Oluf Borbye Pedersen

Oluf Borbye Pedersen

Visiting professor, Clinical Professor

Member of:

  • Internal medicine: infection medicine

  • Internal Medicine: Endocrinology

ORCID: 0000-0002-3321-3972

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  1. Published

    'Omics'-driven discoveries in prevention and treatment of type 2 diabetes

    Gjesing, A. M. P. & Pedersen, Oluf Borbye, 2012, In: European Journal of Clinical Investigation. Supplement. 42, 6, p. 579-88 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    (1)H-MRS measured ectopic fat in liver and muscle is associated with the metabolic syndrome in Danish girls but not in boys with overweight and obesity

    Nissen, A., Fonvig, C. E., Chabanova, E., Bøjsøe, C., Trier, C., Pedersen, Oluf Borbye, Hansen, Torben, Thomsen, Henrik S. & Holm, Jens-Christian, Dec 2016, In: Obesity Science & Practice. 2, 4, p. 376-384 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    14-fold increased prevalence of rare glucokinase gene variant carriers in unselected Danish patients with newly diagnosed type 2 diabetes

    Gjesing, A. P., Engelbrechtsen, L., Cathrine B. Thuesen, A., Have, C. T., Hollensted, M., Grarup, N., Linneberg, A., Steen Nielsen, J., Christensen, L. B., Thomsen, R. W., Johansson, K. E., Cagiada, M., Gersing, S., Hartmann-Petersen, R., Lindorff-Larsen, K., Vaag, A., Sørensen, H. T., Brandslund, I., Beck-Nielsen, H., Pedersen, O. & 2 others, Rungby, Jørgen & Hansen, Torben, 2022, In: Diabetes Research and Clinical Practice. 194, 9 p., 110159.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    TCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a 10-wk randomized hypoenergetic diet

    Grau, K., Cauchi, S., Holst, C., Astrup, A., Martinez, J. A., Saris, W. H. M., Blaak, E. E., Oppert, J., Arner, P., Rössner, S., Macdonald, I. A., Klimcakova, E., Langin, D., Pedersen, Oluf Borbye, Froguel, P. & Sørensen, Thorkild I.A., 2010, In: American Journal of Clinical Nutrition. 91, 2, p. 472-479 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    FTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals

    Qi, Q., Oskari Kilpeläinen, T., Downer, M. K., Tanaka, T., Smith, C. E., Sluijs, I., Sonestedt, E., Chu, A. Y., Renström, F., Lin, X., Angquist, L. H., Huang, J., Liu, Z., Li, Y., Asif Ali, M., Xu, M., Ahluwalia, T. V. S., Boer, J. M. A., Chen, P., Daimon, M. & 89 others, Eriksson, J., Perola, M., Friedlander, Y., Gao, Y., Heppe, D. H. M., Holloway, J. W., Houston, D. K., Kanoni, S., Kim, Y., Laaksonen, M. A., Jääskeläinen, T., Lee, N. R., Lehtimäki, T., Lemaitre, R. N., Lu, W., Luben, R. N., Manichaikul, A., Männistö, S., Marques-Vidal, P., Monda, K. L., Ngwa, J. S., Perusse, L., van Rooij, F. J. A., Xiang, Y., Wen, W., Wojczynski, M. K., Zhu, J., Borecki, I. B., Bouchard, C., Cai, Q., Cooper, C., Dedoussis, G. V., Deloukas, P., Ferrucci, L., Forouhi, N. G., Hansen, Torben, Christiansen, L., Hofman, A., Johansson, I., Jørgensen, T., Karasawa, S., Khaw, K., Kim, M., Kristiansson, K., Li, H., Lin, X., Liu, Y., Lohman, K. K., Long, J., Mikkilä, V., Mozaffarian, D., North, K., Pedersen, Oluf Borbye, Raitakari, O., Rissanen, H., Tuomilehto, J., van der Schouw, Y. T., Uitterlinden, A. G., Carola Zillikens, M., Franco, O. H., Shyong Tai, E., Ou Shu, X., Siscovick, D. S., Toft, Ulla Marie Nørgaard, Monique Verschuren, W. M., Vollenweider, P., Wareham, N. J., Witteman, J. C. M., Zheng, W., Ridker, P. M., Kang, J. H., Liang, L., Jensen, M. K., Curhan, G. C., Pasquale, L. R., Hunter, D. J., Mohlke, K. L., Uusitupa, M., Adrienne Cupples, L., Rankinen, T., Orho-Melander, M., Wang, T., Chasman, D. I., Franks, P. W., Sørensen, Thorkild I.A., Hu, F. B., Loos, R. J. F., Nettleton, J. A. & Qi, L., 7 Aug 2014, In: Human Molecular Genetics. 23, 25, p. 6961-6972 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    FUT2–ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses

    Ahluwalia, T. S., Eliasen, A. U., Sevelsted, A., Pedersen, C-E. T., Stokholm, J., Chawes, B., Bork-Jensen, J., Grarup, N., Pedersen, O., Hansen, T., Linneberg, A., Sharma, A., Weiss, S. T., Evans, M. D., Jackson, D. J., Morin, A., Krogfelt, K. A., Schjørring, S., Mortensen, P. B., Hougaard, D. M. & 13 others, Bybjerg-Grauholm, J., Bækvad-Hansen, M., Mors, O., Nordentoft, Merete, Børglum, A. D., Werge, Thomas, Agerbo, E., Gern, J. E., Lemanske, R. F., Ober, C., Pedersen, A. G., Bisgaard, H. & Bønnelykke, Klaus, 2020, In: Nature Communications. 11, 12 p., 6398.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    In vivo and ex vivo inflammatory markers of common metabolic phenotypes in humans

    Mærkedahl, R. B., Frøkiær, Hanne, Stenbæk, M. G., Nielsen, C. B., Lind, M. V., Lundtoft, C., Bohr, M. B., Ibrügger, S., Metzdorff, S. B., drb459, drb459, Pedersen, Oluf Borbye & Lauritzen, Lotte, 2018, In: Metabolic Syndrome and Related Disorders. 16, 1, p. 29-39 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study

    Schmidt, A. F., Swerdlow, D. I., Holmes, M. V., Patel, R. S., Fairhurst-Hunter, Z., Lyall, D. M., Hartwig, F. P., Horta, B. L., Hyppönen, E., Power, C., Moldovan, M., van Iperen, E., Hovingh, G. K., Demuth, I., Norman, K., Steinhagen-Thiessen, E., Demuth, J., Bertram, L., Liu, T., Coassin, S. & 31 others, Willeit, J., Kiechl, S., Willeit, K., Mason, D., Wright, J., Morris, R., Wanamethee, G., Whincup, P., Ben-Shlomo, Y., McLachlan, S., Price, J. F., Kivimaki, M., Welch, C., Sanchez-Galvez, A., Marques-Vidal, P., Nicolaides, A., Panayiotou, A. G., Onland-Moret, N. C., van der Schouw, Y. T., Matullo, G., Fiorito, G., Guarrera, S., Sacerdote, C., Wareham, N. J., Langenberg, C., Scott, R., Grarup, Niels, Pedersen, Oluf Borbye, Hansen, Torben, Linneberg, Allan René & LifeLines Cohort study group, L. C. S. G., Feb 2017, In: The Lancet Diabetes & Endocrinology. 5, 2, p. 97–105

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    1H-MRS Measured Ectopic Fat in Liver and Muscle in Danish Lean and Obese Children and Adolescents

    Fonvig, C. E., Chabanova, E., Andersson, E. A., Ohrt, J. D., Pedersen, Oluf Borbye, Hansen, Torben, Thomsen, Henrik S. & Holm, Jens-Christian, 2015, In: PLOS ONE. 10, 8, 15 p., e0135018.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    A -30G>A polymorphism of the beta-cell-specific glucokinase promoter associates with hyperglycemia in the general population of whites

    Rose, C. S., Ek, J., Urhammer, S. A., Glümer, C., Borch-Johnsen, K., Jørgensen, T., Pedersen, Oluf Borbye & Hansen, Torben, 2005, In: Diabetes. 54, 10, p. 3026-31 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    A Genome-Wide Association Study of IVGTT-Based Measures of First Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants

    Wood, A. R., Jonsson, A., Jackson, A. U., Wang, T-N., van Leewen, N., Palmer, N. D., Kobes, S., Deelen, J., Boquete-Vilarino, L., Paananen, J., Stančáková, A., Boomsma, D. I., de Geus, E. J., Eekhoff, E. M., Fritsche, A., Kramer, M., Nijpels, G., Simonis-Bik, A. M. C., van Haeften, T. W., Mahajan, A. & 31 others, Boehnke, M., Bergman, R. N., Tuomilehto, J., Collins, F. S., Mohlke, K. L., Banasik, Karina, Groves, C. J., McCarthy, M. I., Pearson, E. R., Natali, A., Mari, A., Buchanan, T. A., Taylor, K. D., Xiang, A. H., Gjesing, A. P., Grarup, Niels, Eiberg, Hans Rudolf Lytchoff, Pedersen, Oluf Borbye, Chen, Y., Laakso, M., Norris, J. M., Smith, U., Wagenknecht, L. E., Baier, L., Bowden, D. W., Hansen, Torben, Walker, M., Watanabe, R. M., 't Hart, L. M., Hanson, R. L. & Frayling, T. M., 2017, In: Diabetes. 66, 8, p. 2296-2309

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    A Gly482Ser missense mutation in the peroxisome proliferator-activated receptor gamma coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima Indians

    Muller, Y. L., Bogardus, C., Pedersen, Oluf Borbye & Baier, L., 2003, In: Diabetes. 52, 3, p. 895-8 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    A Human Variant of Glucose-Regulated Protein 94 That Inefficiently Supports IGF Production

    Marzec, Michal Tomasz, Hawkes, C. P., Eletto, D., Boyle, S., Rosenfeld, R. G., Hwa, V., Wit, J. M., van Duyvenvoorde, H. A., Oostdijk, W., Losekoot, M., Pedersen, Oluf Borbye, Yeap, B. B., Flicker, L., Barzilai, N., Atzmon, G., Grimberg, A. & Argon, Y., May 2016, In: Endocrinology. 157, 5, p. 1914-1928 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    A Low-Frequency Inactivating Akt2 Variant Enriched in the Finnish Population is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk

    Manning, A., Highland, H. M., Gasser, J., Sim, X., Tukiainen, T., Fontanillas, P., Grarup, N., Rivas, M. A., Mahajan, A., Locke, A. E., Cingolani, P., Pers, T. H., Viñuela, A., Brown, A. A., Wu, Y., Flannick, J., Fuchsberger, C., Gamazon, E. R., Gaulton, K. J., Im, H. K. & 243 others, Teslovich, T. M., Blackwell, T. W., Bork-Jensen, J., Burtt, N. P., Chen, Y., Green, T., Hartl, C., Kang, H. M., Kumar, A., Ladenvall, C., Ma, C., Moutsianas, L., Pearson, R. D., Perry, J. R. B., Rayner, N. W., Robertson, N. R., Scott, L. J., van de Bunt, M., Eriksson, J. G., Jula, A., Koskinen, S., Lehtimäki, T., Palotie, A., Raitakari, O. T., Jacobs, S. B., Wessel, J., Chu, A. Y., Scott, R. A., Goodarzi, M. O., Blancher, C., Buck, G., Buck, D., Chines, P. S., Gabriel, S., Gjesing, A. M. P., Groves, C. J., Hollensted, M., Huyghe, J. R., Jackson, A. U., Jun, G., Justesen, Johanne Marie, Mangino, M., Murphy, J., Neville, M., Onofrio, R., Small, K. S., Stringham, H. M., Trakalo, J., Banks, E., Carey, J., Carneiro, M. O., DePristo, M., Farjoun, Y., Fennell, T., Goldstein, J. I., Grant, G., Hrabé de Angelis, M., Maguire, J., Neale, B. M., Poplin, R., Purcell, S., Schwarzmayr, T., Shakir, K., Smith, J. D., Strom, T. M., Wieland, T., Lindstrom, J., Brandslund, I., Christensen, C., Surdulescu, G. L., Lakka, T. A., Doney, A. S. F., Nilsson, P., Wareham, N. J., Langenberg, C., V Varga, Tibor, Franks, P. W., Rolandsson, O., Rosengren, A. H., Farook, V. S., Thameem, F., Puppala, S., Kumar, S., Lehman, D. M., Jenkinson, C. P., Curran, J. E., Hale, D. E., Fowler, S. P., Arya, R., DeFronzo, R. A., Abboud, H. E., Syvänen, A., Hicks, P. J., Palmer, N. D., Ng, M. C. Y., Bowden, D. W., Freedman, B. I., Esko, T., Mägi, R., Milani, L., Mihailov, E., Metspalu, A., Narisu, N., Kinnunen, L., Bonnycastle, L. L., Swift, A., Pasko, D., Wood, A. R., Fadista, J., Pollin, T. I., Barzilai, N., Atzmon, G., Glaser, B., Thorand, B., Strauch, K., Peters, A., Roden, M., Müller-Nurasyid, M., Liang, L., Kriebel, J., Illig, T., Grallert, H., Gieger, C., Meisinger, C., Lannfelt, L., Musani, S. K., Griswold, M., Taylor, H. A., Wilson, G., Correa, A., Oksa, H., Scott, W. R., Afzal, U., Tan, S., Loh, M., Chambers, J. C., Sehmi, J., Kooner, J. S., Lehne, B., Cho, Y. S., Lee, J., Han, B., Käräjämäki, A., Qi, Q., Qi, L., Huang, J., Hu, F. B., Melander, O., Orho-Melander, M., Below, J. E., Aguilar, D., Wong, T. Y., Liu, J., Khor, C., Chia, K. S., Lim, W. Y., Cheng, C., Chan, E., Tai, E. S., Aung, T., Linneberg, Allan René, Isomaa, B., Meitinger, T., Tuomi, T., Hakaste, L., Kravic, J., Jørgensen, M. E., Lauritzen, T., Deloukas, P., Stirrups, K. E., Owen, K. R., Farmer, A. J., Frayling, T. M., O'Rahilly, S. P., Walker, M., Levy, J. C., Hodgkiss, D., Hattersley, A. T., Kuulasmaa, T., Stančáková, A., Barroso, I., Bharadwaj, D., Chan, J., Chandak, G. R., Daly, M. J., Donnelly, P. J., Ebrahim, S. B., Elliott, P., Fingerlin, T., Froguel, P., Hu, C., Jia, W., Ma, R. C. W., McVean, G., Park, T., Prabhakaran, D., Sandhu, M., Scott, J., Sladek, R., Tandon, N., Teo, Y. Y., Zeggini, E., Watanabe, R. M., Koistinen, H. A., Kesaniemi, Y. A., Uusitupa, M., Spector, T. D., Salomaa, V., Rauramaa, R., Palmer, C. N. A., Prokopenko, I., Morris, A. D., Bergman, R. N., Collins, F. S., Lind, L., Ingelsson, E., Tuomilehto, J., Karpe, F., Groop, L., Jørgensen, T., Hansen, Torben, Pedersen, Oluf Borbye, Kuusisto, J., Abecasis, G., Bell, G. I., Blangero, J., Cox, N. J., Duggirala, R., Seielstad, M., Wilson, J. G., Dupuis, J., Ripatti, S., Hanis, C. L., Florez, J. C., Mohlke, K. L., Meigs, J. B., Laakso, M., Morris, A. P., Boehnke, M., Altshuler, D., McCarthy, M. I., Gloyn, A. L. & Lindgren, C. M., Dec 2017, In: Diabetes. 66, p. 2019-2032 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    A Splice Region Variant in LDLR Lowers Non-high Density Lipoprotein Cholesterol and Protects against Coronary Artery Disease

    Gretarsdottir, S., Helgason, H., Helgadottir, A., Sigurdsson, A., Thorleifsson, G., Magnusdottir, A., Oddsson, A., Steinthorsdottir, V., Rafnar, T., de Graaf, J., Daneshpour, M. S., Hedayati, M., Azizi, F., Grarup, N., Jørgensen, T., Vestergaard, H., Hansen, T., Eyjolfsson, G., Sigurdardottir, O., Olafsson, I. & 8 others, Kiemeney, L. A., Pedersen, Oluf Borbye, Sulem, P., Thorgeirsson, G., Gudbjartsson, D. F., Holm, H., Thorsteinsdottir, U. & Stefansson, K., Sep 2015, In: P L o S Genetics. 11, 9, 20 p., e1005379.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study

    Staiger, H., Stancáková, A., Zilinskaite, J., Vänttinen, M., Hansen, T., Marini, M. A., Hammarstedt, A., Jansson, P., Sesti, G., Smith, U., Pedersen, Oluf Borbye, Laakso, M., Stefan, N., Fritsche, A. & Häring, H., 2008, In: Diabetes. 57, 2, p. 514-7 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    A combined analysis of 48 type 2 diabetes genetic risk variants shows no discriminative value to predict time to first prescription of a glucose lowering drug in Danish patients with screen detected type 2 diabetes.

    Hornbak, M., Allin, K. H., Jensen, M. L., Lau, C. J., Witte, D. R., Jørgensen, M. E., Sandbæk, A., Lauritzen, T., Andersson, Åsa, Pedersen, Oluf Borbye & Hansen, Torben, 2014, In: PloS One. 9, 8, 10 p., e104837.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes

    Moltke, I., Grarup, N., Jørgensen, M. E., Bjerregaard, P., Treebak, J. T., Fumagalli, M., Korneliussen, T. S., Andersen, M. A., Nielsen, T. S., Krarup, N. T., Gjesing, A. M. P., Zierath, J. R., Linneberg, A., Wu, X., Sun, G., Jin, X., Al-Aama, J., Wang, J., Borch-Johnsen, K., Pedersen, O. & 3 others, Nielsen, R., Albrechtsen, Anders & Hansen, Torben, 2014, In: Nature. 512, 7513, p. 190-193 4 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  19. Published

    A common haplotype in the G-protein-coupled receptor gene GPR74 is associated with leanness and increased lipolysis

    Dahlman, I., Dicker, A., Jiao, H., Kere, J., Blomqvist, L., van Harmelen, V., Hoffstedt, J., Borch-Johnsen, K., Jorgensen, T., Hansen, Torben, Pedersen, Oluf Borbye, Laakso, M. & Arner, P., 2007, In: American Journal of Human Genetics. 80, 6, p. 1115-24 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    A common polymorphism in the promoter of the IGF-I gene associates with increased fasting serum triglyceride levels in glucose-tolerant subjects

    Nielsen, E. D., Hansen, L., Lajer, M., Andersen, K. L., Echwald, S. M., Urhammer, S. A., Hansen, Torben & Pedersen, Oluf Borbye, 2004, In: Clinical Biochemistry. 37, 8, p. 660-5 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    A computational framework to integrate high-throughput "-omics" datasets for the identification of potential mechanistic links

    Pedersen, H. K., Forslund, S. K., Gudmundsdottir, V., Petersen, A. Ø., Hildebrand, F., Hyötyläinen, T., Nielsen, T., Hansen, Torben, Bork, P., Ehrlich, S. D., Brunak, Søren, Oresic, M., Pedersen, Oluf Borbye & Nielsen, H. B., 2018, In: Nature Protocols. 13, 12, p. 2781-2800 20 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    A cost analysis of intensified vs conventional multifactorial therapy in individuals with type 2 diabetes: a post hoc analysis of the Steno-2 study

    Gæde, J., Oellgaard, J., Ibsen, R., Gæde, P., Nortoft, E., Parving, H., Kjellberg, J. & Pedersen, Oluf Borbye, 2019, In: Diabetologia. 62, 1, p. 147-155

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    A diet-induced gut microbiota component and related plasma metabolites are associated with depressive-like behaviour in rats

    Abildgaard, A., Kern, T., Pedersen, Oluf Borbye, Hansen, Torben, Lund, S. & Wegener, G., 2021, In: European Neuropsychopharmacology. 43, p. 10-21

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    A functional amino acid substitution in the glucose-dependent insulinotropic polypeptide receptor (GIPR) gene is associated with lower bone mineral density and increased fracture risk

    Torekov, Signe Sørensen, Harsløf, T., Rejnmark, L., Eiken, P., Jensen, Jens-Erik Beck, Herman, A. P., Hansen, Torben, Pedersen, Oluf Borbye, Holst, Jens Juul & Langdahl, B. L., Apr 2014, In: The Journal of clinical endocrinology and metabolism. 99, 4, p. E729-33 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    A genome-wide association search for type 2 diabetes genes in African Americans

    Palmer, N. D., McDonough, C. W., Hicks, P. J., Roh, B. H., Wing, M. R., An, S. S., Hester, J. M., Cooke, J. N., Bostrom, M. A., Rudock, M. E., Talbert, M. E., Lewis, J. P., Ferrara, A., Lu, L., Ziegler, J. T., Sale, M. M., Divers, J., Shriner, D., Adeyemo, A., Rotimi, C. N. & 31 others, Ng, M. C. Y., Langefeld, C. D., Freedman, B. I., Bowden, D. W., Voight, B. F., Scott, L. J., Steinthorsdottir, V., Morris, A. P., Dina, C., Welch, R. P., Zeggini, E., Huth, C., Aulchenko, Y. S., Thorleifsson, G., McCulloch, L. J., Ferreira, T., Grallert, H., Amin, N., Wu, G., Willer, C. J., Raychaudhuri, S., McCarroll, S. A., Langenberg, C., Grarup, Niels, Jørgensen, T., Sparsø, T., Hansen, Torben, Pedersen, Oluf Borbye, Schwarz, Peter, Karpe, F. & DIAGRAM Consortium, D. C., 2012, In: P L o S One. 7, 1, p. e29202

    Research output: Contribution to journal › Journal article › Research › peer-review

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ID: 919113