Ulrik Gether

Ulrik Gether

Head of Department, Professor


  1. Published

    Delineating structure-function relationships in the dopamine transporter from natural and engineered Zn2+ binding sites

    Gether, Ulrik, Norregaard, L. & Loland, Claus Juul, 2001, In: Life Sciences. 68 (19-20), p. 2187-2198

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Delineation of an endogenous zinc-binding site in the human dopamine transporter.

    Norregaard, L., Frederiksen, D., Nielsen, E. Ø. & Gether, Ulrik, 1998, In: EMBO Journal. 17, p. 4266-4273

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Differences between early and late onset adult depression

    Bukh, Jens Otto Drachmann, Bock, C., Vinberg, Maj, Gether, Ulrik & Kessing, Lars Vedel, 2011, In: Clinical Practice and Epidemiology in Mental Health. 7, p. 140-7 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Differential Internalization Rates and Postendocytic Sorting of the Norepinephrine and Dopamine Transporters Are Controlled by Structural Elements in the N Termini

    Vuorenpää, A. E., Jørgensen, T. N., Newman, A. H., Madsen, Kenneth Lindegaard, Scheinin, M. & Gether, Ulrik, 11 Mar 2016, In: Journal of Biological Chemistry. 291, 11, p. 5634-5651 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Differential effects of chemogenetic inhibition on dopamine and norepinephrine neurons in the mouse 5-choice serial reaction time task

    Fitzpatrick, C. M., Runegaard, A. H., Christiansen, S. H., Hansen, Nikolaj Winther, Jørgensen, Søren Heide, McGirr, J. C., de Diego Ajenjo, A., Sørensen, Andreas Toft, Perrier, Jean-Francois Marie, Petersen, A., Gether, Ulrik, Woldbye, David Paul Drucker & Andreasen T., Jesper, 2019, In: Progress in Neuro-Psychopharmacology & Biological Psychiatry. 90, 2, p. 264-276 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Direct assessment of conformational changes in G protein coupled receptors using fluorescence spectroscopy

    Gether, Ulrik & Kobilka, B. K., 1999, In Signal Transduction - A practical Approach, in The practical Approach series, 2nd edition. Oxford: Oxford University Press, p. 01-17

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  7. Published

    Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR

    qrc243, qrc243, Gotfryd, K., Larsen, F. H., Mortensen, Jonas Sigurd, Geiger, M., van Rossum, B., Oschkinat, H., Gether, Ulrik, Teilum, Kaare & Loland, Claus Juul, 2017, In: eLife. 6, 9 p., e19314.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Direct-Pathway Spiny Projection Neuron Inhibition Evokes Transient Circuit Imbalance Manifested as Rotational Behavior

    Christensen, M., Nørr, Søren Emil, Gether, Ulrik & Rickhag, Karl Mattias, 2021, In: Neuroscience. 453, p. 32-42 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Disruption of the PDZ domain-binding motif of the dopamine transporter uniquely alters nanoscale distribution, dopamine homeostasis, and reward motivation

    Sørensen, G., Rickhag, Karl Mattias, Leo, D., Lycas, M. D., Ridderstrøm, P. H., Weikop, P., Lilja, J. H., Rifes, P., Herborg, Freja, Woldbye, David Paul Drucker, Wörtwein, Gitta, Gainetdinov, R. R., Fink-Jensen, Anders & Gether, Ulrik, 2021, In: Journal of Biological Chemistry. 297, 6, 101361.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Do stressful life events predict medical treatment outcome in first episode of depression?

    Bock, C., Bukh, J. D., Vinberg, Maj, Gether, Ulrik & Kessing, Lars Vedel, 2009, In: Social Psychiatry and Psychiatric Epidemiology. 44, p. 752-760

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Does bereavement-related first episode depression differ from other kinds of first depressions?

    Kessing, Lars Vedel, Bukh, Jens Otto Drachmann, Bock, C., Vinberg, Maj, Gether, Ulrik, Kessing, Lars Vedel, Bukh, J. D., Bock, C., Vinberg, Maj & Gether, U., 2009, In: Social Psychiatry and Psychiatric Epidemiology.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Dopaminergic neurons establish a distinctive axonal arbor with a majority of non-synaptic terminals

    Ducrot, C., Bourque, M., Delmas, C. V. L., Racine, A., Guadarrama Bello, D., Delignat-Lavaud, B., Domenic Lycas, M., Fallon, A., Michaud-Tardif, C., Burke Nanni, S., Herborg, Freja, Gether, Ulrik, Nanci, A., Takahashi, H., Parent, M. & Trudeau, L., 2021, In: FASEB Journal. 35, 8, 24 p., 21791.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Drosophila melanogaster: a novel animal model for the behavioral characterization of autism-associated mutations in the dopamine transporter gene

    Hamilton, P. J., Campbell, N. G., Sharma, S., Erreger, K., Herborg, Freja, Saunders, C., Belovich, A. N., Sahai, M. A., Cook, E. H., Gether, Ulrik, McHaourab, H. S., Matthies, H. J. G., Sutcliffe, J. S. & Galli, A., Dec 2013, In: Molecular Psychiatry. 18, 12, p. 1235

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Effect of Walker A mutation (K86M) on oligomerization and surface targeting of the multidrug resistance transporter ABCG2

    Henriksen, U. B., Gether, Ulrik & Litman, Thomas, 1 Apr 2005, In: Journal of Cell Science. 118, Pt 7, p. 1417-26 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Effect of chronic escitalopram versus placebo on personality traits in healthy first-degree relatives of patients with depression: a randomized trial

    Knorr, U., Vinberg, Maj, Mortensen, Erik Lykke, Winkel, P., Gluud, C., Wetterslev, J., Gether, Ulrik & Kessing, Lars Vedel, 29 Feb 2012, In: P L o S One. 7, 2, p. e31980 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Effect of escitalopram versus placebo on GRα messenger RNA expression in peripheral blood cells of healthy individuals with a family history of depression - a secondary outcome analysis from the randomized AGENDA trial

    Knorr, Ulla Benedichte Søsted, Koefoed, P., Gluud, C., Wetterslev, J., Winkel, P., Gether, Ulrik, Vinberg, Maj & Kessing, Lars Vedel, 11 Jan 2016, In: Nordic Journal of Psychiatry. 70, 4, p. 297-302 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Effects of guanine, inosine, and xanthine nucleotides on beta(2)-adrenergic receptor/G(s) interactions: evidence for multiple receptor conformations

    Seifert, R., Gether, Ulrik, Wenzel-Seifert, K. & Kobilka, B. K., 1999, In: Molecular Pharmacology. 56, p. 348-358

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Elucidating Conformational Changes in the {gamma}-Aminobutyric Acid Transporter-1

    Meinild, A., Loo, D. D. F., Hansen, S. S., Gether, Ulrik & MacAulay, Nanna, 2009, In: Journal of Biological Chemistry. 284, 24, p. 16226-35 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Elucidating the Mechanism Behind Sodium-Coupled Neurotransmitter Transporters by Reconstitution

    Schmidt, S. G., Gether, Ulrik & Loland, Claus Juul, 2022, In: Neurochemical Research. 47, p. 127–137 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Engineered Zn(2+)switches in the gamma-aminobutyric acid (GABA) transporter-1. Differential effects on GABA uptake and currents

    MacAulay, Nanna, Bendahan, A., Loland, Claus Juul, Zeuthen, Thomas, Kanner, B. I. & Gether, Ulrik, 2001, In: Journal of Biological Chemistry. 276, p. 40476-40485

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Escitalopram and neuroendocrine response in healthy first-degree relatives to depressed patients--a randomized placebo-controlled trial

    Knorr, Ulla Benedichte Søsted, Vinberg, Maj, Hansen, A., Klose, M., Feldt-Rasmussen, Ulla, Hilsted, Linda, Hasselstrøm, J., Gether, Ulrik, Winkel, P., Gluud, C., Wetterslev, J. & Kessing, Lars Vedel, 2011, In: P L o S One. 6, 6, p. e21224 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Evidence for distinct sodium-, dopamine-, and cocaine-dependent conformational changes in transmembrane segments 7 and 8 of the dopamine transporter

    Norregaard, L., Loland, Claus Juul & Gether, Ulrik, 15 Aug 2003, In: The Journal of Biological Chemistry. 278, 33, p. 30587-96 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Evidence for distinct sodium-, dopamine-, cocaine-dependent conformational changes in transmembrane segments 7 and 8 of the dopamine

    Norregaard, L., Loland, Claus Juul & Gether, Ulrik, 2003, In: Journal of Biological Chemistry. Vol. 278 (33), p. 30587-96

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Examining the efficiency of receptor/G-protein coupling with a cleavable beta2-adrenoceptor-Gsalpha fusion protein

    Seifert, R., Wenzel-Seifert, K., Gether, Ulrik, Lam, V. T. & Kobilka, B. K., 1999, In: European Journal of Biochemistry. 260, p. 661-666

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Fluorescence spectrosocpy analysis of conformational changes in the Β2 adrenergic receptor

    Gether, Ulrik, 1999, In Structure/Function of G-protein coupled receptors, in the Receptor Biochemistry and Methodology. New York: Wiley, p. 315-334

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  26. Published

    Functional differences between full and partial agonists: evidence for ligand-specific receptor conformations

    Seifert, R., Wenzel-Seifert, K., Gether, Ulrik & Kobilka, B. K., 2001, In: Journal of Pharmacology and Experimental Therapeutics. 297 (3), p. 1218-1226

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Functional regulation of amphetamine-induced efflux by CaMKII

    Sitte, H. H., Steinkellner, T., Montgomery, T. R., Hofmaier, T., Kudlacek, O., Yang, J., Jung, G., Lubec, G., Gether, Ulrik, Freissmuth, M. & Pollak, D. D., Aug 2015, In: Amino Acids. 47, 8, p. 1659-1659 1 p.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  28. Published

    G protein-coupled receptor pharmacology-The next generation

    Bräuner, Hans, Rosenkilde, Mette, Gether, Ulrik & Gloriam, David E., 2020, In: Basic & Clinical Pharmacology & Toxicology. 126, Supplement 6, p. 3-4 2 p.

    Research output: Contribution to journalEditorialResearch

  29. Published

    G protein-coupled receptor signaling in VTA dopaminergic neurons bidirectionally regulates the acute locomotor response to amphetamine but does not affect behavioral sensitization

    Runegaard, A. H., Dencker, D., Wörtwein, Gitta & Gether, Ulrik, 2019, In: Neuropharmacology. 161, 107663.

    Research output: Contribution to journalReviewResearchpeer-review

  30. Published

    GLP-1 and nicotine combination therapy engages hypothalamic and mesolimbic pathways to reverse obesity

    Falk, S., Petersen, Jonas Odgaard, Svendsen, C. S. A., Leguizamon, Cesar Ramon Romero, Jørgensen, Søren Heide, Krauth, Nathalie, Ludwig, M. Q., Jørgensen, Kathrine Lundø, Roostalu, U., Hjort-Gregersen, G. S., Nielsen, D. A. G., Ejdrup, Aske Lykke, Pers, Tune H, Dmytriyeva, O., Hecksher-Soerensen, J., Gether, Ulrik, Kohlmeier, Kristi Anne & Clemmensen, Christoffer, 2023, In: Cell Reports. 42, 5, 18 p., 112466.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Gender Differences among Patients with a Single Depressive Episode

    Bukh, Jens Otto Drachmann, Bock, C., Vinberg, Maj, Gether, Ulrik, Kessing, Lars Vedel, Bukh, J. O. D., Bock, C., Vinberg, Maj, Gether, U. & Kessing, Lars Vedel, 2010, In: Psychopathology. 43, 3, p. 159-169 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Generation of an activating ZN(2+) switch in the dopamine transporter: Mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle

    Loland, Claus Juul, Norregaard, L., Litman, Thomas & Gether, Ulrik, 2002, In: Proceedings of the National Academy of Science of the United States of America. vol. 99(3), p. 1683-8

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Generation of an activating Zn(2+) switch in the dopamine transporter: mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle

    Loland, Claus Juul, Norregaard, L., Litman, Thomas & Gether, Ulrik, 5 Feb 2002, In: Proceedings of the National Academy of Sciences of the United States of America. 99, 3, p. 1683-8 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Genetic Polymorphisms and the outcome of antidepressant Treatment

    Bukh, J. D., Bock, C., Christensen, M. V., Gether, Ulrik & Kessing, L. V., 2008, In: European Psychiatry. 23, p. S200-S200

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Genome-wide association study of genetic variants in LPS-stimulated IL-6, IL-8, IL-10, IL-1ra and TNF-α cytokine response in a Danish Cohort

    Larsen, M. H., Albrechtsen, Anders, Thørner, L. W., Werge, T., Hansen, T., Gether, Ulrik, Haastrup, E. & Ullum, H., 2013, In: PLOS ONE. 8, 6, 6 p., e66262.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Glucagon-like peptide-1 receptor regulation of basal dopamine transporter activity is species-dependent

    Jensen, M. E., Galli, A., Thomsen, M., Jensen, Kathrine Louise, Thomsen, G. K., Klausen, M. K., Vilsbøll, Tina, Christensen, Mikkel Bring, Holst, Jens Juul, Owens, A., Robertson, S., Daws, L., Zanella, D., Gether, Ulrik, Knudsen, Gitte Moos & Fink-Jensen, Anders, 2020, In: Neurochemistry International. 138, 9 p., 104772.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Glucose-neopentyl glycol (GNG) amphiphiles for membrane protein study

    Chae, P. S., Rana, R. R., Gotfryd, K., Rasmussen, Søren Gøgsig Faarup, Kruse, A. C., Cho, K. H., Capaldi, S., Carlsson, E., Kobilka, B., Loland, Claus Juul, Gether, Ulrik, Banerjee, S., Byrne, B., Lee, J. K. & Gellman, S. H., 21 Mar 2013, In: Chemical communications (Cambridge, England). 49, 23, p. 2287-9 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Glycine transporter dimers - Evidence for occurrence in the plasma membrane

    Bartholomaeus, I., Milan-Lobo, L., Nicke, A., Dutertre, S., Hastrup, H., Jha, A., Gether, Ulrik, Sitte, H. H., Betz, H. & Eulenburg, V., 2008, In: Journal of Biological Chemistry. 283, 16, p. 10978-10991 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Glycine transporter dimers: evidence for occurrence in the plasma membrane

    Bartholomäus, I., Milan-Lobo, L., Nicke, A., Dutertre, S., Hastrup, H., Jha, A., Gether, Ulrik, Sitte, H. H., Betz, H. & Eulenburg, V., 2008, In: Journal of Biological Chemistry. 283, 16, p. 10978-91 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    High-performance liquid chromatography of phenylthiocarbamyl derivatives of amino acids and side-chain derivatized amino acids.

    O'Hare, M., Tortora, O., Gether, Ulrik, Nielsen, Henrik & Schwartz, Thue W., Mar 1987, In: Journal of Chromatography.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    How curved membranes recruit amphipathic helices and protein anchoring motifs

    Hatzakis, Nikos, Bhatia, V. K., Larsen, J., Madsen, Kenneth Lindegaard, Bolinger, P., Kunding, A. H., Castillo Leon, J. J., Gether, Ulrik, Hedegård, Per & Stamou, Dimitrios, 2009, In: Nature Chemical Biology. 5, 11, p. 835-841 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD

    Thorsen, T. S., Madsen, Kenneth Lindegaard, Rebola, N., Rathje, Mette, Anggono, V., Bach, Anders, Moreira, I. S., Stuhr-Hansen, N., Dyhring, T., Peters, D., Beuming, T., Huganir, R., Weinstein, H., Mulle, C., Strømgaard, Kristian, Rønn, L. C. B. & Gether, Ulrik, 2010, In: Proceedings of the National Academy of Science of the United States of America. 107, 1, p. 413-8 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Identification of intra- and intermolecular disulfide bridges in the multidrug resistance transporter ABCG2

    Henriksen, U. B., Fog, J. U., Litman, Thomas & Gether, Ulrik, 4 Nov 2005, In: Journal of Biological Chemistry. 280, 44, p. 36926-34 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Identification of intracellular residues in the dopamine transporter critical for regulation of transporter conformation and cocaine binding

    Loland, Claus Juul, Grånäs, C., Javitch, J. A. & Gether, Ulrik, 30 Jan 2004, In: The Journal of Biological Chemistry. 279, 5, p. 3228-38 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Identification of intracellular residues in the dopamine transporter critical for regulation of transporter conformation and cocaine binding (vol 279, pg 3228, 2004)

    Loland, C. J., Granas, C., Javitch, J. A. & Gether, Ulrik, 2006, In: Journal of Biological Chemistry. 281, 35, p. 25867-25867

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Identifying dominant-negative actions of a dopamine transporter variant in patients with parkinsonism and neuropsychiatric disease

    Herborg, F., Jensen, K. L., Tolstoy, S., Arends, N., Posselt, L. P., Shekar, A., Aguilar, J., Lund, V. K., Erreger, K., Rickhag, M., Lycas, M. D., Lonsdale, M. N., Rahbek-Clemmensen, T., Sorensen, A. T., Newman, A. H., Lokkegaard, A., Kjaerulff, O., Werge, T., Moller, L. B., Matthies, H. J. G. & 4 others, Galli, A., Hjermind, L. E., Gether, Ulrik & IPSYCH Researchers, I. R., 2021, In: JCI insight. 6, 18, 21 p., 151496.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    In vivo amphetamine action is contingent on αCaMKII

    Steinkellner, T., Mus, L., Eisenrauch, B., Constantinescu, A., Leo, D., Konrad, L., Rickhag, Karl Mattias, Sørensen, G., Efimova, E. V., Kong, E., Willeit, M., Sotnikova, T. D., Kudlacek, O., Gether, Ulrik, Freissmuth, M., Pollak, D. D., Gainetdinov, R. R. & Sitte, H. H., Oct 2014, In: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 39, 11, p. 2681-93 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Increased vulnerability of nigral dopamine neurons after expansion of their axonal arborization size through D2 dopamine receptor conditional knockout

    Giguère, N., Delignat-Lavaud, B., Herborg, Freja, Voisin, A., Li, Yuan, Jacquemet, V., Anand-Srivastava, M., Gether, Ulrik, Giros, B. & Trudeau, L., 2019, In: PLOS Genetics. 15, 8, 26 p., e1008352.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Initial rewarding effects of cocaine and amphetamine assessed in a day using the single-exposure place preference protocol

    Runegaard, A. H., Jensen, Kathrine Louise, Wörtwein, Gitta & Gether, Ulrik, 2019, In: European Journal of Neuroscience. 50, 3, p. 2156-2163 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Insights from endogenous and engineered Zn2+-binding sites in monoanine transporters

    Loland, Claus Juul & Gether, Ulrik, 2004, Molecular Neuropharmacology: Strategies and Methods. p. 191-213

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

ID: 11898