Calcium in Cell-Extracellular Matrix Interactions

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In multicellular organisms, the cells are surrounded by persistent, dynamic extracellular matrix (ECM), the largest calcium reservoir in animals. ECM regulates several aspects of cell behavior including cell migration and adhesion, survival, gene expression and differentiation, thus playing a significant role in health and disease. Calcium is reported to be important in the assembly of ECM, where it binds to many ECM proteins. While serving as a calcium reservoir, ECM macromolecules can directly interact with cell surface receptors resulting in calcium transport across the membrane. This chapter mainly focusses on the role of cell-ECM interactions in cellular calcium regulation and how calcium itself mediates these interactions.

Original languageEnglish
Book seriesAdvances in Experimental Medicine and Biology
Pages (from-to)1079-1102
Number of pages24
Publication statusPublished - 2020

    Research areas

  • Animals, Calcium/metabolism, Cell Movement, Extracellular Matrix/metabolism, Extracellular Matrix Proteins/metabolism

ID: 231600595