John Robert Couchman

John Robert Couchman

Professor emeritus


  1. 2009
  2. Published

    Syndecan proteoglycan contributions to cytoskeletal organization and contractility

    Okina, E., Manon-Jensen, Tina, Whiteford, J. R. & Couchman, John Robert, 2009, In : Scandinavian Journal of Medicine & Science in Sports Online.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Syndecan signaling: when, where and why?

    Multhaupt, Hinke Arnolda B V H, Yoneda, A., Whiteford, J. R., Oh, E., Lee, W. & Couchman, John Robert, 2009, In : Journal of Physiology and Pharmacology. 60 Suppl 4, p. 31-8 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Syndecans as receptors and organizers of the extracellular matrix

    Xian, X., Gopal, S. & Couchman, John Robert, 2009, In : Cell and Tissue Research.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. 2008
  6. Published

    Cellular responses to the HEPII domain of fibronectin require N-sulphation of cell-surface heparan sulphate proteoglycan

    Mahalingam, Y., Gallagher, J. T. & Couchman, John Robert, 2008, In : International Journal of Experimental Pathology. 89, 3

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Cellular roles of ADAM12 in health and disease.

    Kveiborg, Marie, Albrechtsen, Reidar, Couchman, John Robert & Wewer, Ulla M., 2008, In : International Journal of Biochemistry & Cell Biology. 40, 9, p. 1685-702 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Commercial Antibodies: The Good, Bad, and Really Ugly.

    Couchman, John Robert, 2008, In : Journal of Histochemistry and Cytochemistry.

    Research output: Contribution to journalComment/debateResearch

  9. Published

    Heparan sulfate regulates ADAM12 through a molecular switch mechanism.

    Sørensen, H. P., Vives, R. R., Manetopoulos, C., Albrechtsen, Reidar, Lydolph, M. C., Jacobsen, J., Couchman, John Robert & Wewer, Ulla M., 2008, In : Journal of Biological Chemistry.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Heparan sulfate regulates fibrillin-1 N- and C-terminal interactions.

    Cain, S. A., Baldwin, A. K., Mahalingam, Y., Raynal, B., Jowitt, T. A., Shuttleworth, C. A., Couchman, John Robert & Kielty, C. M., 2008, In : Journal of Biological Chemistry. 283, 40, p. 27017-27 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Structural and cell adhesion properties of zebrafish syndecan-4 are shared with higher vertebrates.

    Whiteford, J., Ko, S., Lee, W. & Couchman, John Robert, 2008, In : Journal of Biological Chemistry. 283, 43, p. 29322-30 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    The CMV early enhancer/chicken beta actin (CAG) promoter can be used to drive transgene expression during the differentiation of murine embryonic stem cells into vascular progenitors.

    Alexopoulou, A. N., Couchman, John Robert & Whiteford, J., 2008, In : BMC Cell Biology. 9, p. 2

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. 2007
  14. Published

    A rat monoclonal antibody that recognizes pro- and active MMP-7 indicates polarized expression in vivo.

    Fingleton, B., Powell, W. C., Crawford, H. C., Couchman, John Robert & Matrisian, L. M., 2007, In : Hybridoma: a journal of molecular immunology and experimental and clinical immunotherapy. 26, 1, p. 22-7 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Cell adhesion to fibrillin-1: identification of an Arg-Gly-Asp-dependent synergy region and a heparin-binding site that regulates focal adhesion formation.

    Bax, D. V., Mahalingam, Y., Cain, S., Mellody, K., Freeman, L., Younger, K., Shuttleworth, C. A., Humphries, M. J., Couchman, John Robert & Kielty, C. M., 2007, In : Journal of Cell Science. 120, Pt 8, p. 1383-92 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Syndecans in wound healing, inflammation and vascular biology

    Alexopoulou, A. N., Multhaupt, Hinke Arnolda B V H & Couchman, John Robert, 2007, In : International Journal of Biochemistry & Cell Biology. 39, 3, p. 505-528 23 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Syndecans promote integrin-mediated adhesion of mesenchymal cells in two distinct pathways.

    Whiteford, J., Behrends, V., Kirby, H., Kusche-Gullberg, M., Muramatsu, T. & Couchman, John Robert, 2007, In : Experimental Cell Research. 313, 18, p. 3902-13 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. 2006
  19. Published

    A conserved NXIP motif is required for cell adhesion properties of the syndecan-4 ectodomain.

    Whiteford, J. R. & Couchman, John Robert, 2006, In : Journal of Biological Chemistry. 281, 43, p. 32156-63 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Cellular adhesion responses to the heparin-binding (HepII) domain of fibronectin require heparan sulfate with specific properties.

    Mahalingam, Y., Gallagher, J. T. & Couchman, John Robert, 2006, In : Journal of Biological Chemistry. 282, 5, p. 3221-30 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Fibronectin matrix assembly requires distinct contributions from Rho kinases I and -II.

    Yoneda, A., Ushakov, D., Multhaupt, Hinke Arnolda B V H & Couchman, John Robert, 2006, In : Molecular Biology of the Cell. 18, 1, p. 66-75 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    PKCbeta-dependent activation of RhoA by syndecan-4 during focal adhesion formation.

    Dovas, A., Yoneda, A. & Couchman, John Robert, 2006, In : Journal of Cell Science. 119, Pt 13, p. 2837-46 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. 2005
  24. Published

    Hierarchy of ADAM12 binding to integrins in tumor cells.

    Thodeti, C. K., Fröhlich, C., Nielsen, C. K., Holck, P., Sundberg, C., Kveiborg, Marie, Mahalingam, Y., Albrechtsen, Reidar, Couchman, John Robert & Wewer, Ulla M., 2005, In : Experimental Cell Research. 309, 2, p. 438-50 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Palmitoylation at Cys574 is essential for MT1-MMP to promote cell migration.

    Anilkumar, N., Uekita, T., Couchman, John Robert, Nagase, H., Seiki, M. & Itoh, Y., 2005, In : The FASEB Journal. 19, 10, p. 1326-8 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    RhoGDI: multiple functions in the regulation of Rho family GTPase activities.

    Dovas, A. & Couchman, John Robert, 2005, In : Biochemical Journal. 390, Pt 1, p. 1-9 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Structural basis of syndecan-4 phosphorylation as a molecular switch to regulate signaling.

    Koo, B., Jung, Y. S., Shin, J., Han, I., Mortier, E., Zimmermann, P., Whiteford, J. R., Couchman, John Robert, Oh, E. & Lee, W., 2005, In : Journal of Molecular Biology. 355, 4, p. 651-63 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    The Rho kinases I and II regulate different aspects of myosin II activity.

    Yoneda, A., Multhaupt, Hinke Arnolda B V H & Couchman, John Robert, 2005, In : Journal of Cell Biology. 170, 3, p. 443-53 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. 2004
  30. Published

    Essential contribution of tumor-derived perlecan to epidermal tumor growth and angiogenesis.

    Jiang, X., Multhaupt, Hinke Arnolda B V H, Chan, E., Schaefer, L., Schaefer, R. M. & Couchman, John Robert, 2004, In : Journal of Histochemistry and Cytochemistry. 52, 12, p. 1575-90 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Fibroblast invasive migration into fibronectin/fibrin gels requires a previously uncharacterized dermatan sulfate-CD44 proteoglycan.

    Clark, R. A. F., Lin, F., Greiling, D., An, J. & Couchman, John Robert, 2004, In : Journal of Investigative Dermatology. 122, 2, p. 266-77 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Syndecans-2 and -4; close cousins, but not identical twins.

    Oh, E. & Couchman, John Robert, 2004, In : Molecules and Cells. 17, 2, p. 181-7 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. 2003
  34. Published

    Direct binding of syndecan-4 cytoplasmic domain to the catalytic domain of protein kinase C alpha (PKC alpha) increases focal adhesion localization of PKC alpha.

    Lim, S., Longley, R. L., Couchman, John Robert & Woods, A., 2003, In : Journal of Biological Chemistry. 278, 16, p. 13795-802 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Nondébridement of laser char after two carbon dioxide laser passes results in faster reepithelialization.

    Collawn, S. S., Woods, A. & Couchman, John Robert, 2003, In : Plastic and Reconstructive Surgery. 111, 5, p. 1742-50 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Perlecan and tumor angiogenesis.

    Jiang, X. & Couchman, John Robert, 2003, In : Journal of Histochemistry and Cytochemistry. 51, 11, p. 1393-410 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Regulation of cytoskeletal organization by syndecan transmembrane proteoglycans.

    Yoneda, A. & Couchman, John Robert, 2003, In : Matrix Biology. 22, 1, p. 25-33 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Syndecans: proteoglycan regulators of cell-surface microdomains?

    Couchman, John Robert, 2003, In : Nature Reviews. Molecular Cell Biology. 4, 12, p. 926-37 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. 2002
  40. Published

    ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA.

    Thodeti, C. K., Albrechtsen, Reidar, Grauslund, M., Asmar, M., Larsson, C., Takada, Y., Mercurio, A. M., Couchman, John Robert & Wewer, Ulla M., 2002, In : Journal of Biological Chemistry. 278, 11, p. 9576-84 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Localization of the transmembrane proteoglycan syndecan-4 and its regulatory kinases in costameres of rat cardiomyocytes: a deconvolution microscopic study.

    VanWinkle, W. B., Snuggs, M. B., De Hostos, E. L., Buja, L. M., Woods, A. & Couchman, John Robert, 2002, In : Anatomical Record. 268, 1, p. 38-46 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Molecular characterization of chicken syndecan-2 proteoglycan.

    Chen, L., Couchman, John Robert, Smith, J. & Woods, A., 2002, In : Biochemical Journal. 366, Pt 2, p. 481-90 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Regulation of inositol phospholipid binding and signaling through syndecan-4.

    Couchman, John Robert, Vogt, S., Lim, S., Lim, Y., Oh, E., Prestwich, G. D., Theibert, A., Lee, W. & Woods, A., 2002, In : Journal of Biological Chemistry. 277, 51, p. 49296-303 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Syndecan-4 associates with alpha-actinin.

    Greene, D. K., Tumova, S., Couchman, John Robert & Woods, A., 2002, In : Journal of Biological Chemistry. 278, 9, p. 7617-23 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. 2001
  46. Published

    Basement membrane and interstitial proteoglycans produced by MDCK cells correspond to those expressed in the kidney cortex.

    Erickson, A. C. & Couchman, John Robert, 2001, In : Matrix Biology. 19, 8, p. 769-78 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Detection of proteoglycan core proteins with glycosaminoglycan lyases and antibodies.

    Couchman, John Robert & Tapanadechopone, P., 2001, In : Methods in Molecular Biology. 171, p. 329-33 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    EphB/syndecan-2 signaling in dendritic spine morphogenesis.

    Ethell, I. M., Irie, F., Kalo, M. S., Couchman, John Robert, Pasquale, E. B. & Yamaguchi, Y., 2001, In : Neuron. 31, 6, p. 1001-13 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Epidermal transformation leads to increased perlecan synthesis with heparin-binding-growth-factor affinity.

    Tapanadechopone, P., Tumova, S., Jiang, X. & Couchman, John Robert, 2001, In : Biochemical Journal. 355, Pt 2, p. 517-27 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Proteoglycan isolation and analysis.

    Woods, A. & Couchman, John Robert, 2001, In : Current Protocols in Cell Biology. Chapter 10, p. Unit 10.7

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Rat embryo fibroblasts require both the cell-binding and the heparin-binding domains of fibronectin for survival.

    Jeong, J., Han, I., Lim, Y., Kim, J., Park, I., Woods, A., Couchman, John Robert & Oh, E. S., 2001, In : Biochemical Journal. 356, Pt 2, p. 531-7 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Solution structure of the dimeric cytoplasmic domain of syndecan-4.

    Shin, J., Lee, W., Lee, D., Koo, B. K., Han, I., Lim, Y., Woods, A., Couchman, John Robert & Oh, E. S., 2001, In : Biochemistry. 40, 29, p. 8471-8 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Syndecan-4 and focal adhesion function.

    Woods, A. & Couchman, John Robert, 2001, In : Current Opinion in Cell Biology. 13, 5, p. 578-83 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    Syndecan-4 up-regulation in proliferative renal disease is related to microfilament organization.

    Yung, S., Woods, A., Chan, T. M., Davies, M., Williams, J. D. & Couchman, John Robert, 2001, In : The FASEB Journal. 15, 9, p. 1631-3 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    Syndecans and cell adhesion.

    Couchman, John Robert, Chen, L. & Woods, A., 2001, In : International Review of Cytology. 207, p. 113-50 37 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. 2000
  57. Published

    Control of extracellular matrix assembly by syndecan-2 proteoglycan.

    Klass, C. M., Couchman, John Robert & Woods, A., 2000, In : Journal of Cell Science. 113 ( Pt 3), p. 493-506 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. Published

    Heparan sulfate chains from glypican and syndecans bind the Hep II domain of fibronectin similarly despite minor structural differences.

    Tumova, S., Woods, A. & Couchman, John Robert, 2000, In : Journal of Biological Chemistry. 275, 13, p. 9410-7 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. Published

    Heparan sulfate proteoglycans on the cell surface: versatile coordinators of cellular functions.

    Tumova, S., Woods, A. & Couchman, John Robert, 2000, In : International Journal of Biochemistry & Cell Biology. 32, 3, p. 269-88 19 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  60. Published

    Integrin modulation by lateral association.

    Woods, A. & Couchman, John Robert, 2000, In : Journal of Biological Chemistry. 275, 32, p. 24233-6 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 916617