Nikos Hatzakis

Nikos Hatzakis

Professor

ORCID: 0000-0003-4202-0328

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  1. Published

    A blind benchmark of analysis tools to infer kinetic rate constants from single-molecule FRET trajectories

    Goetz, M., Barth, A., Bohr, S. S-R., Boerner, R., Chen, J., Cordes, T., Erie, D. A., Gebhardt, C., Hadzic, M. C. A. S., Hamilton, G. L., Hatzakis, N. S., Hugel, T., Kisley, L., Lamb, D. C., de Lannoy, C., Mahn, C., Dunukara, D., de Ridder, D., Sanabria, H., Schimpf, J. & 9 others, Seidel, C. A. M., Sigel, R. K. O., Sletfjerding, M. B., Thomsen, J., Vollmar, L., Wanninger, S., Weninger, K. R., Xu, P. & Schmid, S., 2022, In: Nature Communications. 13, 1, 12 p., 5402.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    A discrete number of activity states constitute an efficient mechanism to regulate enzymatic activity

    Hatzakis, Nikos, Wei, L., Jorgensen, S. K., Kunding, A., Hedegard, P. & Stamou, Dimitrios, 2011, In: European Biophysics Journal With Biophysics Letters. 40, suppl 1, p. S217 1 p.

    Research output: Contribution to journal › Journal article › Research

  3. Published

    A large size-selective DNA nanopore with sensing applications

    Thomsen, R. P., Malle, M. G., Okholm, A. H., Krishnan, S., Bohr, S. S., Sørensen, R. S., Ries, O., Vogel, S., Simmel, F. C., Hatzakis, Nikos & Kjems, J., 2019, In: Nature Communications. 10, 1

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    A systematic analysis of regression models for protein engineering

    Michael, Richard, Kæstel-Hansen, Jacob, Groth, Peter Mørch, Bartels, S., Salomon, J., Tian, P., Hatzakis, Nikos & Boomsma, Wouter, 2024, In: PLOS Computational Biology. 20, 5 May, 22 p., e1012061.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    A unifying mechanism accounts for sensing of membrane curvature by BAR domains, amphipathic helices and membrane-anchored proteins

    Bhatia, V. K., Hatzakis, Nikos & Stamou, Dimitrios, Jun 2010, In: Seminars in Cell and Developmental Biology. 21, 4, p. 381-390 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Asymmetric transesterification of secondary alcohols catalyzed by feruloyl esterase from Humicola insolens

    Hatzakis, Nikos & Smonou, I., 2005, In: Bioorganic Chemistry. 33, 4, p. 325-337 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Biased cytochrome P450-mediated metabolism via small-molecule ligands binding P450 oxidoreductase

    Jensen, S. B., Thodberg, S., Parween, S., Moses, M. E., Hansen, Cecilie Ida Cetti, Thomsen, J., Sletfjerding, M. B., Knudsen, C., Del Giudice, R., Lund, P. M., Castaño, P. R., Bustamante, Y. G., Velazquez, M. N. R., Jørgensen, Flemming Steen, Pandey, A. V., Laursen, Tomas, Møller, Birger Lindberg & Hatzakis, Nikos, 2021, In: Nature Communications. 12, 1, 14 p., 2260.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Biased metabolism via small-molecule ligands binding to P450 oxidoreductase

    Hatzakis, Nikos, Jensen, S. B., Thodberg, S., Parween, S., Moses, M. E., Hansen, C. C., Knudsen, C., Giudice, R. D., Lund, P. M., Castano, P., Bustamante, Y. G., Jorgennsen, F. S., Pandey, A. V., Laursen, Tomas & Møller, Birger Lindberg, 1 Feb 2022, In: Biophysical Journal. 121, 3, p. 52a 1 p., 250-Pos.

    Research output: Contribution to journal › Conference abstract in journal › Research

  9. Bionanoconjugation via click chemistry: The creation of functional hybrids of lipases and gold nanoparticles

    Brennan, J. L., Hatzakis, Nikos, Tshikhudo, T. R., Dirvianskyte, N., Razumas, V., Patkar, S., Vind, J., Svendsen, A., Nolte, R. J. M., Rowan, A. E. & Brust, M., 2006, In: Bioconjugate Chemistry. 17, 6, p. 1373-1375 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Carbohydrate-Derived Metal-Chelator-Triggered Lipids for Liposomal Drug Delivery

    Holmstrøm, T., Galsgaard Malle, M., Wu, S., Jensen, Knud Jørgen, Hatzakis, Nikos & Pedersen, Christian Marcus, 2021, In: Chemistry - A European Journal. 27, 23, p. 6917-6922 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Characterization of a dynamic metabolon producing the defense compound dhurrin in sorghum

    Laursen, Tomas, Borch-Jensen, J., Baden, C. K., Bavishi, K., Torta, F., Martens, Helle Jakobe, Silvestro, D., Hatzakis, Nikos, Wenk, M. R., Dafforn, T. R., Olsen, C. E., Motawie, Mohammed Saddik, Hamberger, B. R., Møller, Birger Lindberg & Bassard, J. A., 2016, In: Science (New York, N.Y.). 354, 6314, p. 890-893 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Conformational Activation Promotes CRISPR-Cas12a Catalysis and Resetting of the Endonuclease Activity

    Stella, S., Mesa, Pablo, Thomsen, J., Paul, B., Alcón, P., Jensen, S. B., Saligram, B., Moses, M. E., Hatzakis, Nikos & Montoya, Guillermo, 13 Dec 2018, In: Cell. 175, 7, p. 1856-1871.e21 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Creating a Proteoliposome Assay for Single Photosystem I Activity Assessment

    Jorgensen, S. K., Lassen, L. M. M., Kemmer, G., Pomorski, Thomas Guenther, Stamou, Dimitrios, Bjornholm, T., Jensen, P. E. & Hatzakis, Nikos, 2012, In: Biophysical Journal. 102, 3 Suppl 1, p. 626a-627a 1 p., 3180-Pos.

    Research output: Contribution to journal › Conference abstract in journal › Research

  14. Published

    Deconvoluting the Effect of Cell-Penetrating Peptides for Enhanced and Controlled Insertion of Large-Scale DNA Nanopores

    Zhang, X., Malle, M. G., Thomsen, R. P., Sørensen, R. S., Sørensen, Emily Claire Winther, Hatzakis, Nikos & Kjems, J., 2024, In: ACS Applied Materials and Interfaces. 16, 15, p. 18422−18433 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    DeepFRET, a software for rapid and automated single-molecule FRET data classification using deep learning

    Thomsen, J., Sletfjerding, M. B., Jensen, S. B., Stella, S., Paul, B., Malle, M. G., Montoya, Guillermo, Petersen, Troels Christian & Hatzakis, Nikos, Nov 2020, In: eLife. 9, 21 p., e60404.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Developing an Assay to Probe Activtion and Conformational Dynamics of beta 2-Adrenergic Receptor on Single Molecule Level

    Veshaguri, S., Tutkus, M., Lundgaard, C. V., Tonnesen, A., Mathiasen, Signe, Jorgensen, S. K., Iversen, L., Hatzakis, Nikos, Rasmussen, Søren Gøgsig Faarup & Stamou, Dimitrios, 2013, In: Biophysical Journal. 104, 2, 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research

  17. Published

    Dimensional Reduction for Single-Molecule Imaging of DNA and Nucleosome Condensation by Polyamines, HP1α and Ki-67

    Benning, N. A., Kæstel-Hansen, Jacob, Rashid, F., Park, S., Urteaga, R. M., Liao, T., Hao, J., Berger, J. M., Hatzakis, Nikos & Ha, T., 2023, In: Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical. 127, 9, p. 1922–1931 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Direct Observation of Anisotropy-Driven Formation of Amyloid Spherulites in Real-time by Super-resolution Microscopy

    Zhang, Min, Pinholt, H., Zhou, X., Bohr, S., Banetta, L., Zaccone, A., Foderà, Vito & Hatzakis, Nikos, 2021, 19 p.

    Research output: Working paper › Preprint › Research

  19. Published

    Direct Observation of CRISPR-Cas12 Conformational Sampling by SM FRET and Cryo EM Reveals how Conformational Activation Promotes Catalysis and Resetting of the Endonuclease Activity

    Stella, S., Mesa, Pablo, Thomsen, J., Paul, B., Alcon, P., Jensen, S. B., Moses, M. E., Montoya, Guillermo & Hatzakis, Nikos, 7 Feb 2020, In: Biophysical Journal. 118, 3, p. 223A-224A 2 p.

    Research output: Contribution to journal › Conference abstract in journal › Research

  20. Published

    Direct Observation of Sophorolipid Micelle Docking in Model Membranes and Cells by Single Particle Studies Reveals Optimal Fusion Conditions

    Singh, P. K., Bohr, S. S. & Hatzakis, Nikos, 2020, In: Biomolecules. 10, 9, 16 p., 1291.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Direct observation and classification of heterogeneous protein aggregation in real-time through super-resolution and aggregational fingerprinting

    Bender, S., Kæstel-Hansen, Jacob, Zhang, Min & Hatzakis, Nikos, 2023, In: Biophysical Journal. 122, 3 Supplement 1, p. 16a 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  22. Published

    Direct observation of Thermomyces lanuginosus lipase diffusional states by Single Particle Tracking and their remodeling by mutations and inhibition

    Bohr, S. S., Lund, P. M., Kallenbach, A. S., Pinholt, H., Thomsen, J., Iversen, L., Svendsen, A., Christensen, S. M. & Hatzakis, Nikos, 2019, In: Scientific Reports. 9, 11 p., 16169.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Direct observation of heterogeneous formation of amyloid spherulites in real-time by super-resolution microscopy

    Zhang, Min, Pinholt, H., Zhou, X., Bohr, S., Banetta, L., Zaccone, A., Foderà, Vito & Hatzakis, Nikos, 2022, In: Communications Biology . 5, 1, 10 p., 850.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Direct observation of multiple conformational states in Cytochrome P450 oxidoreductase and their modulation by membrane environment and ionic strength

    Bavishi, K., Li, D., Eiersholt, S., Hooley, E. N., Petersen, Troels Christian, Møller, Birger Lindberg, Hatzakis, Nikos & Laursen, Tomas, 2018, In: Scientific Reports. 8, 9 p., 6817.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Direct observation of proton pumping by a eukaryotic P-type ATPase

    Veshaguri, S., Christensen, S. F., Kemmer, G. C., Ghale, G., Møller, M. P., Lohr, C., Christensen, A. L., Justesen, B. H., Jørgensen, I. L., Schiller, J., Hatzakis, Nikos, Grabe, M., Pomorski, Thomas Guenther & Stamou, Dimitrios, 2016, In: Science. 351, 6280, p. 1469-1473 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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ID: 6090