Thomas Mandel Clausen
Guest Researcher
Glycomics Program
Blegdamsvej 3
2200 København N.
Member of:
VAR2CSA team
- Published
Clofazimine broadly inhibits coronaviruses including SARS-CoV-2
Yuan, S., Yin, X., Meng, X., Chan, J. F. W., Ye, Z. W., Riva, L., Pache, L., Chan, C. C. Y., Lai, P. M., Chan, C. C. S., Poon, V. K. M., Lee, A. C. Y., Matsunaga, N., Pu, Y., Yuen, C. K., Cao, J., Liang, R., Tang, K., Sheng, L., Du, Y. & 25 others, , 2021, In: Nature. 593, p. 418–423Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate
Weiss, R. J., Spahn, P. N., Chiang, A. W. T., Liu, Q., Li, J., Hamill, K. M., Rother, S., Clausen, Thomas Mandel, Hoeksema, M. A., Timm, B. M., Godula, K., Glass, C. K., Tor, Y., Gordts, P. L. S. M., Lewis, N. E. & Esko, J. D., 2021, In: Nature Chemical Biology. 17, p. 684–692Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding
Wang, Kaituo, Dagil, Robert, Lavstsen, Thomas, Misra, S. K., Spliid, C. B., Wang, Y., Gustavsson, Tobias, Sandoval, D. R., Vidal-Calvo, E. E., Choudhary, Swati, Agerbæk, Mette Ørskov, Lindorff-Larsen, Kresten, Nielsen, Morten Agertoug, Theander, Thor Grundtvig, Sharp, J. S., Clausen, Thomas Mandel, Gourdon, Pontus Emanuel & Salanti, Ali, 2021, In: Nature Communications. 12, 1, 10 p., 2956.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer
Toledo, A. G., Pihl, J., Spliid, C. B., Persson, A., Nilsson, J., Pereira, M. A., Gustavsson, Tobias, Choudhary, Swati, Zarni Oo, H., Black, P. C., Daugaard, M., Esko, J. D., Larson, G., Salanti, Ali & Clausen, Thomas Mandel, 2020, In: Glycobiology. 30, 12, p. 989-1002 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of global inhibitors of cellular glycosylation
Sørensen, D. M., Büll, C., Madsen, T. D., Lira-Navarrete, E., Clausen, T. M., Clark, A. E., Garretson, A. F., Karlsson, R., Pijnenborg, J. F. A., Yin, X., Miller, R. L., Chanda, S. K., Boltje, T. J., Schjoldager, K. T., Vakhrushev, S. Y., Halim, A., Esko, J. D., Carlin, A. F., Hurtado-Guerrero, R., Weigert, R. & 2 others, , 2023, In: Nature Communications. 14, 1, 19 p., 948.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular dissection of placental malaria protein VAR2CSA interaction with a chemo-enzymatically synthesized chondroitin sulfate library
Sugiura, N., Clausen, Thomas Mandel, Shioiri, T., Gustavsson, Tobias, Watanabe, H. & Salanti, Ali, Dec 2016, In: Glycoconjugate Journal. 33, 6, p. 985-994 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The specificity of the malarial VAR2CSA protein for chondroitin sulfate depends on 4-O-sulfation and ligand accessibility
Spliid, C. B., Toledo, A. G., Sanderson, P., Mao, Y., Gatto, F., Gustavsson, Tobias, Choudhary, Swati, Saldanha, A. L., Vogelsang, R. P., Gögenur, Ismail, Theander, Thor Grundtvig, Leach, F. E., Amster, I. J., Esko, J. D., Salanti, Ali & Clausen, Thomas Mandel, 2021, In: The Journal of Biological Chemistry. 297, 6, 15 p., 101391.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Beware, commercial chondroitinases vary in activity and substrate specificity
Spliid, C. B., Toledo, A. G., Salanti, Ali, Esko, J. D. & Clausen, Thomas Mandel, 2021, In: Glycobiology. 31, 2, p. 103-115 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
An oncofetal glycosaminoglycan modification provides therapeutic access to Cisplatin-resistant bladder cancer
Seiler, R., Oo, H. Z., Tortora, D., Clausen, T. M., Wang, C. K., Kumar, G., Ayres Pereira, M., Ørum-Madsen, M. S., Agerbæk, M. Ø., Gustavsson, T., Nordmaj, M. A., Rich, J. R., Lallous, N., Fazli, L., Lee, S., Douglas, J., Todenhöfer, T., Esfandnia, S., Battsogt, D., Babcook, J. S. & 10 others, , 2017, In: European Urology Supplements. 72, 1, p. 142-150 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein
Salanti, A., Clausen, T. M., Agerbæk, M. Ø., Al Nakouzi, N., Dahlbäck, M., Oo, H. Z., Lee, S., Gustavsson, T., Rich, J. R., Hedberg, B. J., Mao, Y., Barington, L., Pereira, M. A., LoBello, J., Endo, M., Fazli, L., Soden, J., Wang, C. K., Sander, A. F., Dagil, R. & 15 others, , 2015, In: Cancer Cell. 28, 4, p. 500-14 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Virus-like particle display of HER2 induces potent anti-cancer responses
Palladini, A., Thrane, Susan, Janitzek, C. M., Pihl, J., Clemmensen, S. B., de Jongh, W. A., Clausen, Thomas Mandel, Nicoletti, G., Landuzzi, L., Penichet, M. L., Balboni, T., Ianzano, M. L., Giusti, V., Theander, Thor Grundtvig, Nielsen, Morten Agertoug, Salanti, Ali, Lollini, P., Nanni, P. & Sander, Adam F. , 2018, In: OncoImmunology. 7, 3, 12 p., e1408749.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Oncofetal chondroitin sulfate is a highly expressed therapeutic target in non-small cell lung cancer
Oo, H. Z., Lohinai, Z., Khazamipour, N., Lo, J., Kumar, G., Pihl, J., Adomat, H., Nabavi, N., Behmanesh, H., Zhai, B., Dagil, R., Choudhary, S., Gustavsson, T., Clausen, T. M., Esko, J. D., Allen, J. W., Thompson, M. A., Tran, N. L., Moldvay, J., Dome, B. & 4 others, , 2021, In: Cancers. 13, 17, 16 p., 4489.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Development of a bispecific immune engager using a recombinant malaria protein
Nordmaj, Mie Anemone, Roberts, M. E., Sachse, E. S., Dagil, Robert, Andersen, Anne Poder, Skeltved, Nanna, Grunddal, Kaare Villum, Erdogan, Sayit Mahmut, Choudhary, Swati, Gustavsson, Tobias, Ørum-madsen, M. S., Moskalev, I., Tian, W., Yang, Zhang, Clausen, Thomas Mandel, Theander, Thor Grundtvig, Daugaard, M., Nielsen, Morten Agertoug & Salanti, Ali, 2021, In: Cell Death & Disease. 12, 4, 11 p., 353.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dissecting structure-function of 3-O-sulfated heparin and engineered heparan sulfates
Karlsson, R., Chopra, P., Joshi, A., Yang, Zhang, Vakhrushev, Sergey, Clausen, Thomas Mandel, Painter, C. D., Szekeres, G. P., Chen, Yen-Hsi, Sandoval, D. R., Hansen, Lars, Esko, J. D., Pagel, K., Dyer, D. P., Turnbull, Jeremy Ewan, Clausen, Henrik, Boons, G. J. & Miller, Rebecca Louise, 2021, In: Science Advances. 7, 52, eabl6026.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A simple method for detecting oncofetal chondroitin sulfate glycosaminoglycans in bladder cancer urine
Clausen, Thomas Mandel, Kumar, G., Ibsen, E. K., Ørum-Madsen, M. S., Hurtado-Coll, A., Gustavsson, Tobias, Agerbæk, Mette Ørskov, Gatto, F., Todenhöfer, T., Basso, U., Knowles, M. A., Sanchez-Carbayo, M., Salanti, Ali, Black, P. C. & Daugaard, M., 2020, In: Cell Death Discovery. 6, 65.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Real-time and label free determination of ligand binding-kinetics to primary cancer tissue specimens; a novel tool for the assessment of biomarker targeting
Clausen, Thomas Mandel, Ayres Pereira, M., Oo, H. Z., Resende, M., Gustavsson, Tobias, Mao, Y., Sugiura, N., Liew, J., Fazli, L., Theander, Thor Grundtvig, Daugaard, M. & Salanti, Ali, Jul 2016, In: Sensing and Bio-Sensing Research. 9, p. 23-30 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2
Clausen, T. M., Sandoval, D. R., Spliid, C. B., Pihl, J., Perrett, H. R., Painter, C. D., Narayanan, A., Majowicz, S. A., Kwong, E. M., McVicar, R. N., Thacker, B. E., Glass, C. A., Yang, Z., Torres, J. L., Golden, G. J., Bartels, P. L., Porell, R. N., Garretson, A. F., Laubach, L., Feldman, J. & 16 others, , 2020, In: Cell. 183, 4, p. 1043-1057.e15Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Oncofetal chondroitin sulfate glycosaminoglycans are key players in integrin signaling and tumor cell motility
Clausen, Thomas Mandel, Bento Ayres Pereira, M. M., Al Nakouzi, N., Oo, H. Z., Agerbæk, Mette Ørskov, Lee, S., Ørum-Madsen, M. S., Kristensen, A. R., El-Naggar, A., Grandgenett, P. M., Grem, J. L., Hollingsworth, M. A., Holst, Peter Johannes, Theander, Thor Grundtvig, Sorensen, P. H., Daugaard, M. & Salanti, Ali, Dec 2016, In: Molecular Cancer Research. 14, 12, p. 1288-1299 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malaria
Clausen, Thomas Mandel, Christoffersen, S., Dahlbäck, M., Langkilde, Annette Eva, Jensen, K. E., Resende, M., Agerbæk, Mette Ørskov, Andersen, D., Berisha, B., Ditlev, S. B., Pinto, V. V., Nielsen, Morten Agertoug, Theander, Thor Grundtvig, Larsen, Sine & Salanti, Ali, 2012, In: Journal of Biological Chemistry. 287, 28, p. 23332-45 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The GAGOme: a cell-based library of displayed glycosaminoglycans
Chen, Yen-Hsi, Narimatsu, Yoshiki, Clausen, Thomas Mandel, Gomes, C., Karlsson, R., Steentoft, C., Spliid, C. B., Gustavsson, Tobias, Salanti, Ali, Persson, A., Malmström, A., Willén, D., Ellervik, U., Bennett, Eric Paul, Mao, Y., Clausen, Henrik & Yang, Zhang, 2018, In: Nature Methods. 15, 11, p. 881-888Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Noninvasive detection of any-stage cancer using free glycosaminoglycans
Bratulic, S., Limeta, A., Dabestani, S., Birgisson, H., Enblad, G., Stålberg, K., Hesselager, G., Häggman, M., Höglund, M., Simonson, O. E., Stålberg, P., Lindman, H., Bång-Rudenstam, A., Ekstrand, M., Kumar, G., Cavarretta, I., Alfano, M., Pellegrino, F., Mandel-Clausen, T., Salanti, A. & 16 others, , 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 50, p. e2115328119Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of human placental glycosaminoglycans and regional binding to VAR2CSA in malaria infected erythrocytes
Beaudet, J. M., Mansur, L., Joo, E. J., Kamhi, E., Yang, B., Clausen, Thomas Mandel, Salanti, Ali, Zhang, F. & Linhardt, R. J., Feb 2014, In: Glycoconjugate Journal. 31, 2, p. 109-16 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Capture and Detection of Circulating Glioma Cells Using the Recombinant VAR2CSA Malaria Protein
Bang-Christensen, S. R., Pedersen, R. S., Pereira, M. A., Clausen, T. M., Løppke, C., Sand, N. T., Ahrens, T. D., Jørgensen, A. M., Lim, Y. C., Goksøyr, L., Choudhary, S., Gustavsson, T., Dagil, R., Daugaard, M., Sander, A. F., Torp, M. H., Søgaard, M., Theander, T. G., Østrup, O., Lassen, U. & 3 others, , 2019, In: Cells. 8, 9, 21 p., 998.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Placental sequestration of Plasmodium falciparum malaria parasites is mediated by the interaction between VAR2CSA and chondroitin sulfate A on syndecan-1
Ayres Pereira, M., Clausen, Thomas Mandel, Pehrson, Caroline, Mao, Y., Resende, M., Daugaard, M., Riis Kristensen, A., Spliid, C. B., Mathiesen, Line, Knudsen, Lisbeth E., Damm, Peter, Theander, Thor Grundtvig, R Hansson, S., Nielsen, Morten Agertoug & Salanti, Ali, Aug 2016, In: P L o S Pathogens. 12, 8, 26 p., e1005831.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Reformation of the chondroitin sulfate glycocalyx enables progression of AR-independent prostate cancer
Al Nakouzi, N., Wang, C. K., Oo, H. Z., Nelepcu, I., Lallous, N., Spliid, C. B., Khazamipour, N., Lo, J., Truong, S., Collins, C., Hui, D., Esfandnia, S., Adomat, H., Clausen, T. M., Gustavsson, T., Choudhary, S., Dagil, R., Corey, E., Wang, Y., Chauchereau, A. & 6 others, , 2022, In: Nature Communications. 13, 4760.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The role of proteoglycans in cancer metastasis and circulating tumor cell analysis
Ahrens, T. D., Bang-Christensen, S. R., Jørgensen, A. M., Løppke, Caroline Bang, Spliid, C. B., Sand, Nicolai Tue, Clausen, Thomas Mandel, Salanti, Ali & Agerbæk, Mette Ørskov, 2020, In: Frontiers in Cell and Developmental Biology. 8, 27 p., 749.Research output: Contribution to journal › Review › Research › peer-review
- Published
The VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner
Agerbæk, Mette Ørskov, Bang-Christensen, S. R., Yang, M., Clausen, Thomas Mandel, Pereira, M. A., Sharma, S., Ditlev, S. B., Nielsen, Morten Agertoug, Choudhary, Swati, Gustavsson, Tobias, Sorensen, P. H., Meyer, T., Propper, D., Shamash, J., Theander, Thor Grundtvig, Aicher, A., Daugaard, M., Heeschen, C. & Salanti, Ali, 2018, In: Nature Communications. 9, 1, 13 p., 3279.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Burkitt lymphoma expresses oncofetal chondroitin sulfate without being a reservoir for placental malaria sequestration
Agerbaek, M. Ø., Bento Ayres Pereira, M. M., Clausen, T. M., Pehrson, C., Oo, H. Z., Spliid, C., Rich, J. R., Fung, V., Nkrumah, F., Neequaye, J., Biggar, R. J., Reynolds, S. J., Tosato, G., Pullarkat, S. T., Ayers, L. W., Theander, T. G., Daugaard, M., Bhatia, K., Nielsen, M. A., Mbulaiteye, S. M. & 1 others, , 2017, In: International Journal of Cancer. 140, 7, p. 1597–1608 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 35054027
Most downloads
-
745
downloads
Real-time and label free determination of ligand binding-kinetics to primary cancer tissue specimens; a novel tool for the assessment of biomarker targeting
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
510
downloads
Placental sequestration of Plasmodium falciparum malaria parasites is mediated by the interaction between VAR2CSA and chondroitin sulfate A on syndecan-1
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
236
downloads
The VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner
Research output: Contribution to journal › Journal article › Research › peer-review
Published