Kresten Lindorff-Larsen

Kresten Lindorff-Larsen

Professor

ORCID: 0000-0002-4750-6039

Publication year:
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1 - 100 out of 204Page size: 100
  1. 2024
  2. Published

    A mutational atlas for Parkin proteostasis

    Clausen, L., Voutsinos, Vasileios, Cagiada, Matteo, Johansson, Kristoffer Enøe, Grønbæk-Thygesen, Martin, Nariya, S., Powell, R. L., Have, M. K. N., Østergaard, Vibe Hallundbæk, Stein, Amelie, Fowler, D. M., Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2024, In: Nature Communications. 15, 1, 17 p., 1541.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Conformational ensembles of the human intrinsically disordered proteome

    Tesei, Giulio, Trolle, A. I., Jonsson, Nicolas, Betz, J., Knudsen, F. E., Pesce, Francesco, Johansson, Kristoffer Enøe & Lindorff-Larsen, Kresten, 2024, In: Nature. 626, p. 897-904 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    FRETpredict: a Python package for FRET efficiency predictions using rotamer libraries

    Montepietra, D., Tesei, Giulio, Martins, J. M., Kunze, M. B. A., Best, R. B. & Lindorff-Larsen, Kresten, 2024, In: Communications Biology . 7, 1, 10 p., 298.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. 2023
  6. Published

    Fitting Force Field Parameters to NMR Relaxation Data

    Kümmerer, Felix, Orioli, S. & Lindorff-Larsen, Kresten, 5 Jun 2023, In: Journal of Chemical Theory and Computation. 19, 12, p. 3741-3751 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    A comprehensive map of human glucokinase variant activity

    Andersen, Sarah Gersing, Cagiada, Matteo, Gebbia, M., Gjesing, A. P., Coté, A. G., Seesankar, G., Li, R., Tabet, D., Weile, J., Stein, Amelie, Gloyn, A. L., Hansen, Torben, Roth, F. P., Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2023, In: Genome Biology. 24, 1, 23 p., 97.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Accurate protein stability predictions from homology models

    Valanciute, A., Nygaard, L., Zschach, Henrike, Maglegaard Jepsen, M., Lindorff-Larsen, Kresten & Stein, Amelie, 2023, In: Computational and Structural Biotechnology Journal. 21, p. 66-73 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Activation and substrate specificity of the human P4-ATPase ATP8B1

    Dieudonné, T., Kümmerer, Felix, Laursen, M. J., Stock, C., Flygaard, R. K., Khalid, S., Lenoir, G., Lyons, J. A., Lindorff-Larsen, Kresten & Nissen, P., 2023, In: Nature Communications. 14, 1, 14 p., 7492.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Assessment of models for calculating the hydrodynamic radius of intrinsically disordered proteins

    Pesce, Francesco, Newcombe, Estella Anne, Seiffert, P., Tranchant, E. E., Olsen, Johan Gotthardt, Grace, C. R., Kragelund, Birthe Brandt & Lindorff-Larsen, Kresten, 2023, In: Biophysical Journal. 122, 2, p. 310-321 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Combining Experiments and Simulations to Examine the Temperature-Dependent Behavior of a Disordered Protein

    Pesce, Francesco & Lindorff-Larsen, Kresten, 2023, In: Journal of Physical Chemistry B. 127, 28, p. 6277-6286 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Conformational and oligomeric states of SPOP from small-angle X-ray scattering and molecular dynamics simulations

    Thomasen, Emil, Cuneo, M. J., Mittag, T. & Lindorff-Larsen, Kresten, 2023, In: eLife. 12, 23 p., e84147.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Discovering functionally important sites in proteins

    Cagiada, Matteo, Bottaro, S., Lindemose, Søren, Schenstrøm, S. M., Stein, Amelie, Hartmann-Petersen, Rasmus & Lindorff-Larsen, Kresten, 2023, In: Nature Communications. 14, 1, 13 p., 4175.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Folding of heterologous proteins in bacterial cell factories: Cellular mechanisms and engineering strategies

    Rong, Y., Jensen, S. I., Lindorff-Larsen, Kresten & Nielsen, A. T., 2023, In: Biotechnology Advances. 63, 21 p., 108079.

    Research output: Contribution to journal › Review › Research › peer-review

  15. Published

    Global analysis of multi-mutants to improve protein function

    Johansson, Kristoffer Enøe, Lindorff-Larsen, Kresten & Winther, Jakob R., 2023, In: Journal of Molecular Biology. 435, 8, 15 p., 168034.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    HSP70-binding motifs function as protein quality control degrons

    Abildgaard, A. B., Voutsinos, Vasileios, Petersen, S. D., Larsen, Fia Brunsgaard Valsted, Kampmeyer, Caroline, Johansson, Kristoffer Enøe, Stein, Amelie, Ravid, T., Andréasson, C., Jensen, M. K., Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2023, In: Cellular and Molecular Life Sciences. 80, 1, 17 p., 32.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Improved predictions of phase behaviour of intrinsically disordered proteins by tuning the interaction range

    Tesei, Giulio & Lindorff-Larsen, Kresten, 2023, In: Open Research Europe. 2, 94, 24 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Integrated NMR/Molecular Dynamics Determination of the Ensemble Conformation of a Thermodynamically Stable CUUG RNA Tetraloop

    Oxenfarth, A., Kümmerer, Felix, Bottaro, S., Schnieders, R., Pinter, G., Jonker, H. R. A., Fürtig, B., Richter, C., Blackledge, M., Lindorff-Larsen, Kresten & Schwalbe, H., 2023, In: Journal of the American Chemical Society. 145, 30, p. 16557-16572 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Interpreting the molecular mechanisms of disease variants in human transmembrane proteins

    Tiemann, Johanna Katarina Sofie, Zschach, Henrike, Lindorff-Larsen, Kresten & Stein, Amelie, 2023, In: Biophysical Journal. 122, 11, 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Lynch syndrome, molecular mechanisms and variant classification

    Abildgaard, A. B., Nielsen, S., Bernstein, I., Stein, Amelie, Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2023, In: British Journal of Cancer. 128, 9 p.

    Research output: Contribution to journal › Review › Research › peer-review

  21. Published

    Plant YTHDF proteins are direct effectors of antiviral immunity against an N6-methyladenosine-containing RNA virus

    Martínez-Pérez, M., Aparicio, F., Arribas Hernandez, Laura, Tankmar, Mathias Due, Rennie, Sarah, von Bülow, Sören, Lindorff-Larsen, Kresten, Brodersen, Peter & Pallas, V., 2023, In: EMBO Journal. 42, 18, 17 p., e113378.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Prediction of Quality-control Degradation Signals in Yeast Proteins

    Johansson, Kristoffer Enøe, Mashahreh, B., Hartmann-Petersen, Rasmus, Ravid, T. & Lindorff-Larsen, Kresten, 2023, In: Journal of Molecular Biology. 435, 2, 9 p., 167915.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Rapid protein stability prediction using deep learning representations

    Blaabjerg, Lasse Møller, Kassem, M. M., Good, L. L., Jonsson, Nicolas, Cagiada, Matteo, Johansson, Kristoffer Enøe, Boomsma, Wouter, Stein, Amelie & Lindorff-Larsen, Kresten, 2023, In: eLife. 12, 19 p., e82593.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Rare Catechol-O-methyltransferase Missense Variants Are Structurally Unstable Proteasome Targets

    Larsen, Fia Brunsgaard Valsted, Cagiada, Matteo, Dideriksen, J., Stein, Amelie, Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2023, In: Biochemistry. 62, 8, 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Slow conformational changes in the rigid and highly stable chymotrypsin inhibitor 2

    Gavrilov, Y., Prestel, Andreas, Lindorff-Larsen, Kresten & Teilum, Kaare, 2023, In: Protein Science. 32, 4, 9 p., 4604.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    The effect of linker conformation on performance and stability of a two-domain lytic polysaccharide monooxygenase

    Forsberg, Z., Stepnov, A. A., Tesei, Giulio, Wang, Yong, Buchinger, E., Kristiansen, S. K., Aachmann, F. L., Arleth, Lise, Eijsink, V. G. H., Lindorff-Larsen, Kresten & Courtade, G., 2023, In: Journal of Biological Chemistry. 299, 11, 17 p., 105262.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    The prolactin receptor scaffolds Janus kinase 2 via co-structure formation with phosphoinositide-4,5-bisphosphate

    Araya-Secchi, R., Bugge, K., Seiffert, P., Petry, A., Haxholm, G. W., Lindorff-Larsen, Kresten, Pedersen, Stine Helene Falsig, Arleth, Lise & Kragelund, Birthe Brandt, 2023, In: eLife. 12, 27 p., e84645.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Tyrosine kinases compete for growth hormone receptor binding and regulate receptor mobility and degradation

    Chhabra, Y., Seiffert, P., Gormal, R. S., Vullings, M., Lee, C. M. M., Wallis, T. P., Dehkhoda, F., Indrakumar, S., Jacobsen, Nina Louise, Lindorff-Larsen, Kresten, Durisic, N., Waters, M. J., Meunier, F. A., Kragelund, Birthe Brandt & Brooks, A. J., 2023, In: Cell Reports. 42, 5, 26 p., 112490.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    WASCO: A Wasserstein-based Statistical Tool to Compare Conformational Ensembles of Intrinsically Disordered Proteins

    González-Delgado, J., Sagar, A., Zanon, C., Lindorff-Larsen, Kresten, Bernadó, P., Neuvial, P. & Cortés, J., 2023, In: Journal of Molecular Biology. 435, 14, 11 p., 168053.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. 2022
  31. Published

    14-fold increased prevalence of rare glucokinase gene variant carriers in unselected Danish patients with newly diagnosed type 2 diabetes

    Gjesing, A. P., Engelbrechtsen, L., Cathrine B. Thuesen, A., Have, C. T., Hollensted, M., Grarup, N., Linneberg, A., Steen Nielsen, J., Christensen, L. B., Thomsen, R. W., Johansson, K. E., Cagiada, M., Gersing, S., Hartmann-Petersen, R., Lindorff-Larsen, K., Vaag, A., Sørensen, H. T., Brandslund, I., Beck-Nielsen, H., Pedersen, O. & 2 others, Rungby, Jørgen & Hansen, Torben, 2022, In: Diabetes Research and Clinical Practice. 194, 9 p., 110159.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    A structural biology community assessment of AlphaFold2 applications

    Akdel, M., Pires, D. E., Porta Pardo, E., Jänes, J., Zalevsky, A. O., Meszaros, B., Bryant, P., Good, L. L., Laskowski, R. A., Pozzati, G., Shenoy, A., Zhu, W., Kundrotas, P., Serra, V. R., Rodrigues, C. H. M., Dunham, A. S., Burke, D., Borkakoti, N., Velankar, S., Frost, A. & 14 others, Basquin, J., Lindorff-Larsen, Kresten, Bateman, A., Kajava, A., Valencia, A., Ovchinnikov, S., Durairaj, J., Ascher, D. B., Thornton, J. M., Davey, N. E., Stein, Amelie, Elofsson, A., Croll, T. & Beltrao, P., 2022, In: Nature Structural & Molecular Biology. 29, 11, 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Co-evolution of drug resistance and broadened substrate recognition in HIV protease variants isolated from an Escherichia coli genetic selection system

    Koivisto, J. M., Poulsen, N. R., Larsen, B. S., Weibull, M. G. M., Stein, Amelie, Doro, F., Winther, Jakob R., Lindorff-Larsen, Kresten & Willemoës, Martin, 2022, In: The Biochemical journal. 479, 4, p. 479-501

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Conformational ensembles of intrinsically disordered proteins and flexible multidomain proteins

    Thomasen, Emil & Lindorff-Larsen, Kresten, 2022, In: Biochemical Society Transactions. 50, 1, p. 541-554 14 p.

    Research output: Contribution to journal › Review › Research › peer-review

  35. Published

    Conserved conformational dynamics determine enzyme activity

    Torgeson, K. R., Clarkson, M. W., Granata, D., Lindorff-Larsen, Kresten, Page, R. & Peti, W., 2022, In: Science Advances. 8, 31, 10 p., eabo5546.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Conserved degronome features governing quality control associated proteolysis

    Mashahreh, B., Armony, S., Johansson, Kristoffer Enøe, Chappleboim, A., Friedman, N., Gardner, R. G., Hartmann-Petersen, Rasmus, Lindorff-Larsen, Kresten & Ravid, T., 2022, In: Nature Communications. 13, 1, 13 p., 7588.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Cryo-EM structure of the human NKCC1 transporter reveals mechanisms of ion coupling and specificity

    Neumann, C., Rosenbæk, L. L., Flygaard, R. K., Habeck, M., Karlsen, J. L., Wang, Yong, Lindorff-Larsen, Kresten, Gad, H. H., Hartmann, R., Lyons, J. A., Fenton, R. A. & Nissen, P., 2022, In: EMBO Journal. 41, 23, 15 p., e110169.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Deciphering the Alphabet of Disorder-Glu and Asp Act Differently on Local but Not Global Properties

    Roesgaard, M. A., Lundsgaard, J. E., Newcombe, Estella Anne, Jacobsen, Nina Louise, Pesce, Francesco, Tranchant, E. E., Lindemose, Søren, Prestel, Andreas, Hartmann-Petersen, Rasmus, Lindorff-Larsen, Kresten & Kragelund, Birthe Brandt, 2022, In: Biomolecules. 12, 10, 19 p., 1426.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Disease-linked mutations cause exposure of a protein quality control degron

    Kampmeyer, Caroline, Larsen-Ledet, Sven, Wagnkilde, M. R., Michelsen, M., Iversen, Henriette Kring Mangor, Nielsen, S. V., Lindemose, Søren, Caregnato, A., Ravid, T., Stein, Amelie, Teilum, Kaare, Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2022, In: Structure. 30, 9, p. 1245-1253.e5

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Double Mutant of Chymotrypsin Inhibitor 2 Stabilized through Increased Conformational Entropy

    Gavrilov, Y., Kümmerer, Felix, Orioli, S., Prestel, Andreas, Lindorff-Larsen, Kresten & Teilum, Kaare, 2022, In: Biochemistry. 61, 3, p. 160-170 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Effect of naturally-occurring mutations on the stability and function of cancer-associated NQO1: Comparison of experiments and computation

    Pacheco-Garcia, J. L., Cagiada, Matteo, Tienne-Matos, K., Salido, E., Lindorff-Larsen, Kresten & L. Pey, A., 2022, In: Frontiers in Molecular Biosciences. 9, 17 p., 1063620.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein

    Gaggero, S., Martinez-Fabregas, J., Cozzani, A., Fyfe, P. K., Leprohon, M., Yang, J., Thomasen, F. E., Winkelmann, H., Magnez, R., Conti, A. G., Wilmes, S., Pohler, E., van Gijsel Bonnello, M., Thuru, X., Quesnel, B., Soncin, F., Piehler, J., Lindorff-Larsen, K., Roychoudhuri, R., Moraga, I. & 1 others, Mitra, S., 2022, In: Science immunology. 7, 78, 15 p., eade5686.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Improving Martini 3 for Disordered and Multidomain Proteins

    Thomasen, Emil, Pesce, Francesco, Roesgaard, M. A., Tesei, Giulio & Lindorff-Larsen, Kresten, 2022, In: Journal of Chemical Theory and Computation. 18, 4, p. 2033-2041 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Increasing protein stability by inferring substitution effects from high-throughput experiments

    Norrild, R. K., Johansson, Kristoffer Enøe, O'Shea, Charlotte, Morth, J. P., Lindorff-Larsen, Kresten & Winther, Jakob R., 2022, In: Cell Reports Methods. 2, 11, 11 p., 100333.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Mg2+-dependent conformational equilibria in CorA and an integrated view on transport regulation

    Johansen, Nicolai Tidemand, Bonaccorsi, M., Bengtsen, T., Nørgrd Larsen, Andreas, Tidemand, Frederik Grønbæk, Pedersen, Martin Cramer, Huda, P., Berndtsson, J., Darwish, T., Yepuri, N. R., Martel, A., Pomorski, Thomas Guenther, Bertarello, A., Sansom, M., Rapp, M., Crehuet, R., Schubeis, T., Lindorff-Larsen, Kresten, Pintacuda, G. & Arleth, Lise, 2022, In: eLife. 11, 35 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Predicting and interpreting large-scale mutagenesis data using analyses of protein stability and conservation

    Høie, M. H., Cagiada, Matteo, Frederiksen, A. H. B., Stein, Amelie & Lindorff-Larsen, Kresten, 2022, In: Cell Reports. 38, 2, 15 p., 110207.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    The covalent reactivity of functionalized 5-hydroxy-butyrolactams is the basis for targeting of fatty acid binding protein 5 (FABP5) by the neurotrophic agent MT-21

    Svenningsen, E. B., Ottosen, R. N., Jørgensen, K. H., Nisavic, M., Larsen, C. K., Hansen, B. K., Wang, Yong, Lindorff-Larsen, Kresten, Tørring, T., Hacker, S. M., Palmfeldt, J. & Poulsen, T. B., 2022, In: RSC Chemical Biology. 3, 10, p. 1216-1229 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    The role of water coordination in the pH-dependent gating of hAQP10

    Truelsen, S. F., Missel, Julie Winkel, Gotfryd, K., Pedersen, Per Amstrup, Gourdon, Pontus Emanuel, Lindorff-Larsen, Kresten & Hélix-Nielsen, C., 2022, In: B B A - Biomembranes. 1864, 1, 13 p., 183809.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Transient exposure of a buried phosphorylation site in an autoinhibited protein

    Orioli, S., Henning Hansen, C. G. & Lindorff-Larsen, Kresten, 2022, In: Biophysical Journal. 121, 1, p. 91-101 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. 2021
  51. Published

    VM i molekylære puslespil

    Abildgaard, A. B., Winther, Jakob R., Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 16 Apr 2021, In: Weekendavisen: Ideer. 15, p. 11

    Research output: Contribution to journal › Contribution to newspaper - Feature article › Communication

  52. Published

    Molekylære stavefejl

    Abildgaard, A. B., Winther, Jakob R., Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 28 Jan 2021, In: Weekendavisen, Ideer.

    Research output: Contribution to journal › Contribution to newspaper - Feature article › Communication

  53. Published

    A dual-reporter system for investigating and optimizing protein translation and folding in E. coli

    Zutz, A., Hamborg, L., Pedersen, L. E., Kassem, M. M., Papaleo, E., Koza, A., Herrgård, M. J., Ingemann Jensen, S., Teilum, Kaare, Lindorff-Larsen, Kresten & Nielsen, A. T., 2021, In: Nature Communications. 12, 15 p., 6093.

    Research output: Contribution to journal › Journal article › Research › peer-review

  54. Published

    Accurate model of liquid-liquid phase behavior of intrinsically disordered proteins from optimization of single-chain properties

    Tesei, Giulio, Schulze, T. K., Crehuet, R. & Lindorff-Larsen, Kresten, 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 44, 10 p., e2111696118.

    Research output: Contribution to journal › Journal article › Research › peer-review

  55. Published

    Architecture and assembly dynamics of the essential mitochondrial chaperone complex TIM9·10·12

    Weinhäupl, K., Wang, Yong, Hessel, A., Brennich, M., Lindorff-Larsen, Kresten & Schanda, P., 2021, In: Structure. 29, 9, p. 1065-1073.e4

    Research output: Contribution to journal › Journal article › Research › peer-review

  56. Published

    Charge Interactions in a Highly Charge-Depleted Protein

    Hervø-Hansen, S., Højgaard, C., Johansson, Kristoffer Enøe, Wang, Yong, Wahni, K., Young, D., Messens, J., Teilum, Kaare, Lindorff-Larsen, Kresten & Winther, Jakob R., 2021, In: Journal of the American Chemical Society. 143, 6, p. 2500-2508 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  57. Published

    Computational and Experimental Assessment of Backbone Templates for Computational Redesign of the Thioredoxin Fold

    Marin, Frederikke Isa, Johansson, Kristoffer Enøe, O'Shea, Charlotte, Lindorff-Larsen, Kresten & Winther, Jakob R., 2021, In: The Journal of Physical Chemistry B. 125, 40, p. 11141-11149

    Research output: Contribution to journal › Journal article › Research › peer-review

  58. Published

    Computational and experimental assessment of backbone templates for computational protein design

    Marin, Frederikke Isa, Johansson, K. E., O'Shea, Charlotte, Lindorff-Larsen, Kresten & Winther, Jakob R., 2021, 15 p.

    Research output: Working paper › Preprint › Research

  59. Published

    Conformational Ensembles of Noncoding Elements in the SARS-CoV-2 Genome from Molecular Dynamics Simulations

    Bottaro, S., Bussi, G. & Lindorff-Larsen, Kresten, 2021, In: Journal of the American Chemical Society. 143, 22, p. 8333-8343

    Research output: Contribution to journal › Journal article › Research › peer-review

  60. Published

    Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding

    Wang, Kaituo, Dagil, Robert, Lavstsen, Thomas, Misra, S. K., Spliid, C. B., Wang, Yong, Gustavsson, Tobias, Sandoval, D. R., Vidal-Calvo, E. E., Choudhary, Swati, Agerbæk, Mette Ørskov, Lindorff-Larsen, Kresten, Nielsen, Morten Agertoug, Theander, Thor Grundtvig, Sharp, J. S., Clausen, Thomas Mandel, Gourdon, Pontus Emanuel & Salanti, Ali, 2021, In: Nature Communications. 12, 1, 10 p., 2956.

    Research output: Contribution to journal › Journal article › Research › peer-review

  61. Published

    DEER-PREdict: Software for efficient calculation of spin-labeling EPR and NMR data from conformational ensembles

    Tesei, Giulio, Martins, J. M., Kunze, M. B. A., Wang, Yong, Crehuet, R. & Lindorff-Larsen, Kresten, 2021, In: PLOS Computational Biology. 17, 1, 18 p., e1008551.

    Research output: Contribution to journal › Journal article › Research › peer-review

  62. Published

    Ensuring scientific reproducibility in bio-macromolecular modeling via extensive, automated benchmarks

    Koehler Leman, J., Lyskov, S., Lewis, S. M., Adolf-Bryfogle, J., Alford, R. F., Barlow, K., Ben-Aharon, Z., Farrell, D., Fell, J., Hansen, W. A., Harmalkar, A., Jeliazkov, J., Kuenze, G., Krys, J. D., Ljubetič, A., Loshbaugh, A. L., Maguire, J., Moretti, R., Mulligan, V. K., Nance, M. L. & 30 others, Nguyen, P. T., Ó Conchúir, S., Roy Burman, S. S., Samanta, R., Smith, S. T., Teets, F., Tiemann, Johanna Katarina Sofie, Watkins, A., Woods, H., Yachnin, B. J., Bahl, C. D., Bailey-Kellogg, C., Baker, D., Das, R., DiMaio, F., Khare, S. D., Kortemme, T., Labonte, J. W., Lindorff-Larsen, Kresten, Meiler, J., Schief, W., Schueler-Furman, O., Siegel, J. B., Stein, Amelie, Yarov-Yarovoy, V., Kuhlman, B., Leaver-Fay, A., Gront, D., Gray, J. J. & Bonneau, R., 2021, In: Nature Communications. 12, 15 p., 6947.

    Research output: Contribution to journal › Journal article › Research › peer-review

  63. Published

    Fitting Side-Chain NMR Relaxation Data Using Molecular Simulations

    Kümmerer, Felix, Orioli, S., Harding-Larsen, D., Hoffmann, F., Gavrilov, Y., Teilum, Kaare & Lindorff-Larsen, Kresten, 2021, In: Journal of Chemical Theory and Computation. 17, 8, p. 5262-5275 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  64. Published

    Force Field Effects in Simulations of Flexible Peptides with Varying Polyproline II Propensity

    Jephthah, S., Pesce, Francesco, Lindorff-Larsen, Kresten & Skepö, M., 2021, In: Journal of Chemical Theory and Computation. 17, 10, p. 6634-6646 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  65. Published

    Insight into Calcium-Binding Motifs of Intrinsically Disordered Proteins

    Newcombe, Estella Anne, Fernandes, Catarina, Lundsgaard, J. E., Brakti, Inna, Lindorff-Larsen, Kresten, Langkilde, Annette Eva, Skriver, Karen & Kragelund, Birthe Brandt, 2021, In: Biomolecules. 11, 8, 17 p., 1173.

    Research output: Contribution to journal › Journal article › Research › peer-review

  66. Published

    Interplay of folded domains and the disordered low-complexity domain in mediating hnRNPA1 phase separation

    Martin, E. W., Thomasen, Emil, Milkovic, N. M., Cuneo, M. J., Grace, C. R., Nourse, A., Lindorff-Larsen, Kresten & Mittag, T., 2021, In: Nucleic Acids Research. 49, 5, p. 2931-2945 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  67. Published

    Linking thermodynamics and measurements of protein stability

    Lindorff-Larsen, Kresten & Teilum, Kaare, 2021, In: Protein engineering, design & selection : PEDS. 34, 13 p., gzab002.

    Research output: Contribution to journal › Review › Research › peer-review

  68. Published

    Mapping the degradation pathway of a disease-linked aspartoacylase variant

    Andersen, Sarah Gersing, Wang, Yong, Grønbæk-Thygesen, Martin, Kampmeyer, Caroline, Bjørnkjær, Lene, Willemoës, Martin, Andréasson, C., Stein, Amelie, Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2021, In: PLOS Genetics. 17, 4, 28 p., e1009539.

    Research output: Contribution to journal › Journal article › Research › peer-review

  69. Published

    Multiplexed assays reveal effects of missense variants in MSH2 and cancer predisposition

    Nielsen, S. V., Hartmann-Petersen, Rasmus, Stein, Amelie & Lindorff-Larsen, Kresten, 2021, In: PLOS Genetics. 17, 4, 6 p., e1009496.

    Research output: Contribution to journal › Journal article › Research › peer-review

  70. Published

    On the Potential of Machine Learning to Examine the Relationship Between Sequence, Structure, Dynamics and Function of Intrinsically Disordered Proteins

    Lindorff-Larsen, Kresten & Kragelund, Birthe Brandt, 2021, In: Journal of Molecular Biology. 433, 20, 22 p., 167196.

    Research output: Contribution to journal › Review › Research › peer-review

  71. Published

    Order and disorder - An integrative structure of the full-length human growth hormone receptor

    Kassem, N., Araya-Secchi, R., Bugge, K., Barclay, A., Steinocher, H., Khondker, A., Wang, Yong, Lenard, A. J., Bürck, J., Sahin, Cagla, Ulrich, A. S., Landreh, M., Pedersen, Martin Cramer, Rheinstädter, M. C., Pedersen, Per Amstrup, Lindorff-Larsen, Kresten, Arleth, Lise & Kragelund, Birthe Brandt, 2021, In: Science Advances. 7, 27, 20 p., eabh3805.

    Research output: Contribution to journal › Journal article › Research › peer-review

  72. Published

    Properdin oligomers adopt rigid extended conformations supporting function

    Pedersen, D. V., Pedersen, M. N., Mazarakis, S. M. M., Wang, Yong, Lindorff-Larsen, Kresten, Arleth, Lise & Andersen, G. R., 2021, In: eLife. 10, 22 p., e63356.

    Research output: Contribution to journal › Journal article › Research › peer-review

  73. Published

    Refinement of α-Synuclein Ensembles Against SAXS Data: Comparison of Force Fields and Methods

    Ahmed, M. C., Skaanning, L. K., Jussupow, A., Newcombe, Estella Anne, Kragelund, Birthe Brandt, Camilloni, C., Langkilde, Annette Eva & Lindorff-Larsen, Kresten, 2021, In: Frontiers in Molecular Biosciences. 8, 13 p., 654333.

    Research output: Contribution to journal › Journal article › Research › peer-review

  74. Published

    Refining conformational ensembles of flexible proteins against small-angle x-ray scattering data

    Pesce, Francesco & Lindorff-Larsen, Kresten, 2021, In: Biophysical Journal. 120, 22, p. 5124-5135 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  75. Published

    Structural and functional variation of chitin-binding domains of a lytic polysaccharide monooxygenase from Cellvibrio japonicus

    Madland, E., Forsberg, Z., Wang, Yong, Lindorff-Larsen, Kresten, Niebisch, A., Modregger, J., Eijsink, V. G. H., Aachmann, F. L. & Courtade, G., 2021, In: Journal of Biological Chemistry. 297, 4, 17 p., 101084.

    Research output: Contribution to journal › Journal article › Research › peer-review

  76. Published

    Synergistic stabilization of a double mutant in chymotrypsin inhibitor 2 from a library screen in E. coli

    Hamborg, L., Granata, D., Olsen, Johan Gotthardt, Roche, J. V., Pedersen, L. E., Nielsen, A. T., Lindorff-Larsen, Kresten & Teilum, Kaare, 2021, In: Communications Biology . 4, 9 p., 980.

    Research output: Contribution to journal › Journal article › Research › peer-review

  77. Published

    Ubiquitin Interacting Motifs: Duality Between Structured and Disordered Motifs

    Lambrughi, M., Maiani, E., Fas, B. A., Shaw, G. S., Kragelund, Birthe Brandt, Lindorff-Larsen, Kresten, Teilum, Kaare, Invernizzi, G. & Papaleo, E., 2021, In: Frontiers in Molecular Biosciences. 8, 14 p., 676235.

    Research output: Contribution to journal › Journal article › Research › peer-review

  78. Published

    Understanding the Origins of Loss of Protein Function by Analyzing the Effects of Thousands of Variants on Activity and Abundance

    Cagiada, Matteo, Johansson, Kristoffer Enøe, Valanciute, A., Nielsen, S. V., Hartmann-Petersen, Rasmus, Yang, J. J., Fowler, D. M., Stein, Amelie & Lindorff-Larsen, Kresten, 2021, In: Molecular Biology and Evolution. 38, 8, p. 3235-3246

    Research output: Contribution to journal › Journal article › Research › peer-review

  79. 2020
  80. Published

    Structure and dynamics of a nanodisc by integrating NMR, SAXS and SANS experiments with molecular dynamics simulations.

    Bengtsen, T., Midtgaard, S. R., Holm-Janas, Viktor, Kjølbye, L. R., Johansen, Nicolai Tidemand, Tesei, Giulio, Bottaro, S., Schiøtt, B., Arleth, Lise & Lindorff-Larsen, Kresten, 30 Jul 2020, In: eLife. 9, 24 p., e56518.

    Research output: Contribution to journal › Journal article › Research › peer-review

  81. Published

    Small-angle Neutron Scattering Shows that the Solution Structures of the Bacterial Mg2+-Channel CorA are Overall Similar with and without Mg2+ Bound

    Arleth, Lise, Johansen, Nicolai Tidemand, Bengtsen, T., Larsen, A. H., Tidemand, Frederik Grønbæk, Pomorski, Thomas Guenther & Lindorff-Larsen, Kresten, 7 Feb 2020, In: Biophysical Journal. 118, 3, Suppl. 1, p. 12A 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research

  82. Published

    Classifying disease-associated variants using measures of protein activity and stability

    Jepsen, M. M., Fowler, D. M., Hartmann-Petersen, Rasmus, Stein, Amelie & Lindorff-Larsen, Kresten, 2020, Protein Homeostasis Diseases: Mechanisms and Novel Therapies. Pey, A. L. (ed.). Elsevier, p. 91-107

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  83. Published

    Co-Chaperones in Targeting and Delivery of Misfolded Proteins to the 26S Proteasome

    Abildgaard, A. B., Andersen, Sarah Gersing, Larsen-Ledet, Sven, Nielsen, S. V., Stein, Amelie, Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2020, In: Biomolecules. 10, 8, 24 p., 1141.

    Research output: Contribution to journal › Review › Research › peer-review

  84. Published

    Combining molecular dynamics simulations with small-angle X-ray and neutron scattering data to study multi-domain proteins in solution

    Nørgrd Larsen, Andreas, Wang, Yong, Bottaro, S., Grudinin, S., Arleth, Lise & Lindorff-Larsen, Kresten, 2020, In: P L o S Computational Biology. 16, 4, 29 p., e1007870.

    Research output: Contribution to journal › Journal article › Research › peer-review

  85. Published

    Computing, Analyzing, and Comparing the Radius of Gyration and Hydrodynamic Radius in Conformational Ensembles of Intrinsically Disordered Proteins

    Ahmed, M. C., Crehuet, R. & Lindorff-Larsen, Kresten, 2020, Intrinsically Disordered Proteins: Methods and Protocols. Kragelund, B. B. & Skriver, K. (eds.). Humana Press, p. 429-445 17 p. (Methods in Molecular Biology, Vol. 2141).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  86. Published

    Folliculin variants linked to Birt-Hogg-Dubé syndrome are targeted for proteasomal degradation

    Bjørnkjær, Lene, Stein, Amelie, Grønbæk-Thygesen, Martin, Nygaard, L., Søltoft, C. L., Nielsen, S. V., Lisby, Michael, Ravid, T., Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2020, In: PLOS Genetics. 16, 11, 28 p., e1009187.

    Research output: Contribution to journal › Journal article › Research › peer-review

  87. Published

    Global analysis of protein stability by temperature and chemical denaturation

    Hamborg, L., Horsted, E. W., Johansson, Kristoffer Enøe, Willemoës, Martin, Lindorff-Larsen, Kresten & Teilum, Kaare, 2020, In: Analytical Biochemistry. 605, 7 p., 113863.

    Research output: Contribution to journal › Journal article › Research › peer-review

  88. Published

    How to learn from inconsistencies: Integrating molecular simulations with experimental data

    Orioli, S., Nørgrd Larsen, Andreas, Bottaro, S. & Lindorff-Larsen, Kresten, 2020, Computational Approaches for Understanding Dynamical Systems: Protein Folding and Assembly. Strodel, B. & Barz, B. (eds.). Academic Press, p. 123-176 54 p. (Progress in Molecular Biology and Translational Science, Vol. 170).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  89. Published

    Integrating Molecular Simulation and Experimental Data: A Bayesian/Maximum Entropy Reweighting Approach

    Bottaro, S., Bengtsen, T. & Lindorff-Larsen, Kresten, 2020, Structural Bioinformatics: Methods and Protocols. Gáspári, Z. (ed.). Humana Press, p. 219-240 22 p. (Methods in Molecular Biology, Vol. 2112).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  90. Published

    Integrating NMR and simulations reveals motions in the UUCG tetraloop

    Bottaro, S., Nichols, P. J., Vögeli, B., Parrinello, M. & Lindorff-Larsen, Kresten, 2020, In: Nucleic Acids Research. 48, 11, p. 5839-5848 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  91. Published

    Novel HARS2 missense variants identified in individuals with sensorineural hearing impairment and Perrault syndrome

    Karstensen, H. G., Rendtorff, N. D., Hindbæk, L. S., Colombo, R., Stein, Amelie, Birkebæk, N. H., Hartmann-Petersen, Rasmus, Lindorff-Larsen, Kresten, Højland, A. T., Petersen, M. B. & Tranebjærg, Lisbeth, 2020, In: European Journal of Medical Genetics. 63, 3, 6 p., 103733.

    Research output: Contribution to journal › Journal article › Research › peer-review

  92. Published

    Protein Dynamics Enables Phosphorylation of Buried Residues in Cdk2/Cyclin-A-Bound p27

    Henriques, J. & Lindorff-Larsen, Kresten, 2020, In: Biophysical Journal. 119, 10, p. 2010-2018 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  93. Published

    Protein destabilization and degradation as a mechanism for hereditary disease

    Nielsen, S. V., Schenstrøm, S. M., Christensen, Caspar Elo, Stein, Amelie, Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2020, Protein Homeostasis Diseases: Mechanisms and Novel Therapies. Pey, A. L. (ed.). Elsevier, p. 111-125

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  94. Published

    Structural basis of client specificity in mitochondrial membrane-protein chaperones

    Sučec, I., Wang, Yong, Dakhlaoui, O., Weinhäupl, K., Jores, T., Costa, D., Hessel, A., Brennich, M., Rapaport, D., Lindorff-Larsen, Kresten, Bersch, B. & Schanda, P., 2020, In: Science Advances. 6, 51, 15 p., eabd0263.

    Research output: Contribution to journal › Journal article › Research › peer-review

  95. Published

    What Will Computational Modeling Approaches Have to Say in the Era of Atomistic Cryo-EM Data?

    Fraser, J. S., Lindorff-Larsen, Kresten & Bonomi, M., 2020, In: Journal of Chemical Information and Modeling. 60, 5, p. 2410-2412 3 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  96. 2019
  97. Published

    Molecular dynamics-guided discovery of an ago-allosteric modulator for GPR40/FFAR1

    Lückmann, Michael, Trauelsen, Mette, Bentsen, M. A., Nissen, T. A. D., Martins, J., Fallah, Z., Nygaard, M. M., Papaleo, E., Lindorff-Larsen, Kresten, Schwartz, Thue W. & Frimurer, Thomas Michael, 2 Apr 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 14, p. 7123-7128

    Research output: Contribution to journal › Journal article › Research › peer-review

  98. Published

    PSX, Protein-Solvent Exchange: software for calculation of deuterium-exchange effects in small-angle neutron scattering measurements from protein coordinates

    Pedersen, Martin Cramer, Wang, Yong, Tidemand, Frederik Grønbæk, Martel, A., Lindorff-Larsen, Kresten & Arleth, Lise, 2019, In: Journal of Applied Crystallography. 52, 6, p. 1427-1436 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  99. Published

    A Multi-State Coarse-Grained Simulation Model Captures Conformational Cycling in P-Type ATPases

    Wang, Yong, Saleh, N., Chu, X. & Lindorff-Larsen, Kresten, 2019, In: Biophysical Journal. 116, 3, suppl. 1, p. 300a 1484-Plat.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  100. Published

    Allosteric modulation of the sarcoplasmic reticulum Ca2+ ATPase by thapsigargin via decoupling of functional motions

    Saleh, N., Wang, Yong, Nissen, P. & Lindorff-Larsen, Kresten, 2019, In: Physical Chemistry Chemical Physics. 21, 39, p. 21991-21995

    Research output: Contribution to journal › Journal article › Research › peer-review

  101. Published

    Barnaba: software for analysis of nucleic acid structures and trajectories

    Bottaro, S., Bussi, G., Pinamonti, G., Reisser, S., Boomsma, Wouter & Lindorff-Larsen, Kresten, 2019, In: RNA. 25, 2, p. 219-231

    Research output: Contribution to journal › Journal article › Research › peer-review

  102. Published

    Bayesian-Maximum-Entropy Reweighting of IDP Ensembles Based on NMR Chemical Shifts

    Crehuet, R., Buigues, P. J., Salvatella, X. & Lindorff-Larsen, Kresten, 2019, In: Entropy. 21, 9, 17 p., 898.

    Research output: Contribution to journal › Journal article › Research › peer-review

  103. Published

    Biophysical and Mechanistic Models for Disease-Causing Protein Variants

    Stein, Amelie, Fowler, D. M., Hartmann-Petersen, Rasmus & Lindorff-Larsen, Kresten, 2019, In: Trends in Biochemical Sciences. 44, 7, p. 575-588

    Research output: Contribution to journal › Review › Research › peer-review

  104. Published

    Computational and cellular studies reveal structural destabilization and degradation of MLH1 variants in Lynch syndrome

    Abildgaard, A. B., Stein, Amelie, Nielsen, S. V., Schultz-Knudsen, Katrine, Papaleo, E., Shrikhande, A., Hoffmann, Eva, Bernstein, I., Gerdes, Anne-Marie Axø, Takahashi, M., Ishioka, C., Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2019, In: eLife. 8, 28 p., e49138 .

    Research output: Contribution to journal › Journal article › Research › peer-review

  105. Published

    Dissecting the statistical properties of the linear extrapolation method of determining protein stability

    Lindorff-Larsen, Kresten, 2019, In: Protein engineering, design & selection : PEDS. 32, 10, p. 471-479 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  106. Published

    Fitting Corrections to an RNA Force Field Using Experimental Data

    Cesari, A., Bottaro, S., Lindorff-Larsen, Kresten, Banás, P., Sponer, J. & Bussi, G., 2019, In: Journal of Chemical Theory and Computation. 15, 6, p. 3425-3431

    Research output: Contribution to journal › Journal article › Research › peer-review

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