Søren-Peter Olesen
Professor
Molecular Cardiology and Membrane Proteins
Blegdamsvej 3, 2200 København N.
- 1998
- Published
Characterization of the cloned human intermediate-conductance Ca*O2*O+-activated K*O+ channel
Jensen, B. S., Strøbæk, D., Christophersen, P., Jørgensen, T. D., Hansen, C., Silahtaroglu, Asli, Olesen, Søren-Peter & Ahring, P. K., 1998, In: The American Physiological Society. p. 848-856Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hydralazine-induced vasodilation involves opening of high conductan Ca2+-activated K+ channels
Bang, L., Nielsen-Kudsk, J. E., Gruhn, N., Trautner, S., Theilgaard, S. A., Olesen, Søren-Peter, Boesgaard, S. & Aldershvile, J., 1998, In: European Journal of Pharmacology. 361(1), p. 43-49Research output: Contribution to journal › Journal article › Research › peer-review
- 1999
- Published
Activation of the human intermediate-conductance Ca2+-activated K+ channel by 1-ethyl-2-benzimidazolinone is strongly Ca2+-dependent
Pedersen, K. A., Schrøder, R. L. K., Skanning-Jensen, B., Strøbæk, D., Olesen, Søren-Peter & Christophersen, P., 1999, In: BBA General Subjects. 77660, p. 01-10Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional characterization of a cloned human intermediate-conductance Ca2+-activated K+ channel
Jørgensen, T. D., Jensen, B. S., Strøbæk, D., Christofersen, P., Olesen, Søren-Peter & Ahring, B. K., 1999, In: Annals of the New York Academy of Sciences. 868, p. 423-426Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inhibition of T cell proliferation by selective block of Ca(2+)-activated K(+) channels
Jensen, B. S., Ødum, Niels, Jorgensen, N. K., Christophersen, P. & Olesen, Søren-Peter, 1999, In: Proceedings of the National Academy of Science of the United States of America. 96, 19, p. 10917-21 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inhibition of T cell proliferation by selective block of Ca2+-activated K+ channels
Jensen, B. S., Ødum, Niels, Jørgensen, N. K., Christophersen, P. & Olesen, Søren-Peter, 1999, In: Proceedings of the National Academy of Science of the United States of America. 96, p. 10917-10921Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Vascular smooth muscle contraction is an independent regulator of endothelial nitric oxide production
Bang, L., Nielsen-Kudsk, J. E., Gruhn, N., Theilgaard, S. A., Olesen, Søren-Peter & Aldershvile, J., 1999, In: Scandinavian Cardiovascular Journal. 33, p. 71-78Research output: Contribution to journal › Journal article › Research › peer-review
- 2000
- Published
Activation of the human, intermediate-conductance, Ca2+-activated K+ channel by methylxanthines
Schrøder, R. L. K., Jensen, B. S., Strøbaek, D., Olesen, Søren-Peter & Christophersen, P., 2000, In: Pflügers Archiv: European Journal of Physiology. 440, p. 809-818Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inhibition of the human intermediate-conductance, Ca2+-activated K+ channel by intracellular acidification
Pedersen, K. A., Jørgensen, N. K., Jensen, B. S. & Olesen, Søren-Peter, 2000, In: Pflügers Archiv: European Journal of Physiology. 440(1), p. 153-156Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pharmacological characterization of small-conductance Ca(2+)-activated channels stably expressed in HEK 293 cells
Strobaek, D., Jørgensen, T. D., Christophersen, P., Ahring, P. K. & Olesen, Søren-Peter, 2000, In: British Journal of Pharmacology. 129(5), p. 991-999Research output: Contribution to journal › Journal article › Research › peer-review
- 2001
- Published
Apamin interacts with all subtypes of cloned small-conductance Ca2+-activated K+ channels
Grunnet, Morten, Jensen, B. S., Olesen, Søren-Peter & Klærke, Dan Arne, 2001, In: Pflügers Archiv: European Journal of Physiology. 441, p. 544-550Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of a novel voltage-gated Na+ channel rNav 1.5a in the rat hippocampal progenitor stem cell line HiB5
Korsgaard, M., Grunnet, Morten, Christophersen, P., Ahring, P. K. & Olesen, Søren-Peter, 2001, In: Pflügers Archiv: European Journal of Physiology. 443, p. 18-30Research output: Contribution to journal › Journal article › Research › peer-review
- Published
KCNQ4 channel activation by BMS204352 and retigabine
Schrøder, R. L., Strøbaek, D., Christophersen, P., Jensen Skanning, B. & Olesen, Søren-Peter, 2001, In: Neuropharmacology. 40, p. 888-898Research output: Contribution to journal › Journal article › Research › peer-review
- Published
KCNQ4 channels expressed in mammalian cells: Functional characteristics and pharmacology
Søgaard, R., Ljungstrøm, T., Pedersen, K. A., Olesen, Søren-Peter & Jensen Skanning, B., 2001, In: American Journal of Physiology: Cell Physiology. 280, p. C859-C866Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Ca2+-activated K+ channel of intermediate-conductance: A molecular target for novel treatments?
Jensen Skanning, B., Strøbaek, D., Olesen, Søren-Peter & Christophersen, P., 2001, In: Current Drug Targets. 2, p. 401-422Research output: Contribution to journal › Journal article › Research › peer-review
- Published
An ERG channel inhibitor from the scorpion Buthus eupeus
Korolkova, Y. V., Kozlov, S. A., Lipkin, A. V., Pluzhnikov, K. A., Hadley, J. K., Filippov, A. K., Brown, D. A., Pedersen, K. A., Strøbaek, D., Jespersen, Thomas, Olesen, Søren-Peter, Jensen Skanning, B. & Grishin, E. V., 30 Mar 2001, In: Journal of Biological Chemistry. 276, 13, p. 9868-76 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2002
- Published
Activation of KCNQ5 channels stably expressed in HEK293 cells by BMS-204352.
Dupuis, D. S., Schrøder, R. L., Jespersen, Thomas, Christensen, J. K., Christophersen, P., Jensen, B. S. & Olesen, Søren-Peter, 2002, In: European Journal of Pharmacology. 437, 3, p. 129-37 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
CNTF inhibits high voltage activated Ca2+ currents in fetal mouse cortical neurones.
Holm, N. R., Christophersen, P., Hounsgaard, Jørn Dybkjær, Gammeltoft, S. & Olesen, Søren-Peter, 2002, In: Journal of Neurochemistry. 82, 3, p. 495-503 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
KCNE4 is an inhibitory subunit to the KCNQ1 channel.
Grunnet, Morten, Jespersen, Thomas, Rasmussen, Hanne Borger, Ljungstrøm, T., Jorgensen, N. K., Olesen, Søren-Peter & Klærke, Dan Arne, 2002, In: Journal of Physiology. 542, Pt 1, p. 119-30 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
KCNE5 induces time- and voltage-dependent modulation of the KCNQ1 current.
Angelo, K., Jespersen, Thomas, Grunnet, Morten, Nielsen, Morten Schak, Klærke, Dan Arne & Olesen, Søren-Peter, 2002, In: Biophysical Journal. 83, 4, p. 1997-2006 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
New binding site on common molecular scaffold provides HERG channel specificity of scorpion toxin BeKm-1.
Korolkova, Y. V., Bocharov, E. V., Angelo, K., Maslennikov, I. V., Grinenko, O. V., Lipkin, A. V., Nosyreva, E. D., Pluzhnikov, K. A., Olesen, Søren-Peter, Arseniev, A. S. & Grishin, E. V., 2002, In: Journal of Biological Chemistry. 277, 45, p. 43104-9 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Regulation of cloned, Ca2+-activated K+ channels by cell volume changes.
Grunnet, Morten, MacAulay, Nanna, Jorgensen, N. K., Jensen, S., Olesen, Søren-Peter & Klærke, Dan Arne, 2002, In: Pflügers Archiv: European Journal of Physiology. 444, 1-2, p. 167-77 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Unique binding site on the molecular scaffold of scorpion toxin BeKm-1 provides selectivity for HERG potassium channels
Korolkova, Y. V., Bocharov, E. V., Pedersen, K. A., Maslennikov, I. V., Grinenko, O. V., Lipkin, A. V., Nosireva, E. D., Pluzhnikov, K. A., Olesen, Søren-Peter, Arseniev, A. S. & Grishin, E. V., 2002, In: Journal of Biological Chemistry. 277, p. 43104-43109Research output: Contribution to journal › Journal article › Research › peer-review
- 2003
- Published
A radiolabeled peptide ligand of the hERG channel, [125I]-BeKm-1.
Angelo, K., Korolkova, Y. V., Grunnet, Morten, Grishin, E. V., Pluzhnikov, K. A., Klærke, Dan Arne, Knaus, H., Møller, Morten & Olesen, Søren-Peter, 2003, In: Pflügers Archiv: European Journal of Physiology. 447, 1, p. 55-63 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cell swelling activates cloned Ca(2+)-activated K(+) channels: a role for the F-actin cytoskeleton.
Jorgensen, N. K., Pedersen, Stine Helene Falsig, Rasmussen, Hanne Borger, Grunnet, Morten, Klærke, Dan Arne & Olesen, Søren-Peter, 2003, In: BBA General Subjects. 1615, 1-2, p. 115-25 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of two new dominant ClC-1 channel mutations associated with myotonia.
Grunnet, Morten, Jespersen, Thomas, Colding-Jørgensen, E., Schwartz, M., Klærke, Dan Arne, Vissing, John, Olesen, Søren-Peter & Dunø, M., 2003, In: Muscle & Nerve. 28, 6, p. 722-32 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional coupling between heterologously expressed dopamine D(2) receptors and KCNQ channels.
Ljungstrom, T., Grunnet, Morten, Jensen, B. S. & Olesen, Søren-Peter, 2003, In: Pflügers Archiv: European Journal of Physiology. 446, 6, p. 684-94 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
High throughput electrophysiology: new perspectives for ion channel drug discovery.
Willumsen, N. J., Bech, M., Olesen, Søren-Peter, Jensen, B. S., Korsgaard, M. P. G. & Christophersen, P., 2003, In: Receptors and Channels. 9, 1, p. 3-12 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
KCNE4 is an inhibitory subunit to Kv1.1 and Kv1.3 potassium channels.
Grunnet, Morten, Rasmussen, H. B., Hay-Schmidt, Anders, Rosenstierne, M., Klærke, Dan Arne, Olesen, Søren-Peter & Jespersen, Thomas, 2003, In: Biophysical Journal. 85, 3, p. 1525-37 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
KCNQ1 channels sense small changes in cell volume.
Grunnet, Morten, Jespersen, Thomas, MacAulay, Nanna, Jørgensen, N. K., Schmitt, Nicole, Pongs, O., Olesen, Søren-Peter & Klærke, Dan Arne, 2003, In: Journal of Physiology. 549, Pt 2, p. 419-27 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pharmacological investigation of the role of ion channels in salivary secretion.
Stummann, T. C., Poulsen, J. H., Hay-Schmidt, Anders, Grunnet, Morten, Klærke, Dan Arne, Rasmussen, Hanne Borger, Olesen, Søren-Peter & Jorgensen, N. K., 2003, In: Pflügers Archiv: European Journal of Physiology. 446, 1, p. 78-87 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Subcellular localization of the delayed rectifier K(+) channels KCNQ1 and ERG1 in the rat heart.
Rasmussen, Hanne Borger, Møller, Morten, Knaus, H., Jensen, B. S., Olesen, Søren-Peter & Jørgensen, N. K., 2003, In: American Journal of Physiology: Heart and Circulatory Physiology. 286, 4, p. H1300-9Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The role og K+ and C1- channels in salivary secretion
Stummann, T. C., Poulsen, J. H., Hay-Schmidt, Anders, Grunnet, Morten, Klærke, Dan Arne, Olesen, Søren-Peter & Jørgensen, N. K., 2003, In: Pflügers Archiv: European Journal of Physiology. 446, p. 78-87Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Voltage-independent KCNQ4 currents induced by (+/-)BMS-204352.
Schrøder, R. L., Strøbaek, D., Olesen, Søren-Peter & Christophersen, P., 2003, In: Pflügers Archiv: European Journal of Physiology. 446, 5, p. 607-16 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2004
- Published
Activation of human IK and SK Ca2+ -activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime).
Strøbaek, D., Teuber, L., Jørgensen, T. D., Ahring, P. K., Kjaer, K., Hansen, R. S., Olesen, Søren-Peter, Christophersen, P. & Skaaning-Jensen, B., 2004, In: BBA General Subjects. 1665, 1-2, p. 1-5 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Basolateral localisation of KCNQ1 potassium channels in MDCK cells: molecular identification of an N-terminal targeting motif.
Jespersen, Thomas, Rasmussen, Hanne Borger, Grunnet, Morten, Jensen, H. S., Angelo, K., Dupuis, D. S., Vogel, L. K., Jorgensen, N. K., Klærke, Dan Arne & Olesen, Søren-Peter, 2004, In: Journal of Cell Science. 117, Pt 19, p. 4517-26 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Modulation of KCNQ4 channel activity by changes in cell volume.
Hougaard, C., Klærke, Dan Arne, Hoffmann, E. K., Olesen, Søren-Peter & Jorgensen, N. K., 2004, In: BBA General Subjects. 1660, 1-2, p. 1-6 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Modulation of the KCNQ4 potassium channel by changes in cell volume
Hougaard, C., Klærke, Dan Arne, Olesen, Søren-Peter, Hoffmann, E. K. & Jørgensen, N. K., 2004, In: Acta Physiologica (Print Edition). A45-A163, p. A64-A65Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Subcellular localization of the delayed rectifier potassium channel KCNQ1 and ERG1 in rat heart
Rasmussen, H. B., Møller, M., Knaus, H. G., Jensen, B. S., Olesen, Søren-Peter & Jørgensen, N. K., 2004, In: American Journal of Physiology: Heart and Circulatory Physiology. 286, p. H1300-H1309Research output: Contribution to journal › Journal article › Research › peer-review
- 2005
- Published
Activation of human ether-a-go-go-related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643).
Hansen, R. S., Diness, T. G., Christ, T., Demnitz, J., Ravens, U., Olesen, Søren-Peter & Grunnet, Morten, 2005, In: Molecular Pharmacology. 69, 1, p. 266-77 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Blockade of Ca2+-activated K+ channels in T cells: an option for the treatment of multiple sclerosis?
Madsen, L. S., Christophersen, P. & Olesen, Søren-Peter, 2005, In: European Journal of Immunology. 35, 4, p. 1023-6 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of beta-adrenoceptor blockers on human ether-a-go-go-related gene (HERG) potassium channels.
Dupuis, D. S., Klærke, Dan Arne & Olesen, Søren-Peter, 2005, In: Basic & Clinical Pharmacology & Toxicology. 96, 2, p. 123-30 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional assessment of compound mutations in the KCNQ1 and KCNH2 genes associated with long QT syndrome.
Grunnet, Morten, Behr, E. R., Callø, Kirstine, Hofman-Bang, J., Till, J., Christiansen, M., McKenna, W. J., Olesen, Søren-Peter & Schmitt, Nicole, 2005, In: Heart Rhythm. 2, 11, p. 1238-49 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hypoosmotic cell swelling as a novel mechanism for modulation of cloned HCN2 channels.
Callø, Kirstine, Elmedyb, P., Olesen, Søren-Peter, Jorgensen, N. K. & Grunnet, Morten, 2005, In: Biophysical Journal. 89, 3, p. 2159-69 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mechanism of action of a novel human ether-a-go-go-related gene channel activator.
Casis, O., Olesen, Søren-Peter & Sanguinetti, M. C., 2005, In: Molecular Pharmacology. 69, 2, p. 658-65 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The KCNQ1 potassium channel: from gene to physiological function.
Jespersen, Thomas, Grunnet, Morten & Olesen, Søren-Peter, 2005, In: Physiology. 20, p. 408-16 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The KCNQ5 potassium channel from mouse: a broadly expressed M-current like potassium channel modulated by zinc, pH, and volume changes.
Jensen, H. S., Callø, Kirstine, Jespersen, Thomas, Jensen, B. S. & Olesen, Søren-Peter, 2005, In: Brain Research. 139, 1, p. 52-62 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
hKCNE4 inhibits the hKCNQ1 potassium current without affecting the activation kinetics.
Grunnet, Morten, Olesen, Søren-Peter, Klærke, Dan Arne & Jespersen, Thomas, 2005, In: Biochemical and Biophysical Research Communications. 328, 4, p. 1146-53 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2006
- Published
Activation of HERG potassium channels by the diphenylurea NS1643
Hansen, R. S., Diness, T. G., Christ, T., Demnitz, J., Ravens, U. & Olesen, Søren-Peter, 2006, In: Molecular Pharmacology. 69, p. 266-277Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biophysical characterization of the new human ether-a-go-go-related gene channel opener NS3623[N-(4-bromo-2-(1H-tetrazol-5-yl)-phenyl)-N '-(3 '-trifluoromethylphenyl)urea]
Hansen, R. S., Diness, T. G., Christ, T., Wettwer, E., Ravens, U., Olesen, Søren-Peter & Grunnet, Morten, 2006, In: Molecular Pharmacology. 70, 4, p. 1319-1329 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Frequency-dependent modulation of KCNQ1 and HERG1 potassium channels.
Diness, T. G., Hansen, R. S., Olesen, Søren-Peter & Grunnet, Morten, 2006, In: Biochemical and Biophysical Research Communications. 343, 4, p. 1224-33 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
K(v)7 channels: Function, pharmacology and channel modulators
Dalby-Brown, W., Hansen, H. H., Korsgaard, M. P. G., Mirza, N. & Olesen, Søren-Peter, 2006, In: Current Topics in Medicinal Chemistry. 6, 10, p. 999-1023 24 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
KCNE3 is an inhibitory subunit of the Kv4.3 potassium channel.
Lundby, Alicia & Olesen, Søren-Peter, 2006, In: Biochemical and Biophysical Research Communications. 346, 3, p. 958-67 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mechanism of action of NS1643, a novel hERG channel activator
Casis, O., Olesen, Søren-Peter & Sanguinetti, M. C., 2006, In: Molecular Pharmacology. 69, p. 658-665Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Subtype-specific, bi-component inhibition of SK channels by low internal pH.
Peitersen, T., Jespersen, Thomas, Jorgensen, N. K., Olesen, Søren-Peter & Grunnet, Morten, 2006, In: Biochemical and Biophysical Research Communications. 343, 3, p. 943-9 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The acrylamide (S)-1 differentially affects Kv7 (KCNQ) potassium channels.
Bentzen, Bo Hjorth, Schmitt, Nicole, Callø, Kirstine, Dalby Brown, W., Grunnet, Morten & Olesen, Søren-Peter, 2006, In: Neuropharmacology. 51, 6, p. 1068-77 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The case of BK channel openers
Nardi, A., Calderone, V. & Olesen, Søren-Peter, 2006, In: Letters in Drug Design and Discovery. 3, p. 210-218Research output: Contribution to journal › Journal article › Research
- Published
The corticosteroid hormone induced factor: a new modulator of KCNQ1 channels?
Jespersen, Thomas, Grunnet, Morten, Rasmussen, Hanne Borger, Jørgensen, N. B., Jensen, H., Angelo, K., Olesen, Søren-Peter & Klærke, Dan Arne, 2006, In: Biochemical and Biophysical Research Communications. 341, 4, p. 979-88 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2007
- Published
Acrylamides as potassium channel openers
Nardit, A. & Olesen, Søren-Peter, 2007, In: Expert Opinion on Therapeutic Patents. 17, 10, p. 1215-1226 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Activation of ERG2 potassium channels by the diphenylurea NS1643.
Elmedyb, P., Olesen, Søren-Peter & Grunnet, Morten, 2007, In: Neuropharmacology. 53, 2, p. 283-94 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterizations of a loss-of-function mutation in the Kir3.4 channel subunit.
Callø, Kirstine, Ravn, L. S., Schmitt, Nicole, Sui, J. L., Duno, M., Haunso, S., Grunnet, Morten, Svendsen, J. H. & Olesen, Søren-Peter, 2007, In: Biochemical and Biophysical Research Communications. 364, 4, p. 889-95 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Forsknings- og ytringsfriheden på universiteterne: forskningspolitisk årsmøde 2007
Kærgård, Niels, Bache, C., Flensted-Jensen, M., Harder, Peter, Olesen, Søren-Peter & Wewer, Ulla M., 2007, København: Det Kongelige Danske Videnskabernes Selskab.Research output: Book/Report › Book › Communication
- Published
Inactivation as a new regulatory mechanism for neuronal Kv7 channels.
Jensen, H. S., Grunnet, Morten & Olesen, Søren-Peter, 2007, In: Biophysical Journal. 92, 8, p. 2747-56 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
KCNQ1 mutation Q147R is associated with atrial fibrillation and prolonged QT interval.
Lundby, Alicia, Ravn, L. S., Svendsen, Jesper Hastrup, Olesen, Søren-Peter & Schmitt, Nicole, 2007, In: Heart Rhythm. 4, 12, p. 1532-41 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Modulation of ERG channels by XE991.
Elmedyb, P., Callø, Kirstine, Schmitt, Nicole, Hansen, R. S., Grunnet, Morten & Olesen, Søren-Peter, 2007, In: Basic & Clinical Pharmacology & Toxicology. 100, 5, p. 316-22 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mutations in the Kv1.5 channel gene KCNA5 in cardiac arrest patients.
Nielsen, N. H., Winkel, B. G., Kanters, Jørgen K., Schmitt, Nicole, Hofman-Bang, J., Jensen, H. S., Bentzen, Bo Hjorth, Sigurd, B., Larsen, Lars Allan, Andersen, P. S., Kjeldsen, K., Grunnet, Morten, Christiansen, M., Olesen, Søren-Peter & Haunsø, Stig, 2007, In: Biochemical and Biophysical Research Communications. 354, 3, p. 776-82 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pharmacological activation of rapid delayed rectifier potassium current suppresses bradycardia-induced triggered activity in the isolated guinea pig heart.
Hansen, R. S., Olesen, Søren-Peter & Grunnet, Morten, 2007, In: Journal of Pharmacology and Experimental Therapeutics. 321, 3, p. 996-1002 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Requirement of subunit co-assembly and ankyrin-G for M-channel localization at the axon initial segment.
Rasmussen, Hanne Borger, Frøkjær-Jensen, Christian, Jensen, C. S., Jensen, H. S., Jørgensen, N. K., Misonou, H., Trimmer, J. S., Olesen, Søren-Peter & Schmitt, Nicole, 2007, In: Journal of Cell Science. 120, Pt 6, p. 953-63 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family.
Jespersen, Thomas, Membrez, M., Nicolas, C. S., Pitard, B., Staub, O., Olesen, Søren-Peter, Baró, I. & Abriel, H., 2007, In: Cardiovascular Research. 74, 1, p. 64-74 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The small molecule NS11021 is a potent and specific activator of Ca2+-activated big-conductance K+ channels.
Bentzen, Bo Hjorth, Nardi, A., Callø, Kirstine, Madsen, L. S., Olesen, Søren-Peter & Grunnet, Morten, 2007, In: Molecular Pharmacology. 72, 4, p. 1033-44 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
- Published
A transient outward potassium current activator recapitulates the electrocardiographic manifestations of Brugada syndrome
Callø, Kirstine, Cordeiro, J. M., Di Diego, J. M., Hansen, R. S., Grunnet, Morten, Olesen, Søren-Peter & Antzelevitch, C., 2008, In: Cardiovascular Research. 81, 4, p. 686-94 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antiarrhythmic properties of a rapid delayed-rectifier current activator in rabbit models of acquired long QT syndrome.
Diness, T. G., Yeh, Y., Qi, X. Y., Chartier, D., Tsuji, Y., Hansen, R. S., Olesen, Søren-Peter, Grunnet, Morten & Nattel, S., 2008, In: Cardiovascular Research. 79, 1, p. 61-69 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
BK channel modulators: a comprehensive overview.
Nardi, A. & Olesen, Søren-Peter, 2008, In: Current Medicinal Chemistry. 15, 11, p. 1126-46 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biophysical characterization of the short QT mutation hERG-N588K reveals a mixed gain-and loss-of-function
Grunnet, Morten, Diness, T. G., Hansen, R. S. & Olesen, Søren-Peter, 2008, In: Cellular Physiology and Biochemistry. 22, 5-6, p. 611-624 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of hERG1a and hERG1b potassium channels-a possible role for hERG1b in the I (Kr) current.
Larsen, A. P., Olesen, Søren-Peter, Grunnet, Morten & Jespersen, Thomas, 2008, In: Pflügers Archiv: European Journal of Physiology. 456, 6, p. 1137-48 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Computational analysis of the effects of the hERG channel opener NS1643 in a human ventricular cell model.
Peitersen, T., Grunnet, Morten, Benson, A. P., Holden, A. V., von Holstein-Rathlou, Niels-Henrik & Olesen, Søren-Peter, 2008, In: Heart Rhythm. 5, 5, p. 734-41 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of potassium channel openers in the isolated perfused hypokalaemic murine heart
Killeen, M. J., Thomas, G., Olesen, Søren-Peter, Demnitz, J., Stokoe, K. S., Grace, A. A. & Huang, C. L. H., 2008, In: Acta Physiologica (Print Edition). 193, 1, p. 25-36 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Forskeren i samfundet: Forskningspolitisk årsmøde 2008
Kærgård, Niels, Harder, Peter, Bache, C., Flensted-Jensen, M., Koch, Lene, Olesen, Søren-Peter & Sand-Jensen, Kaj, 2008, Det Kongelige Danske Videnskabernes Selskab. 42 p.Research output: Book/Report › Book › Communication
- Published
In vivo effects of the IKr agonist NS3623 on cardiac electrophysiology of the guinea pig.
Hansen, R. S., Olesen, Søren-Peter, Rønn, L. C. B. & Grunnet, Morten, 2008, In: Journal of Cardiovascular Pharmacology. 52, 1, p. 35-41 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
KCNE3 mutation V17M identified in a patient with lone atrial fibrillation.
Lundby, Alicia, Ravn, L. S., Svendsen, J. H., Hauns, S., Olesen, Søren-Peter & Schmitt, Nicole, 2008, In: Cellular Physiology and Biochemistry. 21, 1-3, p. 47-54 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Phosphatidylinositol-bisphosphate regulates intercellular coupling in cardiac myocytes
Hofgaard, J. P., Banach, K., Mollerup, S., Jørgensen, H. K., Olesen, Søren-Peter, von Holstein-Rathlou, Niels-Henrik & Nielsen, Morten Schak, 2008, In: Pflügers Archiv: European Journal of Physiology. 457, 2, p. 303-13 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Single-copy insertion of transgenes in Caenorhabditis elegans.
Frøkjær-Jensen, Christian, Davis, M. W., Hopkins, C. E., Newman, B. J., Thummel, J. M., Olesen, Søren-Peter, Grunnet, Morten & Jorgensen, E. M., 2008, In: Nature Genetics. 40, 11, p. 1375-83 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2009
- Published
Activation of big conductance Ca(2+)-activated K (+) channels (BK) protects the heart against ischemia-reperfusion injury
Bentzen, Bo Hjorth, Osadchii, O., Jespersen, Thomas, Hansen, R. S., Olesen, Søren-Peter & Grunnet, Morten, 2009, In: Pflügers Archiv: European Journal of Physiology. 457, 5, p. 979-88 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Arvelige hjertesygdomme forårsaget af natriumkanalmutationer
Tfelt-Hansen, J., Olesen, Søren-Peter, Svendsen, Jesper Hastrup & Jespersen, Thomas, 2009, In: Ugeskrift for læger. 171, 15, p. 1261-5 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
BK channel activation by NS11021 decreases excitability and contractility of urinary bladder smooth muscle
Layne, J. J., Nausch, B., Olesen, Søren-Peter & Nelson, M. T., 2009, In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 298, 2, p. R378-84Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chamber-specific effects of hypokalaemia on ventricular arrhythmogenicity in isolated, perfused guinea-pig heart
Osadchii, O. E., Bentzen, Bo Hjorth & Olesen, Søren-Peter, 2009, In: Experimental Physiology. 94, 4, p. 434-46 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Differential effects of the transient outward K(+) current activator NS5806 in the canine left ventricle
Callø, Kirstine, Soltysinska, E., Jespersen, Thomas, Lundby, Alicia, Antzelevitch, C., Olesen, Søren-Peter & Cordeiro, J. M., 2009, In: Journal of Molecular and Cellular Cardiology. 48, 1, p. 191-200 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional properties of human neuronal Kv11 channels
Einarsen, K., Callø, Kirstine, Grunnet, Morten, Olesen, Søren-Peter & Schmitt, Nicole, 2009, In: Pflügers Archiv: European Journal of Physiology. 458, 4, p. 689-700 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Kvalitet og styring i fremtidens universiteter - Ejerskab, ledelseskultur og de faktiske følger af universitetsloven: Forskningspolitisk årsmøde 2009
Harder, Peter, Bache, C., Flensted-Jensen, M., Koch, Lene, Olesen, Søren-Peter & Sand-Jensen, Kaj, 2009, 78 p. Det Kongelige Danske Videnskabernes Selskab.Research output: Other contribution › Communication
- Published
Synthesis and characterisation of NS13558: a new important tool for addressing KCa1.1 channel function ex vivo
Bentzen, Bo Hjorth, Andersen, R. W., Olesen, Søren-Peter, Grunnet, Morten & Nardi, A., 2009, In: NAUNYN-SCHMIEDEBERGS ARCHIV FUR EXPERIMENTELLE PATHOLOGIE UND PHARMAKOLOGIE.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Transmural expression of ion channels and transporters in human nondiseased and end-stage failing hearts
Soltysinska, E., Olesen, Søren-Peter, Christ, T., Wettwer, E., Varró, A., Grunnet, Morten & Jespersen, Thomas, 2009, In: Pflügers Archiv: European Journal of Physiology. 459, 1, p. 11-23 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ventricular tachycardia in an Brugada syndrome patient caused by novel deletion mutation in SCN5A
Tfelt-Hansen, Jacob, Jespersen, T., Hofman-Bang, J., Rasmussen, H., Cedergreen, P. K., Skovby, F., Abriel, H., Svendsen, J., Olesen, Søren-Peter & Christiansen & Haunso, S., 2009, In: Canadian Journal of Cardiology. 25, 3Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Forskning skal ikke gøre ledelsen glad
Harder, Peter, Bache, C., Flensted-Jensen, M., Koch, Lene, Olesen, Søren-Peter & Sand-Jensen, Kaj, 11 Feb 2009, In: Universitetsavisen.Research output: Contribution to journal › Contribution to newspaper - Newspaper article › Communication
- Published
Bureaukrati, Bogholderi og Bullshit
Harder, Peter, Bache, C., Flensted-Jensen, M., Koch, Lene, Olesen, Søren-Peter & Sand-Jensen, Kaj, 30 Oct 2009, In: Weekendavisen.Research output: Contribution to journal › Contribution to newspaper - Newspaper article › Communication
- 2010
- Published
Differential expression of hERG1 channel isoforms reproduces properties of native I(Kr) and modulates cardiac action potential characteristics
Larsen, A. P. & Olesen, Søren-Peter, 2010, In: P L o S One. 5, 2, p. e9021Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of a Kir3.4 Mutation in Congenital Long QT Syndrome
Yang, Y., Yang, Y., Liang, B., Liu, J., Li, J., Grunnet, M., Olesen, S-P., Rasmussen, H. B., Ellinor, P. T., Gao, L., Lin, X., Li, L., Wang, L., Xiao, J., Liu, Y., Liu, Y., Zhang, S., Liang, D., Peng, L., Jespersen, T. & 1 others, , 2010, In: American Journal of Human Genetics. 86, 6, p. 872-80 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
- Published
Characterization of cardiac repolarization in the Göttingen minipig
Laursen, M., Olesen, Søren-Peter, Grunnet, Morten, Mow, T., Jespersen, T. & Jespersen, Thomas, 2011, In: Journal of Pharmacological and Toxicological Methods. 63, 2, p. 186-95 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chronic sympathetic activation promotes downregulation of ß-adrenoceptor-mediated effects in the guinea pig heart independently of structural remodeling and systolic dysfunction
Soltysinska, E., Thiele, S., Osadchiy, O. & Olesen, Søren-Peter, 2011, In: Pflügers Archiv - European Journal of Physiology. 462, 4, p. 529-43 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Comparison of the Effects of a Transient Outward Potassium Channel Activator on Currents Recorded from Atrial and Ventricular Cardiomyocytes.
Callø, Kirstine, Nof, E., Jespersen, Thomas, Di Diego, J. M., Chlus, N., Olesen, Søren-Peter, Antzelevitch, C. & Cordeiro, J. M., 2011, In: Journal of Cardiovascular Electrophysiology. 22, 9, p. 1057-1066 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Extracellular potassium inhibits Kv7.1 potassium channels by stabilizing an inactivated state
Larsen, A. P., Steffensen, Annette Buur, Grunnet, Morten & Olesen, Søren-Peter, 2011, In: Biophysical Journal. 101, 4, p. 818-27 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 13436
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Tissue-specific effects of acetylcholine in the canine heart
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Non-invasive detection of animal nerve impulses with an atomic magnetometer operating near quantum limited sensitivity
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Termination of Vernakalant-Resistant Atrial Fibrillation by Inhibition of Small-Conductance Ca2+-Activated K+ Channels in Pigs
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