Human exonuclease 1 (EXO1) regulatory functions in DNA replication with putative roles in cancer

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Human exonuclease 1 (EXO1), a 5′→3′ exonuclease, contributes to the regulation of the cell cycle checkpoints, replication fork maintenance, and post replicative DNA repair pathways. These processes are required for the resolution of stalled or blocked DNA replication that can lead to replication stress and potential collapse of the replication fork. Failure to restart the DNA replication process can result in double-strand breaks, cell-cycle arrest, cell death, or cellular transformation. In this review, we summarize the involvement of EXO1 in the replication, DNA repair pathways, cell cycle checkpoints, and the link between EXO1 and cancer.

Original languageEnglish
Article number74
JournalInternational Journal of Molecular Sciences
Issue number1
Number of pages15
Publication statusPublished - 2019

    Research areas

  • DNA repair, Double strand break repair, EXO1, Exonuclease 1, Mismatch repair, MMR, NER, Nucleotide excision repair, Strand displacements, TLS, Translesion DNA synthesis

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