Birgitte Nielsen

Birgitte Nielsen

Academic Coordinator, !!Faglig koordinator

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    1 - 100 out of 135Page size: 100
    1. 1987
    2. Published

      Molecular pharmacology of excitatory amino acid receptors: conformational and stereochemical requirements

      Krogsgaard-Larsen, Povl, Madsen, Ulf, Nielsen, Birgitte, Hansen, J. J., Nielsen, E. Ø., Brehm, L. & Curtis, D. R., 1987, Proceedings of the X'th International Congress of Pharmacology. Rand, M. J. & Raper, C. (eds.). Elsevier, p. 113-116 4 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    3. 1989
    4. Published

      Excitatory Amino acid agonists and parital agonists

      Christensen, I. T., Reinhardt, A., Nielsen, Birgitte, Ebert, B., Madsen, Ulf, Nielsen, E. Ø., Brehm, L. & Krogsgaard-Larsen, Povl, 1989, In: drug design and delivery. 5, p. 57-71 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Neurochemical studies on quinoline antibiotics: effects on glutamate, GABA, and adenosine systems in mammalian CNS

      Dodd, P. R., Davies, L. P., Watson, W. E. J., Nielsen, Birgitte, Dyer, J. A., Wong, L. S. & Johnston, G. A. R., 1989, In: Pharmacology & Toxicology. 64, p. 404-411 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Excitatory Amino acid agonists: Enzymic resolution, X-ray structure, and enantioselective activities of (R)- and (S)-bromohomoibotenic acid

      Hansen, J. J., Nielsen, Birgitte, Krogsgaard-Larsen, Povl, Brehm, L., Nielsen, E. Ø. & Curtis, D. R., 1989, In: Journal of Medicinal Chemistry. 32, p. 2254-2260 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Isoxazole amino acids as glutamic acid receptor agonists: conformational and stereochemical aspects

      Hansen, J. J., Madsen, Ulf, Nielsen, E. Ø., Nielsen, Birgitte, Brehm, L. & Krogsgaard-Larsen, Povl, 1989, New Methods in Drug Research. Makriayannis, A. (ed.). Barcelona: Prous Scientific Publishers, Vol. 3. p. 73-101 29 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    8. Published

      Medicinal chemical and pharmacological focus on GABA and glutamic acid receptors in neurodegenerative disorders

      Krogsgaard-Larsen, Povl, Hedegaard, A., Nielsen, L., Nielsen, Birgitte, Madsen, Ulf, Brehm, L., Falch, E., Hjeds, H. & Hansen, J. J., 1989, Trends in Medicinal Chemistry '88. van der Goot, H., Domány, G., Pallos, L. & Timmerman, H. (eds.). Elsevier, Amsterdam, p. 429-452 24 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    9. 1990
    10. Published

      Structural and stereochemical requirements for interactions with subtypes of central excitatory amino acid receptors

      Brehm, L., Christensen, I. T., Nielsen, Birgitte, Reinhardt, A., Ebert, B., Madsen, Ulf, Jørgensen, Flemming Steen, Hansen, J. J. & Krogsgaard-Larsen, Povl, 1990, Frontiers in Drug Research; Alfred Benzon Symposium 28. Jensen, B., Jørgensen, F. S. & Kofod, H. (eds.). Copenhagen: Munksgaard , p. 92-105 14 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    11. Published

      Excitatory Amino acid receptor agonists: enantiomeric resolutions by use of enzymes and chiral HPLC

      Hansen, J. J., Nielsen, Birgitte, Reinhardt, A. & Krogsgaard-Larsen, Povl, 1990, In: Acta Pharmaceutica Nordica. 2, p. 185-192 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Structural, stereochemical and conformational requirements for activation and blockade of central glutamic acid receptors

      Krogsgaard-Larsen, Povl, Madsen, Ulf, Brehm, L., Christensen, I. T., Nielsen, Birgitte, Reinhardt, A., Ebert, B. & Hansen, J. J., 1990, Problems and Wonders of Chirale Molecules. Simonyi, M. (ed.). Budapest: Akadémiai Kiadó, p. 205-225 21 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    13. 1991
    14. Published

      Adskillelse af lægemidlers spejlbilledformer

      Nielsen, Birgitte, Breum, I. & Hansen, J. J., 1991, In: Lægemiddelforskning. p. 40-41 2 p.

      Research output: Contribution to journal › Journal article › Research

    15. 1992
    16. Published

      Excitatory amino acid receptor ligands. Synthesis and biological activity of 3-isoxazolol amino acids structurally related to homoibotenic acid

      Christensen, I. T., Ebert, B., Madsen, Ulf, Nielsen, Birgitte, Brehm, L. & Krogsgaard-Larsen, Povl, 18 Sep 1992, In: Journal of Medicinal Chemistry. 35, 19, p. 3512-3519 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      AMPA receptor agonists: structural, conformational and stereochemical aspects

      Hansen, J., Jørgensen, Flemming Steen, Lund, Trine Meldgaard, Nielsen, Birgitte, Reinhardt, A., Breum, I., Brehm, L. & Krogsgaard-Larsen, Povl, 1992, Excitatory Amino Acid Receptors. Krogsgaard-Larsen, P. & Hansen, J. J. (eds.). Ellis Horwood: Chichester, 30 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    18. Published

      Hydroxylated analogues of 5-aminovaleric acid as 4-aminobutyric acidB receptor antagonists: stereostructure-activity relationships

      Kristiansen, Uffe, bjl587, bjl587, Herdeis, C., Lund, Trine Meldgaard, Nielsen, Birgitte, Hansen, J. J., Falch, E., Hjeds, H. & Krogsgaard-Larsen, Povl, Mar 1992, In: Journal of Neurochemistry. 58, 3, p. 1150-9 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Stereoselective effects of AMOA on non-NMDA receptors expressed in Xenopus oocytes

      Wahl, P., Nielsen, Birgitte, Krogsgaard-Larsen, Povl, Hansen, J. J., Schousboe, Arne & Miledi, R., Nov 1992, In: Journal of Neuroscience Research. 33, 3, p. 392-7 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. 1993
    21. Published

      Excitatory amino acid research in Alzheimer´s disease: activation, enhancement and blockade of receptor subtypes

      Krogsgaard-Larsen, Povl, Nielsen, Birgitte & Hansen, J. J., 1993, Advances in Neuropharmacology. Ross, F. C. (ed.). London: Smith-Gordon and Company Limited, p. 241-248 8 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    22. Published

      Enzymatic resolution of AMPA by use of alpha-chymotrypsin

      Nielsen, Birgitte, Fisker, H., Ebert, B., Madsen, Ulf, Curtis, D. R., Krogsgaard-Larsen, Povl & Hansen, J. J., 1993, In: Bioorganic & Medicinal Chemistry Letters. 3, 1, p. 107–114 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. 1997
    24. Published

      (S)-homo-AMPA, a specific agonist at the mGlu6 subtype of metabotropic glutamic acid receptors

      Ahmadian, H., Nielsen, Birgitte, Bräuner, Hans, Johansen, Tommy Nørskov, Stensbøl, T. B., Sløk, F. A., Sekiyama, N., Nakanishi, S., Krogsgaard-Larsen, Povl & Madsen, Ulf, 24 Oct 1997, In: Journal of Medicinal Chemistry. 40, 22, p. 3700-5

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Molecular pharmacology of 4-substituted glutamic acid analogues at ionotropic and metabotropic excitatory amino acid receptors

      Bräuner, Hans, Nielsen, Birgitte, Stensbøl, T. B., Johansen, Tommy Nørskov, Skjaerbaek, N. & Krogsgaard-Larsen, Povl, 24 Sep 1997, In: European Journal of Pharmacology. 335, 2-3, p. R1-3

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. 1998
    27. Published

      Molecular pharmacology of homologues of ibotenic acid at cloned metabotropic glutamic acid receptors

      Bräuner, Hans, Nielsen, Birgitte & Krogsgaard-Larsen, Povl, 5 Jun 1998, In: European Journal of Pharmacology. 350, 2-3, p. 311-6

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Heteroaryl analogues of AMPA. 2. Synthesis, absolute stereochemistry, photochemistry, and structure-activity relationships

      Falch, E., Brehm, L., Mikkelsen, I., Johansen, Tommy Nørskov, Skjærbæk, N., Nielsen, Birgitte, Stensbøl, T. B., Ebert, B. & Krogsgaard-Larsen, Povl, 1998, In: Journal of Medicinal Chemistry. 41, p. 2513-2523 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      Aryl and cycloalkyl analogues of AMPA: synthetic, pharmacological and stereochemical aspects

      Skjærbæk, N., Brehm, L., Johansen, Tommy Nørskov, Hansen, L. M., Nielsen, Birgitte, Ebert, B., Søby, K., Stensbøl, T. B., Falch, E. & Krogsgaard-Larsen, Povl, 1998, In: Bioorganic & Medicinal Chemistry. 6, 1, p. 119-131 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. 1999
    31. Published

      Synthesis and Pharmacology of the Baclofen Homologues. 5-Amino-4-(4-chlorophenyl)pentanoic Acid and the R- and S-Enantiomers of 5-Amino-3-(4-chlorophenyl)pentanoic Acid

      Karla, R., Ebert, B., Thorkildsen, C., Herdeis, C., Johansen, Tommy Nørskov, Nielsen, Birgitte & Krogsgaard-Larsen, Povl, 1999, In: Journal of Medicinal Chemistry. 42, p. 2053-2059 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. 2000
    33. Published

      synthesis of epimers of L-cyclopentenylglycine using enzymatic resolution

      Andersen, L., Nielsen, Birgitte & Jaroszewski, J. W., 2000, In: Chirality. 12, 9, p. 665-669 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      A new structural class of subtype-selective inhibitor of cloned excitatory amino acid transporter, EAAT2

      Bräuner, Hans, Hermit, M. B., Nielsen, Birgitte, Krogsgaard-Larsen, Povl & Johansen, Tommy Nørskov, 6 Oct 2000, In: European Journal of Pharmacology. 406, 1, p. 41-4

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. 2001
    36. Published

      Resolution, configurational assignment, and enantiopharmacology at glutamate receptors of 2-amino-3-(3-carboxy-5-methyl-4-isoxazolyl)propionic acid (ACPA) and demethyl-ACPA

      Johansen, Tommy Nørskov, Stensbøl, T. B., Nielsen, Birgitte, Vogensen, S. B., Frydenvang, Karla Andrea, Sløk, F. A., Bräuner, Hans, Madsen, Ulf & Krogsgaard-Larsen, Povl, 2001, In: Chirality. 13, 9, p. 523-32 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Synthesis and pharmacology of 3-isoxazolol amino acids as selective antagonists at group I metabotropic glutamic acid receptors

      Madsen, Ulf, Bräuner, Hans, Frydenvang, Karla Andrea, Hvene, L., Johansen, Tommy Nørskov, Nielsen, Birgitte, Sánchez, C., Stensbøl, T. B., Bischoff, F. & Krogsgaard-Larsen, Povl, 2001, In: Journal of Medicinal Chemistry. 44, 7, p. 1051-9 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Structural and stereochemical requirements for activation and blocade of excitatory amino acid receptors

      Sløk, F. A., Bräuner, Hans, Stensbøl, T. B., Johansen, Tommy Nørskov, Ebert, B., Mortensen, M., Nielsen, Birgitte, Madsen, Ulf, Brehm, L., Falch, E. & Krogsgaard-Larsen, Povl, 2001, Medicinal Chemistry into the Millenium. Campbell, M. M. & Blagbrough, I. S. (eds.). UK: Royal Society of Chemistry, p. 52-64 13 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    39. Published

      Stereochemistry and molecular pharmacology of (S)-thio-ATPA, a new potent and selective GluR5 agonist

      Stensbøl, T. B., Jensen, H. S., Nielsen, Birgitte, Johansen, Tommy Nørskov, Egebjerg, J., Frydenvang, Karla Andrea & Krogsgaard-Larsen, Povl, 2001, In: European Journal of Pharmacology. 411, 3, p. 245-53 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. 2002
    41. Published

      Selective agonists at group II metabotropic glutamate receptors: synthesis, stereochemistry, and molecular pharmacology of (S)- and (R)-2-amino-4-(4-hydroxy[1,2,5]thiadiazol-3-yl)butyric acid

      Clausen, Rasmus Prætorius, Bräuner, Hans, Greenwood, J. R., Hermit, M. B., Stensbøl, T. B., Nielsen, Birgitte & Krogsgaard-Larsen, Povl, 12 Sep 2002, In: Journal of Medicinal Chemistry. 45, 19, p. 4240-5

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      Glutamate receptor ligands: synthesis, stereochemistry, and enantiopharmacology of methylated 2-aminoadipic acid analogs

      Guldbrandt, M., Johansen, Tommy Nørskov, Frydenvang, Karla Andrea, Bräuner, Hans, Stensbøl, T. B., Nielsen, Birgitte, Karla, R., Santi, F., Krogsgaard-Larsen, Povl & Madsen, Ulf, 2002, In: Chirality. 14, 4, p. 351-63 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      2-Amino-3-(3-hydroxy-1,2,5-thiadiazol-4-yl)propionic acid: resolution, absolute stereochemistry and enantiopharmacology at glutamate receptors

      Johansen, Tommy Nørskov, Janin, Y. L., Nielsen, Birgitte, Frydenvang, Karla Andrea, Bräuner, Hans, Stensbøl, T. B., Vogensen, S. B., Madsen, Ulf & Krogsgaard-Larsen, Povl, 2002, In: Bioorganic & Medicinal Chemistry. 10, 7, p. 2259-66 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. 2003
    45. Published

      Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO)

      Bjerrum, E. J., Kristensen, Anders Skov, Pickering, D. S., Greenwood, J. R., Nielsen, Birgitte, Liljefors, T., Schousboe, Arne, Bräuner, Hans, Madsen, Ulf & Pickering, Darryl S, 2003, In: Journal of Medicinal Chemistry. 46, 11, p. 2246-9 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      (S)-2-Amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid, a potent and selective agonist at the GluR5 subtype of ionotropic glutamate receptors. Synthesis, modeling, and molecular pharmacology

      Brehm, L., Greenwood, J. R., Hansen, K. B., Nielsen, Birgitte, Egebjerg, J., Stensbøl, T. B., Bräuner, Hans, Sløk, F. A., Kronborg, T. T. A. & Krogsgaard-Larsen, Povl, 10 Apr 2003, In: Journal of Medicinal Chemistry. 46, 8, p. 1350-8

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      Aza-THIP and Related Analogues of THIP as GABAC Antagonists

      Krehan, D., Frølund, Bente, Ebert, B., Nielsen, Birgitte, Krogsgaard-Larsen, Povl, Johnston, G. A. R. & Chebib, M., 2003, In: Bioorganic and Medicinal Chemistry. 11, p. 4891–4896

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Aza-THIP and related analogues of THIP as GABAC antagonists

      Krehan, D., Frølund, Bente, Ebert, B., Nielsen, Birgitte, Krogsgaard-Larsen, Povl, Johnston, G. A. R. & Chebib, M., 17 Nov 2003, In: Bioorganic and Medicinal Chemistry. 11, 23, p. 4891-4896 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Synthesis and in vitro pharmacology at AMPA and kainate preferring glutamate receptors of 4-heteroarylmethylidene glutamate analogues

      Valgeirsson, J., Christensen, J. K., Kristensen, Anders Skov, Pickering, Darryl S, Nielsen, Birgitte, Fischer, C., Bräuner, Hans, Nielsen, E. Ø., Krogsgaard-Larsen, Povl & Madsen, U., 2003, In: Bioorganic & Medicinal Chemistry. 11, 20, p. 4341-9 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. 2004
    51. Published

      Synthesis, theoretical and structural analyses, and enantiopharmacology of 3-carboxy homologs of AMPA

      Brehm, L., Greenwood, J. R., Sløk, F. A., Holm, M. M., Nielsen, Birgitte, Geneser, U., Stensbøl, T. B., Bräuner, Hans, Begtrup, M., Egebjerg, J. & Krogsgaard-Larsen, Povl, Aug 2004, In: Chirality. 16, 7, p. 452-66

      Research output: Contribution to journal › Journal article › Research › peer-review

    52. Published

      The respective N-hydroxypyrazole analogues of the classical glutamate receptor ligands ibotenic acid and (RS)-2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid

      Clausen, Rasmus Prætorius, Hansen, K. B., Calí, P., Nielsen, Birgitte, Greenwood, J. R., Begtrup, M., Egebjerg, J. & Bräuner, Hans, 19 Sep 2004, In: European Journal of Pharmacology. 499, 1-2, p. 35-44 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    53. Published

      Design, synthesis, and pharmacological characterization of novel, potent NMDA receptor antagonists

      Conti, P., De Amici, M., Grazioso, G., Roda, G., Barberis Negra, F. F., Nielsen, Birgitte, Stensbøl, T. B., Madsen, Ulf, Bräuner, Hans, Frydenvang, Karla Andrea, De Sarro, G., Toma, L. & De Micheli, C., 30 Dec 2004, In: Journal of Medicinal Chemistry. 47, 27, p. 6740-8 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    54. Published

      Ibotenic acid and thioibotenic acid: a remarkable difference in activity at group III metabotropic glutamate receptors

      Hermit, M. B., Greenwood, J. R., Nielsen, Birgitte, Bunch, Lennart, Jørgensen, Charlotte Grube, Vestergaard, H. T., Stensbøl, T. B., Sanchez, C., Krogsgaard-Larsen, Povl, Madsen, Ulf & Bräuner, Hans, 23 Feb 2004, In: European Journal of Pharmacology. 486, 3, p. 241-50

      Research output: Contribution to journal › Journal article › Research › peer-review

    55. Published

      A stereochemical anomaly: the cyclised (R)-AMPA analogue (R)-3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-5-carboxylic acid [(R)-5-HPCA] resembles (S)-AMPA at glutamate receptors

      Vogensen, S., Greenwood, J., Varming, A. R., Brehm, L., Pickering, Darryl S, Nielsen, Birgitte, Liljefors, T., Clausen, Rasmus Prætorius, Johansen, Tommy Nørskov & Krogsgaard-Larsen, Povl, 2004, In: Organic & Biomolecular Chemistry. 2, 2, p. 206-213

      Research output: Contribution to journal › Journal article › Research › peer-review

    56. 2005
    57. Published

      Azetidinic amino acids: stereocontrolled synthesis and pharmacological characterization as ligands for glutamate receptors and transporters

      Bräuner, Hans, Bunch, Lennart, Chopin, N., Couty, F., Evano, G., Jensen, Anders A., Kusk, M. L., Nielsen, Birgitte & Rabasso, N., 2005, In: Organic & Biomolecular Chemistry. 3, 21, p. 3926-36 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    58. Published

      Synthesis of novel N1-substituted bicyclic pyrazole amino acids and evaluation of their interaction with glutamate receptors

      Conti, P., Grazioso, G., di Ventimiglia, S. J., Pinto, A., Roda, G., Madsen, Ulf, Bräuner, Hans, Nielsen, Birgitte, Costagli, C. & Galli, A., Jun 2005, In: Chemistry & Biodiversity. 2, 6, p. 748-57

      Research output: Contribution to journal › Journal article › Research › peer-review

    59. Published

      Synthesis, binding affinity at glutamic acid receptors, neuroprotective effects, and molecular modeling investigation of novel dihydroisoxazole amino acids

      Conti, P., De Amici, M., Grazioso, G., Roda, G., Pinto, A., Hansen, K. B., Nielsen, Birgitte, Madsen, Ulf, Bräuner, Hans, Egebjerg, J., Vestri, V., Pellegrini-Giampietro, D. E., Sibille, P., Acher, F. C. & De Micheli, C., 6 Oct 2005, In: Journal of Medicinal Chemistry. 48, 20, p. 6315-25

      Research output: Contribution to journal › Journal article › Research › peer-review

    60. Published

      Potent 4-Aryl- or 4-Arylalkyl-Substituted 3-Isoxazolol GABAA Antagonists: Synthesis, Pharmacology, and Molecular Modeling

      Frølund, Bente, Jensen, L. S., Guandalini, L., Canillo, C., Vestergaard, H. T., Kristiansen, U., Nielsen, Birgitte, Stensbøl, T. B., Madsen, C., Krogsgaard-Larsen, Povl & Liljefors, T., 2005, In: Journal of Medicinal Chemistry. 48, p. 427–439

      Research output: Contribution to journal › Journal article › Research › peer-review

    61. Published

      Tetrazolyl isoxazole amino acids as ionotropic glutamate receptor antagonists: synthesis, modelling and molecular pharmacology

      Frølund, Bente, Greenwood, J. R., Holm, M. M., Egebjerg, J., Madsen, Ulf, Nielsen, Birgitte, Bräuner, Hans, Stensbøl, T. B. & Krogsgaard-Larsen, Povl, 15 Sep 2005, In: Bioorganic & Medicinal Chemistry. 13, 18, p. 5391-8

      Research output: Contribution to journal › Journal article › Research › peer-review

    62. Published

      4-Alkylated homoibotenic acid (HIBO) analogues: versatile pharmacological agents with diverse selectivity profiles towards metabotropic and ionotropic glutamate receptor subtypes

      Madsen, Ulf, Pickering, Darryl S, Nielsen, Birgitte & Bräuner, Hans, 2005, In: Neuropharmacology. 49 Suppl 1, p. 114-9 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    63. Published

      Convergent synthesis and pharmacology of substituted tetrazolyl-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid analogues

      Vogensen, S., Clausen, Rasmus Prætorius, Greenwood, J., Johansen, Tommy Nørskov, Pickering, Darryl S, Nielsen, Birgitte, Ebert, B. & Krogsgaard-Larsen, Povl, 5 May 2005, In: Journal of Medicinal Chemistry. 48, 9, p. 3438-3442

      Research output: Contribution to journal › Journal article › Research › peer-review

    64. Published

      Novel cyclic gamma-hydroxybutyrate (GHB) analogs with high affinity and stereoselectivity of binding to GHB sites in rat brain

      Wellendorph, Petrine, Høg, S., Greenwood, J. R., de Lichtenberg, A., Nielsen, Birgitte, Frølund, Bente, Brehm, L., Clausen, Rasmus Prætorius & Bräuner, Hans, Oct 2005, In: Journal of Pharmacology and Experimental Therapeutics. 315, 1, p. 346-51

      Research output: Contribution to journal › Journal article › Research › peer-review

    65. 2006
    66. Published

      Rational design and enantioselective synthesis of (1R,4S,5R,6S)-3-azabicyclo[3.3.0]octane-4,6-dicarboxylic acid - a novel inhibitor at human glutamate transporter subtypes 1, 2, and 3

      Bunch, Lennart, Nielsen, Birgitte, Jensen, Anders A. & Bräuner, Hans, 2006, In: Journal of Medicinal Chemistry. 49, 1, p. 172-8 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    67. Published

      Synthesis of 3-Hydroxy- and 3-Carboxy-Δ2-isoxazoline Amino Acids and Evaluation of Their Interaction with GABA Receptors and Transporters

      Conti, P., De Amici, M., Pinto, A., Tamborini, L., Grazioso, G., Frølund, Bente, Nielsen, Birgitte, Thomsen, C., Ebert, B. & De Michelli, C., 2006, In: European Journal of Pharmacology. p. 5533–5542

      Research output: Contribution to journal › Journal article › Research › peer-review

    68. Published

      MEDI 480-Novel lipophilic gamma-hydroxybutyrate (GHB) analogs with high affinity to GHB sites in rat brain

      Hog, S., Wellendorph, Petrine, Nielsen, Birgitte, Frølund, Bente & Clausen, Rasmus Prætorius, 10 Sep 2006, In: American Chemical Society. Abstracts of Papers (at the National Meeting). 232

      Research output: Contribution to journal › Conference abstract in journal › Research

    69. Published

      Potent 4-Arylalkyl-Substituted 3-Isothiazolol GABAA Competitive/Noncompetitive Antagonists: Synthesis and Pharmacology

      Krehan, D., i Storustovu, S., Liljefors, T., Ebert, B., Nielsen, Birgitte, Krogsgaard-Larsen, Povl & Frølund, Bente, 2006, In: Journal of Medicinal Chemistry. 49, p. 1388–1396

      Research output: Contribution to journal › Journal article › Research › peer-review

    70. Published

      Hydroxy-1,2,5-oxadiazolyl moiety as bioisoster of the carboxy function.Synthesis, ionization constants and pharmacological characterization of gamma-aminobutyric acid (GABA) related compounds

      Lolli, M. L., Hansen, S. L., Rolando, B., Nielsen, Birgitte, Wellendorph, Petrine, Madsen, K., Larsen, O. M., Kristiansen, Uffe, Fruttero, R., Gasco, A. & Johansen, Tommy Nørskov, 2006, In: J. Med. Chem.. 49, p. 4442-4446 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    71. Published

      Aminolysis of resin-bound N-nosylaziridine-2-carboxylic acids

      Olsen, Christian Adam, Christensen, C., Nielsen, Birgitte, Farah, M. M., Mohamed, F. M., Witt, M., Clausen, Rasmus Prætorius, Kristensen, Jesper Langgaard, Franzyk, Henrik & Jaroszewski, J. W., 2006, In: Organic Letters. 8, 15, p. 3371-4 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    72. 2007
    73. Published

      Synthesis and pharmacological characterization at glutamate receptors of erythro- and threo-tricholomic acid and homologues thereof

      Conti, P., De Amici, M., Roda, G., Pinto, A., Tamborini, L., Madsen, Ulf, Nielsen, Birgitte, Bräuner, Hans & De Micheli, C., 2007, In: Tetrahedron. 63, 10, p. 2249-2256

      Research output: Contribution to journal › Journal article › Research › peer-review

    74. Published

      Synthesis and pharmacological evaluation of novel conformationally constrained homologues of glutamic acid

      Conti, P., Caligiuri, A., Pinto, A., Roda, G., Tamborini, L., Nielsen, Birgitte, Madsen, Ulf, Frydenvang, Karla Andrea, Colombo, A. & De Micheli, C., 2007, In: European Journal of Medicinal Chemistry. 42, 8, p. 1059-1068

      Research output: Contribution to journal › Journal article › Research › peer-review

    75. Published

      Erratum: Synthesis and pharmacology of glutamate receptor ligands: New isothiazole analogues of ibotenic acid (Organic and Biomolecular Chemistry (2007) 5 DOI:10.1039/b615162k)

      Jørgensen, Charlotte Grube, Clausen, Rasmus Prætorius, Hansen, K. B., Bräuner, Hans, Nielsen, Birgitte, Metzler, B., Kehler, J., Krogsgaard-Larsen, Povl & Madsen, Ulf, 2007, In: Organic and Biomolecular Chemistry. 5, 5, p. 848 1 p.

      Research output: Contribution to journal › Comment/debate › Research › peer-review

    76. Published

      Novel 5-substituted 1-pyrazolol analogues of ibotenic acid: synthesis and pharmacology at glutamate receptors

      Jørgensen, Charlotte Grube, Bräuner, Hans, Nielsen, Birgitte, Kehler, J., Clausen, Rasmus Prætorius, Krogsgaard-Larsen, Povl & Madsen, Ulf, 2007, In: Bioorganic & Medicinal Chemistry. 15, 10, p. 3524-3538

      Research output: Contribution to journal › Journal article › Research › peer-review

    77. Published

      Synthesis and pharmacology of glutamate receptor ligands: new isothiazole analogues of ibotenic acid

      Jørgensen, Charlotte Grube, Clausen, Rasmus Prætorius, Hansen, K. B., Bräuner, Hans, Nielsen, Birgitte, Metzler, B., Kehler, J., Krogsgaard-Larsen, Povl & Madsen, Ulf, 2007, In: Organic & Biomolecular Chemistry. 5, 3, p. 463-471

      Research output: Contribution to journal › Journal article › Research › peer-review

    78. Published

      5-substituted imidazole-4-acetic acid analogues: synthesis, modeling, and pharmacological characterization of a series of novel ¿-aminobutyric acidC receptor agonists

      Madsen, C., Jensen, A. A., Liljefors, T., Kristiansen, Uffe, Nielsen, Birgitte, Hansen, C. P., Larsen, M., Ebert, B., Bang-Andersen, B., Krogsgaard-Larsen, Povl & Frølund, Bente, 2007, In: Journal of Medicinal Chemistry. 50, 17, p. 4147-4161

      Research output: Contribution to journal › Journal article › Research › peer-review

    79. Published

      5-Substituted imidazole-4-acetic acid analogues: Synthesis, modeling, and pharmacological characterization of a series of novel γ-aminobutyric acidC receptor agonists

      Madsen, C., Jensen, Anders A., Liljefors, T., Kristiansen, Uffe, Nielsen, Birgitte, Hansen, C. P., Larsen, M., Ebert, B., Bang-Andersen, B., Krogsgaard-Larsen, Povl & Frølund, Bente, 2007, In: Journal of Medicinal Chemistry. 50, p. 4147-4161

      Research output: Contribution to journal › Journal article › Research › peer-review

    80. Published

      A tetrazolyl-substituted subtype-selective AMPA receptor agonist

      Vogensen, S. B., Frydenvang, Karla Andrea, Greenwood, J. R., Postorino, G., Nielsen, Birgitte, Pickering, Darryl S, Ebert, B., Bølcho, U., Egebjerg, J., Gajhede, Michael, Kastrup, Jette Sandholm Jensen, Johansen, Tommy Nørskov, Clausen, Rasmus Prætorius & Krogsgaard-Larsen, Povl, 2007, In: Journal of Medicinal Chemistry. 50, 10, p. 2408-2414

      Research output: Contribution to journal › Journal article › Research › peer-review

    81. 2008
    82. Published

      N-Hydroxypyrazolyl glycine derivatives as selective N-methyl-D-aspartic acid receptor ligands

      Clausen, Rasmus Prætorius, Christensen, C., Hansen, K. B., Greenwood, J. R., Jørgensen, L., Micale, N., Madsen, J. C., Nielsen, Birgitte, Egebjerg, J., Bräuner, Hans, Traynelis, S. F. & Kristensen, Jesper Langgaard, 2008, In: Journal of Medicinal Chemistry. 51, 14, p. 4179-87

      Research output: Contribution to journal › Journal article › Research › peer-review

    83. Published

      Novel high-affinity and selective biaromatic 4-substituted ¿-hydroxybutyric acid (GHB) analogues as GHB ligands: design, synthesis, and binding studies

      Høg, S., Wellendorph, Petrine, Nielsen, Birgitte, Frydenvang, Karla Andrea, Dahl, I. F., Bräuner, Hans, Brehm, L., Frølund, Bente & Clausen, Rasmus Prætorius, 2008, In: Journal of Medicinal Chemistry. 51, 24, p. 8088-8095

      Research output: Contribution to journal › Journal article › Research › peer-review

    84. Published

      Synthesis and pharmacological characterization at glutamate receptors of the four enantiopure isomers of tricholomic acid

      Pinto, A., Conti, P., De Amici, M., Tamborini, L., Madsen, Ulf, Nielsen, Birgitte, Christesen, T., Bräuner, Hans & De Micheli, C., 2008, In: Journal of Medicinal Chemistry. 51, 7, p. 2311-2315

      Research output: Contribution to journal › Journal article › Research › peer-review

    85. Published

      Chemo-enzymatic synthesis of (2S,4R)-2-amino-4-(3-(2,2-diphenylethylamino)-3-oxopropyl)pentanedioic acid: a novel selective inhibitor of human excitatory amino acid transporter subtype 2

      Sagot, E., Jensen, Anders A., Pickering, Darryl S, Pu, X., Umberti, M., Stensbøl, T. B., Nielsen, Birgitte, Assaf, Z., Aboab, B., Bolte, J., Gefflaut, T. & Bunch, Lennart, 2008, In: Journal of Medicinal Chemistry. 51, 14, p. 4085-4092 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    86. Published

      Chemo-enzymatic synthesis of a series of 2,4-syn-functionalized (S)-glutamate analogues: new insight into the structure-activity relation of ionotropic glutamate receptor subtypes 5, 6, and 7.

      Sagot, E., Pickering, Darryl S, Pu, X., Umberti, M., Stensbøl, T. B., Nielsen, Birgitte, Chapelet, M., Bolte, J., Gefflaut, T. & Bunch, Lennart, 2008, In: Journal of Medicinal Chemistry. 51, 14, p. 4093-103

      Research output: Contribution to journal › Journal article › Research › peer-review

    87. 2009
    88. Published

      4,4-Dimethyl- and diastereomeric 4-hydroxy-4-methyl-(2S)-glutamate analogues display distinct pharmacological profiles at ionotropic glutamate receptors and excitatory amino acid transporters

      Bunch, Lennart, Pickering, Darryl S, Gefflaut, T., Vinatier, V., Helaine, V., Amir, A., Nielsen, Birgitte & Jensen, Anders A., 2009, In: ChemMedChem. 4, 11, p. 1925-1929

      Research output: Contribution to journal › Journal article › Research › peer-review

    89. Published

      Pharmacological characterization of (4R)-alkyl glutamate analogues at the ionotropic glutamate receptors: focus on subtypes iGlu5-7

      Bunch, Lennart, Gefflaut, T., Alaux, S., Sagot, E., Nielsen, Birgitte & Pickering, Darryl S, 2009, In: European Journal of Pharmacology. 609, p. 1-4

      Research output: Contribution to journal › Journal article › Research › peer-review

    90. Published

      The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue: synthesis, molecular pharmacology, and biostructural characterization

      Clausen, Rasmus Prætorius, Naur, P., Kristensen, Anders Skov, Greenwood, J. R., Strange, M., Bräuner, Hans, Jensen, Anders A., Nielsen, A. S. T., Geneser, U., Ringgaard, L. M., Nielsen, Birgitte, Pickering, Darryl S, Brehm, L., Gajhede, Michael, Krogsgaard-Larsen, Povl & Kastrup, Jette Sandholm Jensen, 2009, In: Journal of Medicinal Chemistry. 52, 15, p. 4911-4922

      Research output: Contribution to journal › Journal article › Research › peer-review

    91. Published

      Stereocontrolled synthesis and pharmacological evaluation of azetidine-2,3-dicarboxylic acids at NMDA receptors

      Sivaprakasam, M., Hansen, K. B., David, O., Nielsen, Birgitte, Traynelis, S. F., Clausen, Rasmus Prætorius, Couty, F. & Bunch, Lennart, 2009, In: ChemMedChem. 4, 1, p. 110-117

      Research output: Contribution to journal › Journal article › Research › peer-review

    92. Published

      3-Substituted phenylalanines as selective AMPA- and kainate receptor ligands

      Szymanska, E., Pickering, Darryl S, Nielsen, Birgitte & Johansen, Tommy Nørskov, 2009, In: Bioorganic & Medicinal Chemistry. 17, 17, p. 6390-401 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    93. 2010
    94. Published

      Synthesis and antitumor effect in vitro and in vivo of substituted 1,3-dihydroindole-2-ones

      Christensen, M. K., Erichsen, K. D., Trojel-Hansen, C., Tjørnelund, J., Nielsen, S. J., Frydenvang, Karla Andrea, Johansen, Tommy Nørskov, Nielsen, Birgitte, Sehested, M., Jensen, P. B., Ikaunieks, M., Zaichenko, A., Loza, E., Kalvinsh, I. & Björkling, Fredrik, 14 Oct 2010, In: Journal of Medicinal Chemistry. 53, 19, p. 7140-7145 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    95. Published

      Novel 3-carboxy- and 3-phosphonopyrazoline amino acids as potent and selective NMDA receptor antagonists: Design, synthesis, and pharmacological characterization

      Conti, P., Pinto, A., Tamborini, L., Madsen, Ulf, Nielsen, Birgitte, Bräuner, Hans, Hansen, K. B., Landucci, E., Pellegrini-Giampietro, D. E., De Sarro, G., Donato Di Paola, E. & De Micheli, C., 2010, In: ChemMedChem. 5, 9, p. 1465-1475

      Research output: Contribution to journal › Journal article › Research › peer-review

    96. Published

      Biostructural and pharmacological studies of bicyclic analogues of the 3-isoxazolol glutamate receptor agonist ibotenic acid

      Frydenvang, Karla Andrea, Pickering, Darryl S, Greenwood, J. R., Krogsgaard-Larsen, N., Brehm, L., Nielsen, Birgitte, Vogensen, S. B., Hald, H., Kastrup, Jette Sandholm Jensen, Krogsgaard-Larsen, Povl & Clausen, Rasmus Prætorius, 10 Nov 2010, In: Journal of Medicinal Chemistry. 53, 23, p. 8354-8361

      Research output: Contribution to journal › Journal article › Research › peer-review

    97. Published

      4-hydroxy-1,2,5-oxadiazol-3-yl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and molecular pharmacological characterization at ionotropic glutamate receptors of compounds related to glutamate and its homologues

      Lolli, M. L., Giordano, C., Pickering, Darryl S, Rolando, B., Hansen, K. B., Foti, A., Contreras-Sanz, A., Amir, A., Fruttero, R., Gasco, A., Nielsen, Birgitte & Johansen, Tommy Nørskov, 2010, In: Journal of Medicinal Chemistry. 53, 10, p. 4110-8 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    98. Published

      Novel 4-(piperidin-4-yl)-1-hydroxypyrazoles as gamma-aminobutyric acidA receptor ligands: synthesis, pharmacology, and structure-activity relationships

      Møller, H. A., Sander, T., Kristensen, Jesper Langgaard, Nielsen, Birgitte, Krall, J., Bergmann, M. L., Christiansen, B., Balle, T., Jensen, Anders A. & Frølund, Bente, 2010, In: Journal of Medicinal Chemistry. 53, 8, p. 3417-3421

      Research output: Contribution to journal › Journal article › Research › peer-review

    99. Published

      Erratum: Aminolysis of resin-bound N-nosylaziridine-2-carboxylic acids (Organic Letters (2006) 8 (3371))

      Olsen, Christian Adam, Christensen, C., Nielsen, Birgitte, Farah, M. M., Witt, M., Clausen, Rasmus Prætorius, Kristensen, Jesper Langgaard, Franzyk, Henrik & Jaroszewski, J. W., 15 Oct 2010, In: Organic Letters. 12, 20, p. 4708 1 p.

      Research output: Contribution to journal › Comment/debate › Research › peer-review

    100. Published

      A new metabotropic glutamate receptor agonist with in vivo anti-allodynic activity

      Stanley, N. J., Hutchinson, M. R., Kvist, T., Nielsen, Birgitte, Mathiesen, Jesper M., Bräuner, Hans, Avery, T. D., Tiekink, E. R. T., Pedersen, D. S., Irvine, R. J., Abell, A. D. & Taylor, D. K., 2010, In: Bioorganic & Medicinal Chemistry. 18, 16, p. 6089-6098

      Research output: Contribution to journal › Journal article › Research › peer-review

    101. Published

      1,2,3-triazolyl amino acids as AMPA receptor ligands

      Stanley, N. J., Pedersen, D. S., Nielsen, Birgitte, Kvist, T., Mathiesen, Jesper M., Bräuner, Hans, Taylor, D. K. & Abell, A. D., 15 Dec 2010, In: Bioorganic & Medicinal Chemistry Letters. 20, 24, p. 7512-7515

      Research output: Contribution to journal › Journal article › Research › peer-review

    102. 2011
    103. Published

      Discovery of a New Class of Ionotropic Glutamate Receptor Antagonists by the Rational Design of (2S,3R)-3-(3-Carboxyphenyl)-pyrrolidine-2-carboxylic Acid

      Larsen, A. M., Venskutonyte, R., Valadés, E. A., Nielsen, Birgitte, Pickering, Darryl S & Bunch, Lennart, 4 Nov 2011, In: ACS Chemical Neuroscience. 2, 2, p. 107-114 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    104. Published

      A highly selective agonist for the metabotropic glutamate receptor mGluR2

      Nielsen, S. D., Fulco, M., Serpi, M., Nielsen, Birgitte, Hansen, M. B., Hansen, K. L., Thomsen, C., Brodbeck, R., Bräuner, Hans, Pellicciari, R., Norrby, P., Greenwood, J. R. & Clausen, Rasmus Prætorius, 23 Sep 2011, In: MedChemComm. 2, 11, p. 1120-1124

      Research output: Contribution to journal › Journal article › Research › peer-review

    105. Published

      Synthesis of new isoxazoline-based acidic amino acids and investigation of their affinity and selectivity profile at ionotropic glutamate receptors

      Pinto, A., Conti, P., Grazioso, G., Tamborini, L., Madsen, Ulf, Nielsen, Birgitte & De Micheli, C., 1 Feb 2011, In: European Journal of Medicinal Chemistry. 46, 2, p. 787-793

      Research output: Contribution to journal › Journal article › Research › peer-review

    106. Published

      A new phenylalanine derivative acts as an antagonist at the AMPA receptor GluA2 and introduces partial domain closure: Synthesis, resolution, pharmacology, and crystal structure

      Szymanska, E., Frydenvang, Karla Andrea, Contreras-Sanz, A., Pickering, Darryl S, Frola, E., Serafimoska, Z., Nielsen, Birgitte, Kastrup, Jette Sandholm Jensen & Johansen, Tommy Nørskov, 4 Oct 2011, In: Journal of Medicinal Chemistry. 54, 20, p. 7289-7298

      Research output: Contribution to journal › Journal article › Research › peer-review

    107. 2012
    108. Published

      Structure-activity relationship study of selective excitatory amino acid transporter subtype 1 (EAAT1) inhibitor 2-amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101) and absolute configurational assignment using infrared and vibrational circular dichroism spectroscopy in combination with ab initio hartree-fock calculations

      Huynh, Tri Hien Viet, Shim, I., Bohr, H., Abrahamsen, B., Nielsen, Birgitte, Jensen, Anders A. & Bunch, Lennart, 2012, In: Journal of Medicinal Chemistry. 55, 11, p. 5403-12 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    109. Published

      Pharmacological and structural characterization of conformationally restricted (S)-glutamate analogues at ionotropic glutamate receptors

      Juknaite, L., Venskutonyte, R., Assaf, Z., Faure, S., Gefflaut, T., Aitken, D. J., Nielsen, Birgitte, Gajhede, Michael, Kastrup, Jette Sandholm Jensen, Bunch, Lennart, Frydenvang, Karla Andrea & Pickering, Darryl S, 2012, In: Journal of Structural Biology. 180, 1, p. 39-46

      Research output: Contribution to journal › Journal article › Research › peer-review

    110. Published

      Searsia species with affinity to the N-methyl-d-aspartic acid (NMDA) receptor

      Jäger, A., Knap, D. M., Nielsen, Birgitte, Stafford, G. I. & van Staden, J., Jan 2012, In: South African Journal of Botany. 78, p. 312–314 3 p.

      Research output: Contribution to journal › Letter › Research › peer-review

    111. Published

      Structure-activity relationships for negative allosteric mGluR5 modulators

      Kaae, B. H., Harpsøe, Kasper, Kvist, T., Mathiesen, Jesper M., Mølck, C., Gloriam, David E., Jimenez, H. N., Uberti, M. A., Nielsen, S. M., Nielsen, Birgitte, Bräuner, Hans, Sauerberg, P., Clausen, Rasmus Prætorius & Madsen, Ulf, 2012, In: ChemMedChem. 7, 3, p. 440-451

      Research output: Contribution to journal › Journal article › Research › peer-review

    112. Published

      5-(Piperidine-4-yl)-3-hydroxypyrazole: a novel scaffold forprobing the orthosteric GABAA receptor binding site

      Krall, J., Kongstad, Kenneth Thermann, Balle, T., Nielsen, Birgitte, Jensen, A. A. & Frølund, Bente, 2 Sep 2012.

      Research output: Contribution to conference › Poster › Research

    113. 2013
    114. Published

      Chemo-enzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters

      Assaf, Z., Larsen, A. P., Venskutonyte, R., Han, L., Abrahamsen, B., Nielsen, Birgitte, Gajhede, Michael, Kastrup, Jette Sandholm Jensen, Jensen, Anders A., Pickering, Darryl S, Frydenvang, Karla Andrea, Gefflaut, T. & Bunch, Lennart, 2013, In: Journal of Medicinal Chemistry. 56, 4, p. 1614-1628

      Research output: Contribution to journal › Journal article › Research › peer-review

    115. Published

      Erratum: Chemoenzymatic synthesis of new 2,4- syn -functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters (Journal of Medicinal Chemistry (2013) 56 (1614-1628))

      Assaf, Z., Larsen, A. P., Venskutonyteì, R., Han, L., Abrahamsen, B., Nielsen, Birgitte, Gajhede, Michael, Kastrup, Jette Sandholm Jensen, Jensen, A. A., Pickering, Darryl S, Frydenvang, Karla Andrea, Gefflaut, T. & Bunch, Lennart, 25 Jul 2013, In: Journal of Medicinal Chemistry. 56, 14, p. 5985 1 p.

      Research output: Contribution to journal › Comment/debate › Research › peer-review

    116. Published

      Exploring the orthosteric binding site of the γ-aminobutyric acid type A receptor using 4-(piperidin-4-yl)-1-hydroxypyrazoles 3- or 5-imidazolyl substituted: design, synthesis, and pharmacological evaluation

      Krall, J., Jensen, C. H., Sørensen, T. E., Nielsen, Birgitte, Jensen, Anders A., Sander, T., Balle, T. & Frølund, Bente, 15 Jul 2013, In: Journal of Medicinal Chemistry. 56, 16, p. 6536−6540 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    117. Published

      Synthesis and biological evaluation of 4-(aminomethyl)-1-hydroxypyrazole analogues of muscimol as ¿-aminobutyric acidA receptor agonists

      Petersen, J. G., Bergmann, R., Møller, H. A., Jørgensen, Charlotte Grube, Nielsen, Birgitte, Kehler, J., Frydenvang, Karla Andrea, Kristensen, Jesper Langgaard, Balle, T., Jensen, Anders A., Kristiansen, Uffe & Frølund, Bente, 2013, In: Journal of Medicinal Chemistry. 56, 3, p. 993-1006

      Research output: Contribution to journal › Journal article › Research › peer-review

    118. Published

      Development of 2 '-substituted (2S,1 ' R,2 ' S)-2-(carboxycyclopropyl)glycine analogues as potent N-methyl-D-aspartic acid receptor agonists

      Risgaard, R., Nielsen, S. D., Hansen, K. B., Jensen, C. M., Nielsen, Birgitte, Traynelis, S. F. & Clausen, Rasmus Prætorius, 23 May 2013, In: Journal of Medicinal Chemistry. 56, 10, p. 4071-4081

      Research output: Contribution to journal › Journal article › Research › peer-review

    119. Published

      3-Carboxy-pyrazolinalanine as a new scaffold for developing potent and selective NMDA receptor antagonists.

      Tamborini, L., Pinto, A., Mastronardi, F., Iannuzzi, M. C., Cullia, G., Nielsen, Birgitte, De Micheli, C. & Conti, P., Oct 2013, In: European Journal of Medicinal Chemistry. 68, p. 33-37 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    120. 2014
    121. Published

      Analogues of 3-Hydroxyisoxazole-Containing Glutamate Receptor Ligands Based on the 3-Hydroxypyrazole-Moiety: Design, Synthesis and Pharmacological Characterization

      Jørgensen, L., Nielsen, Birgitte, Pickering, Darryl S, Kristensen, Anders Skov, Frydenvang, Karla Andrea, Madsen, Ulf & Clausen, Rasmus Prætorius, 2014, In: Neurochemical Research. 39, 10, p. 1895-1905 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    122. Published

      5-(Piperidin-4-yl)-3-Hydroxypyrazole: A Novel Scaffold for Probing the Orthosteric γ-Aminobutyric Acid Type A Receptor Binding Site

      Krall, J., Kongstad, Kenneth Thermann, Nielsen, Birgitte, Sørensen, T. E., Balle, T., Jensen, Anders A. & Frølund, Bente, 2014, In: ChemMedChem. 9, 11, p. 2475-2485 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    123. Published

      Synthesis and pharmacological evaluation of 6-aminonicotinic acid analogues as novel γ-aminobutyric acidA receptor agonists

      Petersen, J. G., Sørensen, T. E., Damgaard, M., Nielsen, Birgitte, Jensen, Anders A., Balle, T., Bergmann, R. & Frølund, Bente, 2014, In: European Journal of Medicinal Chemistry. 84, p. 404-416 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    124. Published

      Synthesis of (3-hydroxy-pyrazolin-5-yl)glycine based ligands interacting with ionotropic glutamate receptors

      Pinto, A., Tamborini, L., Mastronardi, F., Ettari, R., Safoz, Y., Bunch, Lennart, Nielsen, Birgitte, Jensen, Anders A., De Micheli, C. & Conti, P., 2014, In: European Journal of Medicinal Chemistry. 75, p. 151-158 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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