Tobias Gustavsson
Associate Professor
- 2023
- Published
Bispecific T cell-engager targeting oncofetal chondroitin sulfate induces complete tumor regression and protective immune memory in mice
Skeltved, Nanna, Nordmaj, Mie Anemone, Pagh-Berendtsen, Nicolai, Dagil, Robert, Stormer, E. M. R., Al-Nakouzi, N., Jiang, K., Aicher, A., Heeschen, C., Gustavsson, Tobias, Choudhary, Swati, Gögenur, Ismail, Christensen, Jan Pravsgaard, Theander, Thor Grundtvig, Daugaard, M., Salanti, Ali & Nielsen, Morten Agertoug, 2023, In: Journal of Experimental & Clinical Cancer Research. 42, 16 p., 106.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
First-in-human use of a modular capsid virus-like vaccine platform: An open-label, non-randomised, phase 1 clinical trial of the SARS-CoV-2 vaccine ABNCoV2
Smit, M. J., Sander, A. F., Ariaans, M. B. P. A., Fougeroux, C., Heinzel, C., Fendel, R., Esen, M., Kremsner, P. G., Ter Heine, R., Wertheim, H. F., Idorn, M., Paludan, S. R., Underwood, A. P., Binderup, A., Ramirez, S., Bukh, J., Soegaard, M., Erdogan, S. M., Gustavsson, T., Clemmensen, S. & 14 others, , 2023, In: The Lancet Microbe. 4, 3, p. e140-e148Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Malaria biomimetic for tumor targeted drug delivery
Pihl, J., Clausen, T. M., Zhou, J., Krishnan, N., Ørum-Madsen, M. S., Gustavsson, Tobias, Dagil, Robert, Daugaard, M., Choudhary, Swati, Foged, Camilla, Esko, J. D., Zhang, L., Fang, R. H. & Salanti, Ali, 2023, In: ACS Nano. 17, 14, p. 13500–13509Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
Cryo-EM reveals the conformational epitope of human monoclonal antibody PAM1.4 broadly reacting with polymorphic malarial protein VAR2CSA
Raghavan, Sai Sundar Rajan, Dagil, Robert, Lopez-Perez, Mary, Conrad, J., Bassi, Maria Rosaria, Quintana Varon, Maria del Pilar, Choudhary, Swati, Gustavsson, Tobias, Wang, Y., Gourdon, Pontus Emanuel, Ofori, M. F., Christensen, S. B., Minja, D. T. R., Schmiegelow, Christentze, Nielsen, Morten Agertoug, Barfod, Lea Klingenberg, Hviid, Lars, Salanti, Ali, Lavstsen, Thomas & Wang, Kaituo, 2022, In: PLoS Pathogens. 18, 11, e1010924.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Internalization and trafficking of CSPG-bound recombinant VAR2CSA lectins in cancer cells
Wang, Chris Kedong, Nelepcu, I., Hui, D., Oo, H. Z., Truong, S., Zhao, S., Tahiry, Z., Esfandnia, S., Ghaidi, F., Adomat, H., Dagil, Robert, Gustavsson, Tobias, Choudhary, Swati, Salanti, Ali, Sorensen, P. H., Al Nakouzi, N. & Daugaard, M., 2022, In: Scientific Reports. 12, 3075.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Reformation of the chondroitin sulfate glycocalyx enables progression of AR-independent prostate cancer
Al Nakouzi, N., Wang, C. K., Oo, H. Z., Nelepcu, I., Lallous, N., Spliid, C. B., Khazamipour, N., Lo, J., Truong, S., Collins, C., Hui, D., Esfandnia, S., Adomat, H., Clausen, T. M., Gustavsson, T., Choudhary, S., Dagil, R., Corey, E., Wang, Y., Chauchereau, A. & 6 others, , 2022, In: Nature Communications. 13, 4760.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity
Fougeroux, C., Goksøyr, L., Idorn, M., Soroka, V., Myeni, S. K., Dagil, R., Janitzek, C. M., Søgaard, M., Aves, K-L., Horsted, E. W., Erdogan, S. M., Gustavsson, T., Dorosz, J., Clemmensen, S., Fredsgaard, L., Thrane, S., Vidal-Calvo, E. E., Khalifé, P., Hulen, T. M., Choudhary, S. & 27 others, , 2021, In: Nature Communications. 12, 1, p. 324Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding
Wang, Kaituo, Dagil, Robert, Lavstsen, Thomas, Misra, S. K., Spliid, C. B., Wang, Y., Gustavsson, Tobias, Sandoval, D. R., Vidal-Calvo, E. E., Choudhary, Swati, Agerbæk, Mette Ørskov, Lindorff-Larsen, Kresten, Nielsen, Morten Agertoug, Theander, Thor Grundtvig, Sharp, J. S., Clausen, Thomas Mandel, Gourdon, Pontus Emanuel & Salanti, Ali, 2021, In: Nature Communications. 12, 1, 10 p., 2956.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Detection of VAR2CSA‐captured colorectal cancer cells from blood samples by real‐time reverse transcription PCR
Bang‐christensen, S. R., Katerov, V., Jørgensen, Amalie Mundt, Gustavsson, Tobias, Choudhary, Swati, Theander, Thor Grundtvig, Salanti, Ali, Allawi, H. T. & Agerbæk, Mette Ørskov, 2021, In: Cancers. 13, 23, 5881.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Development of a bispecific immune engager using a recombinant malaria protein
Nordmaj, Mie Anemone, Roberts, M. E., Sachse, E. S., Dagil, Robert, Andersen, Anne Poder, Skeltved, Nanna, Grunddal, Kaare Villum, Erdogan, Sayit Mahmut, Choudhary, Swati, Gustavsson, Tobias, Ørum-madsen, M. S., Moskalev, I., Tian, W., Yang, Zhang, Clausen, Thomas Mandel, Theander, Thor Grundtvig, Daugaard, M., Nielsen, Morten Agertoug & Salanti, Ali, 2021, In: Cell Death & Disease. 12, 4, 11 p., 353.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Oncofetal chondroitin sulfate is a highly expressed therapeutic target in non-small cell lung cancer
Oo, H. Z., Lohinai, Z., Khazamipour, N., Lo, J., Kumar, G., Pihl, J., Adomat, H., Nabavi, N., Behmanesh, H., Zhai, B., Dagil, R., Choudhary, S., Gustavsson, T., Clausen, T. M., Esko, J. D., Allen, J. W., Thompson, M. A., Tran, N. L., Moldvay, J., Dome, B. & 4 others, , 2021, In: Cancers. 13, 17, 16 p., 4489.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The specificity of the malarial VAR2CSA protein for chondroitin sulfate depends on 4-O-sulfation and ligand accessibility
Spliid, C. B., Toledo, A. G., Sanderson, P., Mao, Y., Gatto, F., Gustavsson, Tobias, Choudhary, Swati, Saldanha, A. L., Vogelsang, R. P., Gögenur, Ismail, Theander, Thor Grundtvig, Leach, F. E., Amster, I. J., Esko, J. D., Salanti, Ali & Clausen, Thomas Mandel, 2021, In: The Journal of Biological Chemistry. 297, 6, 15 p., 101391.Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
A simple method for detecting oncofetal chondroitin sulfate glycosaminoglycans in bladder cancer urine
Clausen, Thomas Mandel, Kumar, G., Ibsen, E. K., Ørum-Madsen, M. S., Hurtado-Coll, A., Gustavsson, Tobias, Agerbæk, Mette Ørskov, Gatto, F., Todenhöfer, T., Basso, U., Knowles, M. A., Sanchez-Carbayo, M., Salanti, Ali, Black, P. C. & Daugaard, M., 2020, In: Cell Death Discovery. 6, 65.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer
Toledo, A. G., Pihl, J., Spliid, C. B., Persson, A., Nilsson, J., Pereira, M. A., Gustavsson, Tobias, Choudhary, Swati, Zarni Oo, H., Black, P. C., Daugaard, M., Esko, J. D., Larson, G., Salanti, Ali & Clausen, Thomas Mandel, 2020, In: Glycobiology. 30, 12, p. 989-1002 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Optimization of rVAR2-based isolation of cancer cells in blood for building a robust assay for clinical detection of circulating tumor cells
Sand, Nicolai Tue, Petersen, T. B., Bang-Christensen, S. R., Ahrens, T. D., Løppke, Caroline Bang, Jørgensen, A. M., Gustavsson, Tobias, Choudhary, Swati, Theander, Thor Grundtvig, Salanti, Ali & Agerbæk, Mette Ørskov, 2020, In: International Journal of Molecular Sciences . 21, 7, 2401.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Capture and Detection of Circulating Glioma Cells Using the Recombinant VAR2CSA Malaria Protein
Bang-Christensen, S. R., Pedersen, R. S., Pereira, M. A., Clausen, T. M., Løppke, C., Sand, N. T., Ahrens, T. D., Jørgensen, A. M., Lim, Y. C., Goksøyr, L., Choudhary, S., Gustavsson, T., Dagil, R., Daugaard, M., Sander, A. F., Torp, M. H., Søgaard, M., Theander, T. G., Østrup, O., Lassen, U. & 3 others, , 2019, In: Cells. 8, 9, 21 p., 998.Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
The GAGOme: a cell-based library of displayed glycosaminoglycans
Chen, Yen-Hsi, Narimatsu, Yoshiki, Clausen, Thomas Mandel, Gomes, C., Karlsson, R., Steentoft, C., Spliid, C. B., Gustavsson, Tobias, Salanti, Ali, Persson, A., Malmström, A., Willén, D., Ellervik, U., Bennett, Eric Paul, Mao, Y., Clausen, Henrik & Yang, Zhang, 2018, In: Nature Methods. 15, 11, p. 881-888Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner
Agerbæk, Mette Ørskov, Bang-Christensen, S. R., Yang, M., Clausen, Thomas Mandel, Pereira, M. A., Sharma, S., Ditlev, S. B., Nielsen, Morten Agertoug, Choudhary, Swati, Gustavsson, Tobias, Sorensen, P. H., Meyer, T., Propper, D., Shamash, J., Theander, Thor Grundtvig, Aicher, A., Daugaard, M., Heeschen, C. & Salanti, Ali, 2018, In: Nature Communications. 9, 1, 13 p., 3279.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
An oncofetal glycosaminoglycan modification provides therapeutic access to Cisplatin-resistant bladder cancer
Seiler, R., Oo, H. Z., Tortora, D., Clausen, T. M., Wang, C. K., Kumar, G., Ayres Pereira, M., Ørum-Madsen, M. S., Agerbæk, M. Ø., Gustavsson, T., Nordmaj, M. A., Rich, J. R., Lallous, N., Fazli, L., Lee, S., Douglas, J., Todenhöfer, T., Esfandnia, S., Battsogt, D., Babcook, J. S. & 10 others, , 2017, In: European Urology Supplements. 72, 1, p. 142-150 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
Molecular dissection of placental malaria protein VAR2CSA interaction with a chemo-enzymatically synthesized chondroitin sulfate library
Sugiura, N., Clausen, Thomas Mandel, Shioiri, T., Gustavsson, Tobias, Watanabe, H. & Salanti, Ali, Dec 2016, In: Glycoconjugate Journal. 33, 6, p. 985-994 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Real-time and label free determination of ligand binding-kinetics to primary cancer tissue specimens; a novel tool for the assessment of biomarker targeting
Clausen, Thomas Mandel, Ayres Pereira, M., Oo, H. Z., Resende, M., Gustavsson, Tobias, Mao, Y., Sugiura, N., Liew, J., Fazli, L., Theander, Thor Grundtvig, Daugaard, M. & Salanti, Ali, Jul 2016, In: Sensing and Bio-Sensing Research. 9, p. 23-30 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bacterial superglue enables easy development of efficient virus-like particle based vaccines
Thrane, Susan, Janitzek, C. M., Matondo, S., dos Santos Marques Resende, M., Gustavsson, Tobias, De Jongh, W. A., Clemmensen, S., Roeffen, W., van de Vegte-Bolmer, M., van Gemert, G. J., Sauerwein, R., Schiller, J. T., Nielsen, Morten Agertoug, Theander, Thor Grundtvig, Salanti, Ali & Sander, Adam F. , 27 Apr 2016, In: Journal of Nanobiotechnology. 14, 16 p., 30.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein
Salanti, A., Clausen, T. M., Agerbæk, M. Ø., Al Nakouzi, N., Dahlbäck, M., Oo, H. Z., Lee, S., Gustavsson, T., Rich, J. R., Hedberg, B. J., Mao, Y., Barington, L., Pereira, M. A., LoBello, J., Endo, M., Fazli, L., Soden, J., Wang, C. K., Sander, A. F., Dagil, R. & 15 others, , 2015, In: Cancer Cell. 28, 4, p. 500-14 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
- Published
Biphasic kinetic behavior of E. coli WrbA, an FMN-dependent NAD(P)H:quinone oxidoreductase
Kishko, I., Harish, B., Zayats, V., Reha, D., Tenner, B., Beri, D., Gustavsson, Tobias, Ettrich, R. & Carey, J., 2012, In: PLOS ONE. 7, 8, p. e43902Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
- Published
A cytochrome c fusion protein domain for convenient detection, quantification, and enhanced production of membrane proteins in Escherichia coli--expression and characterization of cytochrome-tagged Complex I subunits
Gustavsson, Tobias, Trane, M., Moparthi, V. K., Miklovyte, E., Moparthi, L., Górecki, K., Leiding, T., Arsköld, S. P. & Hägerhäll, C., Aug 2010, In: Protein Science. 19, 8, p. 1445-60 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Photolabile ubiquinone analogues for identification and characterization of quinone binding sites in proteins
Pei, Z., Gustavsson, Tobias, Roth, R., Frejd, T. & Hägerhäll, C., 15 May 2010, In: Bioorganic & Medicinal Chemistry. 18, 10, p. 3457-66 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2009
- Published
Electrical wiring of live, metabolically enhanced Bacillus subtilis cells with flexible osmium-redox polymers
Coman, V., Gustavsson, Tobias, Finkelsteinas, A., von Wachenfeldt, C., Hägerhäll, C. & Gorton, L., 11 Nov 2009, In: Journal of the American Chemical Society. 131, 44, p. 16171-6 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
- Published
Direct and mediated electron transfer between intact succinate:quinone oxidoreductase from Bacillus subtilis and a surface modified gold electrode reveals redox state-dependent conformational changes
Christenson, A., Gustavsson, Tobias, Gorton, L. & Hägerhäll, C., Sep 2008, In: B B A - Reviews on Cancer. 1777, 9, p. 1203-10 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2007
- Published
WrbA bridges bacterial flavodoxins and eukaryotic NAD(P)H:quinone oxidoreductases
Carey, J., Brynda, J., Wolfová, J., Grandori, R., Gustavsson, Tobias, Ettrich, R. & Smatanová, I. K., Oct 2007, In: Protein Science. 16, 10, p. 2301-5 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 126250167
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743
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Real-time and label free determination of ligand binding-kinetics to primary cancer tissue specimens; a novel tool for the assessment of biomarker targeting
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
555
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Bacterial superglue enables easy development of efficient virus-like particle based vaccines
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
236
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The VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner
Research output: Contribution to journal › Journal article › Research › peer-review
Published