Kristian Strømgaard

Kristian Strømgaard

Professor

ORCID: 0000-0003-2206-4737

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  1. Published

    Interaction of antidepressants with the serotonin and norepinephrine transporters: mutational studies of the S1 substrate binding pocket

    Sørensen, L., Andersen, J., Thomsen, M., Hansen, S. M. R., Zhao, X., Sandelin, Albin Gustav, Strømgaard, Kristian & Kristensen, Anders Skov, 2012, In: The Journal of Biological Chemistry. 287, 52, p. 43694-43707 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Interaction of antidepressants with the serotonin and norepinephrine transporters: mutational studies of the S1 substrate binding pocket

    Sørensen, L., Andersen, J., Thomsen, M., Hansen, S. M. R., Zhao, X., Sandelin, Albin Gustav, Strømgaard, Kristian & Kristensen, Anders Skov, 2012, In: Journal of Biological Chemistry. 287, p. 43694-43707 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Inhibition of AMPA Receptors by Polyamine Toxins is Regulated by Agonist Efficacy and Stargazin

    Poulsen, Mette Homann, Lucas, S., Strømgaard, Kristian & Kristensen, Anders Skov, 22 Feb 2014, In: Neurochemical Research. 39, 10, p. 1906-1913 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Improving the stability of alpha-conotoxin AuIB through N-to-C cyclization: The effect of linker length on stability and activity at nicotinic acetylcholine receptors

    Armishaw, C. J., Jensen, Anders A., Balle, L. D., Scott, K. C. M., Sørensen, L. & Strømgaard, Kristian, 2011, In: Antioxidants & Redox Signaling. 14, 1, p. 65-76

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Importance of the Extracellular Loop 4 in the Human Serotonin Transporter for Inhibitor Binding and Substrate Translocation

    Rannversson, H., Wilson, P., Kristensen, K. B., Sinning, S., Kristensen, Anders Skov, Strømgaard, Kristian & Andersen, J., 5 Jun 2015, In: The Journal of Biological Chemistry. 290, 23, p. 14582-94 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Importance of a Conserved Lys/Arg Residue for Ligand/PDZ Domain Interactions as Examined by Protein Semisynthesis

    Pedersen, S. W., Moran, G. E., Sereikaité, Vita, Kedström, L. M. H. & Strømgaard, Kristian, 17 Oct 2016, In: ChemBioChem. 17, 20, p. 1936-1944 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD

    Thorsen, T. S., Madsen, Kenneth Lindegaard, Rebola, N., Rathje, Mette, Anggono, V., Bach, Anders, Moreira, I. S., Stuhr-Hansen, N., Dyhring, T., Peters, D., Beuming, T., Huganir, R., Weinstein, H., Mulle, C., Strømgaard, Kristian, Rønn, L. C. B. & Gether, Ulrik, 2010, In: Proceedings of the National Academy of Science of the United States of America. 107, 1, p. 413-8 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Identification of GDF15 peptide fragments inhibiting GFRAL receptor signaling

    Alexopoulou, Flora, Buch-Månson, N., Pedersen, S. L., Vrang, N., Fink, L. N. & Strømgaard, Kristian, 2023, In: Peptides. 168, 7 p., 171063.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Identification and characterization of a small-molecule inhibitor of death-associated protein kinase 1

    Wilbek, T. S., Skovgaard, T., Sorrell, F. J., Knapp, S., Berthelsen, J. & Strømgaard, Kristian, 2 Jan 2015, In: ChemBioChem. 16, 1, p. 59-63 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Human Fibrinogen Inhibits Amyloid Assembly of Most Phenol-Soluble Modulins from Staphylococcus aureus

    Najarzadeh, Z., Nielsen, J., Farzadfard, A., Sereikaité, Vita, Strømgaard, Kristian, Meyer, R. L. & Otzen, D. E., 2021, In: ACS Omega. 6, 34, p. 21960-21970

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Submitted

    High-affinity, dimeric inhibitors of PSD-95 as efficient neuroprotectants against ischemic brain damage and for treatment of pain

    Bach, Anders & Strømgaard, Kristian, 2012, (Submitted) Patent No. WO2012/156308 (Granted: EP2707014B1; US9139615B2)

    Research output: Patent

  12. Published

    Heterotrimeric G Proteins as Therapeutic Targets in Drug Discovery

    Li, J., Ge, Y., Huang, J., Strømgaard, Kristian, Zhang, X. & Xiong, X., 2020, In: Journal of Medicinal Chemistry. 63, 10, p. 5013-5030 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Heparin promotes fibrillation of most phenol-soluble modulin virulence peptides from Staphylococcus aureus

    Najarzadeh, Z., Zaman, M., Sereikaité, Vita, Strømgaard, Kristian, Andreasen, M. & Otzen, D. E., 2021, In: Journal of Biological Chemistry. 297, 2, 14 p., 100953.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Ginkgolides and glycine receptors: a structure-activity relationship study

    Jaracz, S., Nakanishi, K., Jensen, Anders A. & Strømgaard, Kristian, 2004, In: Chemistry: A European Journal. 10, 6, p. 1507-18 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Ginkgolides: selective acetylations, translactonization, and biological evaluation

    Jaracz, S., Strømgaard, Kristian & Nakanishi, K., 28 Jun 2002, In: Journal of Organic Chemistry. 67, 13, p. 4623-4626 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Ginkgolide derivatives for photolabeling studies: preparation and pharmacological evaluation

    Strømgaard, Kristian, Saito, D. R., Shindou, H., Ishii, S., Shimizu, T. & Nakanishi, K., 29 Aug 2002, In: Journal of Medicinal Chemistry. 45, 18, p. 4038-4046 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Giftstoffer fra hvepse og edderkopper i forskning og lægemiddeludvikling

    Strømgaard, Kristian, 2008, In: Carlsbergfondet. Aarsskrift. p. 42-47

    Research output: Contribution to journal › Journal article › Communication

  18. Published

    Gephyrin-binding peptides visualize postsynaptic sites and modulate neurotransmission

    Maric, H. M., Hausrat, T. J., Neubert, F., Dalby, N. O., Doose, S., Sauer, M., Kneussel, M. & Strømgaard, Kristian, 2017, In: Nature Chemical Biology. 13, p. 153-160 11 p., 2246.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Genetically encoded photocrosslinkers locate the high-affinity binding site of antidepressant drugs in the human serotonin transporter

    Rannversson, H., Andersen, J., Hall, L. S., Bang-Andersen, B., Park, M., Huber, T., Sakmar, T. P. & Strømgaard, Kristian, 19 Apr 2016, In: Nature Communications. 7, p. 1-9 9 p., 11261.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    General synthesis of β-alanine-containing spider polyamine toxins and discovery of nephila polyamine toxins 1 and 8 as highly potent inhibitors of ionotropic glutamate receptors

    Lucas, S., Poulsen, Mette Homann, Nørager, N. G., Barslund, A. F., Bach, T. B., Kristensen, Anders Skov & Strømgaard, Kristian, 26 Nov 2012, In: Journal of Medicinal Chemistry. 55, 22, p. 10297-10301 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    GLP-1-directed NMDA receptor antagonism for obesity treatment

    Petersen, J., Ludwig, M. Q., Juozaityte, V., Ranea-Robles, P., Svendsen, C., Hwang, E., Kristensen, A. W., Fadahunsi, N., Lund, J., Breum, A. W., Mathiesen, C. V., Sachs, L., Moreno-Justicia, R., Rohlfs, R., Ford, J. C., Douros, J. D., Finan, B., Portillo, B., Grose, K., Petersen, J. E. & 13 others, Trauelsen, Mette, Feuchtinger, A., DiMarchi, R. D., Schwartz, Thue W., Deshmukh, Atul Shahaji, Thomsen, Morten Bækgaard, Kohlmeier, Kristi Anne, Williams, K. W., Pers, Tune H, Frølund, Bente, Strømgaard, Kristian, Klein, A. B. & Clemmensen, Christoffer, 2024, In: Nature. 629, 8014, p. 1133–1141

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    From the selective serotonin transporter inhibitor citalopram to the selective norepinephrine transporter inhibitor talopram: Synthesis and structure-activity relationship studies

    Eildal, J. N. N., Andersen, J., Kristensen, Anders Skov, Jørgensen, A. M., Bang-Andersen, B., Jørgensen, M. & Strømgaard, Kristian, 2008, In: Journal of Medicinal Chemistry. 51, 10, p. 3045-3048

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Fatty acid derivatives of dimeric inhibitors of PSD-95

    Strømgaard, Kristian, Bach, Anders & Nissen, K. B., 4 Jun 2015, IPC No. A61K38/17 , Patent No. WO2015/078477A1, Priority date 1 Dec 2013, Priority No. DK/2013/70735

    Research output: Patent

  24. Published

    Facilitating the structural characterisation of non-canonical amino acids in biomolecular NMR

    Kuschert, S., Stroet, M., Chin, Y. K. Y., Conibear, A. C., Jia, X., Lee, T., Bartling, Christian Reinhard Otto, Strømgaard, Kristian, Güntert, P., Rosengren, K. J., Mark, A. E. & Mobli, M., 2023, In: Magnetic Resonance. 4, 1, p. 57-72

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Facile synthesis of α-hydroxy carboxylic acids from the corresponding α-amino acids

    Stuhr-Hansen, N., Padrah, S. & Strømgaard, Kristian, 2014, In: Tetrahedron Letters. 55, 30, p. 4149-4151 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Expressed protein ligation of ionotropic glutamate receptors

    Jensen, M. S., Kristensen, Anders Skov & Strømgaard, Kristian, 2007, In: Biopolymers. 88, 4, p. 602

    Research output: Contribution to journal › Conference abstract in journal › Research

  27. Published

    Expedient synthesis of 1,3-substituted benzene peptidomimetics

    Bach, Anders & Strømgaard, Kristian, 8 Feb 2011, In: Synthesis. 2011, 5, p. 807-815

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Evaluation of PhTX-74 as Subtype-Selective Inhibitor of GluA2-Containing AMPA Receptors

    Poulsen, Mette Homann, Lucas, S., Strømgaard, Kristian & Kristensen, Anders Skov, Feb 2014, In: Molecular Pharmacology. 85, 2, p. 261-268 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Energetic pathway sampling in a protein interaction domain

    Hultqvist, G., Haq, S. R., Punekar, A. S., Chi, C. N., Engström, A., Bach, Anders, Strømgaard, Kristian, Selmer, M., Gianni, S. & Jemth, P., 25 Jun 2013, In: Structure. 21, 7, p. 1193-1202

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Electrophysiological characterization of analogues of philanthotoxin-343 on ionotropic glutamate receptors

    Frølund, S. U., Ziegler, H. L., Franzyk, Henrik, Strømgaard, Kristian, Kristensen, Anders Skov & Jaroszewski, J. W., 2008.

    Research output: Contribution to conference › Poster › Research

  31. Published

    Effects of the dimeric PSD-95 inhibitor UCCB01-144 on functional recovery after fimbria-fornix transection in rats

    Sommer, J. B., Bach, Anders, Rytter, Hana Malá, Strømgaard, Kristian, Mogensen, J. & Pickering, Darryl S, Oct 2017, In: Pharmacology, Biochemistry and Behavior. 161, p. 62-67 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Effects of the dimeric PSD-95 inhibitor UCCB01-144 in mouse models of pain, cognition and motor function

    Andreasen T., Jesper, Nasser, A., Caballero-Puntiverio, M., Sahlholt, M., Bach, Anders, Gynther, M., Strømgaard, Kristian & Pickering, Darryl S, 5 Jun 2016, In: European Journal of Pharmacology. 780, p. 166-73 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Effects of dimeric PSD-95 inhibition on excitotoxic cell death and outcome after controlled cortical impact in rats: PSD-95 inhibition in experimental TBI

    Sommer, J. B., Bach, Anders, Rytter, Hana Malá, Gynther, M., Bjerre, A., Gram, M. G., Marschner, L., Strømgaard, Kristian, Mogensen, J. & Pickering, Darryl S, 2017, In: Neurochemical Research. 42, 12, p. 3401-3413 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Development of potent fluorescent polyamine toxins and application in labeling of ionotropic glutamate receptors in hippocampal neurons

    Nørager, N. G., Jensen, C. B., Rathje, Mette, Andersen, J., Madsen, Kenneth Lindegaard, Kristensen, Anders Skov & Strømgaard, Kristian, 20 Sep 2013, In: A C S Chemical Biology. 8, 9, p. 2033-2041 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Development of a Potent Cyclic Peptide Inhibitor of the nNOS/PSD-95 Interaction

    Balboa, J. R., Essig, D. J., Ma, S., Karer, N., Clemmensen, L. S., Pedersen, S. W., Joerger, A. C., Knapp, S., Østergaard, S. & Strømgaard, Kristian, 2023, In: Journal of Medicinal Chemistry. 66, 1, p. 976-990

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Development of Peptide-Based PDZ Domain Inhibitors

    Essig, D. J., Balboa, J. R. & Strømgaard, Kristian, 2021, Methods in Molecular Biology. J-P. B. (ed.). Humana Press, p. 157-177 21 p. (Methods in Molecular Biology, Vol. 2256).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  37. Published

    Detecting protein-protein interactions in living cells: development of a bioluminescence resonance energy transfer assay to evaluate the PSD-95/NMDA receptor interaction

    Gottschalk, M., Bach, Anders, Hansen, J. L., Krogsgaard-Larsen, Povl, Kristensen, Anders Skov & Strømgaard, Kristian, 2009, In: Neurochemical Research. 34, 10, p. 1729-1737

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Designing Poly-agonists for Treatment of Metabolic Diseases: Challenges and Opportunities

    Petersen, Jonas Odgaard, Strømgaard, Kristian, Frølund, Bente & Clemmensen, Christoffer, 2019, In: Drugs. 79, 11, p. 1187-1197 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Design, synthesis, and pharmacological characterization of polyamine toxin derivatives: potent ligands for the pore-forming region of AMPA receptors

    Jensen, L. S., Bølcho, U., Egebjerg, J. & Strømgaard, Kristian, Apr 2006, In: ChemMedChem. 1, 4, p. 419-428 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Design, Synthesis, and Characterization of Fatty Acid Derivatives of a Dimeric Peptide-Based Postsynaptic Density-95 (PSD-95) Inhibitor

    Nissen, K. B., Andersen, J. J., Haugaard-Kedström, L. M., Bach, Anders & Strømgaard, Kristian, 2015, In: Journal of Medicinal Chemistry. 58, p. 1575-1580 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Design and synthesis of triazole-based peptidomimetics of a PSD-95 PDZ domain inhibitor

    Bach, Anders, Pedersen, T. B. & Strømgaard, Kristian, 2016, In: MedChemComm. 7, 3, p. 531-536 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Design and synthesis of peptide YY analogues with c-terminal backbone amide-to-ester modifications

    Albertsen, L., Andersen, J. J., Paulsson, J. F., Thomsen, J. K., Norrild, J. C. & Strømgaard, Kristian, 12 Dec 2013, In: A C S Medicinal Chemistry Letters. 4, 12, p. 1228-1232 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Design and synthesis of labeled analogs of PhTX-56, a potent and selective AMPA receptor antagonist

    Andersen, T. F., Vogensen, S. B., Jensen, L. S., Knapp, K. M. & Strømgaard, Kristian, 1 Sep 2005, In: Bioorganic & Medicinal Chemistry. 13, 17, p. 5104-5112 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Design and synthesis of highly potent and plasma-stable dimeric inhibitors of the PSD-95-NMDA receptor interaction

    Bach, Anders, Chi, C. N., Pang, G. F., Olsen, L., Kristensen, Anders Skov, Jemth, P. & Strømgaard, Kristian, 2009, In: Angewandte Chemie - International Edition. 48, 51, p. 9685-9689

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Design and Synthesis of High-Affinity Dimeric Inhibitors Targeting the Interactions between Gephyrin and Inhibitory Neurotransmitter Receptors

    Maric, H., Kasaragod, V. B., Kedström, L. M. H., Hausrat, T. J., Kneussel, M., Schindelin, H. & Strømgaard, Kristian, 7 Jan 2015, In: Angewandte Chemie (International ed. in English). 54, 2, p. 490-4 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Deciphering the kinetic binding mechanism of dimeric ligands using a potent plasma-stable dimeric inhibitor of postsynaptic density protein-95 as an example

    Chi, C. N., Bach, Anders, Gottschalk, M., Kristensen, Anders Skov, Strømgaard, Kristian & Jemth, P., 2010, In: Journal of Biological Chemistry. 285, 36, p. 28252-28260

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Controlling Ca2+ Permeable alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Photochromic Ion Channel Blockers

    Norager, N. G., Poulsen, Mette Homann & Strømgaard, Kristian, 13 Sep 2018, In: Journal of Medicinal Chemistry. 61, 17, p. 8048-8053

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Contrasting actions of philanthotoxin-343 and philanthotoxin-(12) on human muscle nicotinic acetylcholine receptors

    Brier, T. J., Mellor, I. R., Tikhonov, D. B., Neagoe, I., Shao, Z., Brierley, M. J., Strømgaard, Kristian, Jaroszewski, J. W., Krogsgaard-Larsen, Povl & Usherwood, P. N. R., Oct 2003, In: Molecular Pharmacology. 64, 4, p. 954-964 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Conjugation of Therapeutic PSD-95 Inhibitors to the Cell-Penetrating Peptide Tat Affects Blood-Brain Barrier Adherence, Uptake, and Permeation

    Kristensen, Mie, Kucharz, Krzysztof, Alves Fernandes, Eduardo Felipe, Strømgaard, Kristian, Schallburg Nielsen, M., Cederberg Helms, H. C., Bach, Anders, Ulrikkaholm Tofte-Hansen, M., Aldana, Blanca, Lauritzen, Martin & Larsen, Birger Brodin, 2020, In: Pharmaceutics. 12, 7, 24 p., 661.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Comprehensive Peptide Cyclization Examination Yields Optimized APP Scaffolds with Improved Affinity toward Mint2

    Bartling, Christian Reinhard Otto, Alexopoulou, Flora, Kuschert, S., Chin, Y. K. Y., Jia, X., Sereikaité, Vita, Özcelik, D., Jensen, T. M., Jain, P., Nygaard, M. M., Harpsøe, Kasper, Gloriam, David E., Mobli, M. & Strømgaard, Kristian, 2023, In: Journal of Medicinal Chemistry. 66, 4, p. 3045-3057

    Research output: Contribution to journal › Journal article › Research › peer-review

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ID: 1302559