Maiken Nedergaard

Maiken Nedergaard

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    1. Published

      Managing noradrenaline after traumatic brain injury

      Hussain, R. & Nedergaard, Maiken, 2024, In: Clinical and Translational Medicine. 14, 1, 3 p., e1562.

      Research output: Contribution to journal › Comment/debate › Research › peer-review

    2. Published

      Potentiating glymphatic drainage minimizes post-traumatic cerebral oedema

      Hussain, R., Tithof, J., Wang, W., Cheetham-West, A., Song, W., Peng, W., Sigurdsson, B., Kim, D., Sun, Q., Peng, S., Pla Requena, Virginia Teresa, Kelley, D. H., Hirase, Hajime, Castorena-Gonzalez, J. A., Weikop, Pia, Goldman, Steven Alan, Davis, M. J. & Nedergaard, Maiken, 2023, In: Nature. 623, p. 992–1000 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Implications of the discovery of brain lymphatic pathways

      Iliff, J. J., Goldman, Steven Alan & Nedergaard, Maiken, 2015, In: Lancet Neurology. 14, 10, p. 977-979 3 p.

      Research output: Contribution to journal › Journal article › Communication

    4. Published

      Astrocytes in chronic pain and itch

      Ji, R., Donnelly, C. R. & Nedergaard, Maiken, 2019, In: Nature Reviews Neuroscience. 20, 11, p. 667-685

      Research output: Contribution to journal › Review › Research › peer-review

    5. Published

      Impairment of the glymphatic system after diabetes

      Jiang, Q., Zhang, L., Ding, G., Davoodi-Bojd, E., Li, Q., Li, L., Sadry, N., Nedergaard, Maiken, Chopp, M. & Zhang, Z., 1 Apr 2017, In: Journal of Cerebral Blood Flow and Metabolism. 37, 4, p. 1326-1337 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Increased interictal synchronicity of respiratory related brain pulsations in epilepsy

      Kananen, J., Järvelä, M., Korhonen, V., Tuovinen, T., Huotari, N., Raitamaa, L., Helakari, H., Väyrynen, T., Raatikainen, V., Nedergaard, Maiken, Ansakorpi, H., Jacobs, J., LeVan, P. & Kiviniemi, V., 2022, In: Journal of Cerebral Blood Flow and Metabolism. 42, 10, p. 1840-1853 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Altered physiological brain variation in drug-resistant epilepsy

      Kananen, J., Tuovinen, T., Ansakorpi, H., Rytky, S., Helakari, H., Huotari, N., Raitamaa, L., Raatikainen, V., Rasila, A., Borchardt, V., Korhonen, V., LeVan, P., Nedergaard, Maiken & Kiviniemi, V., 2018, In: Brain and Behavior. 8, 9, p. 1-17 17 p., e01090.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Respiratory-related brain pulsations are increased in epilepsy-a two-centre functional MRI study

      Kananen, J., Helakari, H., Korhonen, V., Huotari, N., Jarvela, M., Raitamaa, L., Raatikainen, V., Rajna, Z., Tuovinen, T., Nedergaard, Maiken, Jacobs, J., LeVan, P., Ansakorpi, H. & Kiviniemi, V., 2020, In: Brain Communications. 2, 2, 14 p., 076.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Inflammation in acquired hydrocephalus: pathogenic mechanisms and therapeutic targets

      Karimy, J. K., Reeves, B. C., Damisah, E., Duy, P. Q., Antwi, P., David, W., Wang, K., Schiff, S. J., Limbrick, D. D. ,. J., Alper, S. L., Warf, B. C., Nedergaard, Maiken, Simard, J. M. & Kahle, K. T., 2020, In: Nature Reviews Neurology. 16, p. 285–296 12 p.

      Research output: Contribution to journal › Review › Research › peer-review

    10. Published

      Does Global Astrocytic Calcium Signaling Participate in Awake Brain State Transitions and Neuronal Circuit Function?

      Kjærby, Celia, Rasmussen, R., Andersen, Mie & Nedergaard, Maiken, Jun 2017, In: Neurochemical Research. 42, 6, p. 1810-1822 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Memory-enhancing properties of sleep depend on the oscillatory amplitude of norepinephrine

      Kjærby, Celia, Andersen, Mie, Hauglund, Natalie Linea, Untiet, Verena, Dall, C., Sigurdsson, B., Ding, F., Feng, J., Li, Y., Weikop, Pia, Hirase, Hajime & Nedergaard, Maiken, 2022, In: Nature Neuroscience. 25, p. 1059–1070 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Dynamic fluctuations of the locus coeruleus-norepinephrine system underlie sleep state transitions

      Kjærby, Celia, Andersen, Mie, Hauglund, Natalie Linea, Ding, F., Wang, W., Xu, Q., Deng, S., Kang, N., Peng, S., Sun, Q., Dall, C., Jørgensen, P. K., Feng, J., Li, Y., Weikop, Pia, Hirase, Hajime & Nedergaard, Maiken, 2 Sep 2020, 1 p.

      Research output: Other contribution › Research

    13. Published

      Reply to: 'Do all norepinephrine surges disrupt sleep?'

      Kjærby, Celia, Andersen, Mie, Hauglund, Natalie Linea, Untiet, Verena, Dall, C., Ding, F., Hirase, Hajime & Nedergaard, Maiken, 2023, In: Nature Neuroscience. 26, 3 p.

      Research output: Contribution to journal › Comment/debate › Research › peer-review

    14. Optimal Mass Transport with Lagrangian Workflow Reveals Advective and Diffusion Driven Solute Transport in the Glymphatic System

      Kounda, S., Elkin, R., Nadeem, S., Xue, Y., Constantinou, S., Sanggaard, S., Liu, X., Monte, B., Xu, F., Van Nostrand, W., Nedergaard, Maiken, Lee, H., Wardlaw, J., Benveniste, H. & Tannenbaum, A., 2020, In: Scientific Reports. 10, 1, 18 p., 1990.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Brain Morphometry and Longitudinal Relaxation Time of Spontaneously Hypertensive Rats (SHRs) in Early and Intermediate Stages of Hypertension Investigated by 3D VFA-SPGR MRI

      Koundal, S., Liu, X., Sanggaard, S., Mortensen, K., Wardlaw, J., Nedergaard, Maiken, Benveniste, H. & Lee, H., 2019, In: Neuroscience. 404, p. 14-26

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Perivascular pumping in the mouse brain: Improved boundary conditions reconcile theory, simulation, and experiment

      Ladrón-de-Guevara, A., Shang, J. K., Nedergaard, Maiken & Kelley, D. H., 2022, In: Journal of Theoretical Biology. 542, 111103.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Contributions of the Na⁺/K⁺-ATPase, NKCC1, and Kir4.1 to hippocampal K⁺ clearance and volume responses

      Larsen, B. R., Assentoft, M., Cotrina, M. L., Hua, S. Z., Nedergaard, Maiken, Kaila, K., Voipio, J. & MacAulay, Nanna, Apr 2014, In: Glia. 62, 4, p. 608-22 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      NREM sleep upregulates human brain pulsation detected by Ultrafast Magnetic Resonance Encephalography

      Larsen, S. M. U., Holst, S. C., Olsen, A. S., Zilstorff, D. B., Pleinert, S., Kiviniemi, V., Jennum, Poul, Nedergaard, Maiken & Knudsen, Gitte Moos, 2021, In: European Neuropsychopharmacology. 53, p. S361-S362 3 p.

      Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

    19. Published

      Genetic haplotype of the glymphatic-associated water channel aquaporin 4 modulates slow waves in human non-rapid eye movement sleep

      Larsen, S. M. U., Landolt, H. P., Berger, W., Nedergaard, Maiken, Knudsen, Gitte Moos & Holst, S. C., 2019, In: European Neuropsychopharmacology. 29, Supplement 6, p. S563-S564 2 p.

      Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

    20. Published

      Haplotype of the astrocytic water channel AQP4 is associated with slow wave energy regulation in human NREM sleep

      Larsen, S. M. U., Landolt, H. P., Berger, W., Nedergaard, Maiken, Knudsen, Gitte Moos & Holst, S. C., May 2020, In: PLOS Biology. 18, 5, 14 p., e3000623.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Quantitative Gd-DOTA uptake from cerebrospinal fluid into rat brain using 3D VFA-SPGR at 9.4T

      Lee, H., Mortensen, K., Sanggaard, S., Koch, P., Brunner, H., Quistorff, B., Nedergaard, Maiken & Benveniste, H., 2018, In: Magnetic Resonance in Medicine. 79, 3, p. 1568-1578 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Aquaporin 1 and the Na+/K+/2Cl- cotransporter 1 are present in the leptomeningeal vasculature of the adult rodent central nervous system

      Li, Q., Aalling, Nadia, Förstera, B., Ertürk, A., Nedergaard, Maiken, Møllgård, Kjeld & L R Xavier, Anna , 2020, In: Fluids and Barriers of the CNS. 17, 15 p., 15.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Dexmedetomidine enhances glymphatic brain delivery of intrathecally administered drugs

      Lilius, T. O., Blomqvist, K., Hauglund, Natalie Linea, Liu, G., Stæger, Frederik Filip Vinggaard, Baerentzen, S., Du, T., Ahlstrom, F., Backman, J. T., Kalso, E. A., Rauhala, P. V. & Nedergaard, Maiken, 2019, In: Journal of Controlled Release. 304, p. 29-38 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Glymphatic-assisted perivascular brain delivery of intrathecal small gold nanoparticles

      Lilius, T. O., Mortensen, K. N., Deville, C., Lohela, T. J., Stæger, Frederik Filip Vinggaard, Sigurdsson, B., Fiordaliso, E. M., Rosenholm, Marko, Kamphuis, C., Beekman, F. J., Jensen, A. I. & Nedergaard, Maiken, 2023, In: Journal of Controlled Release. 355, p. 135-148 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      SPECT/CT imaging reveals CNS-wide modulation of glymphatic cerebrospinal fluid flow by systemic hypertonic saline

      Lilius, T. O., Rosenholm, Marko, Klinger, L., Mortensen, K. N., Sigurdsson, B., Mogensen, F. L., Hauglund, Natalie Linea, Nielsen, Malthe Skytte Nordentoft, Rantamaki, T. & Nedergaard, Maiken, 2022, In: iScience. 25, 10, 17 p., 105250.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      Measurements of cerebrospinal fluid production: a review of the limitations and advantages of current methodologies

      Liu, G., Ladrón-de-Guevara, A., Izhiman, Y., Nedergaard, Maiken & Du, Ting, 2022, In: Fluids and Barriers of the CNS. 19, 1, 24 p., 101.

      Research output: Contribution to journal › Review › Research › peer-review

    27. Published

      Direct Measurement of Cerebrospinal Fluid Production in Mice

      Liu, G., Mestre, H., Sweeney, A. M., Sun, Q., Weikop, Pia, Du, T. & Nedergaard, Maiken, 2020, In: Cell Reports. 33, 12, 13 p., 108524.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Dysregulated Glial Differentiation in Schizophrenia May Be Relieved by Suppression of SMAD4- and REST-Dependent Signaling

      Liu, Z., Osipovitch, M., Benraiss, A., Huynh, N. P. T., Foti, R., Bates, J., Chandler-Militello, D., Findling, R. L., Tesar, P. J., Nedergaard, Maiken, Windrem, M. S. & Goldman, Steven Alan, 2019, In: Cell Reports. 27, 13, p. 3832-3843, e1-e6

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      The glymphatic system: implications for drugs for central nervous system diseases

      Lohela, T. J., Lilius, T. O. & Nedergaard, Maiken, 2022, In: Nature Reviews Drug Discovery. 21, 10, p. 763-779 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      Pretargeted Imaging beyond the Blood–Brain Barrier: Utopia or Feasible?

      Lopes van den Broek, S., Shalgunov, Vladimir, García Vázquez, R., Beschorner, Natalie, Bidesi, N. S. R., Nedergaard, Maiken, Knudsen, Gitte Moos, Sehlin, D., Syvänen, S. & Herth, Matthias Manfred, 2022, In: Pharmaceuticals. 15, 10, 13 p., 1191.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      The Alzheimer's disease 5xFAD mouse model is best suited to investigate pretargeted imaging approaches beyond the blood-brain barrier

      Lopes van den Broek, S. I., Sehlin, D., Andersen, Jens Velde, Aldana, Blanca, Beschorner, Natalie, Nedergaard, Maiken, Knudsen, Gitte Moos, Syvanen, S. & Herth, Matthias Manfred, 2023, In: Frontiers in Nuclear Medicine. 2, 7 p., 1001722.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      Purinergic receptor P2RY12-dependent microglial closure of the injured blood-brain barrier

      Lou, N., Takano, T., Pei, Y., L R Xavier, Anna , Goldman, Steven Alan & Nedergaard, Maiken, 26 Jan 2016, In: National Academy of Sciences. Proceedings. 113, 4, p. 1074-1079 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Understanding the functions and relationships of the glymphatic system and meningeal lymphatics

      Louveau, A., Plog, B. A., Antila, S., Alitalo, K., Nedergaard, Maiken & Kipnis, J., 1 Sep 2017, In: The Journal of Clinical Investigation. 127, 9, p. 3210-3219 10 p.

      Research output: Contribution to journal › Review › Research › peer-review

    34. Published

      Glymphatic clearance controls state-dependent changes in brain lactate concentration

      Lundgaard, I., Lu, M. L., Yang, E., Peng, W., Mestre, H., Hitomi, E., Deane, R. & Nedergaard, Maiken, Jun 2017, In: Journal of Cerebral Blood Flow and Metabolism. 37, 6, p. 2112-2124 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Direct neuronal glucose uptake Heralds activity-dependent increases in cerebral metabolism

      Lundgaard, I., Li, B., Xie, L., Kang, H., Sanggaard, S., Haswell, J. D. R., Sun, W., Goldman, S., Blekot, S., Nielsen, Michael Lund, Takano, T., Deane, R. & Nedergaard, Maiken, 2015, In: Nature Communications. 6, 12 p., 6807.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function

      Lundgaard, I., Wang, W., Eberhardt, A., Vinitsky, H. S., Reeves, B. C., Peng, S., Lou, N., Hussain, R. & Nedergaard, Maiken, 2018, In: Scientific Reports. 8, 1, 16 p., 2246.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      TUBE project: Transport-derived ultrafines and the brain effects

      Martikainen, M. V., Aakko-Saksa, P., Broek, L. V. D., Cassee, F. R., Carare, R. O., Chew, S., Dinnyes, A., Giugno, R., Kanninen, K. M., Malm, T., Muala, A., Nedergaard, M., Oudin, A., Oyola, P., Pfeiffer, T. V., Rönkkö, T., Saarikoski, S., Sandström, T., Schins, R. P. F., Topinka, J. & 4 others, Yang, M., Zeng, X., Westerink, R. H. S. & Jalava, P. I., 2022, In: International Journal of Environmental Research and Public Health. 19, 1, 14 p., 311.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Delivery of gene therapy through a cerebrospinal fluid conduit to rescue hearing in adult mice

      Mathiesen, B. K., Miyakoshi, L. M., Cederroth, C. R., Tserga, E., Versteegh, C., Bork, Peter Aleksander Rousing, Hauglund, Natalie Linea, Gomolka, Ryszard Stefan, Mori, Yuki, Edvall, N. K., Rouse, S., Møllgård, Kjeld, Holt, J. R., Nedergaard, Maiken & Canlon, B., 2023, In: Science Translational Medicine. 15, 702, 13 p., eabq3916.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      The Brain's Glymphatic System: Current Controversies

      Mestre, H., Mori, Yuki & Nedergaard, Maiken, 2020, In: Trends in Neurosciences. 43, 7, p. 458-466 9 p.

      Research output: Contribution to journal › Review › Research › peer-review

    40. Published

      Perivascular spaces, glymphatic dysfunction, and small vessel disease

      Mestre, H., Kostrikov, S., Mehta, R. I. & Nedergaard, Maiken, 1 Sep 2017, In: Clinical Science. 131, 17, p. 2257-2274 18 p.

      Research output: Contribution to journal › Review › Research › peer-review

    41. Published

      Aquaporin-4-dependent glymphatic solute transport in the rodent brain

      Mestre, H., Hablitz, L. M., Xavier, A. L. R., Feng, W., Zou, W., Pu, T., Monai, H., Murlidharan, G., Rivera, R. M. C., Simon, M. J., Pike, M. M., Pla, V., Du, T., Kress, B. T., Wang, X., Plog, B. A., Thrane, A. S., Lundgaard, I., Abe, Y., Yasui, M. & 6 others, Thomas, J. H., Xiao, M., Hirase, Hajime, Asokan, A., Iliff, J. J. & Nedergaard, Maiken, 2018, In: eLife. 7, 31 p., :e40070.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      Cerebrospinal fluid influx drives acute ischemic tissue swelling

      Mestre, H., Du, T., Sweeney, A. M., Liu, G., Samson, A. J., Peng, W., Mortensen, K. N., Stæger, F. F., Bork, P. A. R., Bashford, L., Toro, E. R., Tithof, J., Kelley, D. H., Thomas, J. H., Hjorth, P. G., Martens, E. A., Mehta, R. I., Solis, O., Blinder, P., Kleinfeld, D. & 3 others, Hirase, Hajime, Mori, Yuki & Nedergaard, Maiken, 2020, In: Science. 367, 6483, 8 p., eaaw7462.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension

      Mestre, H., Tithof, J., Du, T., Song, W., Peng, W., Sweeney, A. M., Olveda, G., Thomas, J. H., Nedergaard, Maiken & Kelley, D. H., 2018, In: Nature Communications. 9, 1, 9 p., 4878.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Periarteriolar spaces modulate cerebrospinal fluid transport into brain and demonstrate altered morphology in aging and Alzheimer’s disease

      Mestre, H., Verma, N., Greene, T. D., Lin, L. J. A., Ladron-de-Guevara, A., Sweeney, A. M., Liu, G., Thomas, V. K., Galloway, C. A., de Mesy Bentley, K. L., Nedergaard, Maiken & Mehta, R. I., 2022, In: Nature Communications. 13, 1, 8 p., 3897.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      Surface periarterial spaces of the mouse brain are open, not porous

      Min Rivas, F., Liu, J., Martell, B. C., Du, T., Mestre, H., Nedergaard, Maiken, Tithof, J., Thomas, J. H. & Kelley, D. H., 2020, In: Journal of the Royal Society, Interface. 17, 172, 1 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      The state of brain activity modulates cerebrospinal fluid transport

      Miyakoshi, L. M., Stæger, Frederik Filip Vinggaard, Li, Q., Pan, C., Xie, L., Kang, H., Pavan, C., Dang, J., Sun, Q., Ertürk, A. & Nedergaard, Maiken, 2023, In: Progress in Neurobiology. 229, 11 p., 102512.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      The Glymphatic System (En)during Inflammation

      Mogensen, F. L., Delle, Christine & Nedergaard, Maiken, 2021, In: International Journal of Molecular Sciences. 22, 14, 20 p., 7491.

      Research output: Contribution to journal › Review › Research › peer-review

    48. Published

      Adrenergic inhibition facilitates normalization of extracellular potassium after cortical spreading depolarization

      Monai, H., Koketsu, S., Shinohara, Y., Ueki, T., Kusk, P., Hauglund, Natalie Linea, Samson, A. J., Nedergaard, Maiken & Hirase, Hajime, 2021, In: Scientific Reports. 11, 1, 8150.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Adrenergic receptor antagonism induces neuroprotection and facilitates recovery from acute ischemic stroke

      Monai, H., Wang, X., Yahagi, K., Lou, N., Mestre, H., Xu, Q., Abe, Y., Yasui, M., Iwai, Y., Nedergaard, Maiken & Hirase, Hajime, 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 22, p. 11010-11019 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      PDGF-B Is Required for Development of the Glymphatic System

      Munk, A. S., Wang, W., Bèchet, N. B., Eltanahy, A. M., Cheng, A. X., Sigurdsson, B., Benraiss, A., Mäe, M. A., Kress, B. T., Kelley, D. H., Betsholtz, C., Møllgård, Kjeld, Meissner, A., Nedergaard, Maiken & Lundgaard, I., 2019, In: Cell Reports. 26, 11, p. 2955-2969.e3 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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