Søren Brøgger Christensen
Professor emeritus, Professor, emeritus
- 2022
- Published
Drugs That Changed Society: Microtubule-Targeting Agents Belonging to Taxanoids, Macrolides and Non-Ribosomal Peptides
Christensen, Søren Brøgger, 2022, In: Molecules. 27, 17, 29 p., 5648.Research output: Contribution to journal › Review › Research › peer-review
- Published
Validation of anti-malarial leads from natural products and traditional medicine for treatment of malaria
Christensen, Søren Brøgger, 2022, In Evidence-Based validation of herbal medicine. Mukherjee, P. K. (ed.). 2 ed. Amsterdam: Elsevier, p. 389-407Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- 2021
- Published
Drugs That Changed Society: History and Current Status of the Early Antibiotics: Salvarsan, Sulfonamides, and β-Lactams
Christensen, Søren Brøgger, 2021, In: Molecules. 26, 19, 31 p., 6057.Research output: Contribution to journal › Review › Research › peer-review
- Published
From Plant to Patient: Thapsigargin, a Tool for Understanding Natural Product Chemistry, Total Syntheses, Biosynthesis, Taxonomy, ATPases, Cell Death, and Drug Development
Christensen, Søren Brøgger, Simonsen, H. T., Engedal, N., Nissen, P., Møller, J. V., Denmeade, S. R. & Isaacs, J. T., 2021, In: Progress in the chemistry of organic natural products. 115, p. 59-114Research output: Contribution to journal › Review › Research › peer-review
- Published
Mipsagargin: The Beginning—Not the End—of Thapsigargin Prodrug-Based Cancer Therapeutics
Isaacs, J. T., Brennen, W. N., Christensen, Søren Brøgger & Denmeade, S. R., 2021, In: Molecules. 26, 24, 7469.Research output: Contribution to journal › Review › Research › peer-review
- Published
Natural Products that Changed Society
Christensen, Søren Brøgger, 2021, In: Biomedicines. 9, 5, 31 p., 472.Research output: Contribution to journal › Review › Research › peer-review
- Published
Targeting Toxins toward Tumors
Franzyk, Henrik & Christensen, Søren Brøgger, 2021, In: Molecules. 26, 5, 23 p., 1292.Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
Cell death induced by the ER stressor thapsigargin involves death receptor 5, a non-autophagic function of MAP1LC3B, and distinct contributions from unfolded protein response components
Lindner, P., Christensen, Søren Brøgger, Nissen, Poul, Moller, J. V. & Engedal, N., 2020, In: Cell Communication and Signaling. 18, 23 p., 12.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Large Scale Conversion of Trilobolide into the Payload of Mipsagargin: 8-O-(12-Aminododecanoyl)- 8-O-Debutanoylthapsigargin
Zimmermann, T., Drasar, P., Rempelova, S., Christensen, Søren Brøgger, Khripach, V. & Jurasek, M., 2020, In: Biomolecules. 10, 11 p., 1640.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Missing Selectivity of Targeted 4β-Phorbol Prodrugs Expected to be Potential Chemotherapeutics
Tarvainen, I., Zimmermann, T., Heinonen, P., Jäntti, M. H., Yli-Kauhaluoma, J., Talman, V., Franzyk, Henrik, Tuominen, R. K. & Christensen, Søren Brøgger, 2020, In: A C S Medicinal Chemistry Letters. 11, 5, p. 671-677 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Biosynthesis of tovarol and other sesquiterpenoids in Thapsia laciniata Rouy
Andersen, T. B., Rasmussen, S. A., Christensen, Søren Brøgger & Simonsen, H. T., Jan 2019, In: Phytochemistry. 157, https://doi.org/10.1016/j.phytochem.2018.10.027, p. 168-174 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A new flavonol glycoside and other flavonoids from the aerial parts of Taverniera aegyptiaca
Hassan, A. R., Amer, K. F., El-Toumy, S. A., Nielsen, J. & Christensen, Søren Brøgger, 2019, In: Natural Product Research. 33, 8, p. 1135-1139Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
Difluoroacetic Acid as a New Reagent for Direct C-H Difluoromethylation of Heteroaromatic Compounds - Scope, Limitations and Perspectives
Nielsen, J., Christensen, Søren Brøgger & Tung, T. T., Dec 2018, In: Synthesis. 50, 23, p. A193-A196 4 p.Research output: Contribution to journal › Conference article › Research › peer-review
- Published
Nonlinear relationship between ER Ca2+ depletion versus induction of the unfolded protein response, autophagy inhibition, and cell death
Szalai, P., Parys, J. B., Bultynckb, G., Christensen, Søren Brøgger, Nissen, P., Møller, J. V. & Engedal, N., Dec 2018, In: Cell Calcium. 76, p. 48-61 14 p., https://doi.org/10.1016/j.ceca.2018.09.005.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Phorbol Rearrangements
Zimmermann, T., Franzyk, Henrik & Christensen, Søren Brøgger, 28 Sep 2018, In: Journal of Natural Products. 81, 9, p. 2134-2137 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Direct difluoromethylation of heterocycles using difluoroacetic acid
Nielsen, J., Truong Thanh Tung & Christensen, Søren Brøgger, 19 Aug 2018.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
Preparation of Enzyme-Activated Thapsigargin Prodrugs by Solid-Phase Synthesis
Zimmermann, T., Christensen, Søren Brøgger & Franzyk, Henrik, 15 Jun 2018, In: Molecules. 23, 6, 13 p., 1463.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cover Feature: LEGO-Inspired Drug Design: Unveiling a Class of Benzo[d ]thiazoles Containing a 3,4-Dihydroxyphenyl Moiety as Plasma Membrane H+ -ATPase Inhibitors (ChemMedChem 1/2018)
Tung, T., Dao, T. T., Junyent, M. G., Palmgren, Michael, Pomorski, Thomas Guenther, Fuglsang, Anja Thoe, Christensen, Søren Brøgger & Nielsen, J., 8 Jan 2018, In: ChemMedChem. 13, 1, 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
LEGO-inspired drug design: unveiling a class of Benzo[d]thiazoles containing a 3,4-Dihydroxyphenyl moiety as plasma membrane H+-ATPase inhibitors
Thanh Tung, T., Dao, T. T., Grifell Junyent, M., Palmgren, Michael, Pomorski, Thomas Guenther, Fuglsang, Anja Thoe, Christensen, Søren Brøgger & Nielsen, J., 2018, In: ChemMedChem. 13, 1, 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
Metformin, an Anthropogenic Contaminant of Seidlitzia rosmarinus Collected in a Desert Region near the Gulf of Aqaba, Sinai Peninsula
Hassan, A. R., El-Kousy, S. M., El-Toumy, S. A., Frydenvang, Karla Andrea, Tung, T. T., Olsen, J., Nielsen, J. & Christensen, Søren Brøgger, 27 Oct 2017, In: Journal of Natural Products. 80, p. 2830-2834 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cover picture: Difluoroacetic Acid as a New Reagent for Direct C−H Difluoromethylation of Heteroaromatic Compounds
Thanh Tung, T., Christensen, Søren Brøgger & Nielsen, J., 25 Oct 2017, In: Chemistry - A European Journal. 2 p.Research output: Contribution to journal › Journal article › Communication
- Published
Difluoroacetic Acid as a New Reagent for Direct C-H Difluoromethylation of Heteroaromatic Compounds
Thanh Tung, T., Christensen, Søren Brøgger & Nielsen, J., 11 Oct 2017, In: Chemistry: A European Journal. 23, p. 18125-18128Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inhibition of the sarco/endoplasmic reticulum (ER) Ca2+-ATPase by thapsigargin analogs induces cell death via ER Ca2+ depletion and the unfolded protein response
Sehgal, P., Szalai, P., Praetorius, H. A., Nissen, Poul, Christensen, Søren Brøgger, Engedal, N. & Møller, J. V., 2 Oct 2017, In: Journal of Biological Chemistry. 292, 48, p. 19656-19673Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cranberry juice and combinations of its organic acids are effective against experimental urinary tract infection
Jensen, H. D., Struve, C., Christensen, Søren Brøgger & Krogfelt, K. A., 4 Apr 2017, In: Frontiers in Microbiology. 8, 6 p., 542.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
LEGO-inspired drug design: Discovery of novel fungal Plasma membrane H+-ATPase (Pma1) inhibitors from small molecule libraries: An introduction of HFSA-SBS_DOS-RD strategy in drug discovery.
Tung, T. T., Dao, T. T., Palmgren, M. B., Fuglsang, A. T., Christensen, Søren Brøgger & Nielsen, J., 2 Apr 2017.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
Perturbing dissimilar biomolecular targets from natural product scaffolds and focused chemical decoration.
Nielsen, J., Tung, T. T., Tim, H. J., Trong Tuan, D., Anja T., F., Michael, G. & Christensen, Søren Brøgger, 2 Apr 2017. 1 p.Research output: Contribution to conference › Poster › Research › peer-review
- Published
Accelerating the domestication of new crops: feasibility and approaches
Østerberg, J. T., Xiang, Wen, Olsen, L. I., Edenbrandt, A. K., Vedel, S. E., Christiansen, Andreas, Landes, X., Andersen, M. M., Pagh-Rasmussen, Peter, Sandøe, Peter, Nielsen, J., Christensen, Søren Brøgger, Thorsen, Bo Jellesmark, Kappel, Klemens, Gamborg, Christian & Palmgren, Michael, 2017, In: Trends in Plant Science. 22, 5, p. 373-384 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Fusaric acid and analogues as gram-negative bacterial quorum sensing inhibitors
Thanh Tung, T., Jakobsen, Tim Holm, Dao, T. T., Fuglsang, Anja Thoe, Givskov, Michael, Christensen, Søren Brøgger & Nielsen, J., 2017, In: European Journal of Medicinal Chemistry. 126, p. 1011-1020 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Localization and in-vivo characterization of Thapsia garganica CYP76AE2 indicates a role in thapsigargin biosynthesis
Andersen, T. B., Martinez-Swatson, K. A., Rasmussen, S. A., Boughton, B. A., Jørgensen, Kirsten, Andersen-Ranberg, Johan, Nyberg, N., Christensen, Søren Brøgger & Simonsen, H. T., 2017, In: Plant Physiology. 174, 1, p. 56-72 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure/activity Relationship of Thapsigargin Inhibition on the Purified Golgi/secretory Pathway Ca2+/Mn2+-Transport ATPase (SPCA1a)
Jialin, C., de Raeymaecker, J., Hovgaard, J. B., Smaardijk, S., Vandecaetsbeek, I., Wuytack, F., Møller, J. V., Eggermont, J., de Meyer, M., Christensen, Søren Brøgger & Vangheluwe, P., 2017, In: Journal of Biological Chemistry. 292, 17, p. 6938-6951 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
Demethoxycurcumin is a potent inhibitor of P-type ATPases from diverse kingdoms of life
Dao, T. T., Sehgal, P., Thanh Tung, T., Møller, J. V., Nielsen, J., Palmgren, Michael, Christensen, Søren Brøgger & Fuglsang, Anja Thoe, 2016, In: P L o S One. 11, 9, 19 p., e0163260.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Iminolactones as Tools for Inversion of the Absolute Configuration of alpha-Amino Acids and as Inhibitors of Cancer Cell Proliferation
Jensen, C. M., Chow, H., Chen, M., Zhai, L., Frydenvang, Karla Andrea, Liu, H., Franzyk, Henrik & Christensen, Søren Brøgger, 2016, In: European Journal of Medicinal Chemistry. 114, p. 118-133 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neglected diseases
Christensen, Søren Brøgger & Bygbjerg, Ib Christian, 2016, Textbook of Drug Design and Discovery, Fifth Edition. CRC Press, p. 347-368 22 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- 2015
- Published
Novel thapsigargin analogues and methods of preparing them
Doan, T. Q. N., Christensen, Søren Brøgger & Crestey, F. L. J., 30 Dec 2015, Patent No. WO2015197860 A2, Priority date 27 Jun 2014, Priority No. DK20140070395 20140627Research output: Patent
- Published
Thapsigargin, origin, chemistry, structure-activity relationships and prodrug development.
Doan, T. Q. N. & Christensen, Søren Brøgger, Oct 2015, In: Current Pharmaceutical Design. 21, 38, p. 5505-5517 13 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Concise Synthesis of Thapsigargin from Nortrilobolide
Crestey, F., Toma, M. & Christensen, Søren Brøgger, 8 Sep 2015, In: Tetrahedron Letters. 56, 43, p. 5896-5898 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Drugs and drug leads based on natural products for treatment and prophylaxis of malaria
Christensen, Søren Brøgger, 25 Feb 2015, Evidence-based validation of herbal medicine: Elsevier. Amsterdam, p. 307-319Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Are we ready for back-to-nature crop breeding?
Palmgren, Michael, Edenbrandt, A. K., Vedel, S. E., Andersen, M. M., Landes, X., Østerberg, J. T., Falhof, J., Olsen, L. I., Christensen, Søren Brøgger, Sandøe, Peter, Gamborg, Christian, Kappel, Klemens, Thorsen, Bo Jellesmark & Pagh-Rasmussen, Peter, 2015, In: Trends in Plant Science. 20, 3, p. 155-164 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chemo- and regioselective functionalization of nortrilobolide: application for semi-synthesis of the natural product 2-acetoxytrilobolide
Doan, T. Q. N., Crestey, F., Olsen, C. E. & Christensen, Søren Brøgger, 2015, In: Journal of Natural Products. 78, 6, p. 1406-1414Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Iminolactones from Schizophyllum commune
Liu, X., Frydenvang, Karla Andrea, Liu, H., Zhai, L., Chen, M., Olsen, C. E. & Christensen, Søren Brøgger, 2015, In: Journal of Natural Products. 78, 5, p. 1165-1168 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Targeting thapsigargin towards tumors
Christensen, Søren Brøgger, Doan, T. Q. N., Paulsen, E. S., Sehgal, P., Møller, J. V., Nissen, P., Denmeade, S. R., Isaacs, J. T. & Dionne, C. A., 2015, In: Steroids. 97, p. 2-7 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
Serotonin transporter protein (SERT) and P-glycoprotein (P-gp) binding activity of montanine and coccinine from three species of Haemanthus L. (Amaryllidaceae)
Stafford, G. I., Birer, C., Larsen, Birger Brodin, Christensen, Søren Brøgger, Eriksson, A. H., Jäger, A. & Rønsted, Nina, Sep 2013, In: South African Journal of Botany. 88, p. 101-106 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Water-mediated interactions influence the binding of thapsigargin to sarco/endoplasmic reticulum calcium adenosinetriphosphatase
Paulsen, E. S., Villadsen, J., Tenori, E., Liu, Huizhen, Bonde, D. F., Lie, M. A., Bublitz, M., Olesen, C. L., Autzen, Henriette Elisabeth, Dach, I., Sehgal, P., Nissen, P., Møller, J., Schiøtt, B. & Christensen, Søren Brøgger, 9 May 2013, In: Journal of Medicinal Chemistry. 56, 9, p. 3609-19 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Differential effects of thapsigargin analogues on apoptosis of prostate cancer cells: complex regulation by intracellular calcium
Christensen, Søren Brøgger, Dubois, C., Abeele, F. V., Sehgal, P., Olesen, C., Junker, S., Prevarskaya, N. & Møller, J. V., 2013, In: F E B S Journal. 280, 21, p. 5430-5440 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Guaianolide Sesquiterpenoids: Pharmacology and biosynthesis
Simonsen, H. T., Weitzel, C. & Christensen, Søren Brøgger, 2013, Natural products: phytochemistry, botany and metabolism of alkaloids, phenolics and terpenes. Ramawat, K. G. & Mérillon, J-M. (eds.). Springer, p. 3069-3098 30 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- 2012
- Published
Alkaloid analysis by high-performance liquid chromatography-solid phase extraction-nuclear magnetic resonance: New strategies going beyond the standard
Kongstad, Kenneth Thermann, Ebild, S. J., Christensen, Søren Brøgger, Godejohann, M. & Jaroszewski, J. W., 28 Dec 2012, In: Journal of Chromatography A. 1270, p. 171-177 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Can phylogeny predict chemical diversity and potential medicinal activity of plants? A case study of Amaryllidaceae
Rønsted, Nina, Symonds, M. R. E., Birkholm, T., Christensen, Søren Brøgger, Meerow, A. W., Schmidt, M. M., Mølgaard, Per, Petersen, G., Rasmussen, N., van Staden, J., Stafford, G. I. & Jäger, A., 14 Sep 2012, In: BMC Evolutionary Biology. 12, 12 p., 182.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Engineering a prostate-specific membrane antigen-activated tumor endothelial cell prodrug for cancer therapy (Science Translational Medicine)
Denmeade, S. R., Mhaka, A. M., Rosen, D. M., Brennen, W. N., Dalrymple, S., Dach, I., Olesen, C., Gurel, B., DeMarzo, A. M., Wilding, G., Carducci, M. A., Dionne, C. A., Møller, J. V., Nissen, Poul, Christensen, Søren Brøgger & Isaacs, J. T., 18 Jul 2012, In: Science Translational Medicine. 4, 143, 143er4.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
Engineering a prostate-specific membrane antigen-activated tumor endothelial cell prodrug for cancer therapy
Denmeade, S. R., Mhaka, A. M., Rosen, D. M., Brennen, W. N., Dalrymple, S., Dach, I., Olesen, C., Gurel, B., DeMarzo, A. M., Wilding, G., Carducci, M. A., Dionne, C. A., Møller, J. V., Nissen, P., Christensen, Søren Brøgger & Isaacs, J. T., 27 Jun 2012, In: Science Translational Medicine. 4, 140, p. 140ra86Research output: Contribution to journal › Journal article › Research › peer-review
- Published
6-O-Methylkrigeine, a new Amaryllidaceae alkaloid from Nerine huttoniae Schönland
Molander, M., Christensen, Søren Brøgger, Jaeger, A. K., Olsen, C. E. & Rønsted, Nina, 2012, In: Natural Product Research. 26, 1, p. 56-60 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chalcone inhibitors of the NorA efflux pump in Staphylococcus aureus whole cells and enriched everted membrane vesicles
Holler, J. G., Slotved, H., Mølgaard, Per, Olsen, C. E. & Christensen, Søren Brøgger, 2012, In: Bioorganic & Medicinal Chemistry. 20, 14, p. 4514 - 4521 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Drugs for the neglected disease malaria based on natural products
Christensen, Søren Brøgger & Bygbjerg, Ib Christian, 2012, Bioactive compounds from natural sources: natural products as lead compounds in drug discovery. Tringali, C. (ed.). 2 ed. Boca Raton: CRC Press, p. 525-550Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Novel inhibitory activity of the Staphylococcus aureus NorA efflux pump by a kaempferol rhamnoside isolated from Persea lingue Nees
Holler, J. G., Christensen, Søren Brøgger, Slotved, H., Rasmussen, H. B., Guzman, A., Olsen, C. E., Petersen, B. & Mølgaard, Per, 2012, In: Journal of Antimicrobial Chemotherapy. 67, 5, p. 1138 - 1144 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
- Published
Oleic and linoleic acids are active principles in Nigella sativa and stabilize an E2P conformation of the Na,K-ATPase. Fatty acids differentially regulate cardiac glycoside interaction with the pump
Mahmmoud, Y. A. & Christensen, Søren Brøgger, Oct 2011, In: BBA General Subjects. 1808, 10, p. 2413-2420Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Amaryllidaceae alkaloids from Rauhia multiflora (Kunth) Ravenna
Birkholm, T., Rasmussen, N., Christensen, Søren Brøgger, Jäger, A. & Rønsted, Nina, Aug 2011, In: Planta Medica. 77, 12, PG12.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Thapsigargin affinity purification of intracellular P2A-type Ca2+ ATPases
Vandecaetsbeek, I., Christensen, Søren Brøgger, Liu, Huizhen, van Veldhoven, P. P., Waelkens, E., Eggermont, J., Raeymaekers, L., Møller, J. V., Nissen, P., Wuytack, F. & Vangheluwe, P., 1 May 2011, In: BBA General Subjects. 1813, 5, p. 1118-1127Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Amaryllidaceae alkaloids from the Australasian tribe Calostemmateae with acetylcholinesterase inhibitory activity
Søvsø Jensen, B., Christensen, Søren Brøgger, Jäger, A. K. & Rønsted, Nina, Apr 2011, In: Biochemical Systematics and Ecology. 39, 2, p. 153-155Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Isolation of immunomodulatory triterpene acids from a standardized rose hip powder (Rosa canina L.)
Saaby, Lasse, Jäger, A. K., Moesby, L., Hansen, E. W. & Christensen, Søren Brøgger, Feb 2011, In: Phytotherapy Research. 25, 2, p. 195-201Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Drugs for the neglected disease malaria based on natural products
Christensen, Søren Brøgger & Bygbjerg, Ib Christian, 1 Jan 2011, Bioactive Compounds from Natural Sources: Natural Products as Lead Compounds in Drug Discovery, Second Edition. CRC Press, p. 525-550 26 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- 2010
- Published
Planternes slægtskab som skattekort til nye lægemidler
Rønsted, Nina, Larsen, Birger Brodin, Christensen, Søren Brøgger, Eriksson, A. H. & Jäger, A. K., Dec 2010, In: Lægemiddelforskning. 2010, p. 19-21Research output: Contribution to journal › Journal article › Communication
- Published
Characterization of anti-inflammatory triterpene acids from rose hip powder (Rosa canina L.)
Saaby, Lasse, Jäger, A., Moesby, L., Hansen, E. W. & Christensen, Søren Brøgger, Aug 2010, In: Planta Medica. 76, 12, p. 1171Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
The pharmacophore of thapsigargin
Christensen, Søren Brøgger, Skytte, D. M., Liu, Huizhen, Nielsen, H. Ø., Svenningsen, L. E., Jensen, C. M. & Møller, J. V., Aug 2010, In: Planta Medica. 76, 12, p. 1187Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
A phenylpropanoid, a slovenolide, two sulphur-containing germacranes and Ca+2-ATPase inhibitors from Thapsia villosa
Rubal, J. J., Moreno-Dorado, F. J., Guerra, F. M., Jorge, Z. D., Galán, M. D. C., Salido, G. M., Christensen, Søren Brøgger, Søhoel, H. & Massanet, G. M., 2010, In: Planta Medica. 76, 3, p. 284-290Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Critical roles of hydrophobicity and orientation of side chains for inactivation of sarcoplasmic reticulum Ca2+-ATPase with thapsigargin and thapsigargin analogs
Winther, A. L., Liu, Huizhen, Sonntag, Y., Olesen, C., le Maire, M., Søhoel, H., Olsen, C. E., Christensen, Søren Brøgger, Nissen, P. & Møller, J. V., 2010, In: Journal of Biological Chemistry. 285, 37, p. 28883-28892Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Elucidation of the topography of the thapsigargin binding site in the sarco-endoplasmic calcium ATPase
Skytte, D. M., Møller, J. V., Liu, Huizhen, Nielsen, H. Ø., Svenningsen, L. E., Jensen, C. M., Olsen, C. E. & Christensen, Søren Brøgger, 2010, In: Bioorganic & Medicinal Chemistry. 18, 15, p. 5634-5646 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neglected diseases
Christensen, Søren Brøgger, 2010, Textbook of drug design and discovery. Krogsgaard-Larsen, P., Strømgaard, K. & Madsen, U. (eds.). 4 ed. Boca Raton: CRC Press, p. 341-358Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education
- Published
Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1
Bach, Anders, Stuhr-Hansen, N., Thorsen, T. S., Bork, N., Moreira, I. S., Frydenvang, Karla Andrea, Padrah, S., Christensen, Søren Brøgger, Madsen, Kenneth Lindegaard, Weinstein, H., Gether, Ulrik & Strømgaard, Kristian, 2010, In: Organic & Biomolecular Chemistry. 8, 19, p. 4281-4288 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2009
- Published
19a-hydroxy-3-oxo-ursa-1,12-dien-28-oic acid, an antiplasmodial triterpenoid isolated from Canthium multiflorum
Traore, M., Ziegler, H. L., Olsen, C. E., Hassanata, M., Pierre, G. I., Nacoulma, O. G., Guiguemdé, T. R. & Christensen, Søren Brøgger, 2009, In: Natural Product Research. 23, 12, p. 1108-1111 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A Trojan horse in drug development: targeting of thapsigargins towards prostate cancer cells
Christensen, Søren Brøgger, Skytte, D. M., Denmeade, S. R., Dionne, C., Møller, J. V., Nissen, P. & Isaacs, J. T., 2009, In: Anti-Cancer Agents in Medicinal Chemistry. 9, 3, p. 276-294Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Amino acid containing thapsigargin analogues deplete androgen receptor protein via synthesis inhibition and induce the death of prostate cancer cells
Griend, D. J. V., Antony, L., Dalrymple, S. L., Xu, Y., Christensen, Søren Brøgger, Denmeade, S. R. & Isaacs, J. T., 2009, In: Molecular Cancer Therapeutics. 8, 5, p. 1340-1349Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
- Published
S-petasin and butterbur lactones dilate vessels through blockage of voltage gated calcium channels and block DNA synthesis
Sheykhzade, Majid, Smajilovic, S., Issa, A., Haunsø, Stig, Christensen, Søren Brøgger & Tfelt-Hansen, J., 28 Sep 2008, In: European Journal of Pharmacology. 593, 1-3, p. 79-86Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A configurational and conformational study of aframodial and its diasteriomers via experimental and theoretical VA and VCD spectroscopies
Jalkanen, K. J., Gale, J. D., Lassen, P. R., Hemmingsen, Lars Bo Stegeager, Rodarte, A., Degtyarenko, I. M., Nieminen, R. M., Knapp-Mohammady, M., Suhai, S. & Christensen, Søren Brøgger, 2008, In: Theoretical Chemistry Accounts. 119, 1-3, p. 177-190 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A new oxygenated ursane derivative from Canthium multiflorum
Traore, M., Jaroszewski, J. W., Olsen, C. E., Ouédraogo, J. B., Pierre, G. I., Nacoulma, O. G., Guiguemdé, T. R. & Christensen, Søren Brøgger, 2008, In: Planta Medica. 74, 5, p. 560-562 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bioassay-guided identification and isolation of anticancer components in Hypholoma fasciculare extract
Pang, W. S. K., Chen, M., Zhai, L. & Christensen, Søren Brøgger, 2008.Research output: Contribution to conference › Poster › Research
- Published
Carroll rearrangement to construct the norneolignan skeleton
Skytte, D. M., Rasmussen, H. B. & Christensen, Søren Brøgger, 2008, In: Natural Product Research. 22, 2, p. 116-123Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evaluation of Medicinal Plants from Chile
Simonsen, H. T., Guzman, A., Adsersen, A., Christensen, Søren Brøgger & Mølgaard, Per, 2008.Research output: Contribution to conference › Conference abstract for conference › Research
- Published
Isolation of linoleic and alpha-linolenic acids as COX-1 and -2 inhibitors in rose hip
Jäger, A., Petersen, K. N., Thomasen, G. & Christensen, Søren Brøgger, 2008, In: Phytotherapy Research. 22, 7, p. 982-984 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Isolation of the MAO-inhibitor naringenin from Mentha aquatica L
Olsen, H. T., Stafford, G. I., van Staden, J., Christensen, Søren Brøgger & Jäger, A. K., 2008, In: Journal of Ethnopharmacology. 117, 3, p. 500-502Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lægemidler fra naturstoffer: fortid eller fremtid?
Jaroszewski, J. W., Christensen, Søren Brøgger, Franzyk, Henrik, Stærk, Dan & Ziegler, H., 2008, In: Lægemiddelforskning. p. 4-6Research output: Contribution to journal › Journal article › Communication
- Published
Mild psychoactive constituents of Mentha aquatica L.
Stafford, G. I., Almqvist, J. P., Vangsøe, S. A. K., Olsen, H. T., Christensen, Søren Brøgger, Adsersen, A., Jäger, A. K. & van Staden, J., 2008, In: South African Journal of Botany. 2, p. 389Research output: Contribution to journal › Conference abstract in journal › Research
- 2007
- Published
Psychotropic constituents of Mentha aquatica L.
Van Staden, J., Stafford, G. ,. I., Almqvist, J. P., Vangsoe, S. A. K., Olsen, H. T., Christensen, Søren Brøgger, Adsersen, A. & Jäger, A., Aug 2007, In: Planta Medica. 73, 9, p. 928-929Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Isolation and characterization of pristimerin as the antiplasmodial and antileishmanial agent of Maytenus senegalensis (Lam.) Exell.
Khalid, S. A., Friedrichsen, G. M., Christensen, Søren Brøgger, El Tahir, A. & Satti, G. M., 29 Jan 2007, In: ARKIVOC. 2007, 9, p. 129-134 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cytotoxic kurubasch aldehyde from Trichilia emetica
Traore, M., Zhai, L., Chen, M., Olsen, C. E., Odile, N., Pierres, G. I., Bosco, O. J., Robert, G. T. & Christensen, Søren Brøgger, 2007, In: Natural Product Reports. 21, 1, p. 13-17Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of natural products using HPLC-SPE combined with CapNMR
Lambert, M., Wolfender, J., Stærk, Dan, Christensen, Søren Brøgger, Hostettmann, K. & Jaroszewski, J. W., 2007, In: Analytical Chemistry. 79, 2, p. 727-735Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Isolation and characterization of pristimerin as the antiplasmodial and antileishmanial agent of Maytenus senegalensis (Lam.) Exell.
Khalid, S. A., Friedrichsen, G. M., Christensen, Søren Brøgger, El Tahir, A. & Satti, G. M., 2007, In: Arkivoc. ix, p. 129-134Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Noter til bioorganisk kemi M23-1
Franzyk, Henrik, Christensen, Søren Brøgger & Jaroszewski, J. W., 2007, København: Københavns Universitet, Det Farmaceutiske Fakultet, Institut for Medicinalkemi.Research output: Book/Report › Compendium/lecture notes › Education
- Published
Prenylated acetophenones from Melicope obscura and Melicope obtusifolia ssp. obtusifolia var. arborea and their distribution in Rutaceae
Adsersen, A., Smitt, U. W., Simonsen, H. T., Christensen, Søren Brøgger & Jaroszewski, J. W., 2007, In: Biochemical Systematics and Ecology. 35, 7, p. 447-453Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Psychotropic constituents of Mentha aquatica L.
van Staden, J., Stafford, G. I., Almqvist, J. P., Vangsøe, S. A. K., Olsen, H. T., Christensen, Søren Brøgger, Adsersen, A. & Jäger, A. K., 2007.Research output: Contribution to conference › Poster › Research
- 2006
- Published
Ancistrocladinium A and B, the first N,C-coupled naphthyldihydroisoquinoline alkaloids, from a Congolese Ancistrocladus species
Bringmann, G., Kajahn, I., Reichert, M., Pedersen, S. E. H., Faber, J. H., Gulder, T., Brun, R., Christensen, Søren Brøgger, Ponte-Sucre, A., Moll, H., Heubl, G. & Mudogo, V., 8 Dec 2006, In: Journal of Organic Chemistry. 71, 25, p. 9348-9356 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification and evaluation of Peruvian plants used to treat malaria and leishmaniasis
Kvist, L. P., Christensen, Søren Brøgger, Rasmussen, H. B., Mejia, K. & Gonzalez, Ana Valeria, 19 Jul 2006, In: Journal of Ethnopharmacology. 106, 3, p. 390-402 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pharmacokinetics, biodistribution, and antitumor efficacy of a human glandular kallikrein 2 (hK2)-activated thapsigargin prodrug
Janssen, S., Rosen, D. M., Ricklis, R. M., Dionne, C. A., Lilja, H., Christensen, Søren Brøgger, Isaacs, J. T. & Denmeade, S. R., 1 Mar 2006, In: Prostate. 66, 4, p. 358-368 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cytotoxic phenylpropanoids and an additional thapsigargin analogue isolated from Thapsia garganica
Liu, Huizhen, Jensen, K. G., Tran, L. M., Chen, M., Zhai, L., Olsen, C. E., Søhoel, H., Denmeade, S. R., Issacs, J. T. & Christensen, Søren Brøgger, 2006, In: Phytochemistry. 67, 24, p. 2651-2658 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sesquiterpenes from Thapsia nitida var. meridionalis and Thapsia nitida var. nitida
Rubal, J. J., Guerra, F. M., Moreno-Dorado, F. J., Jorge, Z. D., Massanet, G. M., Søhoel, H., Smitt, U. W., Frydenvang, Karla Andrea, Christensen, Søren Brøgger, Nielsen, C. & Eriksson, M., 2006, In: Journal of Natural Products. 69, 11, p. 1566-71 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2005
- Published
Applying linear interaction energy method for rational design of noncompetitive allosteric inhibitors of the sarco- and endoplasmic reticulum calcium-ATPase
Singh, P., Mhaka, A. M., Christensen, Søren Brøgger, Gray, J. J., Denmeade, S. R. & Isaacs, J. T., 21 Apr 2005, In: Journal of Medicinal Chemistry. 48, 8, p. 3005-3014 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2004
- Published
Screening a combinatorial peptide library to develop a human glandular kallikrein 2-activated prodrug as targeted therapy for prostate cancer
Janssen, S., Jakobsen, C. M., Rosen, D. M., Ricklis, R. M., Reineke, U., Christensen, Søren Brøgger, Lilja, H. & Denmeade, S. R., 1 Nov 2004, In: Molecular Cancer Therapeutics. 3, 11, p. 1439-1450 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis of the thapsigargins
Ley, S. V., Antonello, A., Balskus, E. P., Booth, D. T., Christensen, Søren Brøgger, Cleator, E., Gold, H., Högenauer, K., Hünger, U., Myers, R. M., Oliver, S. F., Simic, O., Smith, M. D., Søhoel, H. & Woolford, A. J. A., 17 Aug 2004, In: Proceedings of the National Academy of Sciences of the United States of America. 101, 33, p. 12073-12078 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antiplasmodial Constituents of Cajanus cajan
Duker-Eshun, G., Jaroszewski, J. W., Asomaning, W. A., Oppong-Boachie, F. & Christensen, Søren Brøgger, 1 Feb 2004, In: Phytotherapy Research. 18, 2, p. 128-130 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ancistrotanzanine C and related 5,1’- and 7,3’- coupled naphtylisoquinoline alkaloids from Ancistrocladus tanzaniensis
Bringmann, G., Dreyer, M., Faber, J. H., Dalsgaard, P. W., Stærk, Dan, Jaroszewski, J. W., Ndangalasi, H., Mbago, F., Brun, R. & Christensen, Søren Brøgger, 2004, In: Journal of Natural Products. 67, p. 743-748Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The antiparasitic compound Licochalcon A is a potent echinocytogenic agent that modifies erythrocyte membrane in the concentration region where the antiplasmodial activity is observed
Ziegler, H. L., Hansen, Harald S., Stærk, Dan, Christensen, Søren Brøgger, Hägerstrand, H. & Jaroszewski, J. W., 2004, In: Antimicrobial Agents and Chemotherapy. 48, p. 4067-4071Research output: Contribution to journal › Journal article › Research › peer-review
- 2003
- Published
Prostate-specific antigen-activated thapsigargin prodrug as targeted therapy for prostate cancer
Denmeade, S. R., Jakobsen, C. M., Janssen, S., Khan, S. R., Garrett, E. S., Lilja, H., Christensen, Søren Brøgger & Isaacs, J. T., 2 Jul 2003, In: National Cancer Institute. Journal (Online). 95, 13, p. 990-1000 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 1300951
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The antiparasitic compound Licochalcon A is a potent echinocytogenic agent that modifies erythrocyte membrane in the concentration region where the antiplasmodial activity is observed
Research output: Contribution to journal › Journal article › Research › peer-review
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Can phylogeny predict chemical diversity and potential medicinal activity of plants? A case study of Amaryllidaceae
Research output: Contribution to journal › Journal article › Research › peer-review
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303
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Demethoxycurcumin is a potent inhibitor of P-type ATPases from diverse kingdoms of life
Research output: Contribution to journal › Journal article › Research › peer-review
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