Thue W. Schwartz
Professor
Schwartz Group
Blegdamsvej 3B, Mærsk Tårnet, 6. sal, 2200 København N.
Member of:
- 2012
- Published
An aromatic region to induce a switch between agonism and inverse agonism at the ghrelin receptor
Els, S., Schild, E., Petersen, P. S., Kilian, T., Mokrosinski, J., Frimurer, Thomas Michael, Chollet, C., Schwartz, Thue W., Holst, Birgitte & Beck-Sickinger, A. G., 13 Sep 2012, In: Journal of Medicinal Chemistry. 55, 17, p. 7437-49 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Modulation of constitutive activity and signaling bias of the ghrelin receptor by conformational constraint in the second extracellular loop
Mokrosinski, J., Frimurer, Thomas Michael, Sivertsen, B., Schwartz, Thue W. & Holst, Birgitte, Sep 2012, In: Journal of Biological Chemistry. 287, p. 33488-33502 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of intravenous infusions of PYY3-36 and GLP-1, as monoinfusion and in combination, on ad libitum energy intake in healthy obese subjects
Schmidt, J. B., Gregersen, N. T., Pedersen, S. D., Holst, Jens Juul, Schwartz, Thue W., Astrup, A. & Sjödin, Anders Mikael, 10 Aug 2012, In: Regulatory Peptides. 177, Supplement, p. S32 1 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
GPR119 as a fat sensor
Hansen, Harald S., Rosenkilde, Mette, Holst, Jens Juul & Schwartz, Thue W., Jul 2012, In: Trends in Pharmacological Sciences. 33, 7, p. 374-81 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
- Published
Structural biology: snapshot of a signalling complex.
Schwartz, Thue W. & Sakmar, T., Sep 2011, In: Nature.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ligand Modulation of the Epstein-Barr Virus-induced Seven-transmembrane Receptor EBI2: IDENTIFICATION OF A POTENT AND EFFICACIOUS INVERSE AGONIST
Benned-Jensen, T., Smethurst, C., Holst, Peter Johannes, Page, K. R., Sauls, H., Sivertsen, B. B., Schwartz, Thue W., Blanchard, A., Jepras, R. & Rosenkilde, Mette, 19 Aug 2011, In: Journal of Biological Chemistry. 286, p. 29292-29302 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Deficiency of the GPR39 receptor is associated with obesity and altered adipocyte metabolism
Petersen, P. S., Jin, C., Madsen, A. N., Rasmussen, M., Kuhre, Rune Ehrenreich, Egerod, Kristoffer Lihme, Nielsen, L. B., Schwartz, Thue W. & Holst, Birgitte, 22 Jul 2011, In: FASEB Journal. p. 3803-3814 12 p., 4.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Unique interaction pattern for a functionally biased ghrelin receptor agonist
Sivertsen, B. B., Lang, M., Frimurer, T. M., Holliday, N. D., Bach, Anders, Els, S., Engelstoft, M. S., Petersen, P. S., Madsen, A. N., Schwartz, Thue W., Beck-Sickinger, A. G. & Holst, Birgitte, 10 Jun 2011, In: The Journal of Biological Chemistry. 286, 23, p. 20845-20860 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
KU bestemmer selv over sin forskning
Wewer, Ulla M., Holst, Jens Juul, Schwartz, Thue W. & Quistorff, B., 2 Jun 2011, In: Universitetsavisen.Research output: Contribution to journal › Contribution to newspaper - Comment/debate › Communication
- Published
Reversible switching of ultrastrong light-molecule coupling
Schwartz, Thue W., Hutchison, J. A., Genet, C. & Ebbesen, T. W., 13 May 2011, In: Physical Review - Index. 106, p. 196405 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
G protein-coupled receptor modulation with pepducins: moving closer to the clinic
Dimond, P., Carlson, K., Bouvier, M., Gerard, C., Xu, L., Covic, L., Agarwal, A., Ernst, O. P., Janz, J. M., Schwartz, Thue W., Gardella, T. J., Milligan, G., Kuliopulos, A., Sakmar, T. P. & Hunt III, S. W., May 2011, In: New York Academy of Sciences. Annals. 1226, p. 34-49 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
G protein-coupled receptor modulation with pepducins: moving closer to the clinic
Dimond, P., Carlson, K., Bouvier, M., Gerard, C., Xu, L., Covic, L., Agarwal, A., Ernst, O. P., Janz, J. M., Schwartz, Thue W., Gardella, T. J., Milligan, G., Kuliopulos, A., Sakmar, T. P. & Hunt, S. W., 2011, In: Annals of the New York Academy of Sciences. 1226, p. 34-49 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Long-acting lipidated analogue of human pancreatic polypeptide is slowly released into circulation
Bellmann-Sickert, K., Elling, C. E., Madsen, A. N., Little, P. B., Lundgren, K., Gerlach, L., Bergmann, R., Holst, Birgitte, Schwartz, Thue W. & Beck-Sickinger, A. G., 2011, In: Journal of Medicinal Chemistry. 54, 8, p. 2658-67 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
ß-Cell Specific Overexpression of GPR39 Protects against Streptozotocin-Induced Hyperglycemia
Egerod, Kristoffer Lihme, Jin, C., Petersen, P. S., Wierup, N., Sundler, F., Holst, Birgitte & Schwartz, Thue W., 2011, In: International Journal of Endocrinology. 2011, p. 401258Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
- Published
A conserved aromatic lock for the tryptophan rotameric switch in TM-VI of seven-transmembrane receptors
Holst, Birgitte, Nygaard, R., Hansen, L. V., Bach, Anders, Engelstoft, M. S., Petersen, P. S., Frimurer, T. M. & Schwartz, Thue W., 2010, In: Journal of Biological Chemistry. 285, 6, p. 3973-85 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
An enteroendocrine full package solution
Schwartz, Thue W. & Holst, Birgitte, 2010, In: Cell Metabolism. 11, 6, p. 445-7 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conserved water-mediated hydrogen bond network between TM-I, -II, -VI, and -VII in 7TM receptor activation
Nygaard, R., Hansen, L. V., Mokrosinski, J., Frimurer, T. M. & Schwartz, Thue W., 2010, In: Journal of Biological Chemistry. 285, 25, p. 19625-36 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Family and population-based studies of variation within the ghrelin receptor locus in relation to measures of obesity
Gjesing, A. P., Larsen, L. H., Torekov, S. S., Hainerová, I. A., Kapur, R., Johansen, A., Albrechtsen, A., Boj, S., Holst, B., Harper, A., Urhammer, S. A., Borch-Johnsen, K., Pisinger, C. H., Echwald, S. M., Eiberg, H. R. L., Astrup, A., Lebl, J., Ferrer, J., Schwartz, T. W., Hansen, T. & 1 others, , 2010, In: P L o S One. 5, 4, 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
MTNR1B G24E variant associates With BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans
Andersson, E. A., Holst, Birgitte, Sparsø, T., Grarup, Niels, Banasik, Karina, Holmkvist, J., Jørgensen, T., Borch-Johnsen, K., Egerod, Kristoffer Lihme, Lauritzen, T., Sørensen, Thorkild I.A., Bonnefond, A., Meyre, D., Froguel, P., Schwartz, Thue W., Pedersen, Oluf Borbye & Hansen, Torben, 2010, In: Diabetes. 59, 6, p. 1539-48 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular basis for agonism in the BB3 receptor: an epitope located on the interface of transmembrane-III, -VI, and -VII
Gbahou, F., Holst, Birgitte & Schwartz, Thue W., 2010, In: Journal of Pharmacology and Experimental Therapeutics. 333, 1, p. 51-9 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Resequencing of 200 human exomes identifies an excess of low-frequency non-synonymous coding variants
Li, Y., Vinckenbosch, N., Tian, G., Huerta-Sanchez, E., Jiang, T., Jiang, H., Albrechtsen, A., Andersen, G., Cao, H., Korneliussen, T. S., Grarup, N., Guo, Y., Hellman, I., Jin, X., Li, Q., Liu, J., Liu, X., Sparsø, T., Tang, M., Wu, H. & 18 others, , 2010, In: Nature Genetics. 42, 11, p. 969-72 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Targeting CXCR4 in HIV Cell-Entry Inhibition
Steen, A., Schwartz, Thue W. & Rosenkilde, Mette, 2010, In: Mini reviews in medicinal chemistry. 9, 14, p. 1605-21 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The minor binding pocket: a major player in 7TM receptor activation
Rosenkilde, Mette, Benned-Jensen, T., Frimurer, T. M. & Schwartz, Thue W., 2010, In: Trends in Pharmacological Sciences. 31, 12, p. 567-574 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2009
- Published
Construction of covalently coupled, concatameric dimers of 7TM receptors
Terpager, M., Scholl, D. J., Kubale, V., Martini, L., Elling, C. E. & Schwartz, Thue W., 2009, In: Journal of Receptors and Signal Transduction. 29, 5, p. 235-45 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction
Holst, Birgitte, Egerod, Kristoffer Lihme, Jin, C., Petersen, P. S., Østergaard, M. V., Hald, J., Sprinkel, A. M. E., Størling, J., Mandrup-Poulsen, Thomas, Holst, Jens Juul, Thams, P., Orskov, C., Wierup, N., Sundler, F., Madsen, O. D. & Schwartz, Thue W., 2009, In: Endocrinology. 150, 6, p. 2577-85 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ligand binding and micro-switches in 7TM receptor structures
Nygaard, R., Frimurer, T. M., Holst, Birgitte, Rosenkilde, Mette & Schwartz, Thue W., 2009, In: TIPS - Trends in Pharmacological Sciences. 30, 5, p. 249-59 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
[Fine needle aspiration cytology of mammography screening]
Engvad, B., Laenkholm, A. V., Schwartz, Thue W. & Bak, M., 2009, In: Ugeskrift for læger. 171, 34, p. 2379-2382 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
- Published
Positive versus negative modulation of different endogenous chemokines for CC-chemokine receptor 1 by small molecule agonists through allosteric versus orthosteric binding
Jensen, P. C., Thiele, S., Ulven, Trond, Schwartz, Thue W. & Rosenkilde, Mette, 17 Jun 2008, In: Journal of Biological Chemistry. 283, 34, p. 23121-23128 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A gut feeling for obesity: 7TM sensors on enteroendocrine cells
Engelstoft, M. S., Egerod, Kristoffer Lihme, Holst, Birgitte & Schwartz, Thue W., 2008, In: Cell Metabolism. 8, 6, p. 447-9 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A second disulfide bridge from the N-terminal domain to extracellular loop 2 dampens receptor activity in GPR39
Storjohann, L., Holst, Birgitte & Schwartz, Thue W., 2008, In: Biochemistry. 47, 35, p. 9198-207 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of G-protein coupled receptor kinase interaction with the NK-1 receptor using BRET
Joergensen, R., Holliday, N. D., Hansen, J. L., Vrecl, M., Heding, A., Elling, C. E. & Schwartz, Thue W., 2008, In: Molecular Pharmaceutics. 73, 2, p. 349-358 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular mechanism of Zn2+ agonism in the extracellular domain of GPR39
Storjohann, L., Holst, Birgitte & Schwartz, Thue W., 2008, In: FEBS Letters. 582, 17, p. 2583-8 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Overlapping binding site for the endogenous agonist, small-molecule agonists, and ago-allosteric modulators on the ghrelin receptor
Holst, Birgitte, Frimurer, T. M., Mokrosinski, J., Halkjaer, T., Cullberg, K. B., Underwood, C. R. & Schwartz, Thue W., 2008, In: Molecular Pharmacology. 75, 1, p. 44-59 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Positive versus negative modulation of different endogenous chemokines for CC-chemokine receptor 1 by small molecule agonists through allosteric versus orthosteric binding
Jensen, P. C., Thiele, S., Ulven, T., Schwartz, Thue W. & Rosenkilde, Mette, 2008, In: Journal of Biological Chemistry. 283, 34, p. 23121-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Receptorji s sedmimi transmembranskimi območji (7TM) v luči dimerizacije ter eksperimentalni pristopi za proučevanje njihove dimerizacije in medsebojnih vplivov
Kubale, V., Pogačnik, A., Schwartz, Thue W. & Vrecl, M., 2008, In: Slovenian Veterinary Research. 45, 3, p. 89-102 14 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Structural biology: A moving story of receptors
Schwartz, Thue W. & Hubbell, W. L., 2008, In: Nature. 455, 7212, p. 473-4 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2007
- Published
Allosteric enhancers, allosteric agonists and ago-allosteric modulators: where do they bind and how do they act?
Schwartz, Thue W. & Holst, Birgitte, 2007, In: TIPS - Trends in Pharmacological Sciences. 28, 8, p. 366-73 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of G-protein coupled receptor kinase interaction with the neurokinin-1 receptor using bioluminescence resonance energy transfer
Jorgensen, R., Holliday, N. D., Hansen, J. L., Vrecl, M., Heding, A., Schwartz, Thue W. & Elling, C. E., 2007, In: Molecular Pharmacology. 73, 2, p. 349-58 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GPR39 splice variants versus antisense gene LYPD1: expression and regulation in gastrointestinal tract, endocrine pancreas, liver, and white adipose tissue.
Egerod, Kristoffer Lihme, Holst, Birgitte, Petersen, P. S., Hansen, Jacob B., Mulder, J., Hökfelt, T. & Schwartz, Thue W., 2007, In: Molecular Endocrinology. 21, 7, p. 1685-98 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of an efficacy switch region in the ghrelin receptor responsible for interchange between agonism and inverse agonism
Holst, Birgitte, Mokrosinski, J., Lang, M., Brandt, E., Nygaard, R., Frimurer, T. M., Beck-Sickinger, A. G. & Schwartz, Thue W., 2007, In: Journal of Biological Chemistry. 282, 21, p. 15799-811 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Importance of constitutive activity and arrestin-independent mechanisms for intracellular trafficking of the ghrelin receptor
Holliday, N. D., Holst, Birgitte, Rodionova, E. A., Schwartz, Thue W. & Cox, H. M., 2007, In: Molecular Endocrinology. 21, 12, p. 3100-12 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Kaposi sarcoma-associated herpes virus targets the lymphotactin receptor with both a broad spectrum antagonist vCCL2 and a highly selective and potent agonist vCCL3
Lüttichau, H. R., Johnsen, A. H., Jurlander, J., Rosenkilde, Mette & Schwartz, Thue W., 2007, In: Journal of Biological Chemistry. 282, 24, p. 17794-805 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Modest human immunodeficiency virus coreceptor function of CXCR3 is strongly enhanced by mimicking the CXCR4 ligand binding pocket in the CXCR3 receptor
Hatse, S., Huskens, D., Princen, K., Vermeire, K., Bridger, G. J., De Clercq, E., Rosenkilde, Mette, Schwartz, Thue W. & Schols, D., 2007, In: Journal of Virology. 81, 7, p. 3632-9 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular interaction of a potent nonpeptide agonist with the chemokine receptor CCR8
Jensen, P. C., Nygaard, R., Thiele, S., Elder, A., Zhu, G., Kolbeck, R., Ghosh, S., Schwartz, Thue W. & Rosenkilde, Mette, 2007, In: Molecular Pharmacology. 72, 2, p. 327-40 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists in the CXCR4 chemokine receptor
Rosenkilde, Mette, Gerlach, L., Hatse, S., Skerlj, R. T., Schols, D., Bridger, G. J. & Schwartz, Thue W., 2007, In: Journal of Biological Chemistry. 282, 37, p. 27354-65 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Oxyntomodulin differentially affects glucagon-like peptide-1 receptor beta-arrestin recruitment and signaling through Galpha(s)
Jorgensen, R., Kubale, V., Vrecl, M., Schwartz, Thue W. & Elling, C. E., 2007, In: Journal of Pharmacology and Experimental Therapeutics. 322, 1, p. 148-54 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2006
- Published
Activation of the CXCR3 chemokine receptor through anchoring of a small molecule chelator ligand between TM-III, -IV, and -VI
Rosenkilde, Mette, Andersen, Michael Brun, Nygaard, R., Frimurer, T. M. & Schwartz, Thue W., 2006, In: Molecular Pharmacology. 71, 3, p. 930-41 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ago-allosteric modulation and other types of allostery in dimeric 7TM receptors
Schwartz, Thue W. & Holst, Birgitte, 2006, In: Journal of Receptors and Signal Transduction. 26, 1-2, p. 107-28 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conformational constraining of inactive and active States of a seven transmembrane receptor by metal ion site engineering in the extracellular end of transmembrane segment V
Rosenkilde, Mette, David, R., Oerlecke, I., Benned-Jensen, T., Geumann, U., Beck-Sickinger, A. G. & Schwartz, Thue W., 2006, In: Molecular Pharmacology. 70, 6, p. 1892-901 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GPR39 signaling is stimulated by zinc ions but not by obestatin
Holst, Birgitte, Egerod, Kristoffer Lihme, Schild, E., Vickers, S. P., Cheetham, S., Gerlach, L., Storjohann, L., Stidsen, C. E., Jones, R., Beck-Sickinger, A. G. & Schwartz, Thue W., 2006, In: Endocrinology. 148, 1, p. 13-20 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ghrelin receptor inverse agonists: identification of an active peptide core and its interaction epitopes on the receptor
Holst, Birgitte, Lang, M., Brandt, E., Bach, Anders, Howard, A., Frimurer, T. M., Beck-Sickinger, A. & Schwartz, Thue W., 2006, In: Molecular Pharmacology. 70, 3, p. 936-46 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ghrelin receptor mutations--too little height and too much hunger
Holst, Birgitte & Schwartz, Thue W., 2006, In: Journal of Clinical Investigation. 116, 3, p. 637-41 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GluVII : 06 - a highly conserved and selective anchor point for non-peptide ligands in chemokine receptors
Rosenkilde, Mette & Schwartz, Thue W., 2006, In: Current Topics in Medicinal Chemistry. 6, 13, p. 1319-1333 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GluVII:06--a highly conserved and selective anchor point for non-peptide ligands in chemokine receptors
Rosenkilde, Mette & Schwartz, Thue W., 2006, In: Current Topics in Medicinal Chemistry. 6, 13, p. 1319-33 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Metal ion site engineering indicates a global toggle switch model for seven-transmembrane receptor activation
Elling, C. E., Frimurer, T. M., Gerlach, L., Jorgensen, R., Holst, Birgitte & Schwartz, Thue W., 2006, In: Journal of Biological Chemistry. 281, 25, p. 17337-46 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular mechanism of 7TM receptor activation--a global toggle switch model
Schwartz, Thue W., Frimurer, T. M., Holst, Birgitte, Rosenkilde, Mette & Elling, C. E., 2006, In: Annual Review of Pharmacology and Toxicology. 46, p. 481-519 38 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular pharmacological phenotyping of EBI2. An orphan seven-transmembrane receptor with constitutive activity
Rosenkilde, Mette, Benned-Jensen, T., Holst, Peter Johannes, Kledal, T. N., Lüttichau, H. R., Larsen, J. K., Christensen, Jan Pravsgaard, Schwartz, Thue W. & Andersen, H., 2006, In: Journal of Biological Chemistry. 281, 19, p. 13199-208 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The PP-fold solution structure of human polypeptide YY and human PYY3-36 as determined by NMR
Nygaard, R., Nielbo, S., Schwartz, Thue W. & Poulsen, F. M., 2006, In: Biochemistry. 45, 27, p. 8350-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2005
- Published
The human herpes virus 8-encoded chemokine receptor is required for angioproliferation in a murine model of Kaposi's sarcoma.
Jensen, K., Manfra, D., Grisotto, M., Martin, A., Vassileva, G., Kelley, K., Schwartz, Thue W. & Lira, S., Mar 2005, In: Journal of immunology (Baltimore, Md. : 1950).Research output: Contribution to journal › Journal article › Research › peer-review
- Published
AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor
Hatse, S., Princen, K., De Clercq, E., Rosenkilde, Mette, Schwartz, Thue W., Hernandez-Abad, P. E., Skerlj, R. T., Bridger, G. J. & Schols, D., 2005, In: Biochemical Pharmacology. 70, 5, p. 752-61 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
CC and CX3C chemokines differentially interact with the N terminus of the human cytomegalovirus-encoded US28 receptor
Casarosa, P., Waldhoer, M., LiWang, P. J., Vischer, H. F., Kledal, T., Timmerman, H., Schwartz, Thue W., Smit, M. J. & Leurs, R., 2005, In: Journal of Biological Chemistry. 280, 5, p. 3275-3285 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of glucagon-like peptide-1 receptor beta-arrestin 2 interaction: a high-affinity receptor phenotype
Jorgensen, R., Martini, L., Schwartz, Thue W. & Elling, C. E., 2005, In: Molecular Endocrinology. 19, 3, p. 812-23 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterizaton of glucagon-like peptide-1 receptor beta-arrestin 2 interaction: a high-affinity receptor phenotype
Jorgensen, R., Martini, L., Schwartz, Thue W. & Elling, C. E., 2005, In: Molecular Endocrinology. Vol. 19, no.3, p. 812-23Research output: Contribution to journal › Journal article › Research › peer-review
- Published
High constitutive activity of a virus-encoded seven transmembrane receptor in the absence of the conserved DRY motif (Asp-Arg-Tyr) in transmembrane helix 3
Rosenkilde, Mette, Kledal, T. N. & Schwartz, Thue W., 2005, In: Molecular Pharmacology. 68, 1, p. 11-9 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Nonpeptide and peptide growth hormone secretagogues act both as ghrelin receptor agonist and as positive or negative allosteric modulators of ghrelin signaling
Holst, Birgitte, Brandt, E., Bach, Anders, Heding, A. & Schwartz, Thue W., 2005, In: Molecular Endocrinology. 19, 9, p. 2400-11 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Studies of relationships between variation of the human G protein-coupled receptor 40 Gene and Type 2 diabetes and insulin release
Hamid, Y. H., Vissing, H., Holst, Birgitte, Urhammer, S. A., Pyke, C., Hansen, S. K., Glümer, C., Borch-Johnsen, K., Jørgensen, T., Schwartz, Thue W., Pedersen, O. & Hansen, Torben, 2005, In: Diabetic Medicine. 22, 1, p. 74-80 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The human herpes virus 8-encoded chemokine receptor is required for angioproliferation in a murine model of Kaposi's sarcoma
Jensen, K. K., Manfra, D. J., Grisotto, M. G., Martin, A. P., Vassileva, G., Kelley, K., Schwartz, Thue W. & Lira, S. A., 2005, In: Journal of Immunology. 174, 6, p. 3686-94 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The human herpes virus 8-encoded chemokine receptor is required for angioproliferation in a murine model of Kaposis sarcoma
Jensen, K. K., Manfra, D. J., Grisotto, M. G., Martin, A. P., Vassileva, G., Kelley, K., Schwartz, Thue W. & Lira, S. A., 2005, In: Journal of Immunology. Vol. 174, no. 6, p. 3686-94Research output: Contribution to journal › Journal article › Research › peer-review
- 2004
- Published
A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated sorting protein (GASP)
Heydorn, A., Søndergaard, B. P., Ersbøll, B., Holst, Birgitte, Nielsen, Finn Cilius, Haft, C. R., Whistler, J. & Schwartz, Thue W., 2004, In: Journal of Biological Chemistry. 279, 52, p. 54291-303 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Common structural basis for constitutive activity of the ghrelin receptor family
Holst, Birgitte, Holliday, N. D., Bach, Anders, Elling, C. E., Cox, H. M. & Schwartz, Thue W., 2004, In: Journal of Biological Chemistry. 279, 51, p. 53806-17 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Constitutive and regulated activities of virus-encoded 7TM receptors
Rosenkilde, Mette & Schwartz, Thue W., 2004, Handbook of Cellular Signalling. Chapter 29 ed. p. 173-76Research output: Chapter in Book/Report/Conference proceeding › Report chapter › Research
- Published
Constitutive ghrelin receptor activity as a signaling set-point in appetite regulation
Holst, Birgitte & Schwartz, Thue W., 2004, In: TIPS - Trends in Pharmacological Sciences. 25, 3, p. 113-7 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Det chemokine system - en vigtig regulator af angiogenese i sundhed og sygdom
Rosenkilde, Mette & Schwartz, Thue W., 2004, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 112, 7-8, p. 481-95 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Distinct in vitro interaction pattern of dopamine receptor subtypes with adaptor proteins involved in post-endocytotic receptor targeting
Heydorn, A., Søndergaard, B. P., Hadrup, N., Holst, Birgitte, Haft, C. R. & Schwartz, Thue W., 2004, In: FEBS Letters. 556, 1-3, p. 276-80 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inhibition of human immunodeficiency virus replication by a dual CCR5/CXCR4 antagonist
Princen, K., Hatse, S., Vermeire, K., Aquaro, S., De Clercq, E., Gerlach, L., Rosenkilde, Mette, Schwartz, Thue W., Skerlj, R., Bridger, G. & Schols, D., 2004, In: Journal of Virology. 78, 23, p. 12996-3006 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular mechanism of AMD3100 antagonism in the CXCR4 receptor: transfer of binding site to the CXCR3 receptor
Rosenkilde, Mette, Gerlach, L., Jakobsen, J. S., Skerlj, R. T., Bridger, G. & Schwartz, Thue W., 2004, In: Journal of Biological Chemistry. VOl. 279, no. 4, p. 3033-41Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular mechanism of AMD3100 antagonism in the CXCR4 receptor: transfer of binding site to the CXCR3 receptor
Rosenkilde, Mette, Gerlach, L., Jakobsen, J. S., Skerlj, R. T., Bridger, G. J. & Schwartz, Thue W., 2004, In: Journal of Biological Chemistry. 279, 4, p. 3033-41 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Similar activation of signal transduction pathways by the herpesvirus-encoded chemokine receptors US28 and ORF74
McLean, K. A., Holst, Peter Johannes, Martini, L., Schwartz, Thue W. & Rosenkilde, Mette, 2004, In: Virology. 325, 2, p. 241-51 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The CXC chemokine receptor encoded by herpesvirus saimiri, ECRF3, shows ligand-regulated signaling through Gi, Gq, and G12/13 proteins but constitutive signaling only through Gi and G12/13 proteins
Rosenkilde, Mette, McLean, K. A., Holst, Peter Johannes & Schwartz, Thue W., 2004, In: Journal of Biological Chemistry. 279, 31, p. 32524-33 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The chemokine system - a major regulator of angiogenesis in health and disease
Rosenkilde, Mette & Schwartz, Thue W., 2004, In: APMIS : Acta pathologica, microbiologica et immunologica Scandinavica. Supplementum. Vol. 112, 7-8, p. 481-95Research output: Contribution to journal › Journal article › Research › peer-review
- 2003
- Published
A highly selective CCR2 chemokine agonist encoded by human herpesvirus 6
Lüttichau, H. R., Clark-Lewis, I., Jensen, Peter Østrup, Moser, C., Gerstoft, Jan & Schwartz, Thue W., 2003, In: Journal of Biological Chemistry. 278, Vol. 278 (13), p. 10928-33 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
High constitutive signaling of the ghrelin receptor--identification of a potent inverse agonist
Holst, Birgitte, Cygankiewicz, A., Jensen, T. H., Ankersen, M. & Schwartz, Thue W., 2003, In: Molecular Endocrinology. 17, 11, p. 2201-10 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Metal ion enhanced binding of AMD3100 to Asp262 in the CXCR4 receptor
Gerlach, L. O., Jakobsen, J. S., Jensen, K. P., Rosenkilde, Mette, Skerlj, R. T., Ryde, U., Bridger, G. J. & Schwartz, Thue W., 2003, In: Biochemistry. 42, 3, p. 710-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular mechanism of agonism and inverse agonism in the melanocortin receptors: Zn(2+) as a structural and functional probe
Holst, Birgitte & Schwartz, Thue W., 2003, In: Annals of the New York Academy of Sciences. 994, p. 1-11 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mutations at the CXCR4 interaction sites for AMD3100 influence anti-CXCR4 antibody binding and HIV-1 entry
Hatse, S., Princen, K., Vermeire, K., Gerlach, L., Rosenkilde, Mette, Schwartz, Thue W., Bridger, G., De Clercq, E. & Schols, D., 2003, In: FEBS Letters. 546, 2-3, p. 300-6 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The carboxyl terminus of human cytomegalovirus-encoded 7 transmembrane receptor US28 camouflages agonism by mediating constitutive endocytosis
Waldhoer, M., Casarosa, P., Rosenkilde, Mette, Smit, M. J., Leurs, R., Whistler, J. L. & Schwartz, Thue W., 2003, In: Journal of Biological Chemistry. 278, 21, p. 19473-82 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The carboxyl terminus of human cytomegalovirus-encoded 7 transmembrane receptor US28 camouflages agonism by mediating constitutive endoytosis
Waldhoer, M., Casarosa, P., Rosenkilde, Mette, Smit, M. J., Leurs, R., Whistler, J. L. & Schwartz, Thue W., 2003, In: Journal of Biological Chemistry. Vol. 278 (21), p. 19473-82Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The virus-encoded chemokine vMIP-II inhibits virus-induced Tc1-driven inflammation
Lindow, M., Nansen, A., Bartholdy, C., Stryhn, A., Hansen, N. J. V., Boesen, T. P., Wells, T. N. C., Schwartz, Thue W. & Thomsen, Allan Randrup, 2003, In: Journal of Virology. 77, 13, p. 7393-400 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Viral leads for chemokine-modulatory drugs
Lindow, M., Lüttichau, H. R. & Schwartz, Thue W., 2003, In: TIPS - Trends in Pharmacological Sciences. 24, 3, p. 126-30 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Virally encoded chemokines and chemokine receptors in the role of viral infections
Holst, Peter Johannes, Lüttichau, H. R., Schwartz, Thue W. & Rosenkilde, Mette, 2003, In: Contributions to Microbiology. 10, p. 232-52 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2002
- Published
Interaction of a non-peptide agonist with angiotensin II AT1 receptor mutants
Costa-Neto, C. M., Miyakawa, A. A., Pesquero, J. B., Oliveira, L., Hjorth, S. A., Schwartz, Thue W. & Paiva, A. C. M., 2002, In: Canadian Journal of Physiology and Pharmacology. 80, 5, p. 413-7 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Localization of HCMV UL33 and US27 in endocytic compartments and viral membranes
Fraile-Ramos, A., Pelchen-Matthews, A., Kledal, T. N., Browne, H., Schwartz, Thue W. & Marsh, M., 2002, In: Traffic - International Journal of Intracellular Transport. 3, 3, p. 218-32 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Metal ion-mediated agonism and agonist enhancement in melanocortin MC1 and MC4 receptors
Holst, Birgitte, Elling, C. E. & Schwartz, Thue W., 2002, In: Journal of Biological Chemistry. 277, 49, p. 47662-70 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular structure and function of 7TM/G-protein coupled receptors
Schwartz, Thue W. & Holst, Birgitte, 2002, Textbook of receptor Pharmacology. p. 65-84Research output: Chapter in Book/Report/Conference proceeding › Report chapter › Research
- Published
Murine cytomegalovirus (CMV) M33 and human CMV US28 receptors exhibit similar constitutive signaling activities
Waldhoer, M., Kledal, T. N., Farrell, H. & Schwartz, Thue W., 2002, In: Journal of Virology. 76, 16, p. 8161-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
NK1 receptor fused to beta-arrestin displays a single-component, high-affinity molecular phenotype
Martini, L., Hastrup, H., Holst, Birgitte, Fraile-Ramos, A., Marsh, M. & Schwartz, Thue W., 2002, In: Molecular Pharmacology. 62, 1, p. 30-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel method for the study of receptor Ca2+ signalling exemplified by the NK1 receptor
Heding, A., Elling, C. E. & Schwartz, Thue W., 2002, In: Journal of Receptors and Signal Transduction. 22, 1-4, p. 241-52 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Single-chain vascular endothelial growth factor variant with antagonist activity
Boesen, T. P., Soni, B., Schwartz, Thue W. & Halkier, T., 2002, In: Journal of Biological Chemistry. 277, 43, p. 40335-41 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2001
- Published
Enhanced fluorescence resonance energy transfer between spectral variants of green fluorescent protein through zinc-site engineering
Jensen, K. K., Martini, L. & Schwartz, Thue W., 2001, In: Biochemistry. 40 (4), p. 938-945Research output: Contribution to journal › Journal article › Research › peer-review
- Published
MC148 encoded by human molluscum contagiosum poxvirus is an antagonist for human but not murine CCR8
Lüttichau, H. R., Gerstoft, Jan & Schwartz, Thue W., 2001, In: Journal of Leukocyte Biology. 70, 2, p. 277-82 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 11601
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Family and population-based studies of variation within the ghrelin receptor locus in relation to measures of obesity
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PDZ domain-mediated interactions of G protein-coupled receptors with postsynaptic density protein 95: quantitative characterization of interactions
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Receptor structure-based discovery of non-metabolite agonists for the succinate receptor GPR91
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