Kristian Strømgaard

Kristian Strømgaard

Professor

ORCID: 0000-0003-2206-4737

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  1. Published

    Structure-Activity Relationship Studies of the Cyclic Depsipeptide Natural Product YM-254890, Targeting the Gq Protein

    Zhang, H., Xiong, X., Boesgaard, M. W., Underwood, C. R., Bräuner, Hans & Strømgaard, Kristian, 7 Jun 2017, In: ChemMedChem. 12, 11, p. 830-834 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Structure–activity relationship and conformational studies of the natural product cyclic depsipeptides YM-254890 and FR900359

    Zhang, H., Nielsen, A. L., Boesgaard, M. W., Harpsøe, Kasper, Daly, N. L., Xiong, X., Underwood, C. R., Haugaard-kedström, L. M., Bräuner, Hans, Gloriam, David E. & Strømgaard, Kristian, 2018, In: European Journal of Medicinal Chemistry. 156, p. 847-860

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Total synthesis and structure–activity relationship studies of a series of selective G protein inhibitors

    Xiong, X., Zhang, H., Underwood, C. R., Harpsøe, Kasper, Gardella, T. J., Wöldike, M. F., Mannstadt, M., Gloriam, David E., Bräuner, Hans & Strømgaard, Kristian, 2016, In: Nature Chemistry. 8, 11, p. 1035-1041 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Structure–Activity Relationship Study of Spider Polyamine Toxins as Inhibitors of Ionotropic Glutamate Receptors

    Xiong, X., Poulsen, Mette Homann, Hussein, R. A., Nørager, N. G. & Strømgaard, Kristian, Dec 2014, In: ChemMedChem. 9, 12, p. 2661-70 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Polyamine toxins from spiders and wasps: Polyamine toxins from spiders and wasps

    Xiong, X. & Strømgaard, Kristian, 2015, Polyamines: A Universal Molecular Nexus for Growth, Survival, and Specialized Metabolism. Springer, Japan, p. 201-214 14 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  6. Published

    Structure–Activity Relationship Studies of the Natural Product G q/11 Protein Inhibitor YM-254890

    Xiong, X. F., Zhang, H., Boesgaard, M. W., Underwood, C. R., Bräuner, Hans & Strømgaard, Kristian, Apr 2019, In: ChemMedChem. 14, 8, p. 865-870

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Identification and characterization of a small-molecule inhibitor of death-associated protein kinase 1

    Wilbek, T. S., Skovgaard, T., Sorrell, F. J., Knapp, S., Berthelsen, J. & Strømgaard, Kristian, 2 Jan 2015, In: ChemBioChem. 16, 1, p. 59-63 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Ligand binding to the PDZ domains of postsynaptic density protein 95

    Toto, A., Pedersen, S. W., Karlsson, O. A., Moran, G. E., Andersson, E., Chi, C. N., Strømgaard, Kristian, Gianni, S. & Jemth, P., May 2016, In: Protein Engineering Design and Selection (Print). 29, 5, p. 169-75 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD

    Thorsen, T. S., Madsen, Kenneth Lindegaard, Rebola, N., Rathje, Mette, Anggono, V., Bach, Anders, Moreira, I. S., Stuhr-Hansen, N., Dyhring, T., Peters, D., Beuming, T., Huganir, R., Weinstein, H., Mulle, C., Strømgaard, Kristian, Rønn, L. C. B. & Gether, Ulrik, 2010, In: Proceedings of the National Academy of Science of the United States of America. 107, 1, p. 413-8 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    A fluorescence polarization based screening assay for identification of small molecule inhibitors of the PICK1 PDZ domain

    Thorsen, T. S., Madsen, Kenneth Lindegaard, Dyhring, T., Bach, Anders, Peters, D., Strømgaard, Kristian, Rønn, L. C. B. & Gether, Ulrik, 1 Aug 2011, In: Combinatorial Chemistry & High Throughput Screening. 14, 7, p. 590-600 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Interaction of antidepressants with the serotonin and norepinephrine transporters: mutational studies of the S1 substrate binding pocket

    Sørensen, L., Andersen, J., Thomsen, M., Hansen, S. M. R., Zhao, X., Sandelin, Albin Gustav, Strømgaard, Kristian & Kristensen, Anders Skov, 2012, In: The Journal of Biological Chemistry. 287, 52, p. 43694-43707 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Characterization of intracellular regions in the human serotonin transporter for phosphorylation sites

    Sørensen, L., Strømgaard, Kristian & Kristensen, Anders Skov, 18 Apr 2014, In: ACS chemical biology. 9, 4, p. 935-44 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Interaction of antidepressants with the serotonin and norepinephrine transporters: mutational studies of the S1 substrate binding pocket

    Sørensen, L., Andersen, J., Thomsen, M., Hansen, S. M. R., Zhao, X., Sandelin, Albin Gustav, Strømgaard, Kristian & Kristensen, Anders Skov, 2012, In: Journal of Biological Chemistry. 287, p. 43694-43707 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Synthetic and mechanistic insight into nosylation of glycine residues

    Stuhr-Hansen, N., Sølling, Theis Ivan & Strømgaard, Kristian, 14 Apr 2013, In: Organic & Biomolecular Chemistry. 11, 14, p. 2288-2293 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Facile synthesis of α-hydroxy carboxylic acids from the corresponding α-amino acids

    Stuhr-Hansen, N., Padrah, S. & Strømgaard, Kristian, 2014, In: Tetrahedron Letters. 55, 30, p. 4149-4151 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Mechanistic insight into benzenethiol catalyzed amide bond formations from thioesters and primary amines

    Stuhr-Hansen, N., Bork, N. & Strømgaard, Kristian, 14 Aug 2014, In: Organic & Biomolecular Chemistry. 12, 30, p. 5745-51 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Synthesis of symmetrical and non-symmetrical bivalent neurotransmitter ligands

    Stuhr-Hansen, N., Andersen, J., Thygesen, Mikkel Boas & Strømgaard, Kristian, 2016, In: ChemistrySelect. 1, 3, p. 407-413 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Preparation of peptide thioesters through fmoc-based solid-phase peptide synthesis by using amino thioesters

    Stuhr-Hansen, N., Wilbek, T. S. & Strømgaard, Kristian, 1 Aug 2013, In: European Journal of Organic Chemistry. 2013, 24, p. 5290-5294 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Skræddersyede proteiner: uden naturens begrænsninger

    Strømgaard, Kristian, Jensen, M. S. & Kristensen, Anders Skov, 2009, In: Lægemiddelforskning. p. 10-12

    Research output: Contribution to journal › Journal article › Communication

  20. Published

    A heteromeric snake toxin and the molecular details of pain perception

    Strømgaard, Kristian & Kristensen, Anders Skov, 23 Apr 2012, In: Angewandte Chemie International Edition. 51, 17, p. 4009-4011

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Chemical biology

    Strømgaard, Kristian, 2010, Textbook of drug design and discovery. Krogsgaard-Larsen, P., Strømgaard, K. & Madsen, U. (eds.). 4 ed. Boca Raton: CRC Press, p. 59-74

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education

  22. Published

    Fatty acid derivatives of dimeric inhibitors of PSD-95

    Strømgaard, Kristian, Bach, Anders & Nissen, K. B., 4 Jun 2015, IPC No. A61K38/17 , Patent No. WO2015/078477A1, Priority date 1 Dec 2013, Priority No. DK/2013/70735

    Research output: Patent

  23. Published

    Effects of the dimeric PSD-95 inhibitor UCCB01-144 on functional recovery after fimbria-fornix transection in rats

    Sommer, J. B., Bach, Anders, Rytter, Hana Malá, Strømgaard, Kristian, Mogensen, J. & Pickering, Darryl S, Oct 2017, In: Pharmacology, Biochemistry and Behavior. 161, p. 62-67 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    In vitro and in vivo effects of a novel dimeric inhibitor of PSD‐95 on excitotoxicity and functional recovery after experimental traumatic brain injury

    Sommer, J. B., Bach, Anders, Rytter, Hana Malá, Strømgaard, Kristian, Mogensen, J. & Pickering, Darryl S, 20 Jan 2017, In: European Journal of Neuroscience. 45, 2, p. 238-248 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Effects of dimeric PSD-95 inhibition on excitotoxic cell death and outcome after controlled cortical impact in rats: PSD-95 inhibition in experimental TBI

    Sommer, J. B., Bach, Anders, Rytter, Hana Malá, Gynther, M., Bjerre, A., Gram, M. G., Marschner, L., Strømgaard, Kristian, Mogensen, J. & Pickering, Darryl S, 2017, In: Neurochemical Research. 42, 12, p. 3401-3413 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Probing Backbone Hydrogen Bonds in Proteins by Amide-to-Ester Mutations

    Sereikaité, Vita, Jensen, T. M. T., Bartling, Christian Reinhard Otto, Jemth, P., Pless, Stephan & Strømgaard, Kristian, 18 Oct 2018, In: ChemBioChem. 19, 20, p. 2136-2145

    Research output: Contribution to journal › Review › Research › peer-review

  27. Published

    Targeting the gamma-Aminobutyric Acid Type B (GABA(B)) Receptor Complex: Development of Inhibitors Targeting the K+ Channel Tetramerization Domain (KCTD) Containing Proteins/GABA(B) Receptor Protein-Protein Interaction

    Sereikaité, Vita, Fritzius, T., Kasaragod, V. B., Bader, N., Maric, H. M., Schindelin, H., Bettler, B. & Strømgaard, Kristian, 2019, In: Journal of Medicinal Chemistry. 62, 19, p. 8819-8830

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Knockin mouse with mutant Gα11 mimics human inherited hypocalcemia and is rescued by pharmacologic inhibitors

    Roszko, K. L., Bi, R., Gorvin, C. M., Bräuner, Hans, Xiong, X., Inoue, A., Thakker, R. V., Strømgaard, Kristian, Gardella, T. & Mannstadt, M., 9 Feb 2017, In: JCI insight. 2, 3, 15 p., e91079.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Genetically encoded photocrosslinkers locate the high-affinity binding site of antidepressant drugs in the human serotonin transporter

    Rannversson, H., Andersen, J., Hall, L. S., Bang-Andersen, B., Park, M., Huber, T., Sakmar, T. P. & Strømgaard, Kristian, 19 Apr 2016, In: Nature Communications. 7, p. 1-9 9 p., 11261.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Mapping the Binding Site for Escitalopram and Paroxetine in the Human Serotonin Transporter Using Genetically Encoded Photo-Cross-Linkers

    Rannversson, H., Andersen, J., Bang-Andersen, B. & Strømgaard, Kristian, 20 Oct 2017, In: ACS chemical biology. 12, 10, p. 2558-2562 5 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  31. Published

    Importance of the Extracellular Loop 4 in the Human Serotonin Transporter for Inhibitor Binding and Substrate Translocation

    Rannversson, H., Wilson, P., Kristensen, K. B., Sinning, S., Kristensen, Anders Skov, Strømgaard, Kristian & Andersen, J., 5 Jun 2015, In: The Journal of Biological Chemistry. 290, 23, p. 14582-94 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Evaluation of PhTX-74 as Subtype-Selective Inhibitor of GluA2-Containing AMPA Receptors

    Poulsen, Mette Homann, Lucas, S., Strømgaard, Kristian & Kristensen, Anders Skov, Feb 2014, In: Molecular Pharmacology. 85, 2, p. 261-268 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Binding of ArgTX-636 in the NMDA receptor ion channel

    Poulsen, M. H., Andersen, J., Christensen, R., Hansen, K. B., Traynelis, S. F., Strømgaard, Kristian & Kristensen, Anders Skov, 16 Jan 2015, In: Journal of Molecular Biology. 427, 1, p. 176-89 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Structure-activity relationship studies of argiotoxins: selective and potent inhibitors of ionotropic glutamate receptors

    Poulsen, Mette Homann, Lucas, S., Bach, T. B., Barslund, A. F., Wenzler, C., Jensen, C. B., Kristensen, Anders Skov & Strømgaard, Kristian, 14 Feb 2013, In: Journal of Medicinal Chemistry. 56, 3, p. 1171-1181 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Inhibition of AMPA Receptors by Polyamine Toxins is Regulated by Agonist Efficacy and Stargazin

    Poulsen, Mette Homann, Lucas, S., Strømgaard, Kristian & Kristensen, Anders Skov, 22 Feb 2014, In: Neurochemical Research. 39, 10, p. 1906-1913 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Designing Poly-agonists for Treatment of Metabolic Diseases: Challenges and Opportunities

    Petersen, Jonas Odgaard, Strømgaard, Kristian, Frølund, Bente & Clemmensen, Christoffer, 2019, In: Drugs. 79, 11, p. 1187-1197 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    The role of backbone hydrogen bonds in the transition state for protein folding of a PDZ domain

    Pedersen, S. W., Hultqvist, G., Strømgaard, Kristian & Jemth, P., 2014, In: PLOS ONE. 9, 4, p. 1-7 7 p., e95619.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Synthesis of peptides using tert-butyloxycarbonyl (Boc) as the α-amino protection group

    Pedersen, S. W., Armishaw, C. J. & Strømgaard, Kristian, 2013, Peptide synthesis and applications. Humana Press, Vol. 1047. p. 65-80 16 p. (Methods in Molecular Biology).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  39. Published

    Site-Specific Phosphorylation of PSD-95 PDZ Domains Reveals Fine-Tuned Regulation of Protein-Protein Interactions

    Pedersen, S. W., Albertsen, L., Moran, G. E., Levesque, B., Pedersen, S. B., Bartels, L., Wapenaar, H., Ye, F., Zhang, M., Bowen, M. E. & Strømgaard, Kristian, 15 Sep 2017, In: ACS chemical biology. 12, 9, p. 2313-2323 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Importance of a Conserved Lys/Arg Residue for Ligand/PDZ Domain Interactions as Examined by Protein Semisynthesis

    Pedersen, S. W., Moran, G. E., Sereikaité, Vita, Kedström, L. M. H. & Strømgaard, Kristian, 17 Oct 2016, In: ChemBioChem. 17, 20, p. 1936-1944 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Probing backbone hydrogen bonding in PDZ/ligand interactions by protein amide-to-ester mutations

    Pedersen, S. W., Pedersen, S. B., Anker, L., Hultqvist, G., Kristensen, Anders Skov, Jemth, P. & Strømgaard, Kristian, 2014, In: Nature Communications. 5, p. 1-11 11 p., 3215.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Small molecules from spiders used as chemical probes

    Olsen, C. A., Kristensen, Anders Skov & Strømgaard, Kristian, 25 Nov 2011, In: Angewandte Chemie International Edition. 50, 48, p. 11296-11311

    Research output: Contribution to journal › Review › Research › peer-review

  43. Published

    Development of potent fluorescent polyamine toxins and application in labeling of ionotropic glutamate receptors in hippocampal neurons

    Nørager, N. G., Jensen, C. B., Rathje, Mette, Andersen, J., Madsen, Kenneth Lindegaard, Kristensen, Anders Skov & Strømgaard, Kristian, 20 Sep 2013, In: A C S Chemical Biology. 8, 9, p. 2033-2041 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Structure-activity relationship studies of N-methylated and N-hydroxylated spider polyamine toxins as inhibitors of ionotropic glutamate receptors

    Nørager, N. G., Poulsen, Mette Homann, Jensen, A. G., Jeppesen, N. S., Kristensen, Anders Skov & Strømgaard, Kristian, 12 Jun 2014, In: Journal of Medicinal Chemistry. 57, 11, p. 4940-9 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Controlling Ca2+ Permeable alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Photochromic Ion Channel Blockers

    Norager, N. G., Poulsen, Mette Homann & Strømgaard, Kristian, 13 Sep 2018, In: Journal of Medicinal Chemistry. 61, 17, p. 8048-8053

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Targeting Protein-Protein Interactions with Trimeric Ligands: High Affinity Inhibitors of the MAGUK Protein Family

    Nissen, K. B., Kedström, L. M. H., Wilbek, T. S., Nielsen, L. S., Åberg, E., Kristensen, Anders Skov, Bach, Anders, Jemth, P. & Strømgaard, Kristian, 2015, In: PLOS ONE. 10, 2, p. 1-17 17 p., e0117668.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Design, Synthesis, and Characterization of Fatty Acid Derivatives of a Dimeric Peptide-Based Postsynaptic Density-95 (PSD-95) Inhibitor

    Nissen, K. B., Andersen, J. J., Haugaard-Kedström, L. M., Bach, Anders & Strømgaard, Kristian, 2015, In: Journal of Medicinal Chemistry. 58, p. 1575-1580 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Synthesis and biological activity of argiotoxin 636 and analogues: selective antagonists for ionotropic glutamate receptors

    Nelson, J. K., Frølund, S. U., Tikhonov, D. B., Kristensen, Anders Skov & Strømgaard, Kristian, 2009, In: Angewandte Chemie - International Edition. 48, 17, p. 3087-3091

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Plant polyphenols inhibit functional amyloid and biofilm formation in Pseudomonas strains by directing monomers to off-pathway oligomers

    Najarzadeh, Z., Mohammad-Beigi, H., Pedersen, J. N., Christiansen, G., Sønderby, T. V., Shojaosadati, S. A., Morshedi, D., Strømgaard, Kristian, Meisl, G., Sutherland, D., Pedersen, J. S. & Otzen, D. E., 2019, In: Biomolecules. 9, 11, 21 p., 659.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    PDZ domain-mediated interactions of G protein-coupled receptors with postsynaptic density protein 95: quantitative characterization of interactions

    Møller, T. C., Wirth, V. F., Roberts, N. I., Bender, J., Bach, Anders, Jacky, B. P. S., Strømgaard, Kristian, Deussing, J. M., Schwartz, Thue W. & Martinez, Karen Laurence, 2013, In: PLOS ONE. 8, 5, e63352.

    Research output: Contribution to journal › Journal article › Research › peer-review

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