Kresten Lindorff-Larsen
Professor
Biomolecular Sciences
Ole Maaløes Vej 5
2200 København N.
- 2014
- Published
Robust estimation of diffusion-optimized ensembles for enhanced sampling
Tian, P., Jónsson, S. Æ., Ferkinghoff-Borg, J., Krivov, S. V. .., Lindorff-Larsen, Kresten, Irbäck, A. & Boomsma, Wouter, 2014, In: Journal of Chemical Theory and Computation. 10, 2, p. 543–553 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
A two-step protein quality control pathway for a misfolded DJ-1 variant in fission yeast
Mathiassen, S. G., Larsen, I. B., Poulsen, E. G., Madsen, C. T., Papaleo, E., Lindorff-Larsen, Kresten, Kragelund, Birthe Brandt, Nielsen, Michael Lund, Kriegenburg, F. & Hartmann-Petersen, Rasmus, 2015, In: The Journal of Biological Chemistry. 290, 34, p. 21141-21153 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Comparing molecular dynamics force fields in the essential subspace
Martin-García, F., Papaleo, E., Gomez-Puertas, P., Boomsma, Wouter & Lindorff-Larsen, Kresten, 2015, In: PLoS ONE. 10, 3, 16 p., e0121114.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
ENCORE: Software for Quantitative Ensemble Comparison
Tiberti, M., Papaleo, E., Bengtsen, T., Boomsma, Wouter & Lindorff-Larsen, Kresten, 2015, In: PLoS Computational Biology. 11, 10, 16 p., e1004415.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Exploiting hydrophobicity for efficient production of transmembrane helices for structure determination by NMR spectroscopy
Bugge, K. Ø., Steinocher, H., Brooks, A. J., Lindorff-Larsen, Kresten & Kragelund, Birthe Brandt, 2015, In: Analytical Chemistry. 87, 18, p. 9126–9131 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Interaction networks in protein folding via atomic-resolution experiments and long-time-scale molecular dynamics simulations
Sborgi, L., Verma, A., Piana, S., Lindorff-Larsen, Kresten, Cerminara, M., Santiveri, C. M., Shaw, D. E., De Alba, E. & Muñoz, V., 2015, In: Journal of the American Chemical Society. 137, 20, p. 6506-6516 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure of a functional amyloid protein subunit computed using sequence variation
Tian, P., Boomsma, Wouter, Wang, Y., Otzen, D., Jensen, Mogens Høgh & Lindorff-Larsen, Kresten, 2015, In: Journal of the American Chemical Society. 137, 1, p. 22–25 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
What does evolution tell us about the structure of a functional amyloid protein?
Tian, P., Boomsma, Wouter, Wang, Y., Otzen, D. E., Jensen, Mogens Høgh & Lindorff-Larsen, Kresten, 2015, In: Biophysical Journal. 108, 2, Supplement 1, p. 227a 1 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- 2016
- Published
A Monte Carlo study of the early steps of functional amyloid formation
Tian, P., Lindorff-Larsen, Kresten, Boomsma, Wouter, Jensen, Mogens Høgh & Otzen, D. E., 2016, In: P L o S One. 11, 1, 18 p., e0146096.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A combined computational and structural model of the full-length human prolactin receptor
Bugge, K. Ø., Papaleo, E., Haxholm, G. W., Hopper, J. T. S., Robinson, C. V., Olsen, Johan Gotthardt, Lindorff-Larsen, Kresten & Kragelund, Birthe Brandt, 2016, In: Nature Communications. 7, 11 p., 11578.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A soluble, folded protein without charged amino acid residues
Højgaard, C., Kofoed, Christian, Espersen, R., Johansson, Kristoffer Enøe, Villa, M., Willemoës, Martin, Lindorff-Larsen, Kresten, Teilum, Kaare & Winther, Jakob R., 2016, In: Biochemistry. 55, 28, p. 3949–3956 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bioinformatics analysis identifies several intrinsically disordered human E3 ubiquitin-protein ligases
Boomsma, Wouter, Nielsen, S. V., Lindorff-Larsen, Kresten, Hartmann-Petersen, Rasmus & Ellgaard, Lars, 2016, In: PeerJ. 4, 18 p., e1725.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Computational redesign of thioredoxin is hypersensitive towards minor conformational changes in the backbone template
Johansson, Kristoffer Enøe, Johansen, Nicolai Tidemand, Christensen, S., Horowitz, S., Bardwell, J. C. A., Olsen, Johan Gotthardt, Willemoës, Martin, Lindorff-Larsen, Kresten, Ferkinghoff-Borg, J., Hamelryck, Thomas Wim & Winther, Jakob R., 2016, In: Journal of Molecular Biology. 428, 21, p. 4361-4377 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
DNA-binding protects p53 from interactions with cofactors involved in transcription-independent functions
Lambrughi, M., De Gioia, L., Gervasio, F. L., Lindorff-Larsen, Kresten, Nussinov, R., Urani, C., Bruschi, M. & Papaleo, E., 2016, In: Nucleic Acids Research. 44, 19, p. 9096-9109 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mapping transiently formed and sparsely populated conformations on a complex energy landscape
Wang, Y., Papaleo, E. & Lindorff-Larsen, Kresten, 2016, In: eLife. 5, 35 p., e17505.Research output: Contribution to journal › Journal article › Research › peer-review
Picosecond to Millisecond Structural Dynamics in Human Ubiquitin
Lindorff-Larsen, Kresten, Maragakis, P., Piana, S. & Shaw, D. E., 2016, In: Journal of Physical Chemistry B. 120, 33, p. 8313-8320 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure of the bacterial cytoskeleton protein bactofilin by NMR chemical shifts and sequence variation
Kassem, M. M., Wang, Y., Boomsma, Wouter & Lindorff-Larsen, Kresten, 2016, In: Biophysical Journal. 110, 11, p. 2342-2348 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The role of protein loops and linkers in conformational dynamics and allostery
Papaleo, E., Saladino, G., Lambrughi, M., Lindorff-Larsen, Kresten, Gervasio, F. L. & Nussinov, R., 2016, In: Chemical Reviews. 116, 11, p. 6391-6423 33 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Topological constraints and modular structure in the folding and functional motions of GlpG, an intramembrane protease
Schafer, N. P., Truong, H. H., Otzen, D. E., Lindorff-Larsen, Kresten & Wolynes, P. G., 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 8, p. 2098-2103 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Understanding single-pass transmembrane receptor signaling from a structural viewpoint—what are we missing?
Bugge, K. Ø., Lindorff-Larsen, Kresten & Kragelund, Birthe Brandt, Dec 2016, In: The FEBS Journal. 283, 24, p. 4424-4451 28 p.Research output: Contribution to journal › Review › Research › peer-review
- 2017
- Published
Class I Cytokine Receptors: Towards the Inside
Steinocher, H., Bugge, K. Ø., Nikolajsen, L. F., Lindorff-Larsen, Kresten, Brooks, A. & Kragelund, Birthe Brandt, 2017, In: Biophysical Society. Annual Meeting. Abstracts. 112, 3. Suppl. 1, p. 171A 1 p., 845-Plat.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Conformational rigidity and protein dynamics at distinct timescales regulate PTP1B activity and allostery
Choy, M. S., Li, Y., Machado, L. E. S. F., Kunze, M. B. A., Connors, C. R., Wei, X., Lindorff-Larsen, Kresten, Page, R. & Peti, W., 16 Feb 2017, In: Molecular Cell. 65, 4, p. 644-658 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Diversity-oriented peptide stapling: a third generation copper-catalysed azide–alkyne cycloaddition stapling and functionalisation strategy
Tran, T. P., Larsen, C. Ø., Røndbjerg, T., de Foresta, M., Kunze, M. B. A., Marek, A., Hartvig Løper, J., Boyhus, L., Knuhtsen, A., Lindorff-Larsen, Kresten & Pedersen, D. S., 8 Mar 2017, In: Chemistry: A European Journal. 23, 14, p. 3490-3495 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Predicting the impact of Lynch syndrome-causing missense mutations from structural calculations
Nielsen, S. V., Stein, Amelie, Dinitzen, A. B., Papaleo, E., Tatham, M. H., Poulsen, E. G., Kassem, M. M., Rasmussen, Lene Juel, Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 19 Apr 2017, In: PLoS Genetics. 13, 4, 26 p., e1006739.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mapping the universe of RNA tetraloop folds
Bottaro, S. & Lindorff-Larsen, Kresten, 25 Jul 2017, In: Biophysical Journal. 113, 2, p. 257-267 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
An efficient method for estimating the hydrodynamic radius of disordered protein conformations
Nygaard, M., Kragelund, Birthe Brandt, Papaleo, E. & Lindorff-Larsen, Kresten, 8 Aug 2017, In: Biophysical Journal. 113, 3, p. 550-557 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A phosphorylation-motif for tuneable helix stabilisation in intrinsically disordered proteins - Lessons from the sodium proton exchanger 1 (NHE1)
Hendus-Altenburger, R., Lambrughi, M., Terkelsen, Thilde Bagger, Pedersen, Stine Helene Falsig, Papaleo, E., Lindorff-Larsen, Kresten & Kragelund, Birthe Brandt, Sep 2017, In: Cellular Signalling. 37, p. 40-51 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biomolecular conformational changes and ligand binding: from kinetics to thermodynamics
Wang, Y., Martins, J. & Lindorff-Larsen, Kresten, Sep 2017, In: Chemical Science. 8, 9, p. 6466-6473 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Blocking protein quality control to counter hereditary cancers
Kampmeyer, Caroline, Nielsen, S. V., Bjørnkjær, Lene, Stein, Amelie, Gerdes, Anne-Marie Axø, Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, Dec 2017, In: Genes, Chromosomes & Cancer. 56, 12, p. 823-831 9 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Evolution i overhalingsbanen
Abildgaard, A. B., Hartmann-Petersen, Rasmus, Lindorff-Larsen, Kresten & Winther, Jakob R., 15 Dec 2017, In: Weekendavisen. 2017, 50, p. Ideer: 13 1 p.Research output: Contribution to journal › Contribution to newspaper - Feature article › Communication
- 2018
- Published
A Robust Proton Flux (pHlux) Assay for Studying the Function and Inhibition of the Influenza A M2 Proton Channel
Santner, P., Martins, J. M. D. S., Laursen, J. S., Behrendt, L., Riber, Leise, Olsen, Christian Adam, Arkin, I. T., Winther, Jakob R., Willemoës, Martin & Lindorff-Larsen, Kresten, 2018, In: Biochemistry. 57, 41, p. 5949-5956Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biophysical experiments and biomolecular simulations: a perfect match?
Bottaro, S. & Lindorff-Larsen, Kresten, 2018, In: Science. 361, 6400, p. 355-360 6 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments
Bouchard, J. J., Otero, J. H., Scott, D. C., Szulc, E., Martin, E. W., Sabri, N., Granata, D., Marzahn, M. R., Lindorff-Larsen, Kresten, Salvatella, X., Schulman, B. A. & Mittag, T., 2018, In: Molecular Cell. 72, 1, p. 19-36, e1-e8Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Editorial overview: Theory and simulation: Interpreting experimental data at the molecular level
Best, R. B. & Lindorff-Larsen, Kresten, 2018, In: Current Opinion in Structural Biology. 49, p. iv-v 2 p.Research output: Contribution to journal › Editorial › Research › peer-review
- Published
Enhancing coevolution-based contact prediction by imposing structural self-consistency of the contacts
Kassem, M. M., Christoffersen, L. B., Cavalli, A. & Lindorff-Larsen, Kresten, 2018, In: Scientific Reports. 8, 11112.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Frequency adaptive metadynamics for the calculation of rare-event kinetics
Wang, Y., Valsson, O., Tiwary, P., Parrinello, M. & Lindorff-Larsen, Kresten, 2018, In: Journal of Chemical Physics. 149, 7, p. 1-7 072309.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Gs protein peptidomimetics as allosteric modulators of the β2-adrenergic receptor
Boyhus, L. E., Danielsen, Mia, Bengtson, N. S., Kunze, M. B. A., Kubiak, X., Sminia, T. J., Løper, J. H., Tran, P. T., Lindorff-Larsen, Kresten, Rasmussen, Søren Gøgsig Faarup, Mathiesen, Jesper M. & Pedersen, D. S., 2018, In: RSC Advances. 8, 4, p. 2219-2228 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
How well do force fields capture the strength of salt bridges in proteins?
Ahmed, M. C. H., Papaleo, E. & Lindorff-Larsen, Kresten, 2018, In: PeerJ. 6, 17 p., 4967.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular dynamics ensemble refinement of the heterogeneous native state of NCBD using chemical shifts and NOEs
Papaleo, E., Camilloni, C., Teilum, Kaare, Vendruscolo, M. & Lindorff-Larsen, Kresten, 2018, In: PeerJ. 6, p. 1-24 e5125.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Monte Carlo Sampling of Protein Folding by Combining an All-Atom Physics-Based Model with a Native State Bias
Wang, Y., Tian, P., Boomsma, Wouter & Lindorff-Larsen, Kresten, 2018, In: Journal of Physical Chemistry B. 122, 49, p. 11174-11185Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Random mutagenesis analysis of the Influenza A M2 proton channel reveals novel resistance mutants
Santner, P., Martins, J. M. D. S., Kampmeyer, Caroline, Hartmann-Petersen, Rasmus, Laursen, J. S., Stein, Amelie, Olsen, Christian Adam, Arkin, I. T., Winther, Jakob R., Willemoës, Martin & Lindorff-Larsen, Kresten, 2018, In: Biochemistry. 57, 41, p. 5957-5968Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Role of protein dynamics in transmembrane receptor signalling
Wang, Y., Bugge, K. Ø., Kragelund, Birthe Brandt & Lindorff-Larsen, Kresten, 2018, In: Current Opinion in Structural Biology. 48, p. 74-82 9 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Structural Basis of Membrane Protein Chaperoning through the Mitochondrial Intermembrane Space
Weinhaupl, K., Lindau, C., Hessel, A., Wang, Y., Schültze, C., Jores, T., Melchionda, L., Schönfisch, B., Kalbacher, H., Bersch, B., Rapaport, D., Brennich, M., Lindorff-Larsen, Kresten, Wiedemann, N. & Schanda, P., 2018, In: Cell. 175, 5, p. 1365-1379, e25Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural heterogeneity and dynamics in protein evolution and design
Johansson, Kristoffer Enøe & Lindorff-Larsen, Kresten, 2018, In: Current Opinion in Structural Biology. 48, p. 157-163 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A Combined Simulation and SAXS Study of the Dynamics of Lipid Nanodiscs
Bengtsen, T., Holm-Janas, Viktor, Midtgaard, S. R., Arleth, Lise & Lindorff-Larsen, Kresten, 17 Feb 2018, In: Biophysical Journal. 114, 3, Supp. 1, p. 559A-559A 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dynamic activation and regulation of the mitogen-activated protein kinase p38
Kumar, G. S., Clarkson, M. W., Kunze, M. B. A., Granata, D., Wand, A. J., Lindorff-Larsen, Kresten, Page, R. & Peti, W., 1 May 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 18, p. 4655-4660 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conformational ensembles of RNA oligonucleotides from integrating NMR and molecular simulations
Bottaro, S., Bussi, G., Kennedy, S. D., Turner, D. H. & Lindorff-Larsen, Kresten, 18 May 2018, In: Science Advances. 4, 5, 8 p., eaar8521.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
On the Calculation of SAXS Profiles of Folded and Intrinsically Disordered Proteins from Computer Simulations
Henriques, J., Arleth, Lise, Lindorff-Larsen, Kresten & Skepo, M., 3 Aug 2018, In: Journal of Molecular Biology. 430, 16, SI, p. 2521-2539Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
PSX, Protein-Solvent Exchange: software for calculation of deuterium-exchange effects in small-angle neutron scattering measurements from protein coordinates
Pedersen, Martin Cramer, Wang, Y., Tidemand, Frederik Grønbæk, Martel, A., Lindorff-Larsen, Kresten & Arleth, Lise, 2019, In: Journal of Applied Crystallography. 52, 6, p. 1427-1436 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A Multi-State Coarse-Grained Simulation Model Captures Conformational Cycling in P-Type ATPases
Wang, Y., Saleh, N., Chu, X. & Lindorff-Larsen, Kresten, 2019, In: Biophysical Journal. 116, 3, suppl. 1, p. 300a 1484-Plat.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
ID: 35228567
Most downloads
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Protein structure validation and refinement using amide proton chemical shifts derived from quantum mechanics
Research output: Contribution to journal › Journal article › Research › peer-review
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913
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Similarity measures for protein ensembles
Research output: Contribution to journal › Journal article › Research › peer-review
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Evaluating the effects of cutoffs and treatment of long-range electrostatics in protein folding simulations
Research output: Contribution to journal › Journal article › Research › peer-review