Jens Bukh

Jens Bukh

Professor

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    ORCID: 0000-0002-7815-4806

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    1. Published

      In vitro Characterization of Fitness and Convalescent Antibody Neutralization of SARS-CoV-2 Cluster 5 Variant Emerging in Mink at Danish Farms

      Lassaunière, R., Fonager, J., Rasmussen, M., Frische, A., Polacek, C., Rasmussen, T. B., Lohse, L., Belsham, Graham John, Underwood, Alexander Paul James, Winckelmann, A. A., Bollerup, S., Bukh, Jens, Weis, Nina, Sækmose, S. G., Aagaard, B., Alfaro-Núñez, A., Mølbak, Kåre, Bøtner, A. & Fomsgaard, A., 2021, In: Frontiers in Microbiology. 12, 9 p., 698944.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      In vitro adaptation and characterization of attenuated hypervariable region 1 swap chimeras of hepatitis C virus

      Olesen, C. H., Augestad, Elias Honerød, Troise, F., Bukh, Jens & Prentø, Jannick, 2021, In: PLOS Pathogens. 17, July, 29 p., e1009720.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      A comprehensive system for consistent numbering of HCV sequences, proteins and epitopes.

      Kuiken, C., Combet, C., Bukh, Jens, Shin-I, T., Deleage, G., Mizokami, M., Richardson, R., Sablon, E., Yusim, K., Pawlotsky, J., Simmonds, P. & Los Alamos HIV Database Group, L. A. H. D. G., 2006, In: Hepatology. 44, 5, p. 1355-61 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      A distinct dexamethasone-dependent gene expression profile in the lungs of COVID-19 patients

      Fahnøe, Ulrik, Ronit, A., Berg, Ronan Martin Griffin, Jørgensen, S. E., Mogensen, T. H., Underwood, Alexander Paul James, Scheel, Troels Kasper Høyer, Bukh, Jens & Plovsing, R. R., 2022, In: The Journal of Infectious Diseases. 226, 12, p. 2137–2141

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      A hepatitis C virus (HCV) vaccine comprising envelope glycoproteins gpE1/gpE2 derived from a single isolate elicits broad cross-genotype neutralizing antibodies in humans

      Law, J. L. M., Chen, C., Wong, J., Hockman, D., Santer, D. M., Frey, S. E., Belshe, R. B., Wakita, T., Bukh, Jens, Jones, C. T., Rice, C. M., Abrignani, S., Tyrrell, D. L. & Houghton, M., 2013, In: PloS one. 8, 3, p. 1-7 8 p., e59776.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      A milestone for hepatitis C virus research: a virus generated in cell culture is fully viable in vivo.

      Bukh, Jens & Purcell, R. H., 2006, In: Proceedings of the National Academy of Sciences of the United States of America. 103, 10, p. 3500-1 2 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      A near full-length open reading frame next generation sequencing assay for genotyping and identification of resistance-associated variants in hepatitis C virus

      Pedersen, M. S., Fahnøe, Ulrik, Hansen, T. A., Pedersen, A. G., Jenssen, H., Bukh, Jens & Schønning, Kristian, 2018, In: Journal of Clinical Virology. 105, p. 49-56 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Adapted J6/JFH1-based Hepatitis C virus recombinants with genotype-specific NS4A show similar efficacies against lead protease inhibitors, alpha interferon, and a putative NS4A inhibitor

      Gottwein, Judith Margarete, Jensen, S. B., Serre, S. B. N., Ghanem, L., Scheel, Troels Kasper Høyer, Jensen, T. B., Krarup, H., Uzcategui, N., Mikkelsen, L. S. & Bukh, Jens, Dec 2013, In: Antimicrobial Agents and Chemotherapy. 57, 12, p. 6034-49 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Adaptive Mutations Enhance Assembly and Cell-to-Cell Transmission of a High-Titer Hepatitis C Virus Genotype 5a Core-NS2 JFH1-Based Recombinant

      Mathiesen, C. K., Prentø, Jannick, Meredith, L. W., Jensen, T. B., Krarup, H., McKeating, J. A., Gottwein, Judith Margarete & Bukh, Jens, Aug 2015, In: Journal of Virology. 89, 15, p. 7758-7775 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Adaptive mutations allow establishment of JFH1-based cell culture systems for hepatitis C virus genotype 4A: Patent #: 8,454,974

      Scheel, T. K. H., Gottwein, Judith Margarete, Eugen-Olsen, J. & Bukh, Jens, 4 Jun 2013, IPC No. A61K 39/29 (20060101); C07H 21/00 (20060101); C12N 15/06 (20060101); C12N 7/02 (20060101); C12Q 1/02 (20060101), Patent No. WO2008/125119, 23 Oct 2008, Priority date 11 Apr 2008, Priority No. PCT/DK2008/050085

      Research output: Patent

    11. Published

      Advantages of a single-cycle production assay to study cell culture-adaptive mutations of hepatitis C virus

      Russell, R. S., Meunier, J., Takikawa, S., Faulk, K., Engle, R. E., Bukh, Jens, Purcell, R. H. & Emerson, S. U., 18 Mar 2008, In: PNAS Early Edition. 105, 11, p. 4370-5 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      An alternate conformation of HCV E2 neutralizing face as an additional vaccine target

      Tzarum, N., Giang, E., Kadam, R. U., Chen, F., Nagy, K., Augestad, E. H., Velázquez-Moctezuma, R., Keck, Z. Y., Hua, Y., Stanfield, R. L., Dreux, M., Prentø, Jannick, Foung, S. K. H., Bukh, Jens, Wilson, I. A. & Law, M., 2020, In: Science Advances. 6, 30, abb5642.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      An inactivated SARS-CoV-2 vaccine induced cross-neutralizing persisting antibodies and protected against challenge in small animals

      Offersgaard, Anna Falden, Duarte Hernandez, Carlos Rene, Feng, S., Marichal-Gallardo, P., Holmbeck, Kenn, Pihl, A. F., Fernandez-Antunez, C., Alzua, G. P., Hartmann, Katrine Top, Pham, Long, Zhou, Y., Gammeltoft, Karen Anbro, Fahnøe, Ulrik, Schneider, Uffe Vest, Pedersen, Gabriel Kristian, Jensen, Henrik Elvang, Christensen, Jan Pravsgaard, Ramirez Almeida, Santseharay, Bukh, Jens & Gottwein, Judith Margarete, 2023, In: iScience. 26, 2, 105949.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Analysis of Neutralization Titers against SARS-CoV-2 in Health-Care Workers Vaccinated with Prime-Boost mRNA–mRNA or Vector–mRNA COVID-19 Vaccines

      Sølund, C., Underwood, Alexander Paul James, Fernandez-Antunez, C., Bollerup, S., Mikkelsen, L. S., Villadsen, S. L., Fahnøe, Ulrik, Winckelmann, Anni Assing, Feng, S., Nørløv Vinten, C. A., Dalegaard, M. I., Vizgirda, G., Sørensen, A. L., Ramirez Almeida, Santseharay, Bukh, Jens & Weis, Nina, 2022, In: Vaccines. 10, 1, 75.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Analysis of functional differences between hepatitis C virus NS5A of genotypes 1-7 in infectious cell culture systems

      Scheel, Troels Kasper Høyer, Prentø, Jannick, Carlsen, T. H. R., Mikkelsen, L. S., Gottwein, Judith Margarete & Bukh, Jens, 2012, In: P L o S Pathogens. 8, 5, p. 1-16 17 p., e1002696.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Analysis of hepatitis C virus core/NS5A protein co-localization using novel cell culture systems expressing core-NS2 and NS5A of genotypes 1-7

      Galli, A., Scheel, Troels Kasper Høyer, Prentø, Jannick, Mikkelsen, L. S., Gottwein, Judith Margarete & Bukh, Jens, Oct 2013, In: The Journal of general virology. 94, Pt 10, p. 2221-35 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Analysis of virus population profiles within pigs infected with virulent Classical Swine Fever viruses; evidence for bottlenecks in transmission but absence of tissue specific virus variants

      Johnston, C. M., Fahnøe, Ulrik, Lohse, L., Bukh, Jens, Belsham, Graham John & Rasmussen, T. B., 2020, In: Journal of Virology. 94, 19, 20 p., e01119-20.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Animal models for the study of hepatitis C virus infection and related liver disease

      Bukh, Jens, May 2012, In: Gastroenterology. 142, 6, p. 1279-1287.e3 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Antibody Responses to Immunization With HCV Envelope Glycoproteins as a Baseline for B-Cell–Based Vaccine Development

      Chen, F., Nagy, K., Chavez, D., Willis, S., McBride, R., Giang, E., Honda, A., Bukh, Jens, Ordoukhanian, P., Zhu, J., Frey, S., Lanford, R. & Law, M., 2020, In: Gastroenterology. 158, 4, p. 1058-1071.e6

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Antigenic and immunogenic evaluation of permutations of soluble hepatitis C virus envelope protein E2 and E1 antigens

      Prentø, Jannick, Janitzek, C. M., Velázquez-Moctezuma, R., Goksøyr, L., Olsen, Rebecca Wendelboe, Fanalista, Margherita, Augestad, Elias Honerød, Thrane, Susan, Pihl, A. F., Gottwein, Judith Margarete, Sander, Adam F. & Bukh, Jens, 2021, In: PLoS ONE. 16, e0255336.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Antiviral Effect of Ribavirin against HCV Associated with Increased Frequency of G-to-A and C-to-U Transitions in Infectious Cell Culture Model

      Galli, Andrea, Mens, H., Gottwein, Judith Margarete, Gerstoft, Jan & Bukh, Jens, 2018, In: Scientific Reports. 8, 1, 13 p., 4619.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Applying antibody-sensitive hypervariable region 1-deleted hepatitis C virus to the study of escape pathways of neutralizing human monoclonal antibody AR5A

      Velazquez-Moctezuma, R., Law, M., Bukh, Jens & Prentø, Jannick, Feb 2017, In: PLOS Pathogens. 13, 2, 29 p., 1006214.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      At the Core of Depression: A Diagnostic Interview of the Core Features of Depression

      Bukh, Jens, Fabrazzo, M., Christensen, E. M., Mikkelsen, R. L., Larsen, J. K., Hageman, I., Bendsen, B. B., Bolwig, T., Vinberg, Maj, Bech, P., Dam, O. H., Maj, M. & Kessing, Lars Vedel, 11 Mar 2022, In: Psychopathology. 55, 3-4, p. 219–225 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Breadth of neutralization and synergy of clinically relevant human monoclonal antibodies against HCV genotypes 1a, 1b, 2a, 2b, 2c, and 3a

      Carlsen, T. H. R., Pedersen, J., Prentø, Jannick, Giang, E., Keck, Z., Mikkelsen, L. S., Law, M., Foung, S. K. H. & Bukh, Jens, Nov 2014, In: Hepatology. 60, 5, p. 1551-62 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Broadening CD4(+) and CD8(+) T Cell Responses against Hepatitis C Virus by Vaccination with NS3 Overlapping Peptide Panels in Cross-Priming Liposomes

      Filskov, J., Mikkelsen, M., Hansen, Paul Robert, Christensen, Jan Pravsgaard, Thomsen, Allan Randrup, Andersen, P., Bukh, Jens & Agger, E., Jul 2017, In: Journal of Virology. 91, 14, 18 p., e00130-17.

      Research output: Contribution to journal › Journal article › Research › peer-review

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    ID: 12437