Mette Trauelsen
Postdoc
Schwartz Group
Blegdamsvej 3B, Mærsk Tårnet, 6. sal
2200 København N.
- Published
Activation of metabolite receptor GPR91 promotes platelet aggregation and transcellular biosynthesis of leukotriene C4
Tang, X., Fuchs, D., Tan, S., Trauelsen, Mette, Schwartz, Thue W., Wheelock, C. E., Li, N. & Haeggstrom, J. Z., 2020, In: Journal of Thrombosis and Haemostasis. 18, 4, p. 976-984 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Activation of succinate receptor 1 boosts human mast cell reactivity and allergic bronchoconstriction
Tang, X., Rönnberg, E., Säfholm, J., Thulasingam, M., Trauelsen, Mette, Schwartz, Thue W., Wheelock, C. E., Dahlén, S. E., Nilsson, G. & Haeggström, J. Z., 2022, In: Allergy: European Journal of Allergy and Clinical Immunology. 77, 9, p. 2677-2687Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cell selectivity in succinate receptor SUCNR1/GPR91 signaling in skeletal muscle
Abdelmoez, A. M., Dmytriyeva, O., Zurke, Y. X., Trauelsen, Mette, Marica, A. A., Savikj, M., Smith, J. A. B., Monaco, C., Schwartz, Thue W., Krook, A. & Pillon, N. J., 2023, In: American Journal of Physiology - Endocrinology and Metabolism. 324, 4, p. E289-E298 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Extracellular succinate hyperpolarizes M2 macrophages through SUCNR1/GPR91-mediated Gq signaling
Trauelsen, Mette, Hiron, T. K., Lin, D., Petersen, Jacob Emil, Breton, B., Husted, Anna Sofie, Hjorth, Siv Annegrethe, Inoue, A., Frimurer, Thomas Michael, Bouvier, M., O'Callaghan, C. A. & Schwartz, Thue W., 2021, In: Cell Reports. 35, 11, 15 p., 109246.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Free fatty acid receptor 1 stimulates cAMP production and gut hormone secretion through Gq-mediated activation of adenylate cyclase 2
Petersen, Jacob Emil, Pedersen, M. H., Dmytriyeva, O., Nellemose, E., Arora, Tulika, Engelstoft, M. S., Asher, W. B., Javitch, J. A., Schwartz, Thue W. & Trauelsen, Mette, 2023, In: Molecular Metabolism. 74, 10 p., 101757.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
G-Protein-Coupled Receptor 91-Dependent Signalling Does Not Influence Vascular Inflammation and Atherosclerosis in Hyperlipidaemic Mice
Griepke, S., Trauelsen, Mette, Nilsson, M. D., Hansen, J., Steffensen, L. B., Schwartz, Thue W. & Ketelhuth, D. F. J., 2023, In: Cells. 12, 21, 14 p., 2580.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GLP-1-directed NMDA receptor antagonism for obesity treatment
Petersen, J., Ludwig, M. Q., Juozaityte, V., Ranea-Robles, P., Svendsen, C., Hwang, E., Kristensen, A. W., Fadahunsi, N., Lund, J., Breum, A. W., Mathiesen, C. V., Sachs, L., Moreno-Justicia, R., Rohlfs, R., Ford, J. C., Douros, J. D., Finan, B., Portillo, B., Grose, K., Petersen, J. E. & 13 others, , 2024, In: Nature. 629, 8014, p. 1133–1141Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GPCR-Mediated Signaling of Metabolites
Husted, Anna Sofie, Trauelsen, Mette, Rudenko, Olga, Hjorth, Siv Annegrethe & Schwartz, Thue W., 4 Apr 2017, In: Cell Metabolism. 25, 4, p. 777-796 20 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Lactate receptor GPR81 drives breast cancer growth and invasiveness through regulation of ECM properties and Notch ligand DLL4
Jørgensen, Kathrine Lundø, Dmytriyeva, O., Spøhr, L., Alves, Eliana Carolina Goncalves, Yao, Jiayi, Puig Blasco, Laia, Trauelsen, Mette, Ponniah, M., Severin, M., Sandelin, Albin Gustav, Kveiborg, Marie, Schwartz, Thue W. & Pedersen, Stine Helene Falsig, 2023, In: BMC Cancer. 23, 1, 20 p., 1136.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular dynamics-based identification of binding pathways and two distinct high-affinity sites for succinate in succinate receptor 1/GPR91
Iliyaz, Aslihan Shenol, Lückmann, Michael, Trauelsen, Mette, Lambrughi, M., Tiberti, M., Papaleo, E., Frimurer, Thomas Michael & Schwartz, Thue W., 2024, In: Molecular Cell. 84, 5, p. 955-966.e4 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular dynamics-guided discovery of an ago-allosteric modulator for GPR40/FFAR1
Lückmann, Michael, Trauelsen, Mette, Bentsen, M. A., Nissen, T. A. D., Martins, J., Fallah, Z., Nygaard, M. M., Papaleo, E., Lindorff-Larsen, Kresten, Schwartz, Thue W. & Frimurer, Thomas Michael, 2 Apr 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 14, p. 7123-7128Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular mechanism of ligand binding pathways and activation of the succinate receptor
Iliyaz, Aslihan Shenol, Lückmann, Michael, Trauelsen, Mette, Frimurer, Thomas Michael & Schwartz, Thue W., 2021, In: European Biophysics Journal. 50, Suppl. 1, p. 160 1 p., P-234.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Protective succinate-SUCNR1 metabolic stress signaling gone bad
Winther, Sally, Trauelsen, Mette & Schwartz, Thue W., 2021, In: Cell Metabolism. 33, 7, p. 1276-1278 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pyruvate dehydrogenase kinase regulates vascular inflammation in atherosclerosis and increases cardiovascular risk
Forteza, M. J., Berg, M., Edsfeldt, A., Sun, J., Baumgartner, R., Kareinen, I., Casagrande, F. B., Hedin, U., Zhang, S., Vuckovic, I., Dzeja, P. P., Polyzos, K. A., Gisterå, A., Trauelsen, M., Schwartz, T. W., Dib, L., Herrmann, J., Monaco, C., Matic, L., Gonçalves, I. & 1 others, , 2023, In: Cardiovascular Research. 119, 7, p. 1524-1536 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Receptor structure-based discovery of non-metabolite agonists for the succinate receptor GPR91
Trauelsen, Mette, Ulven, Elisabeth Rexen, Hjorth, Siv Annegrethe, Brvar, M., Monaco, C., Frimurer, Thomas Michael & Schwartz, Thue W., Dec 2017, In: Molecular Metabolism. 6, 12, p. 1585-1596 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural basis for GPCR signaling by small polar versus large lipid metabolites-discovery of non-metabolite ligands
Lückmann, Michael, Trauelsen, Mette, Frimurer, Thomas Michael & Schwartz, Thue W., 2020, In: Current Opinion in Cell Biology. 63, p. 38-48Research output: Contribution to journal › Review › Research › peer-review
- Published
Structure-Activity Investigations and Optimisations of Non-metabolite Agonists for the Succinate Receptor 1
Ulven, Elisabeth Rexen, Trauelsen, Mette, Brvar, M., Lückmann, Michael, Bielefeldt, L. Ø., Jensen, L. K. I., Schwartz, Thue W. & Frimurer, Thomas Michael, 2018, In: Scientific Reports. 8, 1, p. 1-18 10010.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
TRAF2 mediates JNK and STAT3 activation in response to IL-1β and IFNγ and facilitates apoptotic death of insulin-producing β-cells
Prause, Michala Cecilie Burstein, Berchtold, L. A., Urizar, A. I., Trauelsen, Mette, Billestrup, Nils, Mandrup-Poulsen, Thomas & Størling, Joachim, 15 Jan 2016, In: Molecular and Cellular Endocrinology. 420, p. 24-36 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The HETE Is on FFAR1 and Pancreatic Islet Cells
Trauelsen, Mette, Lückmann, Michael, Frimurer, Thomas Michael & Schwartz, Thue W., 2018, In: Cell Metabolism. 27, 2, p. 273-275 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
ID: 127320520
Most downloads
-
609
downloads
Receptor structure-based discovery of non-metabolite agonists for the succinate receptor GPR91
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
143
downloads
Structure-Activity Investigations and Optimisations of Non-metabolite Agonists for the Succinate Receptor 1
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
132
downloads
Molecular dynamics-guided discovery of an ago-allosteric modulator for GPR40/FFAR1
Research output: Contribution to journal › Journal article › Research › peer-review
Published