John Robert Couchman

John Robert Couchman

Professor emeritus


  1. 2018
  2. Published

    Keratinocytes negatively regulate the N-cadherin levels of melanoma cells via contact-mediated calcium regulation. / Chung, Heesung; Jung, Hyejung; Jho, Eek-Hoon; Multhaupt, Hinke A. B.; Couchman, John R; Oh, Eok-Soo.

    In: Biochemical and Biophysical Research Communications, Vol. 503, No. 2, 2018, p. 615-620.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Proteoglycan Isolation and Analysis. / Woods, Anne; Couchman, John R.

    In: Current Protocols in Cell Biology, Vol. 80, No. 1, e59, 2018.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. 2017
  5. Published

    IGF-IR cooperates with ERα to inhibit breast cancer cell aggressiveness by regulating the expression and localisation of ECM molecules. / Afratis, Nikolaos A; Bouris, Panagiotis; Skandalis, Spyros S; Multhaupt, Hinke A; Couchman, John R; Theocharis, Achilleas D; Karamanos, Nikos K.

    In: Scientific Reports, Vol. 7, 40138, 2017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Syndecans – key regulators of cell signaling and biological functions. / Afratis, Nikolaos A.; Nikitovic, Dragana; Multhaupt, Hinke A.B.; Theocharis, Achilleas D.; Couchman, John R.; Karamanos, Nikos K.

    In: FEBS Journal, Vol. 284, No. 1, 01.01.2017, p. 27-41.

    Research output: Contribution to journalReviewResearchpeer-review

  7. Published

    Proteoglycans, ion channels and cell-matrix adhesion. / Mitsou, Ioli; Multhaupt, Hinke A.B.; Couchman, John R.

    In: Biochemical Journal, Vol. 474, No. 12, 15.06.2017, p. 1965-1979.

    Research output: Contribution to journalReviewResearchpeer-review

  8. Published

    Syndecan-1 limits the progression of liver injury and promotes liver repair in acetaminophen-induced liver injury in mice. / Nam, Eon Jeong; Hayashida, Kazutaka; Aquino, Rafael S.; Couchman, John R.; Kozar, Rosemary A.; Liu, Jian; Park, Pyong Woo.

    In: Hepatology, Vol. 66, No. 5, 01.11.2017, p. 1601-1615.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Cell-extracellular matrix and cell-cell adhesion are linked by syndecan-4. / Pakideeri Karat, Sandeep Gopal; Multhaupt, Hinke A B; Pocock, Roger; Couchman, John R.

    In: Matrix Biology, Vol. 60-61, 07.2017, p. 57-69.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. 2016
  11. Published

    New structural insight of C-terminal region of Syntenin-1, enhancing the molecular dimerization and inhibitory function related on Syndecan-4 signaling. / Choi, Youngsil; Yun, Ji-Hye; Yoo, Jiho; Lee, Inhwan; Kim, Heeyoun; Son, Hye-Nam; Kim, In-San; Yoon, Ho Sup; Zimmermann, Pascale; Couchman, John R; Cho, Hyun-Soo; Oh, Eok-Soo; Lee, Weontae.

    In: Scientific Reports, Vol. 6, 36818, 10.11.2016.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Minireview : Syndecans and their crucial roles during tissue regeneration. / Chung, Heesung; Multhaupt, Hinke A B; Oh, Eok-Soo; Couchman, John R.

    In: FEBS letters, Vol. 590, No. 15, 08.2016, p. 2408-2417.

    Research output: Contribution to journalReviewResearchpeer-review

  13. Published

    Recent Insights into Cell Surface Heparan Sulphate Proteoglycans and Cancer. / Couchman, John R; Multhaupt, Hinke; Sanderson, Ralph D.

    In: F1000Research, Vol. 5, 1541, 2016.

    Research output: Contribution to journalReviewResearchpeer-review

  14. Published

    Syndecan heparan sulfate proteoglycans : Regulation, signaling and impact on tumor biology. / Gomes, Angélica Maciel; Sinkeviciute, Dovile; Multhaupt, Hinke A.B.; Yoneda, Atsuko; Couchman, John R.

    In: Trends in Glycoscience and Glycotechnology, Vol. 28, No. 163, 2016, p. E79-E90.

    Research output: Contribution to journalReviewResearchpeer-review

  15. Published

    Redefining the role of syndecans in C. elegans biology. / Gopal, Sandeep; Couchman, John; Pocock, Roger.

    In: Worm, Vol. 5, No. 1, e1142042, 14.04.2016.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    The Phosphorylation and Distribution of Cortactin Downstream of Integrin α9β1 Affects Cancer Cell Behaviour. / Høye, Anette M; Couchman, John R; Wewer, Ulla M; Yoneda, Atsuko.

    In: Scientific Reports, Vol. 6, 28529, 2016.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Extracellular matrix component signaling in cancer. / Multhaupt, Hinke A. B.; Leitinger, Birgit; Gullberg, Donald; Couchman, John R.

    In: Advanced Drug Delivery Reviews, Vol. 97, 01.02.2016, p. 28–40.

    Research output: Contribution to journalReviewResearchpeer-review

  18. 2015
  19. Published

    Fell-Muir Lecture : Syndecans: from peripheral coreceptors to mainstream regulators of cell behaviour. / Couchman, John R.; Gopal, Sandeep ; Lim, Hooi Ching; Nørgaard, Steffen; Multhaupt, Hinke A. B.

    In: International Journal of Experimental Pathology, Vol. 96, No. 1, 02.2015, p. 1-10.

    Research output: Contribution to journalReviewResearchpeer-review

  20. Published

    Constants in an era of change. / Couchman, John Robert.

    In: Journal of Histochemistry and Cytochemistry, Vol. 63, No. 1, 01.2015, p. 7.

    Research output: Contribution to journalEditorialResearch

  21. Published

    Transmembrane proteoglycans control stretch-activated channels to set cytosolic calcium levels. / Gopal, Sandeep; Søgaard, Pernille; Multhaupt, Hinke A B; Pataki, Csilla; Okina, Elena; Xian, Xiaojie; Pedersen, Mikael E; Stevens, Troy; Griesbeck, Oliver; Park, Pyong Woo; Pocock, Roger David John; Couchman, John R.

    In: Journal of Cell Biology, Vol. 210, No. 7, 28.09.2015, p. 1199-211.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Cell surface heparan sulfate proteoglycans control adhesion and invasion of breast carcinoma cells. / Lim, Hooi Ching; Multhaupt, Hinke A. B.; Couchman, John R.

    In: Molecular Cancer, Vol. 14, No. 15, 27.01.2015, p. 1-18.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Wnt Signaling Cascades and the Roles of Syndecan Proteoglycans. / Pataki, Csilla A; Couchman, John R; Brábek, Jan.

    In: Journal of Histochemistry and Cytochemistry, Vol. 63, No. 7, 24.04.2015, p. 465-80.

    Research output: Contribution to journalReviewResearchpeer-review

  24. Published

    Insights into the key roles of proteoglycans in breast cancer biology and translational medicine. / Theocharis, Achilleas D.; Skandalis, Spyros S.; Neill, Thomas; Multhaupt, Hinke A. B.; Hubo, Mario; Frey, Helena; Gopal, Sandeep; Gomes, Angelica; Afratis, Nikos; Lim, Hooi Ching; Couchman, John R.; Filmus, Jorge; Sanderson, Ralph D.; Schaefer, Liliana; Iozzo, Renato V.; Karamanos, Nikos K.

    In: BBA Reviews on Cancer, Vol. 1855, No. 2, 04.2015, p. 276–300.

    Research output: Contribution to journalReviewResearchpeer-review

  25. 2014
  26. Published

    Peer review and reproducibility. Crisis or time for course correction? / Couchman, John Robert.

    In: Journal of Histochemistry and Cytochemistry, Vol. 62, No. 1, 01.2014, p. 9-10.

    Research output: Contribution to journalEditorialResearch

  27. Published

    Protein kinase C, focal adhesions and the regulation of cell migration. / Fogh, Betina S; Multhaupt, Hinke A B; Couchman, John Robert.

    In: Journal of Histochemistry and Cytochemistry, Vol. 62, No. 3, 03.2014, p. 172-84.

    Research output: Contribution to journalReviewResearchpeer-review

  28. Published

    Attenuation of hedgehog acyltransferase-catalyzed sonic Hedgehog palmitoylation causes reduced signaling, proliferation and invasiveness of human carcinoma cells. / Konitsiotis, Antonios D; Chang, Shu-Chun; Jovanović, Biljana; Ciepla, Paulina; Masumoto, Naoko; Palmer, Christopher P; Tate, Edward W; Couchman, John Robert; Magee, Anthony I.

    In: PloS one, Vol. 9, No. 3, e89899, 2014, p. 1-13.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Syndecan-2 regulation of morphology in breast carcinoma cells is dependent on RhoGTPases. / Lim, Hooi Ching; Couchman, John Robert.

    In: BBA General Subjects, Vol. 1840, No. 8, 18.01.2014, p. 2482–2490.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. 2013
  31. Published

    Celebrating 60 years. / Couchman, John R.

    In: Journal of Histochemistry and Cytochemistry, Vol. 61, No. 1, 01.2013, p. 9-10.

    Research output: Contribution to journalEditorialResearch

  32. Published

    Mapping of matrix metalloproteinase cleavage sites on syndecan-1 and syndecan-4 ectodomains. / Manon-Jensen, Tina; Multhaupt, Hinke A B; Couchman, John R.

    In: F E B S Journal, Vol. 280, No. 10, 05.2013, p. 2320-31.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Phosphorylation and mRNA splicing of collapsin response mediator protein-2 determine inhibition of rho-associated protein kinase (ROCK) II function in carcinoma cell migration and invasion. / Morgan-Fisher, Marie; Couchman, John R; Yoneda, Atsuko.

    In: The Journal of Biological Chemistry, Vol. 288, No. 43, 25.10.2013, p. 31229-40.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    An epidermal microRNA regulates neuronal migration through control of the cellular glycosylation state. / Pedersen, Mikael Egebjerg; Snieckute, Goda; Kagias, Konstantinos; Nehammer, Camilla; Multhaupt, Hinke A B; Couchman, John R; Pocock, Roger.

    In: Science, Vol. 341, No. 6152, 20.09.2013, p. 1404-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. 2012
  36. Published

    Diacylglycerol kinase ζ regulates RhoA activation via a kinase-independent scaffolding mechanism. / Ard, Ryan; Mulatz, Kirk; Abramovici, Hanan; Maillet, Jean-Christian; Fottinger, Alexandra; Foley, Tanya; Byham, Michèle-Renée; Iqbal, Tasfia Ahmed; Yoneda, Atsuko; Couchman, John R; Parks, Robin J; Gee, Stephen H.

    In: Molecular Biology of the Cell, Vol. 23, No. 20, 10.2012, p. 4008-19.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    An introduction to proteoglycans and their localization. / Couchman, John R; Pataki, Andreea Csilla.

    In: Journal of Histochemistry and Cytochemistry, Vol. 60, No. 12, 12.2012, p. 885-97.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Prdm5 Regulates Collagen Gene Transcription by Association with RNA Polymerase II in Developing Bone. / Galli, Giorgio Giacomo; Honnens de Lichtenberg, Kristian; Carrara, Matteo; Hans, Wolfgang; Wuelling, Manuela; Mentz, Bettina; Multhaupt, Hinke Arnolda; Tonnesen, Cathrine Kolster Fog; Jensen, Klaus Thorleif; Rappsilber, Juri; Vortkamp, Andrea; Coulton, Les; Fuchs, Helmut; Gailus-Durner, Valérie; Hrabe de Angelis, Martin; Calogero, Raffaele Adolfo; Couchman, John Robert; Lund, Anders Henrik.

    In: P L o S Genetics (Online), Vol. 8, No. 5, 2012, p. e1002711.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    On the roles and regulation of chondroitin sulfate and heparan sulfate in zebrafish pharyngeal cartilage morphogenesis. / Holmborn, Katarina; Habicher, Judith; Kasza, Zsolt; Eriksson, Anna S; Filipek-Gorniok, Beata; Gopal, Sandeep; Couchman, John R; Ahlberg, Per E; Wiweger, Malgorzata; Spillmann, Dorothe; Kreuger, Johan; Ledin, Johan.

    In: The Journal of Biological Chemistry, Vol. 287, No. 40, 28.09.2012, p. 33905-16.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    The newcomer in the integrin family: Integrin α9 in biology and cancer. / Høye, Anette Melissa; Couchman, John Robert; Wewer, Ulla M.; Yoneda, Atsuko; Fukami, Kiyoko.

    In: Advances in Biological Regulation, Vol. 52, No. 2, 05.2012, p. 326-339.

    Research output: Contribution to journalReviewResearchpeer-review

  41. Published

    Heparan sulfate biosynthesis : methods for investigation of the heparanosome. / Multhaupt, Hinke A B; Couchman, John R.

    In: Journal of Histochemistry and Cytochemistry, Vol. 60, No. 12, 12.2012, p. 908-15.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Alpha-actinin interactions with syndecan-4 are integral to fibroblast-matrix adhesion and regulate cytoskeletal architecture. / Okina, Elena; Grossi, Alberto Blak; Pakideeri Karat, Sandeep Gopal; Multhaupt, Hinke Arnolda B V H; Couchman, John Robert.

    In: International Journal of Biochemistry & Cell Biology, Vol. 44, No. 12, 2012, p. 2161-2174.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    A collapsin response mediator protein 2 isoform controls myosin II-mediated cell migration and matrix assembly by trapping ROCK II. / Yoneda, Atsuko; Morgan-Fisher, Marie; Wait, Robin; Couchman, John R; Wewer, Ulla M.

    In: Molecular and Cellular Biology, Vol. 32, No. 10, 2012, p. 1788-804.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Breast and ovarian cancers: a survey and possible roles for the cell surface heparan sulfate proteoglycans. / Yoneda, Atsuko; Lendorf, Maria E; Couchman, John R; Multhaupt, Hinke A B.

    In: Journal of Histochemistry and Cytochemistry, Vol. 60, No. 1, 2012, p. 9-21.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. 2011
  46. Published

    Two distinct sites in sonic Hedgehog combine for heparan sulfate interactions and cell signaling functions. / Chang, Shu-Chun; Mulloy, Barbara; Magee, Anthony I; Couchman, John R.

    In: Journal of Biological Chemistry, Vol. 286, No. 52, 2011, p. 44391-402.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Syndecans as cell surface receptors: Unique structure equates with functional diversity. / Choi, Youngsil; Chung, Heesung; Jung, Heyjung; Couchman, John R; Oh, Eok-Soo.

    In: Matrix Biology, Vol. 30, No. 2, 01.03.2011, p. 93-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Syndecan-1 and syndecan-4 are independent indicators in breast carcinoma. / Lendorf, Maria E; Manon-Jensen, Tina; Kronqvist, Pauliina; Multhaupt, Hinke A B; Couchman, John R.

    In: Journal of Histochemistry and Cytochemistry, Vol. 59, No. 6, 01.06.2011, p. 615-29.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Syndecan-2 is a novel ligand for the protein tyrosine phosphatase receptor CD148. / Whiteford, James R; Xian, Xiaojie; Chaussade, Claire; Vanhaesebroeck, Bart; Nourshargh, Sussan; Couchman, John R.

    In: Molecular Biology of the Cell, Vol. 22, No. 19, 2011, p. 3609-24.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. 2010
  51. Published

    Transmembrane Signaling Proteoglycans. / Couchman, John R.

    In: Annual Review of Cell and Developmental Biology, Vol. 26, 10.11.2010, p. 89-114.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Serine34 phosphorylation of RHO guanine dissociation inhibitor (RHOGDI{alpha}) links signaling from conventional protein kinase C to RHO GTPase in cell adhesion. / Dovas, Athanassios; Choi, Youngsil; Yoneda, Atsuko; Multhaupt, Hinke A B; Kwon, Seung-Hae; Kang, Dongmin; Oh, Eok-Soo; Couchman, John R.

    In: Journal of Biological Chemistry, Vol. 285, No. 30, 15.05.2010, p. 23296-308.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Heparan sulfate chain valency controls syndecan-4 function in cell adhesion. / Gopal, Sandeep; Bober, Adam; Whiteford, James R; Multhaupt, Hinke A B; Yoneda, Atsuko; Couchman, John R.

    In: Journal of Biological Chemistry, Vol. 285, No. 19, 12.02.2010, p. 14247-58.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    Characterisation of stromal-cellular mechanotransduction through syndecan-4. / Hollosi, Peter; Grossi, Alberto; Couchman, John Robert.

    2010. Poster session presented at FECTS meeting, .

    Research output: Contribution to conferencePosterResearch

  55. Published

    Proteoglycans in health and disease: the multiple roles of syndecan shedding. / Manon-Jensen, Tina; Itoh, Yoshifumi; Couchman, John R.

    In: FEBS Journal, Vol. 277, No. 19, 2010, p. 3876-89.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. 2009
  57. Published

    Dynamics of extracellular matrix in ovarian follicles and corpora lutea of mice. / Irving-Rodgers, Helen F; Hummitzsch, Katja; Murdiyarso, Lydia S; Bonner, Wendy M; Sado, Yoshikazu; Ninomiya, Yoshifumi; Couchman, John R; Sorokin, Lydia M; Rodgers, Raymond J.

    In: Cell and Tissue Research, Vol. 339, No. 3, 2009, p. 613-24.

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. Published

    Alpha9beta1 integrin in melanoma cells can signal different adhesion states for migration and anchorage. / Lydolph, Magnus C; Morgan-Fisher, Marie; Høye, Anette M; Couchman, John R; Wewer, Ulla M; Yoneda, Atsuko.

    In: Experimental Cell Research, Vol. 315, No. 19, 2009, p. 3312-24.

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. Published

    Syndecan signaling: when, where and why? / Multhaupt, H A B; Yoneda, A; Whiteford, J R; Oh, E-S; Lee, W; Couchman, J R.

    In: Journal of Physiology and Pharmacology, Vol. 60 Suppl 4, 2009, p. 31-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  60. Published

    Syndecan proteoglycan contributions to cytoskeletal organization and contractility. / Okina, E; Manon-Jensen, T; Whiteford, J R; Couchman, J R.

    In: Scandinavian Journal of Medicine & Science in Sports Online, 2009.

    Research output: Contribution to journalJournal articleResearchpeer-review

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