Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model
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Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model. / Christensen, Louise; van Gennip, Maria; Jakobsen, Tim H; Alhede, Morten; Hougen, Hans Petter; Høiby, Niels; Bjarnsholt, Thomas; Givskov, Michael; Alhede, Maria.
In: The Journal of antimicrobial chemotherapy, Vol. 67, No. 5, 05.2012, p. 1198-206.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model
AU - Christensen, Louise
AU - van Gennip, Maria
AU - Jakobsen, Tim H
AU - Alhede, Morten
AU - Hougen, Hans Petter
AU - Høiby, Niels
AU - Bjarnsholt, Thomas
AU - Givskov, Michael
AU - Alhede, Maria
PY - 2012/5
Y1 - 2012/5
N2 - Quorum sensing (QS)-deficient Pseudomonas aeruginosa biofilms formed in vitro are more susceptible to tobramycin than QS-proficient P. aeruginosa biofilms, and combination treatment with a QS inhibitor (QSI) and tobramycin shows synergistic effects on the killing of in vitro biofilms. We extended these results to an in vivo P. aeruginosa foreign-body biofilm model. The effect of treatment initiated prophylactically was compared with treatment initiated 11 days post-insertion.
AB - Quorum sensing (QS)-deficient Pseudomonas aeruginosa biofilms formed in vitro are more susceptible to tobramycin than QS-proficient P. aeruginosa biofilms, and combination treatment with a QS inhibitor (QSI) and tobramycin shows synergistic effects on the killing of in vitro biofilms. We extended these results to an in vivo P. aeruginosa foreign-body biofilm model. The effect of treatment initiated prophylactically was compared with treatment initiated 11 days post-insertion.
KW - Animals
KW - Anti-Bacterial Agents
KW - Bacterial Load
KW - Disease Models, Animal
KW - Drug Synergism
KW - Drug Therapy, Combination
KW - Female
KW - Foreign Bodies
KW - Histocytochemistry
KW - Mice
KW - Mice, Inbred BALB C
KW - Peritonitis
KW - Pseudomonas Infections
KW - Pseudomonas aeruginosa
KW - Quorum Sensing
KW - Tobramycin
U2 - 10.1093/jac/dks002
DO - 10.1093/jac/dks002
M3 - Journal article
C2 - 22302561
VL - 67
SP - 1198
EP - 1206
JO - Journal of Antimicrobial Chemotherapy
JF - Journal of Antimicrobial Chemotherapy
SN - 0305-7453
IS - 5
ER -
ID: 105877773