Stine Harloff-Helleberg
Assistant professor
Drug Delivery and Biophysics of Biopharmaceuticals
Universitetsparken 2, 2100 København Ø, Building: 13-4-423b
Stine is Postdoc at Section for Biologics at the Department of Pharmacy, University of Copenhagen. She holds a Master in Pharmaceutical Sciences from University of Copenhagen and a PhD in food biophysics from the Faculty of Science, University of Copenhagen.
For the last 7 years, Stine has been working in academia including both research in close collaboration with the industry (Arla during the PhD and as an external Novo Nordisk fellow during her postdoc), lecturing and supervision of especially master students. Also, she has developed teaching material for Development of teaching material to the European Patients' Academy Expert Training Course for Patients and Patient Representatives (EUPATI) on the Medicines Research & Development Process.
Based on a master project at LEO Pharma focusing on cutaneous drug delivery of small molecules including use of ex vivo skin models, her PhD was within physico-chemical characterization of fat-based emulsions including utilization of large synchrotron facilities. With this interdisciplinary background, Stine moved on to a postdoc in the field of oral delivery of large molecules, especially focusing on in vitro and in vivo evaluation hereof. During her PhD, she extensively used advanced physical and biophysical analytical, all highly applicable to development and characterization of the physico-chemical behavior of drug delivery systems (DDS). Stine’s current work includes development of DDS primarily being hydrogels including permeation enhancers such as lipids, membrane modulating peptides and cell penetrating peptides. The work is with a particular focus on a detailed understanding of the physico-chemical structure of DDS is key to fully to understand their mechanistic behavior in vitro and in vivo. Also, focus is on the mechanistic behavior, safety, kinetics and dynamics of the DDS has subsequently been studied using advanced in vitro models and in complex in vivo models.
Stine is currently associated to employed on an EU project, COMPACT, where she is Project leader and responsible for in vitro and in vivo methodology. In relation to this, she holds of an in vivo license which includes monitoring and approval of protocols used under the license, quality assurance of the technical skills of the people working under the license, assurance of ethical aspects in agreement with both legislation and license, yearly reporting to the Animal Experiments Inspectorate, The Ministry of Environment and Food of Denmark.
Selected publications
- Published
Cell-penetrating peptides as carriers for transepithelial drug delivery in vitro
Harloff-Helleberg, Stine, Kristensen, Mie & Nielsen, Hanne Mørck, 2015, Cell-penetrating peptides : Methods and Protocols. Langel, Ü. (ed.). Vol. 1324. p. 261-277 17 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
The effect of butter grains on physical properties of butter-like emulsions
Harloff-Helleberg, Stine, Buldo, P., Mortensen, Kell, Andersen, U., Knudsen, J. C. & Wiking, L., 2014, In : Journal of Dairy Science. 97, 4, p. 1929-1938 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Metodeudvikling: Reologi til bestemmelse af fedtbaserede produkters materialeegenskaber
Harloff-Helleberg, Stine, Knudsen, J. C. & Mortensen, Kell, 2013, In : Dansk Kemi. 94, 11, p. 33-34 2 p.Research output: Contribution to journal › Journal article › Communication
- Published
Fat crystallization in dairy products: Rheology and microstructure of fat crystals
Harloff-Helleberg, Stine, 2013, Department of Food Science, University of Copenhagen. 283 p.Research output: Book/Report › Ph.D. thesis
- Published
Effect of cream cooling rate and water content on butter microstructure during four weeks of storage
Harloff-Helleberg, Stine, Kirkensgaard, Jacob Judas Kain, Mortensen, Kell & Knudsen, J. C., 2014, In : Food Hydrocolloids. 34, p. 169-176 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The effect of capacity, rotational speed and storage on crystallization and rheological properties of puff pastry butter
Harloff-Helleberg, Stine, Kirkensgaard, Jacob Judas Kain, Høyer, K. F., Mortensen, Kell & Knudsen, J. C., 2014, In : Journal of the American Oil Chemists' Society. 91, 1, p. 29-38Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The effective factors on the structure of butter and other milk fat-based products
Harloff-Helleberg, Stine, Mortensen, Kell & Knudsen, J. C., 2013, In : Comprehensive Reviews in Food Science and Food Safety. 12, 5, p. 468-482 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Small deformation rheology for characterization of anhydrous milk fat/rapeseed oil samples
Harloff-Helleberg, Stine, Mortensen, Kell & Knudsen, J. C., 2014, In : Journal of Texture Studies. 45, 1, p. 20-29 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Polymorphism, microstructure and rheology of butter. Effects of cream heat treatment
Harloff-Helleberg, Stine, Kirkensgaard, Jacob Judas Kain, Pedersen, T. B., Mortensen, Kell & Knudsen, J. C., 2012, In : Food Chemistry. 135, 3, p. 1730-1739 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Microstructural and rheological characterization of fat crystals
Harloff-Helleberg, Stine, Mortensen, Kell, Hassenkam, Tue & Knudsen, J. C., 2010. 1 p.Research output: Contribution to conference › Poster › Research
- Published
Calcipotriol delivery into the skin with PEGylated liposomes
Knudsen, N. Ø., Harloff-Helleberg, Stine, Salte, R. D., Jørgensen, Lene, Thormann, T., Basse, L. H., Hansen, J., Frøkjær, Sven & Foged, Camilla, 2012, In : European Journal of Pharmaceutics and Biopharmaceutics. 81, 3, p. 532-9 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lipid-protein interactions in nanodiscs: how to enhance stability
Wadsäter, M. H., Cardenas Gomez, M., Harloff-Helleberg, Stine, Maric, S., Skar-Gislinge, N., Midtgaard, S. R., Arleth, Lise, Mortensen, Kell, Ryan, R. O. & Simonsen, J. B., 2012, In : Biophysical Journal. 102, 3, p. 236a 1 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Fedtstruktur: innovation af smør og blandingsprodukter
Harloff-Helleberg, Stine, Knudsen, J. C., Mortensen, Kell, Kaufmann, N., Buldo, P., Wiking, L. & Andersen, U., 2012, In : Maelkeritidende. 6, p. 8-9 2 p.Research output: Contribution to journal › Journal article › Research
- Published
Danmark kan lære meget af australske erfaringer med klinisk farmaci
Harloff-Helleberg, Stine, 2008, In : Pharma. 7, p. 32-34 3 p.Research output: Contribution to journal › Journal article › Communication
Selected activities
2014 AAPS Annual meeting and EXPO
Harloff-Helleberg, Stine (Speaker)2 Nov 2014 → 6 Nov 2014Activity: Participating in or organising an event types › Participation in workshop, seminar, course
COMPACT
Harloff-Helleberg, Stine (Speaker)3 Feb 2015 → 5 Feb 2015Activity: Participating in or organising an event types › Participation in workshop, seminar, course
EUPATI
Harloff-Helleberg, Stine (Speaker)1 Jan 2014 → …Activity: Participating in or organising an event types › Participation in workshop, seminar, course
Cell Penetrating Peptides
Harloff-Helleberg, Stine (Participant)7 Oct 2013 → 13 Oct 2013Activity: Participating in or organising an event types › Participation in workshop, seminar, course
ID: 18182987
Most downloads
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80
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Exploring the mucoadhesive behavior of sucrose acetate isobutyrate: a novel excipient for oral delivery of biopharmaceuticals
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
65
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Optical catapulting of microspheres in mucus models-toward overcoming the mucus biobarrier
Research output: Contribution to journal › Journal article › Research › peer-review
Published