An epidermal microRNA regulates neuronal migration through control of the cellular glycosylation state
Research output: Contribution to journal › Journal article › peer-review
An appropriate balance in glycosylation of proteoglycans is crucial for their ability to regulate animal development. Here, we report that the Caenorhabditis elegans microRNA mir-79, an ortholog of mammalian miR-9, controls sugar-chain homeostasis by targeting two proteins in the proteoglycan biosynthetic pathway: a chondroitin synthase (SQV-5; squashed vulva-5) and a uridine 5'-diphosphate-sugar transporter (SQV-7). Loss of mir-79 causes neurodevelopmental defects through SQV-5 and SQV-7 dysregulation in the epidermis. This results in a partial shutdown of heparan sulfate biosynthesis that impinges on a LON-2/glypican pathway and disrupts neuronal migration. Our results identify a regulatory axis controlled by a conserved microRNA that maintains proteoglycan homeostasis in cells.
Original language | English |
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Journal | Science |
Volume | 341 |
Issue number | 6152 |
Pages (from-to) | 1404-8 |
Number of pages | 5 |
ISSN | 0036-8075 |
DOIs | |
Publication status | Published - 20 Sep 2013 |
ID: 50947454