brakebusch, Cord Herbert, Martin, K., Krell, H. W., Weidle, U. H., Addicks, K. & Fässler, R., 1997, In: Journal of Cell Biology. 139, 1, p. 265-78 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Beta1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response.
Brakebusch, Cord Herbert, Fillatreau, S., Potocnik, A. J., Bungartz, G., Wilhelm, P., Svensson, M., Kearney, P., Körner, H., Gray, D. & Fässler, R., 2002, In: Immunity. 16, 3, p. 465-77 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Beta1 integrin promotes but is not essential for metastasis of ras-myc transformed fibroblasts.
Brakebusch, Cord Herbert, Wennerberg, K., Krell, H. W., Weidle, U. H., Sallmyr, A., Johansson, S. & Fässler, R., 1999, In: Oncogene. 18, 26, p. 3852-61 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Beta1 integrin-mediated adhesion signalling is essential for epidermal progenitor cell expansion
Piwko-Czuchra, A., Koegel, H., Meyer, H., Bauer, M., Werner, S., Brakebusch, Cord Herbert & Fässler, R., 2009, In: PLoS ONE. 4, 5, p. e5488Research output: Contribution to journal › Journal article › Research › peer-review
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Beta1 integrins activate a MAPK signalling pathway in neural stem cells that contributes to their maintenance.
Campos, L. S., Leone, D. P., Relvas, J. B., Brakebusch, Cord Herbert, Fässler, R., Suter, U. & ffrench-Constant, C., 2004, In: Development. 131, 14, p. 3433-44 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Beta1 integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity
Bauer, M., Brakebusch, Cord Herbert, Coisne, C., Sixt, M., Wekerle, H., Engelhardt, B. & Fässler, R., 2009, In: Proceedings of the National Academy of Science of the United States of America. 106, 6, p. 1920-5 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis.
Aszodi, A., Hunziker, E. B., Brakebusch, Cord Herbert & Fässler, R., 2003, In: Genes & Development. 17, 19, p. 2465-79 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Brevican-deficient mice display impaired hippocampal CA1 long-term potentiation but show no obvious deficits in learning and memory.
Brakebusch, Cord Herbert, Seidenbecher, C. I., Asztely, F., Rauch, U., Matthies, H., Meyer, H., Krug, M., Böckers, T. M., Zhou, X., Kreutz, M. R., Montag, D., Gundelfinger, E. D. & Fässler, R., 2002, In: Molecular and Cellular Biology. 22, 21, p. 7417-27 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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CDC42 Deletion Elicits Cerebral Vascular Malformations via Increased MEKK3-Dependent KLF4 Expression
Castro, M., Laviña, B., Ando, K., Álvarez-Aznar, A., Abu Taha, A., Brakebusch, Cord Herbert, Dejana, E., Betsholtz, C. & Gaengel, K. B., 2019, In: Circulation Research. 124, 8, p. 1240-1252 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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CRISPR Genome Editing: How to Make a Fantastic Method Even Better
Brakebusch, Cord Herbert, 2021, In: Cells. 10, 2, p. 1-2 408.Research output: Contribution to journal › Editorial › Research › peer-review
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Cancer-associated fibroblasts: how do they contribute to metastasis?
Kwa, M. Q., Herum, K. M. & Brakebusch, Cord Herbert, 2019, In: Clinical and Experimental Metastasis. 36, 2, p. 71-86Research output: Contribution to journal › Review › Research › peer-review
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Cardiac fibroblast sub-types in vitro reflect pathological cardiac remodeling in vivo
Herum, K. M., Weng, Guangzheng, Kahnert, Konstantin, Waikel, R., Milburn, G., Conger, A., Anaya, P., Campbell, K. S., Lundby, Alicia, Won, K. J. & Brakebusch, Cord Herbert, 2022, In: Matrix Biology Plus. 15, 100113.Research output: Contribution to journal › Journal article › Research › peer-review
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Cdc42 Controls Vascular Network Assembly Through Protein Kinase C{iota} During Embryonic Vasculogenesis
Qi, Y., Liu, J., Wu, X., Brakebusch, Cord Herbert, Leitges, M., Han, Y., Corbett, S. A., Lowry, S. F., Graham, A. M. & Li, S., 1 Aug 2011, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 31, 8, p. 1861-70 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice
Sakamori, R., Das, S., Yu, S., Feng, S., Stypulkowski, E., Guan, Y., Douard, V., Tang, W., Ferraris, R. P., Harada, A., Brakebusch, Cord Herbert, Guo, W. & Gao, N., 1 Mar 2012, In: Journal of Clinical Investigation. 122, 3, p. 1052-65 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cdc42 and Rac1 signaling are both required for and act synergistically in the correct formation of myelin sheaths in the CNS.
Thurnherr, T., Benninger, Y., Wu, X., Chrostek, A., Krause, S. M., Nave, K., Franklin, R. J. M., Brakebusch, Cord Herbert, Suter, U. & Relvas, J. B., 2006, In: Journal of Neuroscience. 26, 40, p. 10110-9 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cdc42 and phosphoinositide 3-kinase drive Rac-mediated actin polymerization downstream of c-Met in distinct and common pathways.
Bosse, T., Ehinger, J., Czuchra, A., Benesch, S., Steffen, A., Wu, X., Schloen, K., Niemann, H. H., Scita, G., Stradal, T. E. B., Brakebusch, Cord Herbert & Rottner, K., 2007, In: Molecular and Cellular Biology. 27, 19, p. 6615-28 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin.
Wu, X., Quondamatteo, F., Lefever, T., Czuchra, A., Meyer, H., Chrostek, A., Paus, R., Langbein, L. & Brakebusch, Cord Herbert, 2006, In: Genes & Development. 20, 5, p. 571-85 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cdc42 expression in keratinocytes is required for the maintenance of the basement membrane in skin.
Wu, X., Quondamatteo, F. & Brakebusch, Cord Herbert, 2006, In: Matrix Biology. 25, 8, p. 466-74 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cdc42 is a key regulator of B cell differentiation and is required for antiviral humoral immunity
Burbage, M., Keppler, S. J., Gasparrini, F., Martínez-Martín, N., Gaya, M., Feest, C., Domart, M., Brakebusch, Cord Herbert, Collinson, L., Bruckbauer, A. & Batista, F. D., 2015, In: The Journal of Experimental Medicine. 212, 1, p. 53-72Research output: Contribution to journal › Journal article › Research › peer-review
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Cdc42 is crucial for the establishment of epithelial polarity during early mammalian development.
Wu, X., Li, S., Chrostek-Grashoff, A., Czuchra, A., Meyer, H., Yurchenco, P. D. & Brakebusch, Cord Herbert, 2007, In: Developmental Dynamics. 236, 10, p. 2767-78 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cdc42 is crucial for the maturation of primordial cell junctions in keratinocytes independent of Rac1
Du, D., Pedersen, E., Wang, Z., Karlsson, R., Chen, Z., Wu, X. & Brakebusch, Cord Herbert, 2008, In: Experimental Cell Research.Research output: Contribution to journal › Journal article › Research › peer-review
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Cdc42 is not essential for filopodium formation, directed migration, cell polarization, and mitosis in fibroblastoid cells.
Czuchra, A., Wu, X., Meyer, H., van Hengel, J., Schroeder, T., Geffers, R., Rottner, K. & Brakebusch, Cord Herbert, 2005, In: Molecular Biology of the Cell. 16, 10, p. 4473-84 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cdc42 promotes host defenses against fatal infection
Lee, K., Boyd, K. L., Parekh, D. V., Kehl-Fie, T. E., Baldwin, H. S., Brakebusch, Cord Herbert, Skaar, E. P., Boothby, M. & Zent, R., 20 May 2013, In: Infection and Immunity. 81, 8, p. 2714-2723 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cdc42 regulates cofilin during the establishment of neuronal polarity.
Garvalov, B. K., Flynn, K. C., Neukirchen, D., Meyn, L., Teusch, N., Wu, X., Brakebusch, Cord Herbert, Bamburg, J. R. & Bradke, F., 2007, In: Journal of Neuroscience. 27, 48, p. 13117-29 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cdc42 regulates epithelial cell polarity and cytoskeletal function during kidney tubule development
Elias, B. C., Das, A., Parekh, D. V., Mernaugh, G., Adams, R., Yang, Z., Brakebusch, Cord Herbert, Pozzi, A., Marciano, D. K., Carroll, T. J. & Zent, R., 1 Dec 2015, In: Journal of Cell Science. 128, 23, p. 4293-305 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cdc42-dependent actin dynamics controls maturation and secretory activity of dendritic cells
Schulz, A. M., Stutte, S., Hogl, S., Luckashenak, N., Dudziak, D., Leroy, C., Forné, I., Imhof, A., Müller, S. A., Brakebusch, Cord Herbert, Lichtenthaler, S. F. & Brocker, T., 9 Nov 2015, In: Journal of Cell Biology. 211, 3, p. 553-67 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cdc42-dependent leading edge coordination is essential for interstitial dendritic cell migration
Lammermann, T., Renkawitz, J., Wu, X., Hirsch, K., Brakebusch, Cord Herbert & Sixt, M., 2009, In: Blood.Research output: Contribution to journal › Journal article › Research › peer-review
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Cdc42-dependent structural development of auditory supporting cells is required for wound healing at adulthood
Anttonen, T., Kirjavainen, A., Belevich, I., Laos, M., Richardson, W. D., Jokitalo, E., Brakebusch, Cord Herbert & Pirvola, U., 2012, In: Scientific Reports. 2, p. 978Research output: Contribution to journal › Journal article › Research › peer-review
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Cdc42-mediated tubulogenesis controls cell specification
Kesavan, G., Sand, F. W., Greiner, T. U., Johansson, J. K., Kobberup, S., Wu, X., Brakebusch, Cord Herbert & Semb, Tor Henrik, 2009, In: Cell. 139, 4, p. 791-801 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Changes in dermal matrix in the absence of Rac1 in keratinocytes
Stanley, A., Pedersen, E. D. K., Brakebusch, Cord Herbert & Quondamatteo, F., May 2016, In: Journal of Anatomy. 228, 5, p. 826-37 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of TGF-β signaling in a human organotypic skin model reveals that loss of TGF-βRII induces invasive tissue growth
Ye, Z., Kilic, G., Dabelsteen, Sally, Marinova, I. N., Thøfner, J. F. B., Song, Ming, Levann, Asha Maria Rudjord, Bagdonaite, Ieva , Vakhrushev, Sergey, Brakebusch, Cord Herbert, Olsen, Jesper Velgaard & Wandall, Hans H., 2022, In: Science Signaling. 15, 761, eabo2206.Research output: Contribution to journal › Journal article › Research › peer-review
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Clonal reversal of ageing-associated stem cell lineage bias via a pluripotent intermediate
Wahlestedt, M., Erlandsson, E., Kristiansen, T., Lu, R., Brakebusch, Cord Herbert, Weissman, I. L., Yuan, J., Martin Gonzalez, Javier & Bryder, D., 22 Feb 2017, In: Nature Communications. 8, 8 p., 14533.Research output: Contribution to journal › Journal article › Research › peer-review
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Cofilin phosphorylation is elevated after F-actin disassembly induced by Rac1 depletion
Liu, L., Li, J., Zhang, L., Zhang, F., Zhang, R., Chen, X., Brakebusch, Cord Herbert, Wang, Z. & Liu, X., 27 Oct 2015, In: BioFactors (Oxford, England). 41, 5, p. 352-9 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Complementary roles of glycoprotein VI and alpha2beta1 integrin in collagen-induced thrombus formation in flowing whole blood ex vivo.
Kuijpers, M. J. E., Schulte, V., Bergmeier, W., Lindhout, T., Brakebusch, Cord Herbert, Offermanns, S., Fässler, R., Heemskerk, J. W. M. & Nieswandt, B., 2003, In: The FASEB Journal. 17, 6, p. 685-7 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Complementary signaling through flt3 and interleukin-7 receptor alpha is indispensable for fetal and adult B cell genesis.
Sitnicka, E., Brakebusch, Cord Herbert, Martensson, I., Svensson, M., Agace, W. W., Sigvardsson, M., Buza-Vidas, N., Bryder, D., Cilio, C. M., Ahlenius, H., Maraskovsky, E., Peschon, J. J. & Jacobsen, S. E. W., 2003, In: Journal of Experimental Medicine. 198, 10, p. 1495-506 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Conditional beta1-integrin gene deletion in neural crest cells causes severe developmental alterations of the peripheral nervous system.
Pietri, T., Eder, O., Breau, M. A., Topilko, P., Blanche, M., Brakebusch, Cord Herbert, Fässler, R., Thiery, J. & Dufour, S., 2004, In: Development. 131, 16, p. 3871-83 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Continuous cell injury promotes hepatic tumorigenesis in cdc42-deficient mouse liver.
van Hengel, J., D'Hooge, P., Hooghe, B., Wu, X., Libbrecht, L., De Vos, R., Quondamatteo, F., Klempt, M., Brakebusch, Cord Herbert & van Roy, F., 2008, In: Gastroenterology. 134, 3, p. 781-92 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Control of Homeostasis and Dendritic Cell Survival by the GTPase RhoA
Li, S., Dislich, B., Brakebusch, Cord Herbert, Lichtenthaler, S. F. & Brocker, T., 1 Nov 2015, In: Journal of immunology (Baltimore, Md. : 1950). 195, 9, p. 4244-56 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Control of cortical cytoskeleton-membrane interaction by RhoA regulates peripheral nerve myelination
Seixas, A. I., Morais, M. R. G., Brakebusch, Cord Herbert & Relvas, J. B., 2022, Cold Spring Harbor Laboratory, 15 p. (bioRxiv).Research output: Working paper › Preprint › Research
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Coordination by Cdc42 of Actin, Contractility, and Adhesion for Melanoblast Movement in Mouse Skin
Woodham, E. F., Paul, N. R., Tyrrell, B., Spence, H. J., Swaminathan, K., Scribner, M. R., Giampazolias, E., Hedley, A., Clark, W., Kage, F., Marston, D. J., Hahn, K. M., Tait, S. W. G., Larue, L., Brakebusch, Cord Herbert, Insall, R. H. & Machesky, L. M., 6 Mar 2017, In: Current biology : CB. 27, 5, p. 624-637 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Critical off-target effects of the widely used Rac1 inhibitors NSC23766 and EHT1864 in mouse platelets
Dütting, S., Heidenreich, J., Cherpokova, D., Amin, E., Zhang, S., Ahmadian, M. R., Brakebusch, Cord Herbert & Nieswandt, B., May 2015, In: Journal of Thrombosis and Haemostasis. 13, 5, p. 827-38 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cytoplasmic truncation of the p55 tumour necrosis factor (TNF) receptor abolishes signalling, but not induced shedding of the receptor.
Brakebusch, Cord Herbert, Nophar, Y., Kemper, O., Engelmann, H. & Wallach, D., 1992, In: EMBO Journal. 11, 3, p. 943-50 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cytoskeletal stability in the auditory organ in vivo: RhoA is dispensable for wound healing but essential for hair cell development
Anttonen, T., Belevich, I., Laos, M., Herranen, A., Jokitalo, E., Brakebusch, Cord Herbert & Pirvola, U., 2017, In: eNeuro. 4, 5, 17 p., e0149-17.2017.Research output: Contribution to journal › Journal article › Research › peer-review
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Defective endothelial cell migration in the absence of Cdc42 leads to capillary-venous malformations
Laviña, B., Castro, M., Niaudet, C., Cruys, B., Álvarez-Aznar, A., Carmeliet, P., Bentley, K., Brakebusch, Cord Herbert, Betsholtz, C. & Gaengel, K., 2 Jul 2018, In: Development (Cambridge, England). 145, 13, 20 p., dev161182.Research output: Contribution to journal › Journal article › Research › peer-review
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Defective tubulin organization and proplatelet formation in murine megakaryocytes lacking Rac1 and Cdc42
Pleines, I., Dütting, S., Cherpokova, D., Eckly, A., Meyer, I., Morowski, M., Krohne, G., Schulze, H., Gachet, C., Debili, N., Brakebusch, Cord Herbert & Nieswandt, B., 31 Oct 2013, In: Blood. 122, 18, p. 3178-87 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Differential effect on TCR:CD3 stimulation of a 90-kD glycoprotein (gp90/Mac-2BP), a member of the scavenger receptor cysteine-rich domain protein family.
Silvestri, B., Calderazzo, F., Coppola, V., Rosato, A., Iacobelli, S., Natoli, C., Ullrich, A., Sures, I., Azam, M., Brakebusch, Cord Herbert, Chieco-Bianchi, L. & Amadori, A., 1998, In: Clinical and Experimental Immunology. 113, 3, p. 394-400 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Discoidin domain receptor 1 is activated independently of beta(1) integrin.
Vogel, W., Brakebusch, Cord Herbert, Fässler, R., Alves, F., Ruggiero, F. & Pawson, T., 2000, In: Journal of Biological Chemistry. 275, 8, p. 5779-84 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Distinct roles for dystroglycan, beta1 integrin and perlecan in cell surface laminin organization.
Henry, M. D., Satz, J. S., Brakebusch, Cord Herbert, Costell, M., Gustafsson, E., Fässler, R. & Campbell, K. P., 2001, In: Journal of Cell Science. 114, Pt 6, p. 1137-44 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Divergent functions of the Rho GTPases Rac1 and Cdc42 in podocyte injury
Blattner, S. M., Hodgin, J. B., Nishio, M., Wylie, S. A., Saha, J., Soofi, A. A., Vining, C., Randolph, A., Herbach, N., Wanke, R., Atkins, K. B., Gyung Kang, H., Henger, A., Brakebusch, Cord Herbert, Holzman, L. B. & Kretzler, M., 15 May 2013, In: Kidney International.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dual role of the p75 tumor necrosis factor (TNF) receptor in TNF cytotoxicity.
Bigda, J., Beletsky, I., Brakebusch, Cord Herbert, Varfolomeev, Y., Engelmann, H., Bigda, J., Holtmann, H. & Wallach, D., 1994, In: Journal of Experimental Medicine. 180, 2, p. 445-60 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Embryonic Stem Cell Culture Conditions Support Distinct States Associated with Different Developmental Stages and Potency
Martin Gonzalez, Javier, Morgani, S. M., Bone, Robert Alexander, Bonderup, K., Abelechian, Sahar, Brakebusch, Cord Herbert & Brickman, Joshua Mark, 9 Aug 2016, In: Stem Cell Reports. 7, 2, p. 177-91 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation
Li, H., Yao, Q., Mariscal, A. G., Wu, X., Hülse, J., Pedersen, E., Helin, K., Waisman, A., Vinkel, C., Thomsen, Simon Francis, Avgustinova, A., Benitah, S. A., Lovato, P., Norsgaard, H., Mortensen, M. S., Veng, L., Rozell, B. & Brakebusch, Cord Herbert, 2018, In: Nature Communications. 9, 1, p. 1-18 18 p., 1420.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Epithelial RAC1-dependent cytoskeleton dynamics controls cell mechanics, cell shedding and barrier integrity in intestinal inflammation
Martínez-Sánchez, L. D. C., Ngo, P. A., Pradhan, R., Becker, L-S., Boehringer, D., Soteriou, D., Kubankova, M., Schweitzer, C., Koch, T., Thonn, V., Erkert, L., Stolzer, I., Günther, C., Becker, C., Weigmann, B., Klewer, M., Daniel, C., Amann, K., Tenzer, S., Atreya, R. & 8 others, , 2023, In: Gut. 72, 2, p. 275-294 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development.
Benninger, Y., Thurnherr, T., Pereira, J. A., Krause, S., Wu, X., Chrostek-Grashoff, A., Herzog, D., Nave, K., Franklin, R. J. M., Meijer, D., Brakebusch, Cord Herbert, Suter, U. & Relvas, J. B., 2007, In: Journal of Cell Biology. 177, 6, p. 1051-61 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Expression and cytoprotective activity of the small GTPase RhoB induced by the Escherichia coli cytotoxic necrotizing factor 1
Huelsenbeck, S. C., Roggenkamp, D., May, M., Huelsenbeck, J., Brakebusch, Cord Herbert, Rottner, K., Ladwein, M., Just, I., Fritz, G., Schmidt, G. & Genth, H., Aug 2013, In: International Journal of Biochemistry & Cell Biology. 45, 8, p. 1767-75 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Expression of the 90K immunostimulator gene is controlled by a promoter with unique features.
Brakebusch, Cord Herbert, Jallal, B., Fusco, O., Iacobelli, S. & Ullrich, A., 1997, In: Journal of Biological Chemistry. 272, 6, p. 3674-82 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
FMNL formins boost lamellipodial force generation
Kage, F., Winterhoff, M., Dimchev, V., Mueller, J., Thalheim, T., Freise, A., Brühmann, S., Kollasser, J., Block, J., Dimchev, G. A., Geyer, M., Schnittler, H., Brakebusch, Cord Herbert, Stradal, T. E. B., Carlier, M., Sixt, M., Käs, J., Faix, J. & Rottner, K., 22 Mar 2017, In: Nature Communications. 8, 16 p., 14832.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
FMNL2 and -3 regulate Golgi architecture and anterograde transport downstream of Cdc42
Kage, F., Steffen, A., Ellinger, A., Ranftler, C., Gehre, C., Brakebusch, Cord Herbert, Pavelka, M., Stradal, T. & Rottner, K., 1 Dec 2017, In: Scientific Reports. 7, 1, 17 p., 9791.Research output: Contribution to journal › Journal article › Research › peer-review
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FMNL2 drives actin-based protrusion and migration downstream of Cdc42
Block, J., Breitsprecher, D., Kühn, S., Winterhoff, M., Kage, F., Geffers, R., Duwe, P., Rohn, J. L., Baum, B., Brakebusch, Cord Herbert, Geyer, M., Stradal, T. E. B., Faix, J. & Rottner, K., 5 Jun 2012, In: Current Biology. 22, 11, p. 1005-12 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Fetal and adult hematopoietic stem cells require beta1 integrin function for colonizing fetal liver, spleen, and bone marrow.
Potocnik, A. J., Brakebusch, Cord Herbert & Fässler, R., 2000, In: Immunity. 12, 6, p. 653-63 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Functional consequences of integrin gene mutations in mice.
Bouvard, D., Brakebusch, Cord Herbert, Gustafsson, E., Aszódi, A., Bengtsson, T., Berna, A. & Fässler, R., 2001, In: Circulation Research. 89, 3, p. 211-23 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Functional discrepancies between tumor necrosis factor and lymphotoxin alpha explained by trimer stability and distinct receptor interactions.
Schuchmann, M., Hess, S., Bufler, P., Brakebusch, Cord Herbert, Wallach, D., Porter, A., Riethmüller, G. & Engelmann, H., 1995, In: European Journal of Immunology. 25, 8, p. 2183-9 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon.
Altrock, W. D., tom Dieck, S., Sokolov, M., Meyer, A. C., Sigler, A., Brakebusch, C., Fässler, R., Richter, K., Boeckers, T. M., Potschka, H., Brandt, C., Löscher, W., Grimberg, D., Dresbach, T., Hempelmann, A., Hassan, H., Balschun, D., Frey, J. U., Brandstätter, J. H., Garner, C. C. & 2 others, , 2003, In: Neuron. 37, 5, p. 787-800 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functions of Rac1 in the epidermis
Haase, I. & Brakebusch, Cord Herbert, 2008, In: Journal of Investigative Dermatology. 128, Suppl. 1Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Generation and analysis of genetically modified mice
Brakebusch, Cord Herbert, 2011, Handbook of Laboratory Animal Science: Essential Principles and Practices. Hau, J. & Schapiro, SJ. (eds.). 3rd ed. Boca Raton, London, New York: CRC Press, Vol. 1.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Genetic analysis of beta1 integrin "activation motifs" in mice.
Czuchra, A., Meyer, H., Legate, K. R., Brakebusch, Cord Herbert & Fässler, R., 2006, In: Journal of Cell Biology. 174, 6, p. 889-99 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic analysis of beta1 integrin function: confirmed, new and revised roles for a crucial family of cell adhesion molecules.
Brakebusch, Cord Herbert, Hirsch, E., Potocnik, A. & Fässler, R., 1997, In: Journal of Cell Science. 110 ( Pt 23), p. 2895-904 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic deletion of cdc42 reveals a crucial role for astrocyte recruitment to the injury site in vitro and in vivo
Robel, S., Bardehle, S., Lepier, A., Brakebusch, Cord Herbert & Götz, M., 31 Aug 2011, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 31, 35, p. 12471-82 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genetically Modified Mice in Medical and Pharmaceutical Research
Brakebusch, Cord Herbert, 5 Feb 2008, Modern Biopharmaceuticals: Design, Development and Optimization. Wiley-VCH, Vol. 2. p. 649-660 12 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen.
Nieswandt, B., Brakebusch, Cord Herbert, Bergmeier, W., Schulte, V., Bouvard, D., Mokhtari-Nejad, R., Lindhout, T., Heemskerk, J. W., Zirngibl, H. & Fässler, R., 2001, In: EMBO Journal. 20, 9, p. 2120-30 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatocyte dysplasia and tumor nodule formation in CDC42-deficient mouse liver
Hengel, J. V., D'Hooge, P., Wu, X. W., Libbrecht, L., Vos, R. D., Brakebusch, Cord Herbert & Roy, F. V., 2008, In: Acta Clinica Belgica. 63, 1, p. 56-56Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatocyte-specific deletion of Cdc42 results in delayed liver regeneration after partial hepatectomy in mice
Yuan, H., Zhang, H., Wu, X., Zhang, Z., Du, D., Zhou, W., Zhou, S., Brakebusch, Cord Herbert & Chen, Z., 2009, In: Hepatology. 49, 1, p. 240-9 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
How to Bury the Dead: Elimination of Apoptotic Hair Cells from the Hearing Organ of the Mouse
Anttonen, T., Belevich, I., Kirjavainen, A., Laos, M., Brakebusch, Cord Herbert, Jokitalo, E. & Pirvola, U., 30 Jul 2014, In: J A R O. 15, 6, p. 975-992 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
INFRAFRONTIER-providing mutant mouse resources as research tools for the international scientific community
Meehan, T. F., Chen, C. K., Koscielny, G., Relac, M., Wilkinson, P., Flicek, P., Parkinson, H., Bottomley, J., Ramirez-Solis, R., Smedley, D., Castro, A., Fessele, S., Steinkamp, R., Hagn, M., Raess, M., De Angelis, M. H., Ball, S., Blake, A., Fray, M., Kenyon, J. & 23 others, , 28 Jan 2015, In: Nucleic Acids Research. 43, D1, p. D1171-D1175Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impaired epidermal wound healing in vivo upon inhibition or deletion of Rac1.
Tscharntke, M., Pofahl, R., Chrostek-Grashoff, A., Smyth, N., Niessen, C., Niemann, C., Hartwig, B., Herzog, V., Klein, H. W., Krieg, T., Brakebusch, Cord Herbert & Haase, I., 2007, In: Journal of Cell Science. 120, Pt 8, p. 1480-90 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Improving Precise CRISPR Genome Editing by Small Molecules: Is there a Magic Potion?
Bischoff, N., Wimberger, S., Maresca, M. & Brakebusch, Cord Herbert, 2020, In: Cells. 9, 5Research output: Contribution to journal › Review › Research › peer-review
- Published
Increased levels of apoptosis in the prefusion neural folds underlie the craniofacial disorder, Treacher Collins syndrome.
Dixon, J., Brakebusch, Cord Herbert, Fässler, R. & Dixon, M. J., 2000, In: Human Molecular Genetics. 9, 10, p. 1473-80 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Induction of cell scattering by expression of beta1 integrins in beta1-deficient epithelial cells requires activation of members of the rho family of GTPases and downregulation of cadherin and catenin function.
Gimond, C., van Der Flier, A., van Delft, S., Brakebusch, Cord Herbert, Kuikman, I., Collard, J. G., Fässler, R. & Sonnenberg, A., 1999, In: Journal of Cell Biology. 147, 6, p. 1325-40 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inhibiting PGGT1B Disrupts Function of RHOA, Resulting in T-cell Expression of Integrin α4β7 and Development of Colitis in Mice
López-Posadas, R., Fastancz, P., Martínez-Sánchez, L. D. C., Panteleev-Ivlev, J., Thonn, V., Kisseleva, T., Becker, L. S., Schulz-Kuhnt, A., Zundler, S., Wirtz, S., Atreya, R., Carlé, B., Friedrich, O., Schürmann, S., Waldner, M. J., Neufert, C., Brakebusch, Cord Herbert, Bergö, M. O., Neurath, M. F. & Atreya, I., Nov 2019, In: Gastroenterology. 157, 5, p. 1293-1309 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
Integrin blockade as therapy in chronic inflammation
Brakebusch, Cord Herbert, 1 May 2005, In: Experimental Dermatology. 14, 5, 1 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
Integrin gene targeting.
Talts, J. F., Brakebusch, Cord Herbert & Fässler, R., 1999, In: Methods in Molecular Biology. 129, p. 153-87 34 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Integrins in invasive growth.
Brakebusch, Cord Herbert, Bouvard, D., Stanchi, F., Sakai, T. & Fässler, R., 2002, In: Journal of Clinical Investigation. 109, 8, p. 999-1006 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interactions of the integrin subunit beta1A with protein kinase B/Akt, p130Cas and paxillin contribute to regulation of radiation survival.
Seidler, J., Durzok, R., Brakebusch, Cord Herbert & Cordes, N., 2005, In: Radiotherapy & Oncology. 76, 2, p. 129-34 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Isolation and functional characterization of the human 90K promoter.
Brakebusch, Cord Herbert, Sures, I., Jallal, B., Mossie, K., Fusco, O., Iacobelli, S. & Ullrich, A., 1999, In: Genomics. 57, 2, p. 268-78 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 5296
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Embryonic Stem Cell Culture Conditions Support Distinct States Associated with Different Developmental Stages and Potency
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
205
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Inhibiting PGGT1B Disrupts Function of RHOA, Resulting in T-cell Expression of Integrin α4β7 and Development of Colitis in Mice
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
197
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The Interaction between Laminin-332 and α3β1 Integrin Determines Differentiation and Maintenance of CAFs, and Supports Invasion of Pancreatic Duct Adenocarcinoma Cells
Research output: Contribution to journal › Journal article › Research › peer-review
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