Thue W. Schwartz
Professor
Schwartz Group
Blegdamsvej 3B, Mærsk Tårnet, 6. sal, 2200 København N.
Member of:
- Published
Kredsløbsregulation ved hypovolaemisk shock
Sander Jensen, K., Secher, Niels H., Rørsgaard, S., Warberg, J., Astrup, A., Christensen, N. J., Giese, J., Schwartz, Thue W. & Bie, P., 1986, In: Ugeskrift for læger. 148, 38, p. 2383-2387 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of intravenous infusions of PYY3-36 and GLP-1, as monoinfusion and in combination, on ad libitum energy intake in healthy obese subjects
Schmidt, J. B., Gregersen, N. T., Pedersen, S. D., Holst, Jens Juul, Schwartz, Thue W., Astrup, A. & Sjödin, Anders Mikael, 10 Aug 2012, In: Regulatory Peptides. 177, Supplement, p. S32 1 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Effects of PYY3-36 and GLP-1 on energy intake, energy expenditure and appetite in overweight men
Schmidt, J. B., Gregersen, N. T., Pedersen, S. D., Arentoft, J. L., Ritz, C., Schwartz, Thue W., Holst, Jens Juul, Astrup, A. & Sjödin, Anders Mikael, 2014, In: American Journal of Physiology: Endocrinology and Metabolism. 306, 11, p. E1248-E1256 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Reversible switching of ultrastrong light-molecule coupling
Schwartz, Thue W., Hutchison, J. A., Genet, C. & Ebbesen, T. W., 13 May 2011, In: Physical Review - Index. 106, p. 196405 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The first PP supper--Camelot at Bispebjerg
Schwartz, Thue W. & Verlaege, O., 2001, In: Scandinavian Journal of Clinical and Laboratory Investigation. Supplement. 234, p. 109-21 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural biology: snapshot of a signalling complex.
Schwartz, Thue W. & Sakmar, T., Sep 2011, In: Nature.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ago-allosteric modulation and other types of allostery in dimeric 7TM receptors
Schwartz, Thue W. & Holst, Birgitte, 2006, In: Journal of Receptors and Signal Transduction. 26, 1-2, p. 107-28 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Allosteric enhancers, allosteric agonists and ago-allosteric modulators: where do they bind and how do they act?
Schwartz, Thue W. & Holst, Birgitte, 2007, In: TIPS - Trends in Pharmacological Sciences. 28, 8, p. 366-73 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural biology: Full monty of family B GPCRs
Schwartz, Thue W. & Frimurer, Thomas Michael, 2017, In: Nature Chemical Biology. 13, 8, p. 819-821Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular mechanism of 7TM receptor activation--a global toggle switch model
Schwartz, Thue W., Frimurer, T. M., Holst, Birgitte, Rosenkilde, Mette & Elling, C. E., 2006, In: Annual Review of Pharmacology and Toxicology. 46, p. 481-519 38 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural biology: A moving story of receptors
Schwartz, Thue W. & Hubbell, W. L., 2008, In: Nature. 455, 7212, p. 473-4 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
An enteroendocrine full package solution
Schwartz, Thue W. & Holst, Birgitte, 2010, In: Cell Metabolism. 11, 6, p. 445-7 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The first PP supper - Camelot at Bispebjerg
Schwartz, Thue W. & Verlaege, O., 2001, In: Scandinavian Journal of Clinical and Laboratory Investigation. Supplement. vol. 234, p. 109-21Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular mechanism of action of non-peptide ligands for peptide receptors
Schwartz, Thue W., Gether, Ulrik, Schambye, H. T. & Hjorth, Siv Annegrethe, Oct 1995, In: Current Pharmaceutical Design. 1, 3, p. 325-342 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
How receptor mutagenesis may confirm or confuse receptor classification
Schwartz, Thue W., Perlman, S., Rosenkilde, Mette & Hjorth, S. A., 1997, In: Annals of the New York Academy of Sciences. 817, p. 71-84Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Principles of Agonism - Undressing Efficacy
Schwartz, Thue W. & Ijzermann, A. P., 1998, In: TIPS - Trends in Pharmacological Sciences. 19, no. 11, p. 433-436Research output: Contribution to journal › Journal article › Research › peer-review
- Published
7TM receptorer - fra lugtesans og nye hormoner til HIV-infektion
Schwartz, Thue W., 1997, In: Ugeskrift for læger. 159, p. 1239-1245Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular structure and function of 7TM/G-protein coupled receptors
Schwartz, Thue W. & Holst, Birgitte, 2002, Textbook of receptor Pharmacology. p. 65-84Research output: Chapter in Book/Report/Conference proceeding › Report chapter › Research
- Published
Release of PYY from pig intestinal mucosa; luminal and neural regulation
Sheikh, S. P., Holst, Jens Juul, Ørskov, Cathrine, Ekman, R. & Schwartz, Thue W., Dec 1989, In: Regulatory Peptides. 26, 3, p. 253-66 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular dynamics-based identification of binding pathways and two distinct high-affinity sites for succinate in succinate receptor 1/GPR91
Iliyaz, Aslihan Shenol, Lückmann, Michael, Trauelsen, Mette, Lambrughi, M., Tiberti, M., Papaleo, E., Frimurer, Thomas Michael & Schwartz, Thue W., 2024, In: Molecular Cell. 84, 5, p. 955-966.e4 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Differential regulation of CXCR4 and CCR5 endocytosis
Signoret, N., Rosenkilde, Mette, Klasse, P. J., Schwartz, Thue W., Malim, M. H., Hoxie, J. A. & Marsh, M., 1998, In: Journal of Cell Science. 111, no. 18, p. 2819-2830Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Phorbol esters and SDF-1 induce rapid endocytosis and down-modulation of the chemokine receptor CXCR4
Signoret, N., Oldridge, J., Pelchen-Matthews, A., Klasse, P. J., Tran, T., Brass, L. F., Rosenkilde, Mette, Schwartz, Thue W., Luther, M. A., Wells, T. N. C., Hoxie, J. A. & March, M., 1997, In: Journal of Cell Biology. 139, no. 3, p. 651-664Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist
Simmons, G., Clapham, P. R., Picard, L., Offord, R. E., Rosenkilde, Mette, Schwartz, Thue W., Buser, R., Weels, T. N. C. & Proudfoot, A., 1997, In: Kexue (Shanghai). 276, p. 276-279Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Unique interaction pattern for a functionally biased ghrelin receptor agonist
Sivertsen, B. B., Lang, M., Frimurer, T. M., Holliday, N. D., Bach, Anders, Els, S., Engelstoft, M. S., Petersen, P. S., Madsen, A. N., Schwartz, Thue W., Beck-Sickinger, A. G. & Holst, Birgitte, 10 Jun 2011, In: The Journal of Biological Chemistry. 286, 23, p. 20845-20860 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Targeting CXCR4 in HIV Cell-Entry Inhibition
Steen, A., Schwartz, Thue W. & Rosenkilde, Mette, 2010, In: Mini reviews in medicinal chemistry. 9, 14, p. 1605-21 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular mechanism of Zn2+ agonism in the extracellular domain of GPR39
Storjohann, L., Holst, Birgitte & Schwartz, Thue W., 2008, In: FEBS Letters. 582, 17, p. 2583-8 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A second disulfide bridge from the N-terminal domain to extracellular loop 2 dampens receptor activity in GPR39
Storjohann, L., Holst, Birgitte & Schwartz, Thue W., 2008, In: Biochemistry. 47, 35, p. 9198-207 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
snRNA-seq reveals a subpopulation of adipocytes that regulates thermogenesis
Sun, W., Dong, H., Balaz, M., Slyper, M., Drokhlyansky, E., Colleluori, G., Giordano, A., Kovanicova, Z., Stefanicka, P., Balazova, L., Ding, L., Husted, Anna Sofie, Rudofsky, G., Ukropec, J., Cinti, S., Schwartz, Thue W., Regev, A. & Wolfrum, C., 2020, In: Nature. 587, 31 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis
Sveidahl Johansen, O., Ma, T., Hansen, J. B., Markussen, L. K., Schreiber, R., Reverte-Salisa, L., Dong, H., Christensen, D. P., Sun, W., Gnad, T., Karavaeva, I., Nielsen, T. S., Kooijman, S., Cero, C., Dmytriyeva, O., Shen, Y., Razzoli, M., O'Brien, S. L., Kuipers, E. N., Nielsen, C. H. & 31 others, , 2021, In: Cell. 184, 13, p. 3502-3518 + 50 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GLP1- and GIP-producing cells rarely overlap and differ by bombesin receptor-2 expression and responsiveness
Svendsen, B., Pais, R., Engelstoft, M. S., Milev, N. B., Richards, P., Christiansen, Charlotte Bayer, Egerod, Kristoffer Lihme, Jensen, S. M., Habib, A. M., Gribble, F. M., Schwartz, Thue W., Reimann, F. & Holst, Jens Juul, 2016, In: Journal of Endocrinology. 228, 1, p. 39-48 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Activation of metabolite receptor GPR91 promotes platelet aggregation and transcellular biosynthesis of leukotriene C4
Tang, X., Fuchs, D., Tan, S., Trauelsen, Mette, Schwartz, Thue W., Wheelock, C. E., Li, N. & Haeggstrom, J. Z., 2020, In: Journal of Thrombosis and Haemostasis. 18, 4, p. 976-984 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Activation of succinate receptor 1 boosts human mast cell reactivity and allergic bronchoconstriction
Tang, X., Rönnberg, E., Säfholm, J., Thulasingam, M., Trauelsen, Mette, Schwartz, Thue W., Wheelock, C. E., Dahlén, S. E., Nilsson, G. & Haeggström, J. Z., 2022, In: Allergy: European Journal of Allergy and Clinical Immunology. 77, 9, p. 2677-2687Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Metabolite G-protein coupled receptor signaling: Potential regulation of eicosanoids
Tang, X., Hou, Y., Schwartz, Thue W. & Haeggström, J. Z., 2022, In: Biochemical Pharmacology. 204, 7 p., 115208.Research output: Contribution to journal › Review › Research › peer-review
- Published
Construction of covalently coupled, concatameric dimers of 7TM receptors
Terpager, M., Scholl, D. J., Kubale, V., Martini, L., Elling, C. E. & Schwartz, Thue W., 2009, In: Journal of Receptors and Signal Transduction. 29, 5, p. 235-45 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
High molecular weight PEGylation of human pancreatic polypeptide at position 22 improves stability and reduces food intake in mice
Thieme, V., Jolly, N., Madsen, A. N., Bellmann-Sickert, K., Schwartz, Thue W., Holst, Birgitte, Cox, H. M. & Beck-Sickinger, A. G., Nov 2016, In: British Journal of Pharmacology. 173, 22, p. 3208-3221 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bioorthogonal fluorescent labeling of functional G-protein-coupled receptors
Tian, H., Naganathan, S., Kazmi, M. A., Schwartz, Thue W., Sakmar, T. P. & Huber, T., 18 Aug 2014, In: ChemBioChem. 15, 12, p. 1820-9 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bidirectional GPR119 agonism requires peptide YY and glucose for activity in mouse and human colon mucosa
Tough, I. R., Forbes, S., Herzog, H., Jones, R. M., Schwartz, Thue W. & Cox, H. M., 1 Apr 2018, In: Endocrinology. 159, 4, p. 1704-1717Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthetic G protein-coupled bile acid receptor agonists and bile acids act via basolateral receptors in ileal and colonic mucosa
Tough, I. R., Schwartz, Thue W. & Cox, H. M., 2020, In: Neurogastroenterology and Motility. 32, 12, 14 p., e13943.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Paracrine relationship between incretin hormones and endogenous 5-hydroxytryptamine in the small and large intestine
Tough, I. R., Lund, M. L., Patel, B. A., Schwartz, Thue W. & Cox, H. M., 2023, In: Neurogastroenterology and Motility. 35, 8, 14 p., e14589.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Extracellular succinate hyperpolarizes M2 macrophages through SUCNR1/GPR91-mediated Gq signaling
Trauelsen, Mette, Hiron, T. K., Lin, D., Petersen, Jacob Emil, Breton, B., Husted, Anna Sofie, Hjorth, Siv Annegrethe, Inoue, A., Frimurer, Thomas Michael, Bouvier, M., O'Callaghan, C. A. & Schwartz, Thue W., 2021, In: Cell Reports. 35, 11, 15 p., 109246.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The HETE Is on FFAR1 and Pancreatic Islet Cells
Trauelsen, Mette, Lückmann, Michael, Frimurer, Thomas Michael & Schwartz, Thue W., 2018, In: Cell Metabolism. 27, 2, p. 273-275 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Receptor structure-based discovery of non-metabolite agonists for the succinate receptor GPR91
Trauelsen, Mette, Ulven, Elisabeth Rexen, Hjorth, Siv Annegrethe, Brvar, M., Monaco, C., Frimurer, Thomas Michael & Schwartz, Thue W., Dec 2017, In: Molecular Metabolism. 6, 12, p. 1585-1596 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of non-peptide antagonist and peptide agonist binding sites of the NK1 receptor with fluorescent ligands
Turcatti, G., Drozda, S. E., Chassaing, G., Schwartz, Thue W., Chollet, A., Jensen, S. Z. & Lowe III, J. A., 1997, In: Journal of Biological Chemistry. 272, no. 34, p. 21167-21175Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Preassociation between the 5-HT7 serotonin receptor and G protein Gs: molecular determinants and association with low potency activation of adenylyl cyclase
Ulsund, A. H., Dahl, M., Frimurer, Thomas Michael, Manfra, O., Schwartz, Thue W., Levy, F. O. & Andressen, K. W., 2019, In: FASEB Journal. 33, 3, p. 3870-3886Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Adhesion receptor ADGRG2/GPR64 is in the GI-tract selectively expressed in mature intestinal tuft cells
Grunddal, Kaare Villum, Tonack, S., Egerod, Kristoffer Lihme, Thompson, J. J., Petersen, N., Engelstoft, M. S., Vagne, C., Keinse, C., Gradwohl, G., Offermanns, S. & Schwartz, Thue W., 2021, In: Molecular Metabolism. 51, 17 p., 101231.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mapping Substance P Binding Sites on the Neurokinin-1 Receptor Using Genetic Incorporation of a Photoreactive Amino Acid
Valentin-Hansen, L., Park, M., Huber, T., Grunbeck, A., Naganathan, S., Schwartz, Thue W. & Sakmar, T. P., 27 Jun 2014, In: The Journal of Biological Chemistry. 289, 26, p. 18045-54 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biased Gs Versus Gq Proteins and β-Arrestin Signaling in the NK1 Receptor Determined by Interactions in the Water Hydrogen Bond Network
Valentin-Hansen, L., Frimurer, Thomas Michael, Mokrosinski, J., Holliday, N. D. & Schwartz, Thue W., 2 Oct 2015, In: The Journal of Biological Chemistry. 290, 40, p. 24495-508 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PheVI:09 (Phe6.44) as a sliding microswitch in seven-transmembrane (7TM) G protein-coupled receptor activation
Valentin-Hansen, L., Holst, Birgitte, Frimurer, Thomas Michael, Schwartz, Thue W. & Hansen, L. V., 21 Dec 2012, In: Journal of Biological Chemistry. 287, 52, p. 43516-43526 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A systems biology approach to understand gut microbiota and host metabolism in morbid obesity: design of the BARIA Longitudinal Cohort Study
Van Olden, C. C., Van de Laar, A. W., Meijnikman, A. S., Aydin, O., Van Olst, N., Hoozemans, J. B., De Brauw, L. M., Bruin, S. C., Acherman, Y. I. Z., Verheij, J., Pyykko, J. E., Hagedoorn, M., Sanderman, R., Bosma, N. C., Tremaroli, V., Lundqvist, A., Olofsson, L. E., Herrema, H., Lappa, D., Hjorth, S. & 6 others, , 2021, In: Journal of Internal Medicine. 289, 3, p. 340-354 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Vagal afferent cholecystokinin receptor activation is required for glucagon-like peptide-1–induced satiation
Vana, V., Lærke, M. K., Rehfeld, Jens Frederik, Arnold, M., Dmytriyeva, O., Langhans, W., Schwartz, Thue W. & Hansen, Harald S., 2022, In: Diabetes, Obesity and Metabolism. 24, 2, p. 268-280Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Post-oral fat-induced satiation is mediated by endogenous CCK and GLP-1 in a fat self-administration mouse model
Vana, V., Lærke, M. K., Kleberg, K., Mroz, P. A., Lindberg, B. L., Ekberg, J. H., Rehfeld, Jens Frederik, Schwartz, Thue W. & Hansen, Harald S., 2021, In: Physiology and Behavior. 234, 12 p., 113315.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional and genetic epidemiological characterisation of the FFAR4 (GPR120) p.R270H variant in the Danish population
Vestmar, M. A., Galijatovic, E. A. A., Christensen, C. R., Pedersen, M. H., Glümer, C., Linneberg, Allan René, Witte, D. R., Jørgensen, M. E., Christensen, C., Brandslund, I., Lauritzen, T., Pedersen, Oluf Borbye, Holst, Birgitte, Grarup, Niels, Schwartz, Thue W. & Hansen, Torben, Sep 2016, In: Journal of Medical Genetics. 53, 9, p. 616-23 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The carboxyl terminus of human cytomegalovirus-encoded 7 transmembrane receptor US28 camouflages agonism by mediating constitutive endocytosis
Waldhoer, M., Casarosa, P., Rosenkilde, Mette, Smit, M. J., Leurs, R., Whistler, J. L. & Schwartz, Thue W., 2003, In: Journal of Biological Chemistry. 278, 21, p. 19473-82 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Murine cytomegalovirus (CMV) M33 and human CMV US28 receptors exhibit similar constitutive signaling activities
Waldhoer, M., Kledal, T. N., Farrell, H. & Schwartz, Thue W., 2002, In: Journal of Virology. 76, 16, p. 8161-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The carboxyl terminus of human cytomegalovirus-encoded 7 transmembrane receptor US28 camouflages agonism by mediating constitutive endoytosis
Waldhoer, M., Casarosa, P., Rosenkilde, Mette, Smit, M. J., Leurs, R., Whistler, J. L. & Schwartz, Thue W., 2003, In: Journal of Biological Chemistry. Vol. 278 (21), p. 19473-82Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Plagiarism of the host immune system - lessons about chemokine immunology from viruses
Wells, T. N. C. & Schwartz, Thue W., 1997, In: Current Opinion in Biotechnology. 8, no. 6, p. 741-748Research output: Contribution to journal › Journal article › Research › peer-review
- Published
KU bestemmer selv over sin forskning
Wewer, Ulla M., Holst, Jens Juul, Schwartz, Thue W. & Quistorff, B., 2 Jun 2011, In: Universitetsavisen.Research output: Contribution to journal › Contribution to newspaper - Comment/debate › Communication
- Published
Protective succinate-SUCNR1 metabolic stress signaling gone bad
Winther, Sally, Trauelsen, Mette & Schwartz, Thue W., 2021, In: Cell Metabolism. 33, 7, p. 1276-1278 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Critical role of somatostatin receptor 2 in the vulnerability of the central noradrenergic system: new aspects on Alzheimer's disease
Ádori, C., Glück, L., Barde, S., Yoshitake, T., Kovacs, G. G., Mulder, J., Maglóczky, Z., Havas, L., Bölcskei, K., Mitsios, N., Uhlén, M., Szolcsányi, J., Kehr, J., Rönnbäck, A., Schwartz, Thue W., Rehfeld, Jens Frederik, Harkany, T., Palkovits, M., Schulz, S. & Hökfelt, T., Apr 2015, In: Acta Neuropathologica. 129, 4, p. 541-63 23 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 11601
Most downloads
-
4524
downloads
Family and population-based studies of variation within the ghrelin receptor locus in relation to measures of obesity
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
2786
downloads
PDZ domain-mediated interactions of G protein-coupled receptors with postsynaptic density protein 95: quantitative characterization of interactions
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
609
downloads
Receptor structure-based discovery of non-metabolite agonists for the succinate receptor GPR91
Research output: Contribution to journal › Journal article › Research › peer-review
Published