Membrane curvature enables N-Ras lipid anchor sorting to liquid-ordered membrane phases

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Membrane curvature enables N-Ras lipid anchor sorting to liquid-ordered membrane phases. / Larsen, Jannik Bruun; Jensen, Martin Borch; Bhatia, Vikram Kjøller; Pedersen, Søren Ljungberg; Bjørnholm, Thomas; Iversen, Lars; Uline, Mark; Szleifer, Igal; Jensen, Knud Jørgen; Hatzakis, Nikos; Stamou, Dimitrios.

In: Nature Chemical Biology, Vol. 11, No. 3, 2015, p. 192-194.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Larsen, JB, Jensen, MB, Bhatia, VK, Pedersen, SL, Bjørnholm, T, Iversen, L, Uline, M, Szleifer, I, Jensen, KJ, Hatzakis, N & Stamou, D 2015, 'Membrane curvature enables N-Ras lipid anchor sorting to liquid-ordered membrane phases', Nature Chemical Biology, vol. 11, no. 3, pp. 192-194. https://doi.org/10.1038/nchembio.1733

APA

Larsen, J. B., Jensen, M. B., Bhatia, V. K., Pedersen, S. L., Bjørnholm, T., Iversen, L., Uline, M., Szleifer, I., Jensen, K. J., Hatzakis, N., & Stamou, D. (2015). Membrane curvature enables N-Ras lipid anchor sorting to liquid-ordered membrane phases. Nature Chemical Biology, 11(3), 192-194. https://doi.org/10.1038/nchembio.1733

Vancouver

Larsen JB, Jensen MB, Bhatia VK, Pedersen SL, Bjørnholm T, Iversen L et al. Membrane curvature enables N-Ras lipid anchor sorting to liquid-ordered membrane phases. Nature Chemical Biology. 2015;11(3):192-194. https://doi.org/10.1038/nchembio.1733

Author

Larsen, Jannik Bruun ; Jensen, Martin Borch ; Bhatia, Vikram Kjøller ; Pedersen, Søren Ljungberg ; Bjørnholm, Thomas ; Iversen, Lars ; Uline, Mark ; Szleifer, Igal ; Jensen, Knud Jørgen ; Hatzakis, Nikos ; Stamou, Dimitrios. / Membrane curvature enables N-Ras lipid anchor sorting to liquid-ordered membrane phases. In: Nature Chemical Biology. 2015 ; Vol. 11, No. 3. pp. 192-194.

Bibtex

@article{87e9599cfdc44eb2ac5f3a08156d5a8f,
title = "Membrane curvature enables N-Ras lipid anchor sorting to liquid-ordered membrane phases",
abstract = "Trafficking and sorting of membrane-anchored Ras GTPases are regulated by partitioning between distinct membrane domains. Here, in vitro experiments and microscopic molecular theory reveal membrane curvature as a new modulator of N-Ras lipid anchor and palmitoyl chain partitioning. Membrane curvature was essential for enrichment in raft-like liquid-ordered phases; enrichment was driven by relief of lateral pressure upon anchor insertion and most likely affects the localization of lipidated proteins in general.",
author = "Larsen, {Jannik Bruun} and Jensen, {Martin Borch} and Bhatia, {Vikram Kj{\o}ller} and Pedersen, {S{\o}ren Ljungberg} and Thomas Bj{\o}rnholm and Lars Iversen and Mark Uline and Igal Szleifer and Jensen, {Knud J{\o}rgen} and Nikos Hatzakis and Dimitrios Stamou",
year = "2015",
doi = "10.1038/nchembio.1733",
language = "English",
volume = "11",
pages = "192--194",
journal = "Nature Chemical Biology",
issn = "1552-4450",
publisher = "nature publishing group",
number = "3",

}

RIS

TY - JOUR

T1 - Membrane curvature enables N-Ras lipid anchor sorting to liquid-ordered membrane phases

AU - Larsen, Jannik Bruun

AU - Jensen, Martin Borch

AU - Bhatia, Vikram Kjøller

AU - Pedersen, Søren Ljungberg

AU - Bjørnholm, Thomas

AU - Iversen, Lars

AU - Uline, Mark

AU - Szleifer, Igal

AU - Jensen, Knud Jørgen

AU - Hatzakis, Nikos

AU - Stamou, Dimitrios

PY - 2015

Y1 - 2015

N2 - Trafficking and sorting of membrane-anchored Ras GTPases are regulated by partitioning between distinct membrane domains. Here, in vitro experiments and microscopic molecular theory reveal membrane curvature as a new modulator of N-Ras lipid anchor and palmitoyl chain partitioning. Membrane curvature was essential for enrichment in raft-like liquid-ordered phases; enrichment was driven by relief of lateral pressure upon anchor insertion and most likely affects the localization of lipidated proteins in general.

AB - Trafficking and sorting of membrane-anchored Ras GTPases are regulated by partitioning between distinct membrane domains. Here, in vitro experiments and microscopic molecular theory reveal membrane curvature as a new modulator of N-Ras lipid anchor and palmitoyl chain partitioning. Membrane curvature was essential for enrichment in raft-like liquid-ordered phases; enrichment was driven by relief of lateral pressure upon anchor insertion and most likely affects the localization of lipidated proteins in general.

U2 - 10.1038/nchembio.1733

DO - 10.1038/nchembio.1733

M3 - Journal article

C2 - 25622090

VL - 11

SP - 192

EP - 194

JO - Nature Chemical Biology

JF - Nature Chemical Biology

SN - 1552-4450

IS - 3

ER -

ID: 131361806