Arne Schousboe
Professor, emeritus
Molecular and Cellular Pharmacology
Jagtvej 160
2100 København Ø
- Published
(1S, 3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a potent gamma-aminobutyric acid aminotransferase inactivator for the treatment of cocaine addiction
Pan, Y., Gerasimov, M. R., Kvist, T., Wellendorph, Petrine, Madsen, K. K., Pera, E., Lee, H., Schousboe, Arne, Chebib, M., Bräuner, Hans, Craft, C. M., Brodie, J. D., Schiffer, W. K., Dewey, S. L., Miller, S. R. & Silverman, R. B., 1 Jan 2012, In: Journal of Medicinal Chemistry. 55, 1, p. 357-366Research output: Contribution to journal › Journal article › Research › peer-review
- Published
13C NMR spectroscopy and mass spectrometry analysis of intermediary metabolism in cultured neural cells
Sonnewald, U., Schousboe, Arne & Waagepetersen, Helle S., 18 Mar 2011, Cell Culture Techniques. Aschner, M., Sunol, C. & Bal-Price, A. (eds.). p. 403-415 13 p. (Neuromethods, Vol. 56).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. Structure-activity relationships and identification of potent and selective iGluR5 modulators
Butini, S., Pickering, Darryl S, Morelli, E., Coccone, S. S., Trotta, F., De Angelis, M., Guarino, E., Fiorini, I., Campiani, G., Novellino, E., Schousboe, Arne, Christensen, J. K. & Gemma, S., 2008, In: Journal of Medicinal Chemistry. 51, 20, p. 6614-8Research output: Contribution to journal › Journal article › Research › peer-review
- Published
3H-D-aspartate release from cerebellar granule neurons is differentially regulated by glutamate- and K(+)-stimulation
Belhage, B., Rehder, V., Hansen, Gert Helge, Kater, S. B. & Schousboe, Arne, 1992, In: Journal of Neuroscience Research. 33, 3, p. 436-44 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
40 year anniversary issue of neurochemical research
Schousboe, Arne, 2016, In: Neurochemical Research. 41, 1-2, p. 1-2 2 p.Research output: Contribution to journal › Editorial › Research
- Published
A Tribute to Mary C. McKenna: Glutamate as Energy Substrate and Neurotransmitter-Functional Interaction Between Neurons and Astrocytes
Schousboe, Arne, Jan 2017, In: Neurochemical Research. 42, 1, p. 4-9 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A functioning glycolysis is important for maintenance of glutamate transport in cultured astrocytes
Schousboe, Arne, Sickmann, H. M., Bak, Lasse Kristoffer, Schousboe, I., Bouman, S. D. & Waagepetersen, Helle S., 2010, In: Journal of Neurochemistry. s1, p. 288-289Research output: Contribution to journal › Conference abstract in journal › Research
- Published
A novel selective γ-aminobutyric acid transport inhibitor demonstrates a functional role for GABA transporter subtype GAT2/BGT-1 in the CNS
Frølund, Bente, Clausen, Rasmus Prætorius, Larsson, O. M., Schousboe, Arne, Krogsgaard-Larsen, Povl & White, H. S., 2006, In: Neurochemistry International. 48, p. 637–642Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A possible role of the non-GAT1 GABA transporters in transfer of GABA from GABAergic to glutamatergic neurons in mouse cerebellar neuronal cultures
Suñol, C., Babot, Z., Cristòfol, R., Sonnewald, U., Waagepetersen, Helle S. & Schousboe, Arne, Sep 2010, In: Neurochemical Research. 35, 9, p. 1384-1390 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A single glycine residue at the entrance to the first membrane-spanning domain of the γ-aminobutyric acid type a receptor β2 subunit affects allosteric sensitivity to GABA and anesthetics
Carlson, B. X., Engblom, A. C., Kristiansen, Uffe, Schousboe, Arne & Olsen, R. W., 2000, In: Molecular Pharmacology. 57, 3, p. 474-484 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A subconvulsive dose of kainate selectively compromises astrocytic metabolism in the mouse brain in vivo
Walls, Anne Byriel, Eyjolfsson, E. M., Schousboe, Arne, Sonnewald, U. & Waagepetersen, Helle S., Aug 2014, In: Journal of Cerebral Blood Flow and Metabolism. 34, 8, p. 1340-6 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Accepted/In press
A tribute to Leif Hertz: The historical context of his pioneering studies of the roles of astrocytes in brain energy metabolism, neurotransmission, cognitive functions, and pharmacology identifies important, unresolved topics for future studies
Dienel, G. A., Schousboe, Arne, McKenna, M. C. & Rothman, D. L., 2023, (Accepted/In press) In: Journal of Neurochemistry.Research output: Contribution to journal › Review › Research › peer-review
- Published
AMPA receptor mediated excitotoxicity in neocortical neurons is developmentally regulated and dependent upon receptor desensitization
Jensen, J. B., Schousboe, Arne, Pickering, Darryl S & Pickering, Darryl S, 1998, In: Neurochemistry International. 32, 5-6, p. 505-13 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
AMPK Activation Affects Glutamate Metabolism in Astrocytes
Voss, C. M., Pajęcka, K., Stridh, M. H., Nissen, J. D., Schousboe, Arne & Waagepetersen, Helle S., 7 Apr 2015, In: Neurochemical Research. 40, 12, p. 2431-2442 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Action of bicyclic isoxazole GABA analogues on GABA transporters and its relation to anticonvulsant activity
Bolvig, T., Larsson, O. M., Pickering, Darryl S, Nelson, N., Falch, E., Krogsgaard-Larsen, Povl, Schousboe, Arne & Pickering, Darryl S, 1999, In: European Journal of Pharmacology. 375, 1-3, p. 367-74 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Actions of toxins on cerebral metabolism at cellular level
Sonnewald, U., Syversen, T., Schousboe, Arne, Waagepetersen, Helle S. & Aschner, M., 2007, Handbook of Neurochemistry and Molecular Neurobiology: Brain Energetics. Integration of Molecular and Cellular Processes. Lajtha, A., Gibson, G. E. & Dienel, G. A. (eds.). 3rd. ed. ed. Berlin: Springer, Vol. 3. p. 569-585Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Activity of the lactate-alanine shuttle is independent of glutamate-glutamine cycle activity in cerebellar neuronal-astrocytic cultures
Bak, Lasse Kristoffer, Sickmann, H. M., Schousboe, Arne & Waagepetersen, Helle S., 4 Dec 2004, In: Journal of Neuroscience Research. 79, 1-2, p. 88-96 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Agonist discrimination between AMPA receptor subtypes
Coquelle, T., Christensen, J. K., Banke, T. G., Madsen, U., Schousboe, Arne & Pickering, Darryl S, 2000, In: NeuroReport. 11, 12, p. 2643-8 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Amino acid neurotransmitter synthesis and removal
Schousboe, Arne, Bak, Lasse Kristoffer, Madsen, K. K. & Waagepetersen, Helle S., 2013, Neuroglia. Kettenman, H. & Ransom, B. R. (eds.). 3. ed. Oxford: Oxford University Press, p. 443-456 14 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Amino acids: Glutamate dehydrogenase: An anaplerotic enzyme in neurons and an energy producing enzyme in astrocytes
Schousboe, Arne & Aldana, Blanca, 29 Jul 2021, Encyclopedia of Biological Chemistry: Third Edition. Elsevier, Vol. 1. p. 51-55 5 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Among the branched-chain amino acids, only valine metabolism is up-regulated in astrocytes during glutamate exposure
Bak, Lasse Kristoffer, Johansen, M. L., Schousboe, Arne & Waagepetersen, Helle S., 2007, In: Journal of Neuroscience Research. 86, p. 3465-3470Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Anaplerosis for Glutamate Synthesis in the Neonate and in Adulthood
Brekke, E., Morken, T. S., Walls, Anne Byriel, Waagepetersen, Helle S., Schousboe, Arne & Sonnewald, U., 2016, The Glutamate/ GABA- Glutamine Cycle : Amino Acid Neurotransmitter Homeostasis. Springer, Vol. 13. p. 43-58 16 p. (Advances in Neurobiology, Vol. 13).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Aspartate-glutamate homeostasis in cerebellar neurons changes when shifting from glucose to beta-hydroxybutyrate as substrate
Lund, Trine Meldgaard, Clausen, M., Risa, Ø., Sonnewald, U., Schousboe, Arne & Waagepetersen, Helle S., 2009, In: Journal of Neurochemistry. s1, p. 291-291Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Aspects of astrocyte energy metabolism, amino acid neurotransmitter homoeostasis and metabolic compartmentation
Kreft, M., Bak, Lasse Kristoffer, Waagepetersen, Helle S. & Schousboe, Arne, 2012, In: A S N Neuro. 4, 3, p. 187 199 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Astrocyte energy and neurotransmitter metabolism in Alzheimer's disease: Integration of the glutamate/GABA-glutamine cycle
Andersen, Jens Velde, Schousboe, Arne & Verkhratsky, A., 2022, In: Progress in Neurobiology. 217, 24 p., 102331.Research output: Contribution to journal › Review › Research › peer-review
- Published
Astrocyte glycogen metabolism is required for neural activity during aglycemia or intense stimulation in mouse white matter
Brown, A. M., Sickmann, H. M., Fosgerau, K., Lund, Trine Meldgaard, Schousboe, Arne, Waagepetersen, Helle S. & Ransom, B. R., 2005, In: Journal of Neuroscience Research. 79, 1-2, p. 74-80 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Astrocyte glycogenolysis is triggered by store-operated calcium entry and provides metabolic energy for cellular calcium homeostasis
Müller, M. S., Fox, R., Schousboe, Arne, Waagepetersen, Helle S. & Bak, Lasse Kristoffer, Apr 2014, In: Glia. 62, 4, p. 526-34 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Astrocytes regulate inhibitory neurotransmission through GABA uptake, metabolism, and recycling
Andersen, Jens Velde, Schousboe, Arne & Wellendorph, Petrine, 2023, In: Essays in Biochemistry. 67, 1, p. 77-91Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Astrocytic GABA Transporters: Pharmacological Properties and Targets for Antiepileptic Drugs
Schousboe, Arne, Wellendorph, Petrine, Frølund, Bente, Clausen, Rasmus Prætorius & Krogsgaard-Larsen, Povl, 2017, Glial Amino Acid Transporters. Springer, Vol. 16. p. 283-296 14 p. (Advances in Neurobiology).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication
- Published
Astrocytic Metabolism Focusing on Glutamate Homeostasis: A Short Review Dedicated to Vittorio Gallo
Schousboe, Arne, 2020, In: Neurochemical Research. 45, 3, p. 522-525Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Astrocytic control of biosynthesis and turnover of the neurotransmitters glutamate and GABA
Schousboe, Arne, Bak, Lasse Kristoffer & Waagepetersen, Helle S., 15 Aug 2013, In: Frontiers in Endocrinology. 4, 102.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Astrocytic glycogen metabolism in the healthy and diseased brain
Bak, Lasse Kristoffer, Walls, Anne Byriel, Schousboe, Arne & Waagepetersen, Helle S., 11 May 2018, In: The Journal of Biological Chemistry. 293, 19, p. 7108-7116 9 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Astrocytic pyruvate carboxylation: Status after 35 years
Schousboe, Arne, Waagepetersen, Helle S. & Sonnewald, U., 1 Jan 2019, In: Journal of Neuroscience Research. 97, p. 890-896Research output: Contribution to journal › Review › Research › peer-review
- Published
Availability of neurotransmitter glutamate is diminished when beta-hydroxybutyrate replaces glucose in cultured neurons
Lund, Trine Meldgaard, Risa, Ø., Sonnewald, U., Schousboe, Arne & Waagepetersen, Helle S., 2009, In: Journal of Neurochemistry. 110, 1, p. 80-91 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Brain alanine formation as an ammonia-scavenging pathway during hyperammonemia: effects of glutamine synthetase inhibition in rats and astrocyte-neuron co-cultures
Dadsetan, S., Kukolj, E., Bak, Lasse Kristoffer, Sørensen, M., Ott, P., Vilstrup, H., Schousboe, Arne, Keiding, S. & Waagepetersen, Helle S., Aug 2013, In: Journal of Cerebral Blood Flow and Metabolism. 33, 8, p. 1235-41 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Brain energy and ammonia metabolism
Bak, Lasse Kristoffer, Schousboe, Arne & Waagepetersen, Helle S., 2012, Functional molecular imaging in hepatology. Bentham Science Publishers, Vol. 1. p. 129-144 16 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Brain energy and ammonia metabolism
Bak, Lasse Kristoffer, Waagepetersen, Helle S. & Schousboe, Arne, 2011, Functional molecular imaging in hepatology. Bussum, The Netherlands: Bentham Science Publishers, p. 129-144Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Brain glycogen: new perspectives on its metabolic function and regulation at the subcellular level
Obel, L. L. F., Müller, M. S., Walls, Anne Byriel, Sickmann, H. M., Bak, Lasse Kristoffer, Waagepetersen, Helle S. & Schousboe, Arne, 2 Mar 2012, In: Frontiers in Neuroenergetics. 4, 15 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Brain glycogen and its role in supporting glutamate and GABA homeostasis in a type 2 diabetes rat model
Sickmann, H. M., Waagepetersen, Helle S., Schousboe, Arne, Benie, A. J. & Bouman, S. D., 2012, In: Neurochemistry International. 60, 3, p. 267-75 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Brain glycogen: emergency fuel and dynamic function in neurotransmission
Walls, Anne Byriel & Schousboe, Arne, Feb 2015, In: Metabolic Brain Disease. 30, 1, p. 249-249 1 p.Research output: Contribution to journal › Journal article › Research
- Published
Branched-chain amino acids increase arterial blood ammonia in spite of enhanced intrinsic muscle ammonia metabolism in patients with cirrhosis and healthy subjects
Dam, G., Keiding, S., Munk, O. L., Ott, P., Buhl, M., Vilstrup, H., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Schousboe, Arne, Møller, N. & Sørensen, M., 1 Aug 2011, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 301, 2, p. G269-77Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cell proliferation, migration and CAM-dependent neurite outgrowth as developmental in vitro endpoints for screening teratogenic potential: Application to valproic acid and related analogues of .....
Bacon, C. L., Berezin, V., Bode, G., Bock, E., Bojic, U., Doherty, P., Edvardsen, K., Ehlers, K., Ellerbeck, U., Julien, P., Kawa, A., Maar, T., Nau, H., Pirovano, R., Regan, C., Schousboe, Arne, Spezia, F., Walsh, F. S. & Williams, E. J., 1998, In: Toxicology in Vitro. 12, p. 101-109Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of 1,4-dideoxy-1,4-imino-d-arabinitol (DAB) as an inhibitor of brain glycogen shunt activity
Walls, Anne Byriel, Sickmann, H. M., Brown, A., Bouman, S. D., Ransom, B., Schousboe, Arne & Waagepetersen, Helle S., 2008, In: Journal of Neurochemistry. 105, p. 1462-1470Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of NCAM diversity in cultured neurons
Gegelashvili, G., Andersson, A., Schousboe, Arne & Bock, E., 1993, In: FEBS Letters. 324, p. 337-340Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of depolarization-coupled release of glutamate from cultured mouse cerebellar granule cells using DL-threo-beta-benzyloxyaspartate (DL-TBOA) to distinguish between the vesicular and cytoplasmic pools
Bak, Lasse Kristoffer, Schousboe, Arne & Waagepetersen, Helle S., 14 May 2003, In: Neurochemistry International. 43, 4-5, p. 417-24 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of glutamate-induced formation of N- acylphosphatidylethanolamine and N-acylethanolamine in cultured neocortical neurons
Hansen, Harald S., Lauritzen, Lotte, Strand, A. M., Vinggaard, A. M., Frandsen, Aase & Schousboe, Arne, 1 Aug 1997, In: Journal of Neurochemistry. 69, 2, p. 753-761 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of microwell cultures of dissociated brain tissue for studies of cell-cell interactions
Maar, T. E., Rønn, L. C. B., Bock, E., Berezin, V., Moran, J., Pasantes-Moralez, H. & Schousboe, Arne, 1997, In: Journal of Neuroscience Research. 47, p. 163-172Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of primary and secondary cultures of astrocytes prepared from mouse cerebral cortex
Jensen, Dorte Skytt, Madsen, K. K., Pajecka, K., Schousboe, Arne & Waagepetersen, Helle S., 2010, In: Neurochemical Research. 35, 12, p. 2043-2052 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of the 1H-cyclopentapyrimidine-2,4(1H,3H)-dione derivative (S)-CPW399 as a novel, potent, and subtype-selective AMPA receptor full agonist with partial desensitization properties
Campiani, G., Morelli, E., Nacci, V., Fattorusso, C., Ramunno, A., Novellino, E., Greenwood, J., Liljefors, T., Griffiths, R., Sinclair, C., Reavy, H., Kristensen, A. S., Pickering, Darryl S, Schousboe, Arne, Cagnotto, A., Fumagalli, E., Mennini, T. & Pickering, Darryl S, 2001, In: Journal of Medicinal Chemistry. 44, 26, p. 4501-4 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Citrate, a Ubiquitous Key Metabolite with Regulatory Function in the CNS
Westergaard, N., Waagepetersen, Helle S., Belhage, B. & Schousboe, Arne, Jun 2017, In: Neurochemical Research. 42, 6, p. 1583-1588 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 1300836
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Astrocytic pyruvate carboxylation: Status after 35 years
Research output: Contribution to journal › Review › Research › peer-review
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115
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Deficient astrocyte metabolism impairs glutamine synthesis and neurotransmitter homeostasis in a mouse model of Alzheimer's disease
Research output: Contribution to journal › Journal article › Research › peer-review
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114
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The 13th International Conference on Brain Energy Metabolism: "How Metabolism Dictates Neurotransmission, Function and Behavior"
Research output: Contribution to journal › Journal article › Research
Published