John Robert Couchman
Nutritional Immunology
BRIC, Ole Maaløes Vej 5, 2200 København N, Building: 1-4-28A
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Syndecan-1 limits the progression of liver injury and promotes liver repair in acetaminophen-induced liver injury in mice
Nam, E. J., Hayashida, K., Aquino, R. S., Couchman, John Robert, Kozar, R. A., Liu, J. & Park, P. W., 1 Nov 2017, In: Hepatology. 66, 5, p. 1601-1615 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Syndecan-4 proteoglycan regulates the distribution and activity of protein kinase C.
Oh, E. S., Woods, A. & Couchman, John Robert, 1997, In: Journal of Biological Chemistry. 272, 13, p. 8133-6 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Multimerization of the cytoplasmic domain of syndecan-4 is required for its ability to activate protein kinase C.
Oh, E. S., Woods, A. & Couchman, John Robert, 1997, In: Journal of Biological Chemistry. 272, 18, p. 11805-11 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Serine phosphorylation of syndecan-2 proteoglycan cytoplasmic domain.
Oh, E. S., Couchman, John Robert & Woods, A., 1997, In: Archives of Biochemistry and Biophysics. 344, 1, p. 67-74 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Syndecan-4 proteoglycan cytoplasmic domain and phosphatidylinositol 4,5-bisphosphate coordinately regulate protein kinase C activity.
Oh, E. S., Woods, A., Lim, S. T., Theibert, A. W. & Couchman, John Robert, 1998, In: Journal of Biological Chemistry. 273, 17, p. 10624-9 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Syndecans-2 and -4; close cousins, but not identical twins.
Oh, E. & Couchman, John Robert, 2004, In: Molecules and Cells. 17, 2, p. 181-7 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Syndecan proteoglycan contributions to cytoskeletal organization and contractility
Okina, E., Manon-Jensen, T., Whiteford, J. R. & Couchman, John Robert, 2009, In: Scandinavian Journal of Medicine & Science in Sports Online.Research output: Contribution to journal › Journal article › Research › peer-review
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Alpha-actinin interactions with syndecan-4 are integral to fibroblast-matrix adhesion and regulate cytoskeletal architecture
Okina, E., Grossi, A. B., Pakideeri Karat, S. G., Multhaupt, Hinke Arnolda B V H & Couchman, John Robert, 2012, In: International Journal of Biochemistry & Cell Biology. 44, 12, p. 2161-2174 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cell-extracellular matrix and cell-cell adhesion are linked by syndecan-4
Pakideeri Karat, S. G., Multhaupt, Hinke Arnolda B V H, Pocock, R. & Couchman, John Robert, Jul 2017, In: Matrix Biology. 60-61, p. 57-69 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure and function of syndecans
Pataki, C. & Couchman, John Robert, 17 Aug 2012, Extracellular Matrix: Pathobiology and Signaling. Mouton de Gruyter, p. 197-208 12 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Wnt Signaling Cascades and the Roles of Syndecan Proteoglycans
Pataki, C. A., Couchman, John Robert & Brábek, J., 24 Apr 2015, In: Journal of Histochemistry and Cytochemistry. 63, 7, p. 465-80 16 p.Research output: Contribution to journal › Review › Research › peer-review
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An epidermal microRNA regulates neuronal migration through control of the cellular glycosylation state
Pedersen, M. E., Snieckute, Goda, Kagias, K., Nehammer, C., Multhaupt, Hinke Arnolda B V H, Couchman, John Robert & Pocock, R., 20 Sep 2013, In: Science. 341, 6152, p. 1404-8 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cell-substratum interactions in the adhesion and locomotion of fibroblasts.
Rees, D. A., Couchman, John Robert, Smith, C. G., Woods, A. & Wilson, G., 1982, In: Philosophical Transactions of the Royal Society of London. Biological Sciences. 299, 1095, p. 169-76 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Conformations, interactions and functions of intrinsically disordered syndecans
Ricard-Blum, S. & Couchman, John Robert, 2023, In: Biochemical Society Transactions. 51, 3, p. 1083-1096 14 p.Research output: Contribution to journal › Review › Research › peer-review
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Targeting syndecan shedding in cancer
Sanderson, R. D. & Couchman, John Robert, 17 Aug 2012, Extracellular Matrix: Pathobiology and Signaling. Mouton de Gruyter, p. 802-812 11 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Immunohistochemical localization of chondroitin sulfate, chondroitin sulfate proteoglycan, heparan sulfate proteoglycan, entactin, and laminin in basement membranes of postnatal developing and adult rat lungs.
Sannes, P. L., Burch, K. K., Khosla, J., McCarthy, K. J. & Couchman, John Robert, 1993, In: American Journal of Respiratory Cell and Molecular Biology. 8, 3, p. 245-51 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Solution structure of the dimeric cytoplasmic domain of syndecan-4.
Shin, J., Lee, W., Lee, D., Koo, B. K., Han, I., Lim, Y., Woods, A., Couchman, John Robert & Oh, E. S., 2001, In: Biochemistry. 40, 29, p. 8471-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Heparan sulfate regulates ADAM12 through a molecular switch mechanism.
Sørensen, H. P., Vives, R. R., Manetopoulos, C., Albrechtsen, Reidar, Lydolph, M. C., Jacobsen, J., Couchman, John Robert & Wewer, Ulla M., 2008, In: Journal of Biological Chemistry.Research output: Contribution to journal › Journal article › Research › peer-review
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Localization of glycosaminoglycan substitution sites on domain V of mouse perlecan.
Tapanadechopone, P., Hassell, J. R., Rigatti, B. & Couchman, John Robert, 1999, In: Biochemical and Biophysical Research Communications. 265, 3, p. 680-90 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Epidermal transformation leads to increased perlecan synthesis with heparin-binding-growth-factor affinity.
Tapanadechopone, P., Tumova, S., Jiang, X. & Couchman, John Robert, 2001, In: Biochemical Journal. 355, Pt 2, p. 517-27 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Insights into the key roles of proteoglycans in breast cancer biology and translational medicine
Theocharis, A. D., Skandalis, S. S., Neill, T., Multhaupt, Hinke Arnolda B V H, Hubo, M., Frey, H., Gopal, S., Gomes, A., Afratis, N., Lim, H. C., Couchman, John Robert, Filmus, J., Sanderson, R. D., Schaefer, L., Iozzo, R. V. & Karamanos, N. K., Apr 2015, In: BBA Reviews on Cancer. 1855, 2, p. 276–300 25 p.Research output: Contribution to journal › Review › Research › peer-review
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Hierarchy of ADAM12 binding to integrins in tumor cells.
Thodeti, C. K., Fröhlich, C., Nielsen, C. K., Holck, P., Sundberg, C., Kveiborg, Marie, Mahalingam, Y., Albrechtsen, Reidar, Couchman, John Robert & Wewer, Ulla M., 2005, In: Experimental Cell Research. 309, 2, p. 438-50 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA.
Thodeti, C. K., Albrechtsen, Reidar, Grauslund, M., Asmar, M., Larsson, C., Takada, Y., Mercurio, A. M., Couchman, John Robert & Wewer, Ulla M., 2002, In: Journal of Biological Chemistry. 278, 11, p. 9576-84 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Rat mesangial cells in vitro synthesize a spectrum of proteoglycan species including those of the basement membrane and interstitium.
Thomas, G. J., Shewring, L., McCarthy, K. J., Couchman, John Robert, Mason, R. M. & Davies, M., 1995, In: Kidney International. 48, 4, p. 1278-89 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Heparan sulfate proteoglycans on the cell surface: versatile coordinators of cellular functions.
Tumova, S., Woods, A. & Couchman, John Robert, 2000, In: International Journal of Biochemistry & Cell Biology. 32, 3, p. 269-88 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Heparan sulfate chains from glypican and syndecans bind the Hep II domain of fibronectin similarly despite minor structural differences.
Tumova, S., Woods, A. & Couchman, John Robert, 2000, In: Journal of Biological Chemistry. 275, 13, p. 9410-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Localization of the transmembrane proteoglycan syndecan-4 and its regulatory kinases in costameres of rat cardiomyocytes: a deconvolution microscopic study.
VanWinkle, W. B., Snuggs, M. B., De Hostos, E. L., Buja, L. M., Woods, A. & Couchman, John Robert, 2002, In: Anatomical Record. 268, 1, p. 38-46 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Immunohistochemical localization of basement membrane components during hair follicle morphogenesis.
Westgate, G. E., Shaw, D. A., Harrap, G. J. & Couchman, John Robert, 1984, In: Journal of Investigative Dermatology. 82, 3, p. 259-64 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Bullous pemphigoid antigen localization suggests an intracellular association with hemidesmosomes.
Westgate, G. E., Weaver, A. C. & Couchman, John Robert, 1985, In: Journal of Investigative Dermatology. 84, 3, p. 218-24 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Syndecans promote integrin-mediated adhesion of mesenchymal cells in two distinct pathways.
Whiteford, J., Behrends, V., Kirby, H., Kusche-Gullberg, M., Muramatsu, T. & Couchman, John Robert, 2007, In: Experimental Cell Research. 313, 18, p. 3902-13 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structural and cell adhesion properties of zebrafish syndecan-4 are shared with higher vertebrates.
Whiteford, J., Ko, S., Lee, W. & Couchman, John Robert, 2008, In: Journal of Biological Chemistry. 283, 43, p. 29322-30 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A conserved NXIP motif is required for cell adhesion properties of the syndecan-4 ectodomain.
Whiteford, J. R. & Couchman, John Robert, 2006, In: Journal of Biological Chemistry. 281, 43, p. 32156-63 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Syndecan-2 is a novel ligand for the protein tyrosine phosphatase receptor CD148
Whiteford, J. R., Xian, X., Chaussade, C., Vanhaesebroeck, B., Nourshargh, S. & Couchman, John Robert, 2011, In: Molecular Biology of the Cell. 22, 19, p. 3609-24 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Signaling from the matrix to the cytoskeleton: role of cell surface proteoglycans in matrix assembly.
Woods, A. & Couchman, John Robert, 1996, In: Kidney International. Supplement. 54, p. S64-7Research output: Contribution to journal › Journal article › Research › peer-review
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Proteoglycan isolation and analysis.
Woods, A. & Couchman, John Robert, 2001, In: Current Protocols in Cell Biology. Chapter 10, p. Unit 10.7Research output: Contribution to journal › Journal article › Research › peer-review
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Protein kinase C involvement in focal adhesion formation.
Woods, A. & Couchman, John Robert, 1992, In: Journal of Cell Science. 101 ( Pt 2), p. 277-90 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Adhesion and cytoskeletal organisation of fibroblasts in response to fibronectin fragments.
Woods, A., Couchman, John Robert, Johansson, S. & Höök, M., 1986, In: EMBO Journal. 5, 4, p. 665-70 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Heparan sulfate proteoglycans of rat embryo fibroblasts. A hydrophobic form may link cytoskeleton and matrix components.
Woods, A., Couchman, John Robert & Höök, M., 1985, In: Journal of Biological Chemistry. 260, 19, p. 10872-9 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Integrin modulation by lateral association.
Woods, A. & Couchman, John Robert, 2000, In: Journal of Biological Chemistry. 275, 32, p. 24233-6 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Focal adhesions and cell-matrix interactions.
Woods, A. & Couchman, John Robert, 1988, In: Collagen and Related Research. 8, 2, p. 155-82 27 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Syndecan 4 heparan sulfate proteoglycan is a selectively enriched and widespread focal adhesion component.
Woods, A. & Couchman, John Robert, 1994, In: Molecular Biology of the Cell. 5, 2, p. 183-92 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Syndecan-4 binding to the high affinity heparin-binding domain of fibronectin drives focal adhesion formation in fibroblasts.
Woods, A., Longley, R. L., Tumova, S. & Couchman, John Robert, 2000, In: Archives of Biochemistry and Biophysics. 374, 1, p. 66-72 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Heparan sulfate proteoglycans and signalling in cell adhesion.
Woods, A. & Couchman, John Robert, 1992, In: Advances in Experimental Medicine and Biology. 313, p. 87-96 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Syndecans: synergistic activators of cell adhesion.
Woods, A. & Couchman, John Robert, 1998, In: Trends in Cell Biolology. 8, 5, p. 189-92 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Syndecan proteoglycans and cell adhesion.
Woods, A., Oh, E. S. & Couchman, John Robert, 1998, In: Matrix Biology. 17, 7, p. 477-83 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A synthetic peptide from the COOH-terminal heparin-binding domain of fibronectin promotes focal adhesion formation.
Woods, A., McCarthy, J. B., Furcht, L. T. & Couchman, John Robert, 1993, In: Molecular Biology of the Cell. 4, 6, p. 605-13 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Syndecan-4 and focal adhesion function.
Woods, A. & Couchman, John Robert, 2001, In: Current Opinion in Cell Biology. 13, 5, p. 578-83 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Proteoglycan Isolation and Analysis
Woods, A. & Couchman, John Robert, 2018, In: Current Protocols in Cell Biology. 80, 1, 21 p., e59.Research output: Contribution to journal › Journal article › Research › peer-review
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cDNA cloning of the basement membrane chondroitin sulfate proteoglycan core protein, bamacan: a five domain structure including coiled-coil motifs.
Wu, R. R. & Couchman, John Robert, 1997, In: Journal of Cell Biology. 136, 2, p. 433-44 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Syndecans as receptors for pericellular molecules
Xian, X., Whiteford, J. R. & Couchman, John Robert, 2012, Extracellular Matrix: Pathobiology and Signaling. Mouton de Gruyter, p. 467-483 17 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
ID: 916617
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Characterisation of stromal-cellular mechanotransduction through syndecan-4
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Recent Insights into Cell Surface Heparan Sulphate Proteoglycans and Cancer
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The Phosphorylation and Distribution of Cortactin Downstream of Integrin α9β1 Affects Cancer Cell Behaviour
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