Stine Jacobsen

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Stine Jacobsen moved from Jutland in the early 1990s to Copenhagen, where she studied at The Royal Veterinary and Agricultural University and obtained her degree in veterinary medicine in 1998. She defended her thesis The bovine acute phase response to endotoxin and Gram-negative bacteria from the same institution and obtained her PhD degree in 2003.

Her main research interests are bovine and equine inflammatory disease and acute phase proteins, the surgical stress response, joint disease and wound healing. The research is characterized by a ‘bench-to-box’ approach with much focus on understanding underlying pathophysiology in commonly occurring diseases in the large animal clinic, combining clinical and laboratory disciplines. Focus has been untoward responses to inflammation and trauma such as hyperresponsiveness during inflammation or aberrant wound healing. Her clinical interests lie broadly within equine and ruminant soft tissue and orthopaedic surgical diseases.

Stine divides her time between research, teaching of veterinary students and clinical work in the Large Animal Teaching Hospital, where she also participated in the surgical night duty.

Since 2009, Stine is a member of the Veterinary Study Board

Privately, she lives in Sengeløse, only few kilometers from The Large Animal Teaching Hospital, with her husband and two small boys.

Primary fields of research

• Inflammation and acute phase proteins
• Wound healing, causes of abarrrent wound healing, biofilm formation in wounds
• Joint disease
• Surgical stress responses
• Animal models of disease

Teaching

• Lectures, seminars and clinical practicals for veterinary students
• Supervision of veterinary bachelor and Master students (> 50)
• Post graduate courses for veterinary practitioners
• Post doc and PhD supervision (8 completed, 4 as main supervisor, 4 as co-supervisor)

Selected publications

1. Published

   Assay validation and diagnostic applications of major acute-phase protein testing in companion animals

   Kjelgaard-Hansen, M. & Jacobsen, Stine, 2011, In: Clinics in Laboratory Medicine. 31, 1, p. 51-70 20 p.

   Research output: Contribution to journal › Journal article › Research › peer-review

2. Published

   The acute phase protein serum amyloid A (SAA) as a marker of inflammation in horses

   Jacobsen, Stine & Andersen, P. H., 2007, In: Equine Veterinary Education. 19, 1, p. 38-46 9 p.

   Research output: Contribution to journal › Review › Research › peer-review

3. Published

   mRNA expression of genes involved in inflammation and haemostasis in equine fibroblast-like synoviocytes following exposure to lipopolysaccharide, fibrinogen and thrombin

   Andreassen, S. M., Berg, Lise Charlotte, Nielsen, Søren Saxmose, Kristensen, Annemarie T. & Jacobsen, Stine, 2015, In: B M C Veterinary Research. 11, 12 p., 141.

   Research output: Contribution to journal › Journal article › Research › peer-review

4. Published

   Influence of disease process and duration on acute phase proteins in serum and peritoneal fluid of horses with colic

   Pihl, Tina, Scheepers, E., Sanz, M., Goddard, A., Page, P., Toft, N., Andersen, P. H. & Jacobsen, Stine, Mar 2015, In: Journal of Veterinary Internal Medicine. 29, 2, p. 651-658 8 p.

   Research output: Contribution to journal › Journal article › Research › peer-review

5. Published

   Regional disturbances in blood flow and metabolism in equine limb wound healing with formation of exuberant granulation tissue

   Sørensen, M. A., Petersen, L. J., Bundgaard, L., Toft, N. & Jacobsen, Stine, 2014, In: Wound Repair and Regeneration. 22, 5, p. 647-653 7 p.

   Research output: Contribution to journal › Journal article › Research › peer-review

6. Published

   Development of a method for absolute quantification of equine acute phase proteins using concatenated peptide standards and selected reaction monitoring

   Bundgaard, L., Jacobsen, Stine, Dyrlund, T. F., Sørensen, M. A., Harman, V. M., Beynon, R. J., Brownridge, P. J., Petersen, L. J. & Bendixen, E., 2014, In: Journal of Proteome Research. 13, 12, p. 5635-5647 13 p.

   Research output: Contribution to journal › Journal article › Research › peer-review

7. Published

   The Equine PeptideAtlas: a resource for developing proteomics-based veterinary research

   Bundgaard, L., Jacobsen, Stine, Sørensen, M. A., Sun, Z., Deutsch, E. W., Moritz, R. L. & Bendixen, E., 2014, In: Proteomics. 14, 6, p. 763-773 11 p.

   Research output: Contribution to journal › Journal article › Research › peer-review

8. Published

   The use of liquid chromatography tandem mass spectrometry to detect proteins in saliva from horses with and without systemic inflammation

   Jacobsen, Stine, Adler, Ditte Marie Top, Bundgaard, L., Sørensen, M. A., Andersen, P. H. & Bendixen, E., 2014, In: Veterinary Journal. 202, 3, p. 483-488 6 p.

   Research output: Contribution to journal › Journal article › Research › peer-review

9. Published

   Acute phase response to surgery of varying intensity in horses: a preliminary study

   Jacobsen, Stine, Nielsen, J. V., Kjelgaard-Hansen, M., Tølbøll, T. H., Fjeldborg, Julie, Thomsen, M. H., Martinussen, Torben & Thøfner, M. B., 2009, In: Veterinary Surgery. 38, 6, p. 762-769 8 p.

   Research output: Contribution to journal › Journal article › Research › peer-review

10. Published

    Serum amyloid A isoforms in serum and synovial fluid in horses with lipopolysaccharide-induced arthritis

    Jacobsen, Stine, Niewold, T. A., Thomsen, M. H., Nanni, S., Olsen, E., Lindegaard, Casper & Andersen, P. H., 2006, In: Veterinary Immunology and Immunopathology. 110, 3-4, p. 325-330 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

11. Published

    Use of serum amyloid A and other acute phase reactants to monitor the inflammatory response after castraction in horses: a field study

    Jacobsen, Stine, Jensen, J. C., Frei, S., Jensen, Asger Lundorff & Thøfner, M., 2005, In: Equine Veterinary Journal. 37, 6, p. 552-556 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

12. Published

    Dose dependency and individual variability of the lipopolysaccharide- induced bovine acute phase protein response

    Jacobsen, Stine, Toelboell, T., Andersen, P. H. & Heegaard, P. M. H., 2004, In: Journal of Dairy Science. 87, 10, p. 3330-3339 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review