Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model
Research output: Contribution to journal › Journal article › Research › peer-review
Quorum sensing (QS)-deficient Pseudomonas aeruginosa biofilms formed in vitro are more susceptible to tobramycin than QS-proficient P. aeruginosa biofilms, and combination treatment with a QS inhibitor (QSI) and tobramycin shows synergistic effects on the killing of in vitro biofilms. We extended these results to an in vivo P. aeruginosa foreign-body biofilm model. The effect of treatment initiated prophylactically was compared with treatment initiated 11 days post-insertion.
Original language | English |
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Journal | The Journal of antimicrobial chemotherapy |
Volume | 67 |
Issue number | 5 |
Pages (from-to) | 1198-206 |
Number of pages | 9 |
ISSN | 0305-7453 |
DOIs | |
Publication status | Published - May 2012 |
- Animals, Anti-Bacterial Agents, Bacterial Load, Disease Models, Animal, Drug Synergism, Drug Therapy, Combination, Female, Foreign Bodies, Histocytochemistry, Mice, Mice, Inbred BALB C, Peritonitis, Pseudomonas Infections, Pseudomonas aeruginosa, Quorum Sensing, Tobramycin
Research areas
ID: 105877773