Nikos Hatzakis

Nikos Hatzakis

Professor

ORCID: 0000-0003-4202-0328

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  1. Oxidation of benzyl alcohols by dimethyldioxirane. The question of concerted versus stepwise mechanisms probed by kinetic isotope effects

    Angelis, Y. S., Hatzakis, Nikos, Smonou, I. & Orfanopoulos, M., 2001, In: Tetrahedron Letters. 42, 22, p. 3753-3756 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Shedding light on protein folding, structural and functional dynamics by single molecule studies

    Bavishi, K. & Hatzakis, Nikos, 2014, In: Molecules. 19, 12, p. 19407-19434 28 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Direct observation of multiple conformational states in Cytochrome P450 oxidoreductase and their modulation by membrane environment and ionic strength

    Bavishi, K., Li, D., Eiersholt, S., Hooley, E. N., Petersen, Troels Christian, Møller, Birger Lindberg, Hatzakis, Nikos & Laursen, Tomas, 2018, In: Scientific Reports. 8, 9 p., 6817.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Half-Life Extending Modifications of Peptide YY3-36 Direct Receptor-Mediated Internalization

    Bech, E. M., Kaiser, A., Bellmann-Sickert, K., Nielsen, S. S., Sørensen, K. K., Elster, L., Hatzakis, Nikos, Pedersen, S. L., Beck-Sickinger, A. G. & Jensen, Knud Jørgen, 2019, In: Molecular Pharmaceutics. 16, 8, p. 3665-3677

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Direct observation and classification of heterogeneous protein aggregation in real-time through super-resolution and aggregational fingerprinting

    Bender, S., Kæstel-Hansen, Jacob, Zhang, Min & Hatzakis, Nikos, 2023, In: Biophysical Journal. 122, 3 Supplement 1, p. 16a 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  6. Published

    SEMORE: SEgmentation and MORphological fingErprinting by machine learning automates super-resolution data analysis

    Bender, S. W. B., Dreisler, M. W., Zhang, Min, Kæstel-Hansen, Jacob & Hatzakis, Nikos, 2024, In: Nature Communications. 15, 1, 13 p., 1763.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Dimensional Reduction for Single-Molecule Imaging of DNA and Nucleosome Condensation by Polyamines, HP1α and Ki-67

    Benning, N. A., Kæstel-Hansen, Jacob, Rashid, F., Park, S., Urteaga, R. M., Liao, T., Hao, J., Berger, J. M., Hatzakis, Nikos & Ha, T., 2023, In: Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical. 127, 9, p. 1922–1931 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    A unifying mechanism accounts for sensing of membrane curvature by BAR domains, amphipathic helices and membrane-anchored proteins

    Bhatia, V. K., Hatzakis, Nikos & Stamou, Dimitrios, Jun 2010, In: Seminars in Cell and Developmental Biology. 21, 4, p. 381-390 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Enhanced hexamerization of insulin via assembly pathway rerouting revealed by single particle studies

    Bohr, Freja Schmidt-Rasmussen, Bohr, S. S. R., Mishra, N. K., González-Foutel, N. S., Pinholt, H. D., Wu, S., Nielsen, E. M., Zhang, Min, Kjaergaard, M., Jensen, Knud Jørgen & Hatzakis, Nikos, 2023, In: Communications Biology . 6, 1, 14 p., 178.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Label-Free Fluorescence Quantification of Hydrolytic Enzyme Activity on Native Substrates Reveals How Lipase Function Depends on Membrane Curvature

    Bohr, S. S., Thorlaksen, C., Kühnel, R. M., Pomorski, Thomas Guenther & Hatzakis, Nikos, 16 Jun 2020, In: Langmuir. 36, 23, p. 6473-6481 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Direct observation of Thermomyces lanuginosus lipase diffusional states by Single Particle Tracking and their remodeling by mutations and inhibition

    Bohr, S. S., Lund, P. M., Kallenbach, A. S., Pinholt, H., Thomsen, J., Iversen, L., Svendsen, A., Christensen, S. M. & Hatzakis, Nikos, 2019, In: Scientific Reports. 9, 11 p., 16169.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Direct observations of drug nanocarrier interactions and mobility within biological interfaces

    Bohr, S. S. R., Streck, S., Pinholt, H., Wan, F., Mcdowell, A., Nielsen, Hanne Mørck & Hatzakis, Nikos, 2022, In: Biophysical Journal. 121, 3, p. 72a-73a 2 p., 355-Pos.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  13. Bionanoconjugation via click chemistry: The creation of functional hybrids of lipases and gold nanoparticles

    Brennan, J. L., Hatzakis, Nikos, Tshikhudo, T. R., Dirvianskyte, N., Razumas, V., Patkar, S., Vind, J., Svendsen, A., Nolte, R. J. M., Rowan, A. E. & Brust, M., 2006, In: Bioconjugate Chemistry. 17, 6, p. 1373-1375 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    tN-Ras, Synaptotagmin1 C2Ab, Annexinb12 and Amphiphysin NBAR can Discriminate Spherical from Cylindrical Membrane Curvature

    kpl171, kpl171, Larsen, J., Rosholm, K. R., Pedersenb, S. L., Munch, H. K., Tkach, Vadym, Sakon, J. J., Bjornholm, T., Weninger, K. R., Bendix, Poul Martin, Jensen, Knud Jørgen, Uline, M. J., Hatzakis, Nikos & Stamou, Dimitrios, 2016, In: Biophysical Journal. 110, 3, 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  15. Published

    Soft Matter Based Nanofluidic Platform for Highly Parallel Mixing of Sub-Attoliter Total Volumes

    Christensen, S., Bolinger, P., Hatzakis, Nikos, Mortensen, M. W. & Stamou, Dimitrios, 2012, In: Biophysical Journal. 102, 3 Supplement 1, p. 600a-601a 2 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  16. Published

    Mixing subattolitre volumes in a quantitative and highly parallel manner with soft matter nanofluidics

    Christensen, S. M., Bolinger, P., Hatzakis, Nikos, Mortensen, M. W. & Stamou, Dimitrios, 2012, In: Nature Nanotechnology. 7, p. 51-55 5 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  17. Functional nano-sized assemblies from amphiphilic biohybrid macromolecules

    Cornelissen, J., Dirks, A., Reynhout, I., Opsteen, J., Hatzakis, Nikos, Sly, J., Rowan, A., van Hest, J. & Nolte, R., 2005, In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.

    Research output: Contribution to journal › Conference abstract in journal › Research

  18. Preparation of biohybrid amphiphiles via the copper catalysed Huisgen [3 + 2] dipolar cycloaddition reaction

    Dirks, A. J., Van Berkel, S. S., Hatzakis, Nikos, Opsteen, J. A., Van Delft, F. L., Cornelissen, J. J. L. M., Rowan, A. E., Van Hest, J. C. M., Rutjes, F. P. J. T. & Nolte, R. J. M., 7 Sep 2005, In: Chemical Communications. 33, p. 4172-4174 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Functional biohybrid amphiphiles

    Dirks, A. J., Hatzakis, Nikos, Cornelissen, J. J. L. M. & Nolte, R. J. M., 2006, In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.

    Research output: Contribution to journal › Conference abstract in journal › Research

  20. Published

    Influence of the preparation route on the supramolecular organization of lipids in a vesicular system

    Elizondo, E., Larsen, J., Hatzakis, Nikos, Cabrera, I., Bjørnholm, T., Veciana, J., Stamou, Dimitrios & Ventosa, N., 2012, In: Journal of the American Chemical Society. 134, 4, p. 1918-1921 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Do enzymes sleep and work?

    Engelkamp, H., Hatzakis, Nikos, Hofkens, J., De Schryver, F. C., Nolte, R. J. M. & Rowan, A. E., 2006, In: Chemical Communications. 9, p. 935-940 6 p.

    Research output: Contribution to journal › Review › Research › peer-review

  22. Published

    β-Cyclodextrin-appended giant amphiphile: Aggregation to vesicle polymersomes and immobilisation of enzymes

    Felici, M., Marzá-Pérez, M., Hatzakis, Nikos, Nolte, R. J. M. & Feiters, M. C., 2008, In: Chemistry - A European Journal. 14, 32, p. 9914-9920 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    A blind benchmark of analysis tools to infer kinetic rate constants from single-molecule FRET trajectories

    Goetz, M., Barth, A., Bohr, S. S-R., Boerner, R., Chen, J., Cordes, T., Erie, D. A., Gebhardt, C., Hadzic, M. C. A. S., Hamilton, G. L., Hatzakis, N. S., Hugel, T., Kisley, L., Lamb, D. C., de Lannoy, C., Mahn, C., Dunukara, D., de Ridder, D., Sanabria, H., Schimpf, J. & 9 others, Seidel, C. A. M., Sigel, R. K. O., Sletfjerding, M. B., Thomsen, J., Vollmar, L., Wanninger, S., Weninger, K. R., Xu, P. & Schmid, S., 2022, In: Nature Communications. 13, 1, 12 p., 5402.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Influence of Lipid Heterogeneity and Phase Behavior on Phospholipase A(2) Action at the Single Molecule Level

    Gudmand, M. J., Rocha, S., Hatzakis, Nikos, Peneva, K., Müllen , K., Stamou, Dimitrios, Uji-I, H., Hofkens , J., Bjørnholm, T. & Heimburg, Thomas Rainer, 5 May 2010, In: Biophysical Journal. 98, 9, p. 1873-82 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    From single to multienzyme assemblies: Do enzymes sleep and work?

    Hatzakis, Nikos, Engelkamp, H., Nolte, R. & Rowan, A., 2006, In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.

    Research output: Contribution to journal › Journal article › Research

  26. Published

    How curved membranes recruit amphipathic helices and protein anchoring motifs

    Hatzakis, Nikos, Bhatia, V. K., Larsen, J., Madsen, Kenneth Lindegaard, Bolinger, P., Kunding, A. H., Castillo Leon, J. J., Gether, Ulrik, Hedegård, Per & Stamou, Dimitrios, 2009, In: Nature Chemical Biology. 5, 11, p. 835-841 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Single Enzyme Studies Reveal the Existence of Discrete Functional States for Monomeric Enzymes and How they are "Selected'' upon Allosteric Regulation

    Hatzakis, Nikos, Wei, L., Jørgensen, S. K., Kunding, A. H., Bolinger, P., Ehrlich, N., Makarov, I., Skjot, M., Svendsen, A., Hedegård, Per, Walsh, S. M. & Stamou, Dimitrios, 29 Jan 2013, In: Biophysical Journal. 104, 2, p. 231A-231A

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Single molecule insights on conformational selection and induced fit mechanism

    Hatzakis, Nikos, 2014, In: Biophysical Chemistry. 186, p. 46-54 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Influence of Lipid Heterogeneity and Phase Behavior on Phospholipase A2 Action at the Single Molecule Level: Biophysical Journal

    Hatzakis, Nikos, 2010, In: Biophysical Society. Annual Meeting. Abstracts.

    Research output: Contribution to journal › Conference abstract in journal › Research

  30. Published

    How membrane curvature drives the up-concentration of N-Ras proteins to ordered lipid domains: correlation of in vivo and in vitro experiments with mean field theory calculations and coarse grain simulations

    Hatzakis, Nikos, Larsen, J. B., Jensen, M. B., Bhatia, V. K., Pedersen, S. L., Koldsoe, H., Fowler, P., Uline, M. J., Szleifer, I. G., Bjørnholm, T., Sansom, M., Jensen, Knud Jørgen & Stamou, Dimitrios, 2014, In: Biophysical Society. Annual Meeting. Abstracts. 106, 2, p. 713a 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  31. Published

    Single enzyme studies reveal the existence of discrete functional states for monomeric enzymes and how they are "selected" upon allosteric regulation

    Hatzakis, Nikos, Wei, L., Jørgensen, S. K., Kunding, A. H., Makarov, I., Skjot, M., Svendsen, A., Hedegård, Per & Stamou, Dimitrios, 2012, In: Journal of the American Chemical Society. 134, 22, p. 9296-9302 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    A discrete number of activity states constitute an efficient mechanism to regulate enzymatic activity

    Hatzakis, Nikos, Wei, L., Jorgensen, S. K., Kunding, A., Hedegard, P. & Stamou, Dimitrios, 2011, In: European Biophysics Journal With Biophysics Letters. 40, suppl 1, p. S217 1 p.

    Research output: Contribution to journal › Journal article › Research

  33. Published

    Synergy of Liquid Ordered "Raft Like" Domains and Membrane Curvature in Promoting Sorting of Lipidated Proteins Such As NRas

    Hatzakis, Nikos, Larsen, J. K., Jensen, M. B., Bhatia, V. K., Pedersen, S. L., Jensen, Knud Jørgen & Stamou, Dimitrios, 2012, In: Biophysical Journal. 102, 3 Supplement 1, p. 18a-19a 2 p.

    Research output: Contribution to journal › Conference abstract in journal › Research

  34. Published

    Making the undetectable detectable: Pushing limits of biomolecular recognition by ultra-sensitive multiplexed single-particle liposome readouts

    Hatzakis, Nikos, 2023, In: Biophysical Journal. 122, 3 Supplement 1, p. 231a-232a 2 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Biased metabolism via small-molecule ligands binding to P450 oxidoreductase

    Hatzakis, Nikos, Jensen, S. B., Thodberg, S., Parween, S., Moses, M. E., Hansen, C. C., Knudsen, C., Giudice, R. D., Lund, P. M., Castano, P., Bustamante, Y. G., Jorgennsen, F. S., Pandey, A. V., Laursen, Tomas & Møller, Birger Lindberg, 1 Feb 2022, In: Biophysical Journal. 121, 3, p. 52a 1 p., 250-Pos.

    Research output: Contribution to journal › Conference abstract in journal › Research

  36. Asymmetric transesterification of secondary alcohols catalyzed by feruloyl esterase from Humicola insolens

    Hatzakis, Nikos & Smonou, I., 2005, In: Bioorganic Chemistry. 33, 4, p. 325-337 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Ferulic acid esterase from Humicola Insolens catalyzes enantioselective transesterification of secondary alcohols

    Hatzakis, Nikos, Daphnomili, D. & Smonou, I., 2003, In: Journal of Molecular Catalysis B: Enzymatic. 21, 4-6, p. 309-311 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Regulation of Enzymatic Activity Occurs by Selection of Discrete Activity States

    Hatzakis, Nikos, Wei, L., Jorgensen, S. K., Kunding, A. H., Hedegard, P. & Stamou, Dimitrios, 2011, In: Biophysical Journal. 100, 3 suppl 1, p. 194a 1 p.

    Research output: Contribution to journal › Journal article › Research

  39. Synthesis and single enzyme activity of a clicked lipase-BSA hetero-dimer

    Hatzakis, Nikos, Engelkamp, H., Velonia, K., Hofkens, J., Christianen, P. C. M., Svendsen, A., Patkar, S. A., Vind, J., Maan, J. C., Rowan, A. E. & Nolte, R. J. M., 2006, In: Chemical Communications. 19, p. 2012-2014 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Enantioselectivity and diastereoselectivity in the transesterification of secondary alcohols mediated by feruloyl esterase from Humicola insolens

    Hatzakis, Nikos & Smonou, I., 2004, In: Tetrahedron Letters. 45, 13, p. 2755-2757 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Carbohydrate-Derived Metal-Chelator-Triggered Lipids for Liposomal Drug Delivery

    Holmstrøm, T., Galsgaard Malle, M., Wu, S., Jensen, Knud Jørgen, Hatzakis, Nikos & Pedersen, Christian Marcus, 2021, In: Chemistry - A European Journal. 27, 23, p. 6917-6922 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Single-Particle Tracking of Thermomyces lanuginosus Lipase Reveals How Mutations in the Lid Region Remodel Its Diffusion

    Iversen, J. F., Bohr, S. S. R., Pinholt, H. D., Moses, M. E., Iversen, L., Christensen, S. M., Hatzakis, Nikos & Zhang, Min, 2023, In: Biomolecules. 13, 4, 11 p., 631.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Biased cytochrome P450-mediated metabolism via small-molecule ligands binding P450 oxidoreductase

    Jensen, S. B., Thodberg, S., Parween, S., Moses, M. E., Hansen, Cecilie Ida Cetti, Thomsen, J., Sletfjerding, M. B., Knudsen, C., Del Giudice, R., Lund, P. M., Castaño, P. R., Bustamante, Y. G., Velazquez, M. N. R., Jørgensen, Flemming Steen, Pandey, A. V., Laursen, Tomas, Møller, Birger Lindberg & Hatzakis, Nikos, 2021, In: Nature Communications. 12, 1, 14 p., 2260.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Creating a Proteoliposome Assay for Single Photosystem I Activity Assessment

    Jorgensen, S. K., Lassen, L. M. M., Kemmer, G., Pomorski, Thomas Guenther, Stamou, Dimitrios, Bjornholm, T., Jensen, P. E. & Hatzakis, Nikos, 2012, In: Biophysical Journal. 102, 3 Suppl 1, p. 626a-627a 1 p., 3180-Pos.

    Research output: Contribution to journal › Conference abstract in journal › Research

  45. Published

    Single Proton Pump Activity Measurements on Single Vesicles for a Quinol Heme-Copper Oxidase

    Jorgensen, S. K., McMillan, D., Krzeminski, L., Stamou, Dimitrios, Jeuken, L. J. C. & Hatzakis, Nikos, 2013, In: Biophysical Journal. 104, 2, Sppl. 1, p. 277a-278a

    Research output: Contribution to journal › Conference abstract in journal › Research

  46. Published

    Insights in enzyme functional dynamics and activity regulation by single molecule studies

    Jørgensen, S. K. & Hatzakis, Nikos, 2013, In: Biophysical Reviews and Letters. 8, 3&4, p. 137-160 24 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Realizing integration in structural biology: The 2022 ISBUC Annual Meeting

    Kragelund, Birthe Brandt, Loland, Claus Juul, Montoya, Guillermo, Hatzakis, Nikos, Martinez, Karen Laurence, Gajhede, Michael, Christensen, Caspar Elo & Holt, Lucy, 2023, In: Structure. 31, 7, p. 747-754

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    The enzyme mechanism of nitrite reductase studied at single-molecule level

    Kuznetsova, S., Zauner, G., Aartsma, T., Engelkamp, H., Hatzakis, Nikos, Rowan, A., Nolte, R., Christianen, P. & Canters, G., 2008, In: Proceedings of the National Academy of Sciences USA (PNAS). 105, 9, p. 3250-3255

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Protein Tracking: Everything, everywhere, almost at once

    Kæstel-Hansen, Jacob & Hatzakis, Nikos, 2024, In: eLife. 13, 3 p., e95362.

    Research output: Contribution to journal › Editorial › Research › peer-review

  50. Published

    Rapid extraction of time-dependent behaviors of endo-lysosomal structures and their cargo aided by deep learning

    Kæstel-Hansen, Jacob, Kreutzberger, A., Kirchhausen, T. & Hatzakis, Nikos, 2023, In: Biophysical Journal. 122, 3 Supplement 1, p. 517a 1 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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