Kresten Lindorff-Larsen

Kresten Lindorff-Larsen

Professor

ORCID: 0000-0002-4750-6039

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  1. Published

    14-fold increased prevalence of rare glucokinase gene variant carriers in unselected Danish patients with newly diagnosed type 2 diabetes

    Gjesing, A. P., Engelbrechtsen, L., Cathrine B. Thuesen, A., Have, C. T., Hollensted, M., Grarup, N., Linneberg, A., Steen Nielsen, J., Christensen, L. B., Thomsen, R. W., Johansson, K. E., Cagiada, M., Gersing, S., Hartmann-Petersen, R., Lindorff-Larsen, K., Vaag, A., Sørensen, H. T., Brandslund, I., Beck-Nielsen, H., Pedersen, O. & 2 others, Rungby, Jørgen & Hansen, Torben, 2022, In: Diabetes Research and Clinical Practice. 194, 9 p., 110159.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    PSX, Protein-Solvent Exchange: software for calculation of deuterium-exchange effects in small-angle neutron scattering measurements from protein coordinates

    Pedersen, Martin Cramer, Wang, Y., Tidemand, Frederik Grønbæk, Martel, A., Lindorff-Larsen, Kresten & Arleth, Lise, 2019, In: Journal of Applied Crystallography. 52, 6, p. 1427-1436 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    A Combined Simulation and SAXS Study of the Dynamics of Lipid Nanodiscs

    Bengtsen, T., Holm-Janas, Viktor, Midtgaard, S. R., Arleth, Lise & Lindorff-Larsen, Kresten, 17 Feb 2018, In: Biophysical Journal. 114, 3, Supp. 1, p. 559A-559A 1 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    A Monte Carlo study of the early steps of functional amyloid formation

    Tian, P., Lindorff-Larsen, Kresten, Boomsma, Wouter, Jensen, Mogens Høgh & Otzen, D. E., 2016, In: P L o S One. 11, 1, 18 p., e0146096.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    A Multi-State Coarse-Grained Simulation Model Captures Conformational Cycling in P-Type ATPases

    Wang, Y., Saleh, N., Chu, X. & Lindorff-Larsen, Kresten, 2019, In: Biophysical Journal. 116, 3, suppl. 1, p. 300a 1484-Plat.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  6. Published

    A Robust Proton Flux (pHlux) Assay for Studying the Function and Inhibition of the Influenza A M2 Proton Channel

    Santner, P., Martins, J. M. D. S., Laursen, J. S., Behrendt, L., Riber, Leise, Olsen, Christian Adam, Arkin, I. T., Winther, Jakob R., Willemoës, Martin & Lindorff-Larsen, Kresten, 2018, In: Biochemistry. 57, 41, p. 5949-5956

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    A combined computational and structural model of the full-length human prolactin receptor

    Bugge, K. Ø., Papaleo, E., Haxholm, G. W., Hopper, J. T. S., Robinson, C. V., Olsen, Johan Gotthardt, Lindorff-Larsen, Kresten & Kragelund, Birthe Brandt, 2016, In: Nature Communications. 7, 11 p., 11578.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    A comprehensive map of human glucokinase variant activity

    Gersing, S., Cagiada, Matteo, Gebbia, M., Gjesing, A. P., Coté, A. G., Seesankar, G., Li, R., Tabet, D., Weile, J., Stein, Amelie, Gloyn, A. L., Hansen, Torben, Roth, F. P., Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2023, In: Genome Biology. 24, 1, 23 p., 97.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    A dual-reporter system for investigating and optimizing protein translation and folding in E. coli

    Zutz, A., Hamborg, L., Pedersen, L. E., Kassem, M. M., Papaleo, E., Koza, A., Herrgård, M. J., Ingemann Jensen, S., Teilum, Kaare, Lindorff-Larsen, Kresten & Nielsen, A. T., 2021, In: Nature Communications. 12, 15 p., 6093.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    A mutational atlas for Parkin proteostasis

    Clausen, L., Voutsinos, Vasileios, Cagiada, Matteo, Johansson, Kristoffer Enøe, Grønbæk-Thygesen, Martin, Nariya, S., Powell, R. L., Have, M. K. N., Østergaard, Vibe Hallundbæk, Stein, Amelie, Fowler, D. M., Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2024, In: Nature Communications. 15, 1, 17 p., 1541.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    A phosphorylation-motif for tuneable helix stabilisation in intrinsically disordered proteins - Lessons from the sodium proton exchanger 1 (NHE1)

    Hendus-Altenburger, R., Lambrughi, M., Terkelsen, Thilde Bagger, Pedersen, Stine Helene Falsig, Papaleo, E., Lindorff-Larsen, Kresten & Kragelund, Birthe Brandt, Sep 2017, In: Cellular Signalling. 37, p. 40-51 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    A soluble, folded protein without charged amino acid residues

    Højgaard, C., Kofoed, Christian, Espersen, R., Johansson, Kristoffer Enøe, Villa, M., Willemoës, Martin, Lindorff-Larsen, Kresten, Teilum, Kaare & Winther, Jakob R., 2016, In: Biochemistry. 55, 28, p. 3949–3956 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    A sticky cage can slow down folding

    Boomsma, Wouter & Lindorff-Larsen, Kresten, 2013, In: Biophysical Journal. 104, 5, p. 964-965 2 p.

    Research output: Contribution to journal › Comment/debate › Research

  14. Published

    A structural biology community assessment of AlphaFold2 applications

    Akdel, M., Pires, D. E., Porta Pardo, E., Jänes, J., Zalevsky, A. O., Meszaros, B., Bryant, P., Good, L. L., Laskowski, R. A., Pozzati, G., Shenoy, A., Zhu, W., Kundrotas, P., Serra, V. R., Rodrigues, C. H. M., Dunham, A. S., Burke, D., Borkakoti, N., Velankar, S., Frost, A. & 14 others, Basquin, J., Lindorff-Larsen, Kresten, Bateman, A., Kajava, A., Valencia, A., Ovchinnikov, S., Durairaj, J., Ascher, D. B., Thornton, J. M., Davey, N. E., Stein, Amelie, Elofsson, A., Croll, T. & Beltrao, P., 2022, In: Nature Structural & Molecular Biology. 29, 11, 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    A two-step protein quality control pathway for a misfolded DJ-1 variant in fission yeast

    Mathiassen, S. G., Larsen, I. B., Poulsen, E. G., Madsen, C. T., Papaleo, E., Lindorff-Larsen, Kresten, Kragelund, Birthe Brandt, Nielsen, Michael Lund, Kriegenburg, F. & Hartmann-Petersen, Rasmus, 2015, In: The Journal of Biological Chemistry. 290, 34, p. 21141-21153 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Accurate model of liquid-liquid phase behavior of intrinsically disordered proteins from optimization of single-chain properties

    Tesei, Giulio, Schulze, T. K., Crehuet, R. & Lindorff-Larsen, Kresten, 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 44, 10 p., e2111696118.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Accurate protein stability predictions from homology models

    Valanciute, A., Nygaard, L., Zschach, Henrike, Maglegaard Jepsen, M., Lindorff-Larsen, Kresten & Stein, Amelie, 2023, In: Computational and Structural Biotechnology Journal. 21, p. 66-73 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Activation and substrate specificity of the human P4-ATPase ATP8B1

    Dieudonné, T., Kümmerer, Felix, Laursen, M. J., Stock, C., Flygaard, R. K., Khalid, S., Lenoir, G., Lyons, J. A., Lindorff-Larsen, Kresten & Nissen, P., 2023, In: Nature Communications. 14, 1, 14 p., 7492.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Allosteric modulation of the sarcoplasmic reticulum Ca2+ ATPase by thapsigargin via decoupling of functional motions

    Saleh, N., Wang, Y., Nissen, P. & Lindorff-Larsen, Kresten, 2019, In: Physical Chemistry Chemical Physics. 21, 39, p. 21991-21995

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    An efficient method for estimating the hydrodynamic radius of disordered protein conformations

    Nygaard, M., Kragelund, Birthe Brandt, Papaleo, E. & Lindorff-Larsen, Kresten, 8 Aug 2017, In: Biophysical Journal. 113, 3, p. 550-557 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Architecture and assembly dynamics of the essential mitochondrial chaperone complex TIM9·10·12

    Weinhäupl, K., Wang, Y., Hessel, A., Brennich, M., Lindorff-Larsen, Kresten & Schanda, P., 2021, In: Structure. 29, 9, p. 1065-1073.e4

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Assessment of models for calculating the hydrodynamic radius of intrinsically disordered proteins

    Pesce, Francesco, Newcombe, Estella Anne, Seiffert, P., Tranchant, E. E., Olsen, Johan Gotthardt, Grace, C. R., Kragelund, Birthe Brandt & Lindorff-Larsen, Kresten, 2023, In: Biophysical Journal. 122, 2, p. 310-321 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Atomic-level characterization of the structural dynamics of proteins

    Shaw, D. E., Maragakis, P., Lindorff-Larsen, Kresten, Piana, S., Dror, R. O., Eastwood, M. P., Bank, J. A., Jumper, J. M., Salmon, J. K., Shan, Y. & Wriggers, W., 2010, In: Science (New York, N.Y.). 330, 6002, p. 341-6 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Atomic-level description of ubiquitin folding

    Piana, S., Lindorff-Larsen, Kresten & Shaw, D. E., 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 15, p. 5915-5920 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Atomistic description of the folding of a dimeric protein

    Piana, S., Lindorff-Larsen, Kresten & Shaw, D. E., 2013, In: Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical. 117, 42, p. 12935-12942 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Automated Event Detection and Activity Monitoring in Long Molecular Dynamics Simulations

    Wriggers, W., Stafford, K. A., Shan, Y., Piana, S., Maragakis, P., Lindorff-Larsen, Kresten, Miller, P. J., Gullingsrud, J., Rendleman, C. A., Eastwood, M. P., Dror, R. O. & Shaw, D. E., 1 Oct 2009, In: Journal of Chemical Theory and Computation. 5, 10, p. 2595-2605 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. BPPred: a Web-based computational tool for predicting biophysical parameters of proteins

    Geierhaas, C. D., Nickson, A. A., Lindorff-Larsen, Kresten, Clarke, J. & Vendruscolo, M., 2007, In: Protein Science. 16, 1, p. 125-34 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Barley lipid transfer protein, LTP1, contains a new type of lipid-like post-translational modification

    Lindorff-Larsen, Kresten, Lerche, M. H., Poulsen, F. M., Roepstorff, P. & Winther, J. R., 2001, In: Journal of Biological Chemistry. 276, 36, p. 33547-53 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Barnaba: software for analysis of nucleic acid structures and trajectories

    Bottaro, S., Bussi, G., Pinamonti, G., Reisser, S., Boomsma, Wouter & Lindorff-Larsen, Kresten, 2019, In: RNA. 25, 2, p. 219-231

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Bayesian-Maximum-Entropy Reweighting of IDP Ensembles Based on NMR Chemical Shifts

    Crehuet, R., Buigues, P. J., Salvatella, X. & Lindorff-Larsen, Kresten, 2019, In: Entropy. 21, 9, 17 p., 898.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Bioinformatics analysis identifies several intrinsically disordered human E3 ubiquitin-protein ligases

    Boomsma, Wouter, Nielsen, S. V., Lindorff-Larsen, Kresten, Hartmann-Petersen, Rasmus & Ellgaard, Lars, 2016, In: PeerJ. 4, 18 p., e1725.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Biomolecular conformational changes and ligand binding: from kinetics to thermodynamics

    Wang, Y., Martins, J. & Lindorff-Larsen, Kresten, Sep 2017, In: Chemical Science. 8, 9, p. 6466-6473 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Biophysical and Mechanistic Models for Disease-Causing Protein Variants

    Stein, Amelie, Fowler, D. M., Hartmann-Petersen, Rasmus & Lindorff-Larsen, Kresten, 2019, In: Trends in Biochemical Sciences. 44, 7, p. 575-588

    Research output: Contribution to journal › Review › Research › peer-review

  34. Published

    Biophysical experiments and biomolecular simulations: a perfect match?

    Bottaro, S. & Lindorff-Larsen, Kresten, 2018, In: Science. 361, 6400, p. 355-360 6 p.

    Research output: Contribution to journal › Review › Research › peer-review

  35. Published

    Blocking protein quality control to counter hereditary cancers

    Kampmeyer, Caroline, Nielsen, S. V., Bjørnkjær, Lene, Stein, Amelie, Gerdes, Anne-Marie Axø, Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, Dec 2017, In: Genes, Chromosomes & Cancer. 56, 12, p. 823-831 9 p.

    Research output: Contribution to journal › Review › Research › peer-review

  36. Published

    CECAM workshop on intrinsically disordered proteins

    Rösner, Heike Ilona, Papaleo, E., Haxholm, G. W., Best, R. B., Kragelund, Birthe Brandt & Lindorff-Larsen, Kresten, 2014, In: Intrinsically Disordered Proteins. 2, 1, p. 1-5 5 p.

    Research output: Contribution to journal › Conference abstract in journal › Research

  37. Calculation of mutational free energy changes in transition states for protein folding

    Lindorff-Larsen, Kresten, Paci, E., Serrano, L., Dobson, C. M. & Vendruscolo, M., 2003, In: Biophysical Journal. 85, 2, p. 1207-14 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments

    Bouchard, J. J., Otero, J. H., Scott, D. C., Szulc, E., Martin, E. W., Sabri, N., Granata, D., Marzahn, M. R., Lindorff-Larsen, Kresten, Salvatella, X., Schulman, B. A. & Mittag, T., 2018, In: Molecular Cell. 72, 1, p. 19-36, e1-e8

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Characterization of the residual structure in the unfolded state of the Delta 131 Delta fragment of staphylococcal nuclease

    Francis, C. J., Lindorff-Larsen, Kresten, Best, R. B. & Bendruscolo, M., 2006, In: Proteins - Structure Function and Bioinformatics. 65, 1, p. 145-52

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Characterizing glucokinase variant mechanisms using a multiplexed abundance assay

    Gersing, S., Schulze, Thea Klarsø, Cagiada, Matteo, Stein, Amelie, Roth, F. P., Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2024, In: Genome Biology. 25, 1, 22 p., 98.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Charge Interactions in a Highly Charge-Depleted Protein

    Hervø-Hansen, S., Højgaard, C., Johansson, Kristoffer Enøe, Wang, Y., Wahni, K., Young, D., Messens, J., Teilum, Kaare, Lindorff-Larsen, Kresten & Winther, Jakob R., 2021, In: Journal of the American Chemical Society. 143, 6, p. 2500-2508 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Class I Cytokine Receptors: Towards the Inside

    Steinocher, H., Bugge, K. Ø., Nikolajsen, L. F., Lindorff-Larsen, Kresten, Brooks, A. & Kragelund, Birthe Brandt, 2017, In: Biophysical Society. Annual Meeting. Abstracts. 112, 3. Suppl. 1, p. 171A 1 p., 845-Plat.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  43. Published

    Classifying disease-associated variants using measures of protein activity and stability

    Jepsen, M. M., Fowler, D. M., Hartmann-Petersen, Rasmus, Stein, Amelie & Lindorff-Larsen, Kresten, 2020, Protein Homeostasis Diseases: Mechanisms and Novel Therapies. Pey, A. L. (ed.). Elsevier, p. 91-107

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  44. Published

    Co-Chaperones in Targeting and Delivery of Misfolded Proteins to the 26S Proteasome

    Abildgaard, A. B., Gersing, S. K., Larsen-Ledet, Sven, Nielsen, S. V., Stein, Amelie, Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2020, In: Biomolecules. 10, 8, 24 p., 1141.

    Research output: Contribution to journal › Review › Research › peer-review

  45. Published

    Co-evolution of drug resistance and broadened substrate recognition in HIV protease variants isolated from an Escherichia coli genetic selection system

    Koivisto, J. M., Poulsen, N. R., Larsen, B. S., Weibull, M. G. M., Stein, Amelie, Doro, F., Winther, Jakob R., Lindorff-Larsen, Kresten & Willemoës, Martin, 2022, In: The Biochemical journal. 479, 4, p. 479-501

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Combining Experiments and Simulations to Examine the Temperature-Dependent Behavior of a Disordered Protein

    Pesce, Francesco & Lindorff-Larsen, Kresten, 2023, In: Journal of Physical Chemistry B. 127, 28, p. 6277-6286 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Combining experiments and simulations using the maximum entropy principle

    Boomsma, Wouter, Ferkinghoff-Borg, J. & Lindorff-Larsen, Kresten, 2014, In: PLoS Computational Biology. 10, 2, 9 p., e1003406.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Combining molecular dynamics simulations with small-angle X-ray and neutron scattering data to study multi-domain proteins in solution

    Nørgrd Larsen, Andreas, Wang, Y., Bottaro, S., Grudinin, S., Arleth, Lise & Lindorff-Larsen, Kresten, 2020, In: P L o S Computational Biology. 16, 4, 29 p., e1007870.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Communication routes in ARID domains between distal residues in Helix 5 and the DNA-binding loops

    Invernizzi, G., Tiberti, M., Lambrughi, M., Lindorff-Larsen, Kresten & Papaleo, E., 2014, In: P L o S Computational Biology (Online). 10, 9, 13 p., e1003744.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Comparing molecular dynamics force fields in the essential subspace

    Martin-García, F., Papaleo, E., Gomez-Puertas, P., Boomsma, Wouter & Lindorff-Larsen, Kresten, 2015, In: PLoS ONE. 10, 3, 16 p., e0121114.

    Research output: Contribution to journal › Journal article › Research › peer-review

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