Brenna Osborne
Assistant Professor, Guest Researcher
Protein hypoacylation induced by Sirt5 overexpression has minimal metabolic effect in mice
Bentley, N. L., Fiveash, C. E., Osborne, Brenna, Quek, L., Ogura, M., Inagaki, N., Cooney, G. J., Polly, P., Montgomery, M. K. & Turner, N., Jul 2018, In: Biochemical and Biophysical Research Communications. 503, 3, p. 1349-1355Research output: Contribution to journal › Journal article › Research › peer-review
Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging
Das, A., Huang, G. X., Bonkowski, M. S., Longchamp, A., Li, C., Schultz, M. B., Kim, L-J., Osborne, B., Joshi, S., Lu, Y., Treviño-Villarreal, J. H., Kang, M-J., Hung, T., Lee, B., Williams, E. O., Igarashi, M., Mitchell, J. R., Wu, L. E., Turner, N., Arany, Z. & 2 others, , 2018, In: Cell. 173, 1, p. 74-89 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
Erratum: Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging (Cell (2018) 173(1) (74–89.e20), (S0092867418301521) (10.1016/j.cell.2018.02.008))
Das, A., Huang, G. X., Bonkowski, M. S., Longchamp, A., Li, C., Schultz, M. B., Kim, L. J., Osborne, B., Joshi, S., Lu, Y., Treviño-Villarreal, J. H., Kang, M. J., Hung, T. T., Lee, B., Williams, E. O., Igarashi, M., Mitchell, J. R., Wu, L. E., Turner, N., Arany, Z. & 2 others, , 7 Feb 2019, In: Cell. 176, 4, p. 944-945 2 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
ORP5 localizes to ER–lipid droplet contacts and regulates the level of PI(4)P on lipid droplets
Du, X., Zhou, L., Aw, Y. C., Mak, H. Y., Xu, Y., Rae, J., Wang, W., Zadoorian, A., Hancock, S. E., Osborne, Brenna, Chen, X., Wu, J., Turner, N., Parton, R. G., Li, P. & Yang, H., 2020, In: Journal of Cell Biology. e201905162.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Akt activation increases cellular cholesterol by promoting the proteasomal degradation of Niemann-Pick C1
Du, X., Zhang, Y., Jo, S. R., Liu, X., Qi, Y., Osborne, Brenna, Byrne, F. L., Smith, G. C., Turner, N., Hoehn, K. L., Brown, A. J. & Yang, H., 15 Oct 2015, In: Biochemical Journal. 471, 2, p. 243-253 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Next Generation Diabetes Scientists Shape Global Research Culture: A reflective proposal from postdoctoral researchers in diabetes research
Gonzalez-Franquesa, A., Carrasquilla Lopez, G. D., Mamidi, A., Ghiasi, S. M., Juel, H. B., Falk, S., Isidor, M. S., Gillberg, L. M. E., Huang, L. O., Quist, J. S., Knudsen, J. R., Quaranta, R., Tozzi, M., Mikkelsen, R. B., Dall, M., Drag, M. H., Small, L. B., Altıntaş, A., Osborne, B., Modvig, I. M. & 11 others, , 2020, In: Acta Physiologica. 229, 2, 5 p., e13455.Research output: Contribution to journal › Comment/debate › Research
Pathways of Acetyl-CoA Metabolism Involved in the Reversal of Palmitate-Induced Glucose Production by Metformin and Salicylate
Hayward, B., Molero, J. C., Windmill, K., Sanigorski, A., Weir, J., McRae, N. L., Aston-Mourney, K., Osborne, Brenna, Liao, B., Walder, K. R., Meikle, P. J., Konstantopoulos, N. & Schmitz-Peiffer, C., 2017, In: Experimental and Clinical Endocrinology and Diabetes. 124, 10, p. 602-612 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Nuclear morphology is a deep learning biomarker of cellular senescence
Heckenbach, Indra John, Mkrtchyan, Garik, Ben Ezra, Michael, Bakula, Daniela Janina, Madsen, Jakob Sture, Nielsen, M. H., Oró, D., Osborne, Brenna, Covarrubias, A. J., Idda, M. L., Gorospe, M., Mortensen, Laust Hvas, Verdin, E., Westendorp, Rudi GJ & Scheibye-Knudsen, Morten, 2022, In: Nature Aging. 2, 8, p. 742-755 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs.
Keane, F., Yao, T., Seelk, S., Gall, M., Chowdhury, S., Poplawski, S., Lai, J., Li, Y., Wu, W., Farrell, P., Vieira, D. R. A., Osborne, Brenna, Yu, D., Seth, D., Rahman, K., Haber, P., Topaloglu, A., Wang, C., Thomson, S. & Hennessy, A., 2013, In: FEBS Open Bio. 4, 1Research output: Contribution to journal › Journal article › Research › peer-review
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Human exonuclease 1 (EXO1) regulatory functions in DNA replication with putative roles in cancer
Keijzers, G., Bakula, Daniela Janina, Petr, Michael Angelo, Madsen, N. G. K., Teklu, Amanuel Abraha, Mkrtchyan, Garik, Osborne, Brenna & Scheibye-Knudsen, Morten, 2019, In: International Journal of Molecular Sciences . 20, 1, 15 p., 74.Research output: Contribution to journal › Review › Research › peer-review
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PPARα -independent actions of omega-3 PUFAs contribute to their beneficial effects on adiposity and glucose homeostasis
Liu, M., Montgomery, M. K., Fiveash, C. E., Osborne, Brenna, Cooney, G. J., Bell-Anderson, K. & Turner, N., 2 Jul 2014, In: Scientific Reports. 4, 5538.Research output: Contribution to journal › Journal article › Research › peer-review
Snail-Overexpression Induces Epithelial-mesenchymal Transition and Metabolic Reprogramming in Human Pancreatic Ductal Adenocarcinoma and Non-tumorigenic Ductal Cells
Liu, M., Hancock, S. E., Sultani, G., Wilkins, B. P., Ding, E., Osborne, Brenna, Quek, L. & Turner, N., 8 Jun 2019, In: Journal of Clinical Medicine. 8, 6, 822.Research output: Contribution to journal › Journal article › Research › peer-review
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ARDD 2020: from aging mechanisms to interventions
Mkrtchyan, G. V., Abdelmohsen, K., Andreux, P., Bagdonaite, I., Barzilai, N., Brunak, S., Cabreiro, F., Cabo, R. D., Campisi, J., Cuervo, A. M., Demaria, M., Ewald, C. Y., Fang, E. F., Faragher, R., Ferrucci, L., Freund, A., Silva-García, C. G., Georgievskaya, A., Gladyshev, V. N., Glass, D. J. & 46 others, , 2020, In: Aging. 12, 24, p. 24486-24503 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Disparate metabolic response to fructose feeding between different mouse strains
Montgomery, M. K., Fiveash, C. E., Braude, J. P., Osborne, Brenna, Brown, Stanley, Mitchell, T. W. & Turner, N., 22 Dec 2015, In: Scientific Reports. 5, 18474.Research output: Contribution to journal › Journal article › Research › peer-review
Regulation of mitochondrial metabolism in murine skeletal muscle by the medium-chain fatty acid receptor Gpr84
Montgomery, M. K., Osborne, Brenna, Brandon, A. E., O'Reilly, L., Fiveash, C. E., Brown, S. H. J., Wilkins, B. P., Samsudeen, A., Yu, J., Devanapalli, B., Hertzog, A., Tolun, A. A., Kavanagh, T., Cooper, A. A., Mitchell, T. W., Biden, T. J., Smith, N. J., Cooney, G. J. & Turner, N., 2019, In: FASEB Journal. 33, 11, p. 12264-12276Research output: Contribution to journal › Journal article › Research › peer-review
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Contrasting metabolic effects of medium-versus long-chain fatty acids in skeletal muscle
Montgomery, M. K., Osborne, Brenna, Brown, S. H. J., Small, Lewin Barkla, Mitchell, T. W., Cooney, G. J. & Turner, N., Dec 2013, In: Journal of Lipid Research. 54, 12, p. 3322-3333 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Regulation of glucose homeostasis and insulin action by ceramide acyl-chain length: A beneficial role for very long-chain sphingolipid species
Montgomery, M. K., Brown, S. H. J., Lim, X. Y., Fiveash, C. E., Osborne, Brenna, Bentley, N. L., Braude, J. P., Mitchell, T. W., Coster, A. C. F., Don, A. S., Cooney, G. J., Schmitz-Peiffer, C. & Turner, N., 1 Nov 2016, In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1861, 11, p. 1828-1839 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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SIRT3 overexpression in rat muscle does not ameliorate peripheral insulin resistance
Osborne, Brenna, Wright, L. E., Brandon, A. E., Stuart, E., Small, Lewin Barkla, Hoeks, J., Schrauwen, P., Sinclair, D. A., Montgomery, M. K., Cooney, G. J. & Turner, N., 2023, In: Journal of Endocrinology. 258, 3, 11 p., e220101.Research output: Contribution to journal › Journal article › Research › peer-review
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Impact of lifestyle and clinical interventions on mitochondrial function in obesity and type 2 diabetes
Osborne, Brenna, Brandon, A. E., Smith, G. C. & Turner, N., 2019, Mitochondria in Obesity and Type 2 Diabetes: Comprehensive Review on Mitochondrial Functioning and Involvement in Metabolic Diseases. Academic Press, p. 367-397 31 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
Liver-specific overexpression of SIRT3 enhances oxidative metabolism, but does not impact metabolic defects induced by high fat feeding in mice
Osborne, Brenna, Reznick, J., Wright, L. E., Sinclair, D. A., Cooney, G. J. & Turner, N., 2022, In: Biochemical and Biophysical Research Communications. 607, p. 131-137 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Are sirtuin deacylase enzymes important modulators of mitochondrial energy metabolism?
Osborne, Brenna, Cooney, G. J. & Turner, N., Apr 2014, In: Biochimica et Biophysica Acta - General Subjects. 1840, 4, p. 1295-1302 8 p.Research output: Contribution to journal › Review › Research › peer-review
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A rare variant in human fibroblast activation protein associated with ER stress, loss of enzymatic function and loss of cell surface localisation
Osborne, Brenna, Yao, T. W., Wang, X. M., Chen, Y., Kotan, L. D., Nadvi, N. A., Herdem, M., McCaughan, G. W., Allen, J. D., Yu, D. M. T., Topaloglu, A. K. & Gorrell, M. D., Jul 2014, In: Biochimica et Biophysica Acta - Proteins and Proteomics. 1844, 7, p. 1248-1259 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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New methodologies in ageing research
Osborne, Brenna, Bakula, Daniela Janina, Ben Ezra, Michael, Dresen, C., Hartmann, E., Kristensen, S. M., Mkrtchyan, Garik, Nielsen, M. H., Petr, Michael Angelo & Scheibye-Knudsen, Morten, 2020, In: Ageing Research Reviews. 62, 11 p., 101094.Research output: Contribution to journal › Review › Research › peer-review
- Published
The role of mitochondrial sirtuins in health and disease
Osborne, Brenna, Bentley, N. L., Montgomery, M. K. & Turner, N., 1 Nov 2016, In: Free Radical Biology and Medicine. 100, p. 164-174 11 p.Research output: Contribution to journal › Review › Research › peer-review
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Pharmacological interventions in human aging
Petr, Michael Angelo, Matiyevskaya, Frida, Osborne, Brenna, Berglind, M., Reves, Simon William Nayberg, Zhang, B., Ben Ezra, Michael, Carmona Marin, Lina Maria, Syadzha, Muhammad Farraz, Mediavilla, M. C., Keijzers, G., Bakula, Daniela Janina, Mkrtchyan, Garik & Scheibye-Knudsen, Morten, 2024, In: Ageing Research Reviews. 95, 14 p., 102213.Research output: Contribution to journal › Review › Research › peer-review
A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction
Somers, K., Wen, V. W., Middlemiss, S. M. C., Osborne, B., Forgham, H., Jung, M., Karsa, M., Clifton, M., Bongers, A., Gao, J., Mayoh, C., Raoufi-Rad, N., Kusnadi, E. P., Hannan, K. M., Scott, D. A., Kwek, A., Liu, B., Flemming, C., Chudakova, D. A., Pandher, R. & 17 others, , 22 May 2019, In: Oncogene. 38, p. 3824–3842Research output: Contribution to journal › Journal article › Research › peer-review
NAD+: A key metabolic regulator with great therapeutic potential
Sultani, G., Samsudeen, A. F., Osborne, Brenna & Turner, N., 2017, In: Journal of Neuroendocrinology. 29, 10, e12508.Research output: Contribution to journal › Review › Research › peer-review
- Published
Repurposing Drugs to Target the Diabetes Epidemic
Turner, N., Zeng, X. Y., Osborne, Brenna, Rogers, S. & Ye, J. M., 1 May 2016, In: Trends in Pharmacological Sciences. 37, 5, p. 379-389 11 p.Research output: Contribution to journal › Review › Research › peer-review
A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism
Turner, N., Lim, X. Y., Toop, H. D., Osborne, B., Brandon, A. E., Taylor, E. N., Fiveash, C. E., Govindaraju, H., Teo, J. D., McEwen, H. P., Couttas, T. A., Butler, S. M., Das, A., Kowalski, G. M., Bruce, C. R., Hoehn, K. L., Fath, T., Schmitz-Peiffer, C., Cooney, G. J., Montgomery, M. K. & 2 others, , Dec 2018, In: Nature Communications. 9, 3165.Research output: Contribution to journal › Journal article › Research › peer-review
A Novel Purification Procedure for Active Recombinant Human DPP4 and the Inability of DPP4 to Bind SARS-CoV-2
Xi, C. R., Fazio, A. D., Nadvi, N. A., Patel, K., Xiang, M. S. W., Zhang, H. E., Deshpande, C., Low, J., Wang, X. T., Chen, Y., McMillan, C., Isaacs, A., Osborne, Brenna, Ribeiro, A. J. V. D., McCaughan, G. W., Mackay, J., Church, W. B. & Gorrell, M., Nov 2020, In: Molecules. 5392.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The dipeptidyl peptidase IV family in cancer and cell biology.
Yu, D., Yao, T., Chowdhury, S., Nadvi, N., Osborne, Brenna, Church, W., McCaughan, G. & Gorrell, M. D., Mar 2010, In: FEBS Journal. 277, 5Research output: Contribution to journal › Journal article › Research › peer-review
ID: 188144250
Most downloads
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191
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New methodologies in ageing research
Research output: Contribution to journal › Review › Research › peer-review
Published -
175
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Human exonuclease 1 (EXO1) regulatory functions in DNA replication with putative roles in cancer
Research output: Contribution to journal › Review › Research › peer-review
Published -
70
downloads
Next Generation Diabetes Scientists Shape Global Research Culture: A reflective proposal from postdoctoral researchers in diabetes research
Research output: Contribution to journal › Comment/debate › Research
Published