Morten Frödin

Morten Frödin

Associate Professor

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    ORCID: 0000-0003-3691-9820

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    1. Published

      90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1.

      Jensen, C. A. J., Buch, M. B., Krag, T. O., Hemmings, B. A., Gammeltoft, S. & Frödin, Morten, 1999, In: Journal of Biological Chemistry. 274, 38, p. 27168-76 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      A Novel Locus Harbouring a Functional CD164 Nonsense Mutation Identified in a Large Danish Family with Nonsyndromic Hearing Impairment

      Nyegaard, M., Rendtorff, N. D., Nielsen, M. S., Corydon, T. J., Demontis, D., Starnawska, A., Hedemand, A., Buniello, A., Niola, F., Overgaard, M. T., Leal, S. M., Ahmad, W., Wikman, F. P., Petersen, K. B., Crueger, D. G., Oostrik, J., Kremer, H., Tommerup, N., Froedin, M., Steel, K. P. & 2 others, Tranebjærg, Lisbeth & Borglum, A. D., Jul 2015, In: P L o S Genetics. 11, 7, p. 1-25 25 p., e1005386.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      A RSK kinase inhibitor reporting its selectivity in vivo.

      Frödin, Morten, 2007, In: Nature Chemical Biology. 3, 3, p. 138-9 1 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1.

      Frödin, Morten, Jensen, C. A. J., Merienne, K. & Gammeltoft, S., 2000, In: EMBO Journal. 19, 12, p. 2924-34 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation.

      Frödin, Morten, Antal, T. L., Dümmler, B. A., Jensen, C. J., Deak, M., Gammeltoft, S. & Biondi, R. M., 2002, In: EMBO Journal. 21, 20, p. 5396-407 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      A βPIX-PAK2 complex confers protection against Scrib-dependent and cadherin-mediated apoptosis

      Frank, S. R., Bell, J. H., Frödin, Morten & Hansen, S. H., 9 Oct 2012, In: Current biology : CB. 22, 19, p. 1747-54 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Activation of p90 Rsk1 is sufficient for differentiation of PC12 cells.

      Silverman, E., Frödin, Morten, Gammeltoft, S. & Maller, J. L., 2004, In: Molecular and Cellular Biology. 24, 24, p. 10573-83 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Analysis of 65 tuberous sclerosis complex (TSC) patients by TSC2 DGGE, TSC1/RSC2 MLPA, and TSC1 long-range PCR sequencing, and report of 28 novel mutations

      Rendtorff, N. D., Bjerregaard, B., Frödin, Morten, Kjaergaard, S., Hove, H., Skovby, F., Brøndum-Nielsen, T. D. T. S. G. K. & Schwartz, M., 2005, In: Human Mutation. 26, 4, p. 374-383 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo.

      Sapkota, G. P., Cummings, L., Newell, F. S., Armstrong, C., Bain, J., Frödin, Morten, Grauert, M., Hoffmann, M., Schnapp, G., Steegmaier, M., Cohen, P. & Alessi, D. R., 2007, In: Biochemical Journal. 401, 1, p. 29-38 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      CRISPR/Cas9 Engineering of Adult Mouse Liver Demonstrates That the Dnajb1–Prkaca Gene Fusion Is Sufficient to Induce Tumors Resembling Fibrolamellar Hepatocellular Carcinoma

      Engelholm, Lars Henning, Riaz, A., Serra, Denise, Dagnæs-Hansen, F., Johansen, Jens Vilstrup, Santoni Rugiu, Eric, Hansen, S. H., Niola, Francesco & Frödin, Morten, 1 Dec 2017, In: Gastroenterology. 153, 6, p. 1662-1673.e10

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      CRISPR/Cas9-mediated knockout of clinically relevant alloantigenes in human primary T cells

      Kamali, E., Rahbarizadeh, F., Hojati, Z. & Frödin, Morten, 2021, In: BMC Biotechnology. 21, 1, 9.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Correction: p190 RhoGAP promotes contact inhibition in epithelial cells by repressing YAP activity

      Frank, S. R., Köllmann, C. P., Luong, P., Galli, G. G., Zou, L., Bernards, A., Getz, G., Calogero, R. A., Frödin, Morten & Hansen, S. H., 2018, In: The Journal of Cell Biology. 217, 9, p. 3313 1 p.

      Research output: Contribution to journal › Comment/debate › Research › peer-review

    13. Published

      Cyclic AMP activates the mitogen-activated protein kinase cascade in PC12 cells.

      Frödin, Morten, Peraldi, P. & Van Obberghen, E., 1994, In: Journal of Biological Chemistry. 269, 8, p. 6207-14 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      De novo expression of human polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6) in colon adenocarcinoma inhibits the differentiation of colonic epithelium

      Lavrsen, K., Dabelsteen, Sally, Vakhrushev, Sergey, Levann, Asha Maria Rudjord, Haue, Amalie Dahl, Dylander, A., Mandel, Ulla, Hansen, Lars, Frödin, Morten, Bennett, Eric Paul & Wandall, Hans H., 2018, In: The Journal of Biological Chemistry. 293, p. 1298-1314

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth.

      Zhao, J., Yuan, X., Frödin, Morten & Grummt, I., 2003, In: Molecular Cell. 11, 2, p. 405-13 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Engineered CHO cells for production of diverse, homogeneous glycoproteins

      Yang, Zhang, Wang, S., Halim, Adnan, Schulz, M. A., Frödin, Morten, Rahman, S. H., Vester-Christensen, M. B., Behrens, C., Kristensen, C., Vakhrushev, Sergey, Bennett, Eric Paul, Wandall, Hans H. & Clausen, Henrik, 20 Jul 2015, In: Nature Biotechnology. 33, 8, p. 842-844 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Fast and sensitive detection of indels induced by precise gene targeting

      Yang, Zhang, Steentoft, C., Hauge, C., Hansen, Lars, Thomsen, A. L., Niola, Francesco, Vester-Christensen, M. B., Frödin, Morten, Clausen, Henrik, Wandall, Hans H. & Bennett, Eric Paul, 2015, In: Nucleic Acids Research. 43, 9, p. 1-8 8 p., e59.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells

      Green, A. C., Marttila, P., Kiweler, N., Chalkiadaki, C., Wiita, E., Cookson, V., Lesur, A., Eiden, K., Bernardin, F., Vallin, K. S. A., Borhade, S., Long, M., Ghahe, E. K., Jiménez-Alonso, J. J., Jemth, A-S., Loseva, O., Mortusewicz, O., Meyers, M., Viry, E., Johansson, A. I. & 14 others, Hodek, O., Homan, E., Bonagas, N., Ramos, L., Sandberg, L., Frödin, Morten, Moussay, E., Slipicevic, A., Letellier, E., Paggetti, J., Sørensen, Claus Storgaard, Helleday, T., Henriksson, M. & Meiser, J., 2023, In: Nature Metabolism. 5, p. 642-659

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Frequency and Functional Characterization of RUNX1 Germline Variants in Myeloid Neoplasms

      Nitschke, N. J., Almosailleakh, M., Niu, Yiyuan, Hansen, Jakob Werner, Raaschou-Jensen, K., Jespersen, Jakob Schmidt, Severinsen, M. T., Roug, A. S., Frödin, Morten, Weischenfeldt, Joachim Lütken, Andersen, M. K. & Grønbæk, Kirsten, 2023, In: Human Mutation. 2023, 11 p., 4738660.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Functional characterization of human RSK4, a new 90-kDa ribosomal S6 kinase, reveals constitutive activation in most cell types.

      Dümmler, B. A., Hauge, C., Silber, J., Yntema, H. G., Kruse, L. S., Kofoed, B., Hemmings, B. A., Alessi, D. R. & Frödin, Morten, 2005, In: Journal of Biological Chemistry. 280, 14, p. 13304-14 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Genome editing using FACS enrichment of nuclease-expressing cells and indel detection by amplicon analysis

      Lonowski, Lindsey Allison, Narimatsu, Yoshiki, Riaz, A., Delay, C. M. E., Yang, Zhang, Niola, Francesco, Duda, K., Ober, Elke, Clausen, Henrik, Wandall, Hans H., Hansen, S. H., Bennett, Eric Paul & Frödin, Morten, Mar 2017, In: Nature Protocols. 12, 3, p. 581-603 23 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Glucose, other secretagogues, and nerve growth factor stimulate mitogen-activated protein kinase in the insulin-secreting beta-cell line, INS-1.

      Frödin, Morten, Sekine, N., Roche, E., Filloux, C., Prentki, M., Wollheim, C. B. & Van Obberghen, E., 1995, In: Journal of Biological Chemistry. 270, 14, p. 7882-9 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Heregulin-induced epigenetic regulation of the utrophin-A promoter.

      Basu, U., Gyrd-Hansen, Mads, Baby, S. M., Lozynska, O., Krag, T. O. B., Jensen, C. J., Frödin, Morten & Khurana, T. S., 2007, In: FEBS Letters. 581, 22, p. 4153-8 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      High-efficiency genome editing via 2A-coupled co-expression of fluorescent proteins and zinc finger nucleases or CRISPR/Cas9 nickase pairs

      Duda, K., Lonowski, Lindsey Allison, Kofoed-Nielsen, M., Ibarra, A., Delay, C. M., Kang, Q., Yang, Zhang, Pruett-Miller, S. M., Bennett, Eric Paul, Wandall, Hans H., Davis, G. D., Hansen, S. H. & Frödin, Morten, 21 Apr 2014, In: Nucleic Acids Research. 42, 10, p. 1-16 16 p., e84.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      High-frequency genome editing using ssDNA oligonucleotides with zinc-finger nucleases

      Chen, F., Pruett-Miller, S. M., Huang, Y., Gjoka, M., Duda, K., Taunton, J., Collingwood, T. N., Frödin, Morten & Davis, G. D., Sep 2011, In: Nature Methods. 8, 9, p. 753-5 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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    ID: 9576