Jens Lykkesfeldt

Jens Lykkesfeldt

Professor

Member of:

  • Lifepharm

ORCID: 0000-0002-6514-8407

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  1. Published

    Inner histopathologic changes and disproportionate zone volumes in foetal growth plates following gestational hypoglycaemia in rats

    Jensen, Vivi Flou Hjorth, Mølck, A., Bøgh, I. B., Nowak, J., Viuff, B. M., Rasmussen, C. L. M., Voetmann, Louise Marie, Fels, J. J., Madsen, S. H., McGuigan, F. E., Tveden-Nyborg, Pernille, Lykkesfeldt, Jens & Akesson, K. E., 2020, In: Scientific Reports. 10, 1, 13 p., 5609.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Toxicological Effects during and following Persistent Insulin-Induced Hypoglycaemia in Healthy Euglycaemic Rats

    Jensen, Vivi Flou Hjorth, Molck, A., Berthelsen, L. O., Alifrangis, L., Andersen, L., Chapman, M., Lykkesfeldt, Jens & Bogh, I. B., Jul 2017, In: Basic & Clinical Pharmacology & Toxicology. 121, 1, p. 53-66

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Chronic Hyperinsulinaemic Hypoglycaemia in Rats Is Accompanied by Increased Body Weight, Hyperleptinaemia, and Decreased Neuronal Glucose Transporter Levels in the Brain

    Jensen, Vivi Flou Hjorth, Molck, A., Chapman, M., Alifrangis, L., Andersen, L., Lykkesfeldt, Jens & Bogh, I. B., 2017, In: International Journal of Endocrinology. 2017, 14 p., 7861236.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Proximal Neuropathy and Associated Skeletal Muscle Changes Resembling Denervation Atrophy in Hindlimbs of Chronic Hypoglycaemic Rats

    Jensen, Vivi Flou Hjorth, Molck, A. M., Soeborg, H., Nowak, J., Chapman, M., Lykkesfeldt, Jens & Bogh, I. B., Jan 2018, In: Basic & Clinical Pharmacology & Toxicology. 122, 1, p. 165-175

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Effect of maternal hypoglycaemia during gestation on materno-foetal nutrient transfer and embryo-foetal development: Evidence from experimental studies focused primarily on the rat

    Jensen, Vivi Flou Hjorth, Mølck, A. M., Lykkesfeldt, Jens & Bøgh, I. B., Apr 2018, In: Reproductive Toxicology. 77, p. 1-24 24 p.

    Research output: Contribution to journal › Review › Research › peer-review

  6. Published

    Prolonged insulin-induced hypoglycaemia reduces ß-cell activity rather than number in pancreatic islets in non-diabetic rats

    Jensen, Vivi Flou Hjorth, Mølck, A. M., Nowak, J., Fels, J. J., Lykkesfeldt, Jens & Bøgh, I. B., 2022, In: Scientific Reports. 12, 14113.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Effect of insulin-induced hypoglycaemia on the peripheral nervous system: focus on adaptive mechanisms, pathogenesis and histopathological changes

    Jensen, Vivi Flou Hjorth, Mølck, A., Bøgh, I. B. & Lykkesfeldt, Jens, 2014, In: Journal of Neuroendocrinology. 26, 8, p. 482-496 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Importance of gestational hypoglycaemia for foetal malformations and skeletal development in rats

    Jensen, Vivi Flou Hjorth, Mølck, A. M., Lykkesfeldt, Jens, Fels, J. J., Andersen, L., Renaut, R., McGuigan, F., Åkesson, K. E. & Bøgh, I. B., 2020, In: Reproductive Toxicology. 91, p. 14-26 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Effect of insulin-induced hypoglycaemia on the central nervous system: evidence from experimental studies

    Jensen, Vivi Flou Hjorth, Bøgh, I. B. & Lykkesfeldt, Jens, 2014, In: Journal of Neuroendocrinology. 26, 3, p. 123-150 28 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Histopathological nerve and skeletal muscle changes in rats subjected to persistent insulin-induced hypoglycemia

    Jensen, Vivi Flou Hjorth, Mølck, A., Heydenreich, A., Jensen, K. J., Bertelsen, L. O., Alifrangis, L., Andersen, L., Søeborg, H., Chapman, M., Lykkesfeldt, Jens & Bøgh, I. B., Jan 2016, In: Toxicologic Pathology. 29, 1, p. 17-30 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Assessment of implantable infusion pumps for continuous infusion of human insulin in rats: potential for group housing

    Jensen, Vivi Flou Hjorth, Molck, A., Martensson, M., Strid, M. A., Chapman, M., Lykkesfeldt, Jens & Bogh, I. B., 2017, In: Laboratory Animals. 51, 3, p. 273-283

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Gamma-tocopherol supplementation inhibits protein nitration and ascorbate oxidation in rats with inflammation

    Jiang, Q., Lykkesfeldt, Jens, Shigenaga, M. K., Shigeno, E. T., Christen, S. & Ames, B. N., 2002, In: Free Radical Biology & Medicine. 33, 11, p. 1534-1542 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Oxidative costs of reproduction in mouse strains selected for different levels of food intake and which differ in reproductive performance

    Jothery, A. H. A., Vaanholt, L. M., Mody, N., Arnous, A., Lykkesfeldt, Jens, Bunger, L., Hill, W. G., Mitchell, S. E., Allison, D. B. & Speakman, J. R., 14 Nov 2016, In: Scientific Reports. 6, 12 p., 36353 .

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Is Diabetes Associated with Lower Vitamin C Status in Pregnant Women? A Prospective Study

    Juhl, B., Lauszus, F. F. & Lykkesfeldt, Jens, Oct 2016, In: International Journal for Vitamin and Nutrition Research. 86, 5-6, p. 184-189

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Poor vitamin C status late in pregnancy is associated with increased risk of complications in type 1 diabetic women: A cross-sectional study

    Juhl, B., Lauszus, F. F. & Lykkesfeldt, Jens, 2017, In: Nutrients. 9, 3, 9 p., 186.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Glycemic control during pregnancy — A predictor of vitamin C status at labor in type 1 diabeticwomen?

    Juhl, B., Lauszus, F. F. & Lykkesfeldt, Jens, 2019, In: Antioxidants. 8, 6, 153.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Asymmetric dimethylarginine in somatically healthy schizophrenia patients treated with atypical antipsychotics: a case-control study

    Jørgensen, Anders, Knorr, Ulla Benedichte Søsted, Soendergaard, M. G., Lykkesfeldt, Jens, Fink-Jensen, Anders, Poulsen, Henrik Enghusen, Jørgensen, Martin Balslev, Olsen, N. V. & Staalsø, J. M., 2015, In: B M C Psychiatry. 15, 8 p., 67.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Increased systemic oxidatively generated DNA and RNA damage in schizophrenia

    Jørgensen, A., Brødbæk, K., Fink-Jensen, Anders, Knorr, U., Greisen Søndergaard, M., Henriksen, T., Weimann, A., Jepsen, P., Lykkesfeldt, Jens, Poulsen, Henrik Enghusen & Jørgensen, Martin Balslev, 2013, In: Psychiatry Research. 209, 3, p. 417–423 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Dietary Intervention Accelerates NASH Resolution Depending on Inflammatory Status with Minor Additive Effects on Hepatic Injury by Vitamin E Supplementation

    Klaebel, J. H., Rakipovski, G., Andersen, B., Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2020, In: Antioxidants. 9, 9, 808.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Atorvastatin and vitamin e accelerates NASH resolution by dietary intervention in a preclinical guinea pig model

    Klaebel, J. H., Skjødt, M., Skat-Rørdam, Josephine, Rakipovski, G., Ipsen, David Højland, Schou-Pedersen, A. M. V., Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2019, In: Nutrients. 11, 11, 20 p., 2834.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Efficacy of fibroblast growth factor 21 in non-alcoholic fatty liver disease in guinea pigs

    Klaebel, J. H., Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2022, In: Basic & Clinical Pharmacology & Toxicology. 130, 3, p. 385-393

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Differential toxicological response to positively and negatively charged nanoparticles in the rat brain

    Knudsen, K. B., Northeved, H., Ek, P. K., Permin, A., Andresen, T. L., Larsen, S., Wegener, K. M., Lam, H. R. & Lykkesfeldt, Jens, 2014, In: Nanotoxicology. 8, 7, p. 764-774 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Biodistribution of rhodamine B fluorescence-labeled cationic nanoparticles in rats

    Knudsen, K. B., Northeved, H., Gjetting, T., Permin, A., Andresen, T. L., Wegener, K. M., Rye Lam, H. & Lykkesfeldt, Jens, 2014, In: Journal of Nanoparticle Research. 16, 1, 11 p., 2221.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    In vivo toxicity of cationic micelles and liposomes

    Knudsen, K. B., Northeved, H., Kumar Ek, P., Permin, A., Gjetting, T., Andresen, T. L., Larsen, S., Wegener, K. M., Lykkesfeldt, Jens, Jantzen, K., Loft, Steffen, Møller, Peter & Roursgaard, Martin, 25 Feb 2015, In: Nanomedicine: Nanotechnology, Biology and Medicine. 11, 2, p. 467-477 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Expression of endothelin type B receptors (EDNRB) on smooth muscle cells is controlled by ternary complex factors and the actin cytoskeleton

    Krawczyk, K. K., Skovsted, Gry Freja, Perisic, L., Rippe, C., Dreier, R., Berg, J. O., Lykkesfeldt, Jens, Hedin, U. & Sward, K., Apr 2018.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  26. Published

    No effect of melatonin on oxidative stress after laparoscopic cholecystectomy: a randomized placebo-controlled trial

    Kücükakin, B., Klein, M., Lykkesfeldt, Jens, Reiter, R. J., Rosenberg, J. & Gögenür, I., 2010, In: Acta Anaesthesiologica Scandinavica. 54, 9, p. 1121-1127 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    No effect of melatonin to modify surgical-stress response after major vascular surgery: a randomised placebo-controlled trial

    Kücükakin, B., Wilhelmsen, M., Lykkesfeldt, Jens, Reiter, R. J., Rosenberg, J. & Gögenur, I., 2010, In: European Journal of Vascular and Endovascular Surgery. 40, 4, p. 461-467 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Storage-induced increase in biomarkers of oxidative stress and inflammation in red blood cell components

    Kücükakin, B., Kocak, V., Lykkesfeldt, Jens, Nielsen, H. J., Magnussen, K., Rosenberg, Jacob & Gögenür, I., 2011, In: Scandinavian Journal of Clinical & Laboratory Investigation. 71, 4, p. 299-303 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Utility of melatonin to treat surgical stress after major vascular surgery - a safety study

    Kücükakin, B., Lykkesfeldt, Jens, Nielsen, H. J., Reiter, R. J., Rosenberg, Jacob & Gögenur, Ismail, 2008, In: Journal of Pineal Research. 44, 4, p. 426-431 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Effects of two- and twelve-weeks sodium-glucose cotransporter 2 inhibition on DNA and RNA oxidation: two randomized, placebo-controlled trials

    Larsen, E. L., Andersen, A., Kjær, L. K., Eickhoff, M. K., Frimodt-Møller, M., Persson, F., Rossing, Peter, Lykkesfeldt, Jens, Knop, Filip Krag, Vilsbøll, Tina, Rungby, Jørgen & Poulsen, Henrik Enghusen, 2023, In: Free Radical Research. 57, 2, p. 140-151

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Clarithromycin, trimethoprim, and penicillin and oxidative nucleic acid modifications in humans: randomised, controlled trials

    Larsen, E. L., Cejvanovic, V., Kjær, L. K., Pedersen, M. T., Popik, S. D., Hansen, L. K., Andersen, Jon Thor Trærup, Solem, Espen Victor Jimenez, Broedbaek, K., Petersen, M., Weimann, A., Henriksen, T., Lykkesfeldt, Jens, Torp-Pedersen, C. & Poulsen, Henrik Enghusen, Aug 2017, In: British Journal of Clinical Pharmacology. 83, 8, p. 1643-1653

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Effect of High Inspiratory Oxygen Fraction on Endothelial Dysfunction in Healthy Volunteers: A Randomized Controlled Cross-over Pilot Study

    Larsen, M. H. H., Ekeløf, S., Kokotovic, D., Schou-Pedersen, A. M. V., Lykkesfeldt, Jens & Gögenur, I., 2017, In: Anesthesia and Analgesia. 125, 5, p. 1793–1796

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Biochemical markers as indicators of the efficiency of antibiotic treatment of Actinobacillus pleuropneumoniae infection in pigs

    Lauritsen, B., Lykkesfeldt, Jens, Angen, Ø. & Friis, C., 2000. 1 p.

    Research output: Contribution to conference › Paper › Research

  34. Published

    Evaluation of a single dose versus a divided dose regimen of danofloxacin in treatment of Actinobacillus pleuropneumoniae infection in pigs

    Lauritzen, B., Lykkesfeldt, Jens & Friis, C., 2003, In: Research in Veterinary Science. 74, 3, p. 271-277 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Putative biomarkers for evaluating antibiotic treatment: an experimental model of porcine Actinobacillus pleuropneumoniae infection

    Lauritzen, B., Lykkesfeldt, Jens, Skaanild, M. T., Angen, Ø., Nielsen, Jens Peter & Friis, C., 2003, In: Research in Veterinary Science. 74, 3, p. 261-270 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Evaluation of a single dose and a split-dose regimen of danofloxacin against Actinobacillus pleuropneumoniae infection in pigs

    Lauritzen, B., Lykkesfeldt, Jens & Friis, C., 2002.

    Research output: Contribution to conference › Paper › Research

  37. Published

    Evaluation of a single dose versus a divided dose regimen of amoxycillin in treatment of Actinobacillus pleuropneumoniae infection in pigs

    Lauritzen, B., Lykkesfeldt, Jens & Friis, C., 2005, In: Research in Veterinary Science. 79, 1, p. 61-67 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Biomarkers in evaluation of antibiotic treatment: an experimental model of porcine Actinobacillus pleuropneumoniae infection

    Lauritzen, B., Lykkesfeldt, Jens, Angen, Ø., Nielsen, Jens Peter & Friis, C., 2002.

    Research output: Contribution to conference › Paper › Research

  39. Published

    Effects of heparin-binding protein (CAP37/azurocidin) in a porcine model of Actinobacillus pleuropneumoniae-induced pneumonia

    Lauritzen, B., Lykkesfeldt, Jens, Djurup, R., Flodgaard, H. & Svendsen, O., 2005, In: Pharmacological Research. 51, 6, p. 509-514 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Pasteurization Procedures for Donor Human Milk Affect Body Growth, Intestinal Structure, and Resistance against Bacterial Infections in Preterm Pigs

    Li, Y., Nguyen, Duc Ninh, de Waard, M., Christensen, Lars, Zhou, P., Jiang, Pingping, Sun, Jing, Bojesen, Anders Miki, Lauridsen, C., Lykkesfeldt, Jens, Dalsgaard, T. K., Bering, S. B. & Sangild, Per Torp, Jun 2017, In: Journal of Nutrition. 147, 6, p. 1121-1130

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Regulation of vitamin C homeostasis during deficiency

    Lindblad, M. M., Tveden-Nyborg, Pernille & Lykkesfeldt, Jens, 2013, In: Nutrients. 5, 8, p. 2860-2879 20 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. E-pub ahead of print

    Validation of computed tomography as a diagnostic tool in guinea pigs with non-alcoholic fatty liver disease

    Lintrup, K., Ipsen, David Højland, Skat-Rørdam, Josephine, Lykkesfeldt, Jens, Tveden-Nyborg, Pernille & Buelund, Lene Elisabeth, 2024, (E-pub ahead of print) In: Laboratory Animals.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Göttingen minipig model of diet-induced atherosclerosis: influence of mild streptozotocin-induced diabetes on lesion severity and markers of inflammation evaluated in obese, obese and diabetic, and lean control animals

    Ludvigsen, Trine Pagh, Kirk, R. K., Christoffersen, B. Ø., Pedersen, H. D., Martinussen, Torben, Kildegaard, J., Heegaard, P. M. H., Lykkesfeldt, Jens & Olsen, Lisbeth Høier, 2015, In: Journal of Translational Medicine. 13, 12 p., 312.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Morphine concentration in plasma andcerebrospinal fluid in the anaesthetised pig after a single intravenous administration

    Lykkegaard, K., Lykkesfeldt, Jens & Svendsen, O., 2000. 1 p.

    Research output: Contribution to conference › Paper › Research

  45. Published

    Morphine reduces spinal c-fos expression dose-dependently during experimental laparotomy in pigs: a combined pharmacokinetic and surgical study

    Lykkegaard, K., Lykkesfeldt, Jens, Lauritzen, B. & Svendsen, O., 2008, In: Research in Veterinary Science. 84, 3, p. 457-464 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Effect of smoking cessation on plasma ascorbic acid concentration

    Lykkesfeldt, Jens, Priemé, H., Loft, Steffen & Poulsen, Henrik Enghusen, 13 Jul 1996, In: B M J (Clinical Research Edition). 313, 7049, p. 91

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Determination of ascorbic acid and dehydroascorbic acid in biological samples by high-performance liquid chromatography using subtraction methods: reliable reduction with tris[2-carboxyethyl]phosphine hydrochloride

    Lykkesfeldt, Jens, 2000, In: Analytical Biochemistry. 282, p. 89-93 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Ascorbate is depleted by smoking and repleted by moderate supplementation: a study in male smokers and nonsmokers with matched dietary antioxidant intakes

    Lykkesfeldt, Jens, Christen, S., Wallock, L. M., Chang, H. H., Jacob, R. A. & Ames, B. N., 2000, In: American Journal of Clinical Nutrition. 71, p. 530-6 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Nitrosamindannende håndkøbspraeparater?

    Lykkesfeldt, Jens & Poulsen, Henrik Enghusen, 13 Dec 1993, In: Ugeskrift for Laeger. 155, 50, p. 4106-4107 2 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  50. Published

    Age-associated decline in ascorbic acid concentration, recycling, and biosynthesis in rat hepatocytes: reversal with (R)-alfa-lipoic acid supplementation

    Lykkesfeldt, Jens, Hagen, T. M., Vinarsky, V. & Ames, B. N., 1998, In: The FASEB Journal. 12, p. 1183-1189 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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ID: 4231856