Syndecan-2 regulation of morphology in breast carcinoma cells is dependent on RhoGTPases
Research output: Contribution to journal › Journal article › peer-review
While syndecan-2 is usually considered a mesenchymal transmembrane proteoglycan, it can be upregulated in some tumour cells, such as the malignant breast carcinoma cell line, MDA-MB231. Depletion of this syndecan by siRNA, but not other syndecans, has a marked effect on cell morphology, increasing spreading, microfilament bundle and focal adhesion formation, with reduced cell migration.
Original language | English |
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Journal | BBA General Subjects |
Volume | 1840 |
Issue number | 8 |
Pages (from-to) | 2482–2490 |
Number of pages | 9 |
ISSN | 0304-4165 |
DOIs | |
Publication status | Published - 18 Jan 2014 |
ID: 109872808