Leila Lo Leggio

Leila Lo Leggio

Professor


  1. 2024
  2. Published

    Chemoenzymatic indican for light-driven denim dyeing

    Bidart, G. N., Teze, D., Jansen, C. U., Pasutto, E., Putkaradze, N., Sesay, A. M., Fredslund, F., Lo Leggio, Leila, Ögmundarson, O., Sukumara, S., Qvortrup, K. & Welner, D. H., 2024, In: Nature Communications. 15, 1, 11 p., 1489.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. E-pub ahead of print

    Exploration of three Dyadobacter fermentans enzymes uncovers molecular activity determinants in CE15

    Carbonaro, M., Mazurkewich, S., Fiorentino, G., Lo Leggio, Leila & Larsbrink, J., 2024, (E-pub ahead of print) In: Applied Microbiology and Biotechnology. 108, 1, p. 11 335.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Polysaccharide utilization loci from Bacteroidota encode CE15 enzymes with possible roles in cleaving pectin-lignin bonds

    Seveso, A., Mazurkewich, S., Banerjee, S., Poulsen, Jens-Christian Navarro, Lo Leggio, Leila & Larsbrink, J., 2024, In: Applied and Environmental Microbiology. 90, 1, 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    CI:Mor interactions in the lysogeny switches of Lactococcus lactis TP901-1 and Staphylococcus aureus φ13 bacteriophages

    Varming, A. K., Huang, Zhiyu, Hamad, G. M., Rasmussen, K. K., Ingmer, Hanne, Kilstrup, M. & Lo Leggio, Leila, 2024, In: Microbiome Research Reports. 3, 2, 16 p., 15.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    A frontier-orbital view of the initial steps of lytic polysaccharide monooxygenase reactions

    Wieduwilt, E. K., Lo Leggio, Leila & Hedegård, E. D., 2024, In: Dalton Transactions (Online). 53, 13, p. 5796-5807 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. 2023
  8. Published

    Glucuronoyl esterases – enzymes to decouple lignin and carbohydrates and enable better utilization of renewable plant biomass

    Larsbrink, J. & Lo Leggio, Leila, 2023, In: Essays in Biochemistry. 67, 3, p. 493-503 11 p.

    Research output: Contribution to journalReviewResearchpeer-review

  9. Published

    Structural and functional investigation of a fungal member of carbohydrate esterase family 15 with potential specificity for rare xylans

    Mazurkewich, S., Scholzen, K. C., Brusch, R. H., Poulsen, Jens-Christian Navarro, Theibich, Yusuf, Hüttner, S., Olsson, L., Larsbrink, J. & Lo Leggio, Leila, 2023, In: Acta crystallographica. Section D, Structural biology. 79, 6, p. 545-555 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Structure, function, and protein engineering of GH53 β-1,4-galactanases

    Muderspach, Sebastian Jannick, Jensen, K., Krogh, K. B. R. M. & Lo Leggio, Leila, 2023, Glycoside Hydrolases: Biochemistry, Biophysics, and Biotechnology. Elsevier, p. 295-322 28 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  11. Published

    AA16 Oxidoreductases Boost Cellulose-Active AA9 Lytic Polysaccharide Monooxygenases from Myceliophthora thermophila

    Sun, P., Huang, Zhiyu, Banerjee, S., Kadowaki, M. A. S., Veersma, R. J., Magri, S., Hilgers, R., Muderspach, Sebastian Jannick, Laurent, C. V. F. P., Ludwig, R., Cannella, D., Lo Leggio, Leila, van Berkel, W. J. H. & Kabel, M. A., 2023, In: ACS Catalysis. 13, 7, p. 4454-4467 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Joint X-ray/neutron structure of Lentinus similis AA9_A at room temperature

    Tandrup, T., Lo Leggio, Leila & Meilleur, F., 2023, In: Acta crystallographica. Section F, Structural biology communications. 79, 1, p. 1-7 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. 2022
  14. Published

    Protonation State of an Important Histidine from High Resolution Structures of Lytic Polysaccharide Monooxygenases

    Banerjee, S., Muderspach, Sebastian Jannick, Tandrup, T., Frandsen, Kristian Erik Høpfner, Singh, R. K., Ipsen, J. O., Hernandez Rollan, Cristina, Nørholm, M. H. H., Bjerrum, Morten Jannik, Johansen, K. S. & Lo Leggio, Leila, 2022, In: Biomolecules. 12, 2, 15 p., 194.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Changes in active-site geometry on X-ray photo-reduction of a lytic polysaccharide monooxygenase active-site copper and saccharide binding

    Tandrup, T., Muderspach, Sebastian Jannick, Banerjee, S., Santoni, G., Ipsen, J. O., Hernandez Rollan, Cristina, Norholm, M. H. H., Johansen, K. S., Meilleur, F. & Lo Leggio, Leila, Sep 2022, In: IUCrJ. 9, 5, p. 666-681 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Flexible linker modulates the binding affinity of the TP901-1 CI phage repressor to DNA

    Varming, A. K., Rasmussen, K. K., Zong, Z., Thulstrup, Peter Waaben, Kilstrup, M. & Lo Leggio, Leila, 2022, In: FEBS Journal. 289, 4, p. 1135-1148 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Mechanism and biomass association of glucuronoyl esterase: an α/β hydrolase with potential in biomass conversion

    Zong, Z., Mazurkewich, S., Pereira, C. S., Fu, H., Cai, W., Shao, X., Skaf, M. S., Larsbrink, J. & Lo Leggio, Leila, Dec 2022, In: Nature Communications. 13, 1, 10 p., 1449.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. 2021
  19. Published

    Scission of Glucosidic Bonds by a Lentinus similis Lytic Polysaccharide Monooxygenases Is Strictly Dependent on H2O2while the Oxidation of Saccharide Products Depends on O2

    Brander, Søren, Tokin, Radina, Ipsen, J., Jensen, Poul Erik, Hernández-Rollán, C., Nørholm, M. H. H., Lo Leggio, Leila, Dupree, P. & Johansen, K. S., 2021, In: ACS Catalysis. 11, 22, p. 13848-13859

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Identification of the molecular determinants driving the substrate specificity of fungal lytic polysaccharide monooxygenases (LPMOs)

    Frandsen, Kristian Erik Høpfner, Haon, M., Grisel, S., Henrissat, B., Lo Leggio, Leila & Berrin, J., 1 Jan 2021, In: Journal of Biological Chemistry. 296, 11 p., 100086.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Lytic polysaccharide monooxygenases and other histidine-brace copper proteins: structure, oxygen activation and biotechnological applications

    Ipsen, J., Hallas-Møller, Magnus, Brander, Søren, Lo Leggio, Leila & Johansen, K. S., 2021, In: Biochemical Society Transactions. 49, 1, p. 531-540 10 p.

    Research output: Contribution to journalReviewResearchpeer-review

  22. Published

    Copper binding and reactivity at the histidine brace motif: insights from mutational analysis of the Pseudomonas fluorescens copper chaperone CopC

    Ipsen, J. Ø., Hernández‐Rollán, C., Muderspach, Sebastian Jannick, Brander, Søren, Bertelsen, A. B., Jensen, Poul Erik, Nørholm, M. H. H., Lo Leggio, Leila, Johansen, K. S. & Ferguson, S. (ed.), 2021, In: FEBS Letters. 595, 12, p. 1708-1720 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Characterization of the genetic switch from phage ɸ13 important for Staphylococcus aureus colonization in humans

    Kristensen, C. S., Varming, A. K., Leinweber, H. A. K., Hammer, K., Lo Leggio, Leila, Ingmer, Hanne & Kilstrup, M., 1 Oct 2021, In: MicrobiologyOpen. 10, 5, 22 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Structural and Functional Analysis of a Multimodular Hyperthermostable Xylanase-Glucuronoyl Esterase from Caldicellulosiruptor kristjansonii

    Krska, D., Mazurkewich, S., Brown, H. A., Theibich, Yusuf, Poulsen, Jens-Christian Navarro, Morris, A. L., Koropatkin, N. M., Lo Leggio, Leila & Larsbrink, J., 13 Jul 2021, In: Biochemistry. 60, 27, p. 2206-2220 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Controlling the fractal dimension in self-assembly of terpyridine modified insulin by Fe2+ and Eu3+ to direct in vivo effects

    Mishra, N. K., Østergaard, M., Midtgaard, S. R., Strindberg, S. S., Winkler, S., Wu, S., Sørensen, Thomas Just, Hassenkam, Tue, Poulsen, Jens-Christian Navarro, Lo Leggio, Leila, Nielsen, Hanne Mørck, Arleth, Lise, Christensen, Niels Johan, Thulstrup, Peter Waaben & Jensen, Knud Jørgen, 2021, In: Nanoscale. 13, 18, p. 8467–8473 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Engineering the substrate binding site of the hyperthermostable archaeal endo-β-1,4-galactanase from Ignisphaera aggregans

    Muderspach, Sebastian Jannick, Fredslund, F., Volf, V., Poulsen, Jens-Christian Navarro, Blicher, T. H., Clausen, M. H., Rasmussen, K. K., Krogh, K. B. R. M., Jensen, K. & Lo Leggio, Leila, 1 Dec 2021, In: Biotechnology for Biofuels. 14, 1, 16 p., 183.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Calmodulin complexes with brain and muscle creatine kinase peptides

    Sprenger, J., Trifan, A., Patel, N., Vanderbeck, A., Bredfelt, J., Tajkhorshid, E., Rowlett, R., Lo Leggio, Leila, Åkerfeldt, K. S. & Linse, S., 2021, In: Current Research in Structural Biology. 3, p. 121-132 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Crystal structures of Val58Ile tryptophan repressor in a domain-swapped array in the presence and absence of L-tryptophan

    Sprenger, J., Lawson, C. L., Von Wachenfeldt, C., Lo Leggio, Leila & Carey, J., 1 Jul 2021, In: Acta Crystallographica Section F: Structural Biology Communications. 77, 7, p. 215-225 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Guest-protein incorporation into solvent channels of a protein host crystal (hostal)

    Sprenger, J., Carey, J., Schulz, Alexander, Drouard, F., Lawson, C. L., Von Wachenfeldt, C., Linse, S. & Lo Leggio, Leila, 2021, In: Acta crystallographica Section D: Structural biology . 77, p. 471-485 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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