Stine Harloff-Helleberg

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Stine is Postdoc at Section for Biologics at the Department of Pharmacy, University of Copenhagen. She holds a Master in Pharmaceutical Sciences from University of Copenhagen and a PhD in food biophysics from the Faculty of Science, University of Copenhagen.

For the last 7 years, Stine has been working in academia including both research in close collaboration with the industry (Arla during the PhD and as an external Novo Nordisk fellow during her postdoc), lecturing and supervision of especially master students. Also, she has developed teaching material for Development of teaching material to the European Patients' Academy Expert Training Course for Patients and Patient Representatives (EUPATI) on the Medicines Research & Development Process.

Based on a master project at LEO Pharma focusing on cutaneous drug delivery of small molecules including use of ex vivo skin models, her PhD was within physico-chemical characterization of fat-based emulsions including utilization of large synchrotron facilities. With this interdisciplinary background, Stine moved on to a postdoc in the field of oral delivery of large molecules, especially focusing on in vitro and in vivo evaluation hereof. During her PhD, she extensively used advanced physical and biophysical analytical, all highly applicable to development and characterization of the physico-chemical behavior of drug delivery systems (DDS). Stine’s current work includes development of DDS primarily being hydrogels including permeation enhancers such as lipids, membrane modulating peptides and cell penetrating peptides. The work is with a particular focus on a detailed understanding of the physico-chemical structure of DDS is key to fully to understand their mechanistic behavior in vitro and in vivo. Also, focus is on the mechanistic behavior, safety, kinetics and dynamics of the DDS has subsequently been studied using advanced in vitro models and in complex in vivo models.

Stine is currently associated to employed on an EU project, COMPACT, where she is Project leader and responsible for in vitro and in vivo methodology. In relation to this, she holds of an in vivo license which includes monitoring and approval of protocols used under the license, quality assurance of the technical skills of the people working under the license, assurance of ethical aspects in agreement with both legislation and license, yearly reporting to the Animal Experiments Inspectorate, The Ministry of Environment and Food of Denmark.

Selected publications

1. Published

   Cell-penetrating peptides as carriers for transepithelial drug delivery in vitro

   Harloff-Helleberg, Stine, Kristensen, Mie & Nielsen, Hanne Mørck, 2015, Cell-penetrating peptides : Methods and Protocols. Langel, Ü. (ed.). Vol. 1324. p. 261-277 17 p.

   Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

2. Published

   The effect of butter grains on physical properties of butter-like emulsions

   Harloff-Helleberg, Stine, Buldo, P., Mortensen, Kell, Andersen, U., Knudsen, J. C. & Wiking, L., 2014, In: Journal of Dairy Science. 97, 4, p. 1929-1938 10 p.

   Research output: Contribution to journal › Journal article › Research › peer-review

3. Published

   Metodeudvikling: Reologi til bestemmelse af fedtbaserede produkters materialeegenskaber

   Harloff-Helleberg, Stine, Knudsen, J. C. & Mortensen, Kell, 2013, In: Dansk Kemi. 94, 11, p. 33-34 2 p.

   Research output: Contribution to journal › Journal article › Communication

4. Published

   Fat crystallization in dairy products: Rheology and microstructure of fat crystals

   Harloff-Helleberg, Stine, 2013, Department of Food Science, University of Copenhagen. 283 p.

   Research output: Book/Report › Ph.D. thesis › Research

5. Published

   Effect of cream cooling rate and water content on butter microstructure during four weeks of storage

   Harloff-Helleberg, Stine, Kirkensgaard, Jacob Judas Kain, Mortensen, Kell & Knudsen, J. C., 2014, In: Food Hydrocolloids. 34, p. 169-176 8 p.

   Research output: Contribution to journal › Journal article › Research › peer-review

6. Published

   The effect of capacity, rotational speed and storage on crystallization and rheological properties of puff pastry butter

   Harloff-Helleberg, Stine, Kirkensgaard, Jacob Judas Kain, Høyer, K. F., Mortensen, Kell & Knudsen, J. C., 2014, In: Journal of the American Oil Chemists' Society. 91, 1, p. 29-38

   Research output: Contribution to journal › Journal article › Research › peer-review

7. Published

   The effective factors on the structure of butter and other milk fat-based products

   Harloff-Helleberg, Stine, Mortensen, Kell & Knudsen, J. C., 2013, In: Comprehensive Reviews in Food Science and Food Safety. 12, 5, p. 468-482 15 p.

   Research output: Contribution to journal › Journal article › Research › peer-review

8. Published

   Small deformation rheology for characterization of anhydrous milk fat/rapeseed oil samples

   Harloff-Helleberg, Stine, Mortensen, Kell & Knudsen, J. C., 2014, In: Journal of Texture Studies. 45, 1, p. 20-29 10 p.

   Research output: Contribution to journal › Journal article › Research › peer-review

9. Published

   Polymorphism, microstructure and rheology of butter. Effects of cream heat treatment

   Harloff-Helleberg, Stine, Kirkensgaard, Jacob Judas Kain, Pedersen, T. B., Mortensen, Kell & Knudsen, J. C., 2012, In: Food Chemistry. 135, 3, p. 1730-1739 10 p.

   Research output: Contribution to journal › Journal article › Research › peer-review

10. Published

    Microstructural and rheological characterization of fat crystals

    Harloff-Helleberg, Stine, Mortensen, Kell, Hassenkam, Tue & Knudsen, J. C., 2010. 1 p.

    Research output: Contribution to conference › Poster › Research

11. Published

    Calcipotriol delivery into the skin with PEGylated liposomes

    Knudsen, N. Ø., Harloff-Helleberg, Stine, Salte, R. D., Jørgensen, Lene, Thormann, T., Basse, L. H., Hansen, J., Frøkjær, Sven & Foged, Camilla, 2012, In: European Journal of Pharmaceutics and Biopharmaceutics. 81, 3, p. 532-9 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

12. Published

    Lipid-protein interactions in nanodiscs: how to enhance stability

    Wadsäter, M. H., Cardenas Gomez, M., Harloff-Helleberg, Stine, Maric, S., Skar-Gislinge, N., Midtgaard, S. R., Arleth, Lise, Mortensen, Kell, Ryan, R. O. & Simonsen, J. B., 2012, In: Biophysical Journal. 102, 3, p. 236a 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

13. Published

    Fedtstruktur: innovation af smør og blandingsprodukter

    Harloff-Helleberg, Stine, Knudsen, J. C., Mortensen, Kell, Kaufmann, N., Buldo, P., Wiking, L. & Andersen, U., 2012, In: Maelkeritidende. 6, p. 8-9 2 p.

    Research output: Contribution to journal › Journal article › Research

14. Published

    Danmark kan lære meget af australske erfaringer med klinisk farmaci

    Harloff-Helleberg, Stine, 2008, In: Pharma. 7, p. 32-34 3 p.

    Research output: Contribution to journal › Journal article › Communication

Selected activities

1. 2014 AAPS Annual meeting and EXPO

   Harloff-Helleberg, Stine (Speaker)

   2 Nov 2014 → 6 Nov 2014

   Activity: Participating in an event - types › Participation in workshop, seminar, course

2. COMPACT

   Harloff-Helleberg, Stine (Speaker)

   3 Feb 2015 → 5 Feb 2015

   Activity: Participating in an event - types › Participation in workshop, seminar, course

3. EUPATI

   Harloff-Helleberg, Stine (Speaker)

   1 Jan 2014 → …

   Activity: Participating in an event - types › Participation in workshop, seminar, course

4. Cell Penetrating Peptides

   Harloff-Helleberg, Stine (Participant)

   7 Oct 2013 → 13 Oct 2013

   Activity: Participating in an event - types › Participation in workshop, seminar, course