Jens Bukh

Jens Bukh

Professor

Member of:

    ORCID: 0000-0002-7815-4806

    Publication year:
    All
    101 - 200 out of 209Page size: 100
    1. 2018
    2. Published

      Outcome and adverse events in patients with chronic hepatitis C treated with direct-acting antivirals: A clinical randomized study

      Sølund, C., cgl303, cgl303, Mössner, B., Laursen, A. L., Røge, B. T., Kjær, M. S., Gerstoft, Jan, Christensen, P. B., Pedersen, M. S., Schønning, Kristian, Fahnøe, Ulrik, Bukh, Jens & Weis, Nina, 2018, In: European Journal of Gastroenterology and Hepatology. 30, 10, p. 1177-1186 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. 2017
    4. Published

      Mouse models of acute and chronic hepacivirus infection

      Billerbeck, E., Wolfisberg, R., Fahnøe, Ulrik, Xiao, J. W., Quirk, C., Luna, J. M., Cullen, J. M., Hartlage, A. S., Chiriboga, L., Ghoshal, K., Lipkin, W. I., Bukh, Jens, Scheel, Troels Kasper Høyer, Kapoor, A. & Rice, C. M., 2017, In: Science. 357, 6347, p. 204-208 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Broadening CD4(+) and CD8(+) T Cell Responses against Hepatitis C Virus by Vaccination with NS3 Overlapping Peptide Panels in Cross-Priming Liposomes

      Filskov, J., Mikkelsen, M., Hansen, Paul Robert, Christensen, Jan Pravsgaard, Thomsen, Allan Randrup, Andersen, P., Bukh, Jens & Agger, E., Jul 2017, In: Journal of Virology. 91, 14, 18 p., e00130-17.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Efficient hepatitis c virus genotype 1b core-NS5A recombinants permit efficacy testing of protease and NS5A inhibitors

      Pham, Long, Ramirez Almeida, Santseharay, Carlsen, T. H. R., Li, Y., Gottwein, Judith Margarete & Bukh, Jens, 2017, In: Antimicrobial Agents and Chemotherapy. 61, 6, 19 p., e00037-17.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Proposed revision to the taxonomy of the genus Pestivirus, family Flaviviridae

      Smith, D. B., Meyers, G., Bukh, Jens, Gould, E. A., Monath, T., Muerhoff, A. S., Pletnev, A., Rico-Hesse, R., Stapleton, J. T., Simmonds, P. & Becher, P., 2017, In: Journal of General Virology. 98, 8, p. 2106-2112 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Applying antibody-sensitive hypervariable region 1-deleted hepatitis C virus to the study of escape pathways of neutralizing human monoclonal antibody AR5A

      Velazquez-Moctezuma, R., Law, M., Bukh, Jens & Prentø, Jannick, Feb 2017, In: PLOS Pathogens. 13, 2, 29 p., 1006214.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. 2016
    10. Published

      The history of hepatitis C virus (HCV): Basic research reveals unique features in phylogeny, evolution and the viral life cycle with new perspectives for epidemic control

      Bukh, Jens, Oct 2016, In: Journal of Hepatology. 65, 1 Suppl., p. S2-S21

      Research output: Contribution to journal › Review › Research › peer-review

    11. Published

      Functional analysis of microRNA-122 binding sequences of hepatitis C virus and identification of variants with high resistance against specific antagomir

      Li, Y., Pham, Long, Uzcategui, N. & Bukh, Jens, Jun 2016, In: Journal of General Virology. 97, p. 1381-1394

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Neutralizing antibodies in patients with chronic hepatitis C and correlation to liver cirrhosis and estimated duration of infection

      Pedersen, J., Lundbo, L. F., Krarup, H., Bukh, Jens & Weis, Nina, Oct 2016, In: Journal of Medical Virology. 88, 10, p. 1791-1803 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      HVR1-mediated antibody evasion of highly infectious in vivo adapted HCV in humanised mice

      Prentø, Jannick, Verhoye, L., Moctezuma, R. V., Buysschaert, C., Farhoudi, A., Wang, R., Alter, H., Meuleman, P. & Bukh, Jens, Dec 2016, In: Gut. 65, 12, p. 1988-1997 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Hypervariable Region 1 Shielding of Hepatitis C Virus Is a Main Contributor to Genotypic Differences in Neutralization Sensitivity

      Prentø, Jannick, Velazquez-Moctezuma, R., Foung, S. K. H., Law, M. & Bukh, Jens, Dec 2016, In: Hepatology. 64, 6, p. 1881-1892 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Robust HCV Genotype 3a Infectious Cell Culture System Permits Identification of Escape Variants With Resistance to Sofosbuvir

      Ramirez Almeida, Santseharay, Mikkelsen, L. S., Gottwein, Judith Margarete & Bukh, Jens, Nov 2016, In: Gastroenterology. 151, 5, p. 973-985.e2

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Hepatitis C Virus Genotype 1 to 6 Protease Inhibitor Escape Variants: In Vitro Selection, Fitness, and Resistance Patterns in the Context of the Infectious Viral Life Cycle.

      Serre, S., Jensen, S., Ghanem, L., Humes, D., Ramirez, S., Li, Y., Krarup, H., Bukh, Jens & Gottwein, Judith Margarete, Jun 2016, In: Antimicrobial Agents and Chemotherapy. 60, 6, p. 3563-3578 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Proposed update to the taxonomy of the genera Hepacivirus and Pegivirus within the Flaviviridae family

      Smith, D. B., Becher, P., Bukh, Jens, Gould, E. A., Meyers, G., Monath, T., Muerhoff, A. S., Pletnev, A., Rico-Hesse, R., Stapleton, J. T. & Simmonds, P., Nov 2016, In: Journal of General Virology. 97, p. 2894-2907 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. 2015
    19. Published

      Immunoglobulin with High-Titer In Vitro Cross-Neutralizing Hepatitis C Virus Antibodies Passively Protects Chimpanzees from Homologous, but Not Heterologous, Challenge

      Bukh, Jens, Engle, R. E., Faulk, K., Wang, R. Y., Farci, P., Alter, H. J. & Purcell, R. H., Sep 2015, In: Journal of Virology. 89, 17, p. 9128-9132 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Cell culture system of a hepatitis C genotype 3a and 2a chimera: Patent #: 8,945,584

      Gottwein, Judith Margarete, Scheel, T. K. H., Eugen-Olsen, J. & Bukh, Jens, 3 Feb 2015, IPC No. A61K 39/29 (20060101); C12N 15/06 (20060101); C12Q 1/02 (20060101); C07H 21/00 (20060101); C12N 7/02 (20060101); A61K 39/12 (20060101), Patent No. WO2008/125117, 23 Oct 2008, Priority date 11 Apr 2008, Priority No. PCT/DK2008/050083

      Research output: Patent

    21. Published

      Infectious hepatitis C viruses of genotype 3A and 4A and uses thereof: Patent #: 8,946,398

      Gottwein, Judith Margarete, Scheel, T. K. H., Purcell, R. E. & Bukh, Jens, 3 Feb 2015, IPC No. C07H 21/04 (20060101); C07H 21/02 (20060101), Patent No. WO2011/038737, 26 Jul 2012, Priority date 16 Sep 2010, Priority No. PCT/DK2010/050236

      Research output: Patent

    22. Published

      Substitutions at NS3 Residue 155, 156, or 168 of Hepatitis C Virus Genotypes 2 to 6 Induce Complex Patterns of Protease Inhibitor Resistance

      Jensen, S. B., Serre, S. B. N., Humes, D. G., Ramirez Almeida, Santseharay, Li, Y., Bukh, Jens & Gottwein, Judith Margarete, Dec 2015, In: Antimicrobial Agents and Chemotherapy. 59, 12, p. 7426-7436 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Efficient infectious cell culture systems of the hepatitis C virus (HCV) prototype strains HCV-1 and H77

      Li, Y., Ramirez Almeida, Santseharay, Mikkelsen, L. & Bukh, Jens, Jan 2015, In: Journal of Virology. 89, 1, p. 811-23 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Adaptive Mutations Enhance Assembly and Cell-to-Cell Transmission of a High-Titer Hepatitis C Virus Genotype 5a Core-NS2 JFH1-Based Recombinant

      Mathiesen, C. K., Prentø, Jannick, Meredith, L. W., Jensen, T. B., Krarup, H., McKeating, J. A., Gottwein, Judith Margarete & Bukh, Jens, Aug 2015, In: Journal of Virology. 89, 15, p. 7758-7775 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. 2014
    26. Published

      Breadth of neutralization and synergy of clinically relevant human monoclonal antibodies against HCV genotypes 1a, 1b, 2a, 2b, 2c, and 3a

      Carlsen, T. H. R., Pedersen, J., Prentø, Jannick, Giang, E., Keck, Z., Mikkelsen, L. S., Law, M., Foung, S. K. H. & Bukh, Jens, Nov 2014, In: Hepatology. 60, 5, p. 1551-62 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      Genetic variation in toll-like receptors and retinoic acid-inducible gene I and outcome of hepatitis C virus infection: a candidate gene association study

      Clausen, L. N., Ladelund, S., Weis, Nina, Bukh, Jens & Benfield, Thomas, Aug 2014, In: Journal of Viral Hepatitis. 21, 8, p. 578-84 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Transfusion-associated hepatitis before the screening of blood for hepatitis risk factors

      Engle, R. E., Bukh, Jens, Alter, H. J., Emerson, S. U., Trenbeath, J. L., Nguyen, H. T., Brockington, A., Mitra, T. & Purcell, R. H., Nov 2014, In: Transfusion. 54, 11, p. 2833-41 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      Comparative analysis of the molecular mechanisms of recombination in hepatitis C virus

      Galli, A. & Bukh, Jens, Jun 2014, In: Trends in Microbiology. 22, 6, p. 354-64 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      Efficient cell culture system for hepatitis C virus genotype 2B: Patent #: 8,663,653

      Gottwein, Judith Margarete, Knudsen, M. L., Scheel, T. K. H. & Bukh, Jens, 31 Mar 2014, IPC No. A61K 39/12 (20060101); A61K 39/29 (20060101); C12N 1/20 (20060101); C12N 5/071 (20100101); C12N 15/00 (20060101); C12Q 1/70 (20060101), Patent No. WO2010/017818, 18 Feb 2010, Priority date 24 Jul 2009, Priority No. PCT/DK2009/050189

      Research output: Patent

    31. Published

      Hepatitis C virus expressing reporter tagged NS5A protein: Patent #: 8,772,022

      Gottwein, Judith Margarete, Scheel, T. K. H., Bukh, Jens, Prentø, Jannick & Jensen, T. B., 8 Jul 2014, IPC No. C12N 15/00 (20060101); C12N 5/00 (20060101); C12N 7/00 (20060101); C12N 15/64 (20060101); A61K 39/29 (20060101); C12N 7/01 (20060101), Patent No. WO2010/037403, 8 Apr 2010, Priority date 5 Oct 2009, Priority No. PCT/DK2009/050263

      Research output: Patent

    32. Published

      Differential sensitivity of 5'UTR-NS5A recombinants of hepatitis C virus genotypes 1-6 to protease and NS5A inhibitors

      Li, Y., Ramirez, S., Humes, D., Jensen, S. B., Gottwein, Judith Margarete & Bukh, Jens, Mar 2014, In: Gastroenterology. 146, 3, p. 812-821.e4 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Production and characterization of high-titer serum-free cell culture grown hepatitis C virus particles of genotype 1-6

      Mathiesen, C. K., Jensen, T. B., Prentø, Jannick, Krarup, H., Nicosia, A., Law, M., Bukh, Jens & Gottwein, Judith Margarete, Jun 2014, In: Virology. 458-459, p. 190-208 19 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      Hypervariable region 1 deletion and required adaptive envelope mutations confer decreased dependency on scavenger receptor class B type I and low-density lipoprotein receptor for hepatitis C virus

      Prentø, Jannick, Serre, S. B. N., Ramirez, S., Nicosia, A. & Bukh, Jens, Feb 2014, In: Journal of Virology. 88, 3, p. 1725-39 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Infectious genotype 1a, 1b, 2a, 2b, 3a, 5a, 6a and 7a hepatitis C virus lacking the hypervariable region 1 (HVR1): Patent #: 8,846,891

      Prentø, Jannick, Gottwein, Judith Margarete, Scheel, T. K. H., Bukh, Jens & Jensen, T. B., 30 Sep 2014, IPC No. C07H 21/04 (20060101); C07H 21/02 (20060101), Patent No. WO2010/022727, 4 Mar 2010, Priority date 7 Aug 2009, Priority No. PCT/DK2009/050197

      Research output: Patent

    36. Published

      Highly efficient infectious cell culture of three hepatitis C virus genotype 2b strains and sensitivity to lead protease, nonstructural protein 5A, and polymerase inhibitors

      Ramirez, S., Li, Y., Jensen, S. B., Pedersen, J., Gottwein, Judith Margarete & Bukh, Jens, Feb 2014, In: Hepatology. 59, 2, p. 395-407 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Expanded classification of hepatitis C virus into 7 genotypes and 67 subtypes: updated criteria and genotype assignment web resource

      Smith, D. B., Bukh, Jens, Kuiken, C., Muerhoff, A. S., Rice, C. M., Stapleton, J. T. & Simmonds, P., Jan 2014, In: Hepatology. 59, 1, p. 318-27 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Nationwide experience of treatment with protease inhibitors in chronic hepatitis C patients in denmark: identification of viral resistance mutations

      Sølund, C., Krarup, H., Ramirez Almeida, Santseharay, Thielsen, P., Røge, B. T., Lunding, S., Barfod, Toke Seierøe, Madsen, Lone Galmstrup, Tarp, B., Christensen, P. B., Gerstoft, Jan, Laursen, A. L., Bukh, Jens, Weis, Nina & DANHEP Group, D. G., 2014, In: PLOS ONE. 9, 12, p. 1-20 20 p., e113034.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Hepatitis C virus cell-cell transmission and resistance to direct-acting antiviral agents

      Xiao, F., Fofana, I., Heydmann, L., Barth, H., Soulier, E., Habersetzer, F., Doffoël, M., Bukh, Jens, Patel, A. H., Zeisel, M. B. & Baumert, T. F., May 2014, In: P L o S Pathogens. 10, 5, p. 1-15 16 p., e1004128.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. 2013
    41. Published

      Persistent human hepatitis B virus infection in cynomolgus monkeys: a novel animal model in the search for a cure?

      Bukh, Jens, Lanford, R. E. & Purcell, R. H., Nov 2013, In: Hepatology. 58, 5, p. 1533-6 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      Characterization of hepatitis C virus recombinants with chimeric E1/E2 envelope proteins and identification of single amino acids in the E2 stem region important for entry

      Carlsen, T. H. R., Scheel, Troels Kasper Høyer, Ramirez Almeida, Santseharay, Foung, S. K. H. & Bukh, Jens, 2013, In: Journal of Virology. 87, 3, p. 1385-99 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Analysis of hepatitis C virus core/NS5A protein co-localization using novel cell culture systems expressing core-NS2 and NS5A of genotypes 1-7

      Galli, A., Scheel, Troels Kasper Høyer, Prentø, Jannick, Mikkelsen, L. S., Gottwein, Judith Margarete & Bukh, Jens, Oct 2013, In: The Journal of general virology. 94, Pt 10, p. 2221-35 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Adapted J6/JFH1-based Hepatitis C virus recombinants with genotype-specific NS4A show similar efficacies against lead protease inhibitors, alpha interferon, and a putative NS4A inhibitor

      Gottwein, Judith Margarete, Jensen, S. B., Serre, S. B. N., Ghanem, L., Scheel, Troels Kasper Høyer, Jensen, T. B., Krarup, H., Uzcategui, N., Mikkelsen, L. S. & Bukh, Jens, Dec 2013, In: Antimicrobial Agents and Chemotherapy. 57, 12, p. 6034-49 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      Combination treatment with hepatitis C virus protease and NS5A inhibitors is effective against recombinant genotype 1a, 2a, and 3a viruses

      Gottwein, Judith Margarete, Jensen, S. B., Li, Y., Ghanem, L., Scheel, Troels Kasper Høyer, Serre, S. B. N., Mikkelsen, L. & Bukh, Jens, Mar 2013, In: Antimicrobial Agents and Chemotherapy. 57, 3, p. 1291-303 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      Viral hepatitis: Cell-culture-derived HCV--a promising vaccine antigen

      Gottwein, Judith Margarete & Bukh, Jens, Sep 2013, In: Nature Reviews. Gastroenterology & Hepatology. 10, 9, p. 508-9 2 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      Efficient cell culture system for hepatitis C virus genotype 6A: Patent #: 8,569,472

      Gottwein, Judith Margarete, Scheel, T. K. H., Jensen, T. B. & Bukh, Jens, 29 Oct 2013, IPC No. C07H 21/00 (20060101); C12N 7/00 (20060101); A61K 39/295 (20060101); A61K 39/12 (20060101); A61K 39/29 (20060101), Patent No. WO2009/080052, 2 Jul 2009, Priority date 19 Dec 2008, Priority No. PCT/DK2008/050332

      Research output: Patent

    48. Published

      Efficient cell culture system for hepatitis C virus genotype 7a: Patent #: 8,506,969

      Gottwein, Judith Margarete, Scheel, T. K. H., Jensen, T. B. & Bukh, Jens, 13 Aug 2013, IPC No. A61K 39/12 (20060101); A61K 39/29 (20060101); C12Q 1/70 (20060101); C12N 15/00 (20060101); C12N 5/071 (20100101); C12N 1/20 (20060101), Patent No. WO2010/017819, 18 Feb 2010, Priority date 31 Jul 2009, Priority No. PCT/DK2009/050193

      Research output: Patent

    49. Published

      Efficient cell culture system for hepatitis C virus genotype 5A: Patent #: 8,618,275

      Jensen, T. B., Gottwein, Judith Margarete, Scheel, T. K. H., Eugen-Olsen, J. & Bukh, Jens, 31 Dec 2013, IPC No. C07H 21/00 (20060101); C12N 7/00 (20060101); A61K 39/295 (20060101); A61K 39/12 (20060101); A61K 39/29 (20060101), Patent No. WO2008/141651, 27 Nov 2008, Priority date 19 May 2008, Priority No. PCT/DK2008/050113

      Research output: Patent

    50. Published

      Cooperativity in virus neutralization by human monoclonal antibodies to two adjacent regions located at the amino terminus of hepatitis C virus E2 glycoprotein

      Keck, Z., Wang, W., Wang, Y., Lau, P., Carlsen, T. H. R., Prentø, Jannick, Xia, J., Patel, A. H., Bukh, Jens & Foung, S. K. H., 2013, In: Journal of Virology. 87, 1, p. 37-51 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    51. Published

      A hepatitis C virus (HCV) vaccine comprising envelope glycoproteins gpE1/gpE2 derived from a single isolate elicits broad cross-genotype neutralizing antibodies in humans

      Law, J. L. M., Chen, C., Wong, J., Hockman, D., Santer, D. M., Frey, S. E., Belshe, R. B., Wakita, T., Bukh, Jens, Jones, C. T., Rice, C. M., Abrignani, S., Tyrrell, D. L. & Houghton, M., 2013, In: PloS one. 8, 3, p. 1-7 8 p., e59776.

      Research output: Contribution to journal › Journal article › Research › peer-review

    52. Published

      Neutralizing antibodies in patients with chronic hepatitis C, genotype 1, against a panel of genotype 1 culture viruses

      Pedersen, J., Jensen, T. B., Carlsen, T. H. R., Schønning, Kristian, Christensen, P. B., Laursen, A. L., Krarup, H., Bukh, Jens & Weis, Nina, 2013, In: P L o S One. 8, 5, 16 p., e62674.

      Research output: Contribution to journal › Journal article › Research › peer-review

    53. Published

      Neutralization resistance of hepatitis C virus can be overcome by recombinant human monoclonal antibodies

      Pedersen, J. L., Carlsen, T. H. R., Prentø, Jannick, Ramirez, S., Jensen, T. B., Forns, X., Alter, H., Foung, S. K. H., Law, M., Gottwein, Judith Margarete, Weis, Nina & Bukh, Jens, 2013, In: Hepatology. 58, 5, p. 1587-1597 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    54. Published

      Productive homologous and non-homologous recombination of hepatitis C virus in cell culture

      Scheel, Troels Kasper Høyer, Galli, A., Li, Y., Mikkelsen, L. S., Gottwein, Judith Margarete & Bukh, Jens, Mar 2013, In: P L o S Pathogens. 9, 3, p. 1-12 13 p., e1003228.

      Research output: Contribution to journal › Journal article › Research › peer-review

    55. Published

      Adaptive mutations allow establishment of JFH1-based cell culture systems for hepatitis C virus genotype 4A: Patent #: 8,454,974

      Scheel, T. K. H., Gottwein, Judith Margarete, Eugen-Olsen, J. & Bukh, Jens, 4 Jun 2013, IPC No. A61K 39/29 (20060101); C07H 21/00 (20060101); C12N 15/06 (20060101); C12N 7/02 (20060101); C12Q 1/02 (20060101), Patent No. WO2008/125119, 23 Oct 2008, Priority date 11 Apr 2008, Priority No. PCT/DK2008/050085

      Research output: Patent

    56. Published

      Efficient cell culture system for hepatitis C virus genotype 1a and 1b: Patent #: 8,563,706

      Scheel, T. K. H., Gottwein, Judith Margarete, Prentø, Jannick, Jensen, T. B. & Bukh, Jens, 22 Oct 2013, IPC No. C07H 21/00 (20060101); A61K 39/29 (20060101); A61K 39/12 (20060101); A61K 39/295 (20060101); C12N 7/00 (20060101), Patent No. WO2009/080053, 2 Jul 2009, Priority date 19 Dec 2008, Priority No. PCT/DK2008/050333

      Research output: Patent

    57. Published

      Identification of alpha interferon-induced envelope mutations of hepatitis C virus in vitro associated with increased viral fitness and interferon resistance

      Serre, S. B. N., Krarup, H. B., Bukh, Jens & Gottwein, Judith Margarete, Dec 2013, In: Journal of Virology. 87, 23, p. 12776-93 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    58. 2012
    59. Published

      Animal models for the study of hepatitis C virus infection and related liver disease

      Bukh, Jens, May 2012, In: Gastroenterology. 142, 6, p. 1279-1287.e3 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    60. Published

      Negative HCV-RNA 2 weeks after initiation of treatment predicts sustained virological response to pegylated interferon alfa-2a and ribavirin in patients with chronic hepatitis C

      Christensen, P. B., Krarup, H. B., Laursen, A. L., Madsen, P. H., Pedersen, C., Schlichting, P., Orholm, M., Larsen, H. R., Bukh, Jens & Krogsgaard, K., Sep 2012, In: Scandinavian Journal of Gastroenterology. 47, 8-9, p. 1115-1119

      Research output: Contribution to journal › Journal article › Research › peer-review

    61. Published

      Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus

      Giang, E., Dorner, M., Prentø, Jannick, Dreux, M., Evans, M. J., Bukh, Jens, Rice, C. M., Ploss, A., Burton, D. R. & Law, M., 17 Apr 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 16, p. 6205-10 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    62. Published

      Human monoclonal antibodies to a novel cluster of conformational epitopes on HCV E2 with resistance to neutralization escape in a genotype 2a isolate

      Keck, Z., Xia, J., Wang, Y., Wang, W., Krey, T., Prentø, Jannick, Carlsen, T., Li, A. Y., Patel, A. H., Lemon, S. M., Bukh, Jens, Rey, F. A. & Foung, S. K. H., 2012, In: P L o S Pathogens. 8, 4, 21 p., e1002653.

      Research output: Contribution to journal › Journal article › Research › peer-review

    63. Published

      Highly efficient full-length hepatitis C virus genotype 1 (strain TN) infectious culture system

      Li, Y., Ramirez, S., Jensen, S. B., Purcell, R. H., Gottwein, Judith Margarete & Bukh, Jens, 27 Nov 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 48, p. 19757-62 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    64. Published

      Robust full-length hepatitis C virus genotype 2a and 2b infectious cultures using mutations identified by a systematic approach applicable to patient strains

      Li, Y., Ramirez, S., Gottwein, Judith Margarete, Scheel, Troels Kasper Høyer, Mikkelsen, L., Purcell, R. H. & Bukh, Jens, 2012, In: Proceedings of the National Academy of Sciences USA (PNAS). 109, 18, p. E1101-E1110 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    65. Published

      Hepatitis C virus epitope exposure and neutralization by antibodies is affected by time and temperature

      Sabo, M. C., Luca, V. C., Ray, S. C., Bukh, Jens, Fremont, D. H. & Diamond, M. S., 20 Jan 2012, In: Virology. 422, 2, p. 174-84 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    66. Published

      Efficient replication of genotype 3a and 4a hepatitis C virus replicons in human hepatoma cells

      Saeed, M., Scheel, Troels Kasper Høyer, Gottwein, Judith Margarete, Marukian, S., Dustin, L. B., Bukh, Jens & Rice, C. M., Oct 2012, In: Antimicrobial Agents and Chemotherapy. 56, 10, p. 5365-73 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    67. Published

      Analysis of functional differences between hepatitis C virus NS5A of genotypes 1-7 in infectious cell culture systems

      Scheel, Troels Kasper Høyer, Prentø, Jannick, Carlsen, T. H. R., Mikkelsen, L. S., Gottwein, Judith Margarete & Bukh, Jens, 2012, In: P L o S Pathogens. 8, 5, p. 1-16 17 p., e1002696.

      Research output: Contribution to journal › Journal article › Research › peer-review

    68. 2011
    69. Published

      FLAVIVIRDAE

      Bukh, Jens, Oct 2011, Virus Taxonomy: 9. report of the International Committee on Taxonomy of Viruses. Mq King, A., Lefkowitz, E., Adams, M. J. & Carstens, E. B. (eds.). 1 ed. Elsevier, p. 1003-1020 14 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    70. Published

      Hepatitis C homolog in dogs with respiratory illness

      Bukh, Jens, 2011, In: PNAS Early Edition. 108, 31, p. 12563-4 2 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    71. Published

      Transmission of clonal hepatitis C virus genomes reveals the dominant but transitory role of CD8¿ T cells in early viral evolution

      Callendret, B., Bukh, Jens, Eccleston, H. B., Heksch, R., Hasselschwert, D. L., Purcell, R. H., Hughes, A. L. & Walker, C. M., 2011, In: Journal of Virology. 85, 22, p. 11833-45 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    72. Published

      Interleukin-28B polymorphisms are associated with hepatitis C virus clearance and viral load in a HIV-1-infected cohort

      Clausen, L. N., Weis, Nina, Astvad, K., Schønning, Kristian, Fenger, M., Krarup, H., Bukh, Jens & Benfield, Thomas, 2011, In: Journal of Viral Hepatitis. 18, 4, p. e66-e74 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    73. Published

      Correlates of spontaneous clearance of hepatitis C virus in a Danish human immunodeficiency virus type 1 cohort

      Clausen, L. N., Weis, Nina, Schønning, Kristian, Fenger, M., Krarup, H., Bukh, Jens & Benfield, Thomas, Oct 2011, In: Scandinavian Journal of Infectious Diseases. 43, 10, p. 798-803 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    74. Published

      Development and application of hepatitis C reporter viruses with genotype 1 to 7 core-nonstructural protein 2 (NS2) expressing fluorescent proteins or luciferase in modified JFH1 NS5A

      Gottwein, J. M., Jensen, T. B., Mathiesen, C. K., Meuleman, P., Serre, S. B. N., Lademann, J. B., Ghanem, L., Scheel, Troels Kasper Høyer, Leroux-Roels, G. & Bukh, Jens, 2011, In: Journal of Virology. 85, 17, p. 8913-28 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    75. Published

      Differential efficacy of protease inhibitors against HCV genotypes 2a, 3a, 5a, and 6a NS3/4A protease recombinant viruses

      Gottwein, J. M., Scheel, Troels Kasper Høyer, Jensen, T. B., Ghanem, L. & Bukh, Jens, 2011, In: Gastroenterology Today. 141, 3, p. 1067-1079 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    76. Published

      Effectiveness of treatment with pegylated interferon and ribavirin in an unselected population of patients with chronic hepatitis C: a Danish nationwide cohort study

      Hansen, N., Obel, Niels, Christensen, P., Kjær, M. S., Laursen, A. L., Krarup, H. B., Møller, A., Schliehting, P., Bukh, Jens, Weis, Nina, Danish Database for Hepatitis B and C (DANHEP)- group, D. D. F. H. B. A. C. (. G. & Nørregaard, Peter, 1 Jan 2011, In: B M C Infectious Diseases. 11, p. 177 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    77. Published

      Non-genotype-specific role of the hepatitis C virus 5' untranslated region in virus production and in inhibition by interferon

      Li, Y., Ramirez, S., Gottwein, J. M. & Bukh, Jens, 2011, In: Virology: Research and Treatment. 421, 2, p. 222-34 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    78. Published

      MicroRNA-122 antagonism against hepatitis C virus genotypes 1-6 and reduced efficacy by host RNA insertion or mutations in the HCV 5' UTR

      Li, Y., Gottwein, J., Scheel, Troels Kasper Høyer, Jensen, T. B. & Bukh, Jens, 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 12, p. 4991-4996

      Research output: Contribution to journal › Journal article › Research › peer-review

    79. Published

      In vivo evaluation of the cross-genotype neutralizing activity of polyclonal antibodies against hepatitis C virus

      Meuleman, P., Bukh, Jens, Verhoye, L., Farhoudi, A., Vanwolleghem, T., Wang, R. Y., Desombere, I., Alter, H., Purcell, R. H. & Leroux-Roels, G., 2011, In: Hepatology. 53, 3, p. 755-62

      Research output: Contribution to journal › Journal article › Research › peer-review

    80. Published

      Neutralizing antibodies to hepatitis C virus in perinatally infected children followed up prospectively

      Meunier, J., Bukh, Jens, Diaz, G., Tovo, P., Casadei, A. M., Quinti, I., Iorio, R., Emerson, S., Purcell, R. H. & Farci, P., 2011, In: Journal of Infectious Diseases. 204, 11, p. 1741-5 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    81. Published

      Vaccine-induced cross-genotype reactive neutralizing antibodies against hepatitis C virus

      Meunier, J., Gottwein, J. M., Houghton, M., Russell, R. S., Emerson, S. U., Bukh, Jens & Purcell, R. H., 2011, In: Journal of Infectious Diseases. 204, 8, p. 1186-90 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    82. Published

      Enhanced and sustained CD8+ T cell responses with an adenoviral vector-based hepatitis C virus vaccine encoding NS3 linked to the MHC class II chaperone protein invariant chain

      Mikkelsen, M., Holst, Peter Johannes, Bukh, Jens, Thomsen, Allan Randrup & Christensen, Jan Pravsgaard, 15 Feb 2011, In: Journal of Immunology. 186, 4, p. 2355-64 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    83. Published

      Hepatitis C virus expressing flag-tagged envelope protein 2 has unaltered infectivity and density, is specifically neutralized by flag antibodies and can be purified by affinity chromatography

      Prentø, Jannick & Bukh, Jens, 2011, In: Virology. 409, 2, p. 148-55

      Research output: Contribution to journal › Journal article › Research › peer-review

    84. Published

      Hypervariable region 1 differentially impacts viability of hepatitis C virus strains of genotypes 1 to 6 and impairs virus neutralization

      Prentø, Jannick, Jensen, T. B., Meuleman, P., Serre, S., Scheel, Troels Kasper Høyer, Leroux-Roels, G., Gottwein, J. & Bukh, Jens, 2011, In: Journal of Virology. 85, 5, p. 2224-34 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    85. Published

      Neutralizing monoclonal antibodies against hepatitis C virus E2 protein bind discontinuous epitopes and inhibit infection at a postattachment step

      Sabo, M. C., Luca, V. C., Prentø, Jannick, Hopcraft, S. E., Blight, K. J., Yi, M., Lemon, S. M., Ball, J. K., Bukh, Jens, Evans, M. J., Fremont, D. H. & Diamond, M. S., 2011, In: Journal of Virology. 85, 14, p. 7005-19 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    86. Published

      Recombinant HCV variants with NS5A from genotypes 1-7 have different sensitivities to an NS5A inhibitor but not interferon-a

      Scheel, Troels Kasper Høyer, Gottwein, J. M., Mikkelsen, L. S., Jensen, T. B. & Bukh, Jens, 2011, In: Gastroenterology Today. 140, 3, p. 1032-42 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    87. Published

      Efficient Culture Adaptation of Hepatitis C Virus Recombinants with Genotype-Specific Core-NS2 by Using Previously Identified Mutations

      Scheel, Troels Kasper Høyer, Gottwein, J. M., Carlsen, T. H. R., Li, Y., Jensen, T. B., Spengler, U., Weis, Nina & Bukh, Jens, Mar 2011, In: Journal of Virology. 85, 6, p. 2891-2906 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    88. Published

      The GB viruses: a review and proposed classification of GBV-A, GBV-C (HGV), and GBV-D in genus Pegivirus within the family Flaviviridae

      Stapleton, J. T., Foung, S., Muerhoff, A. S., Bukh, Jens & Simmonds, P., 2011, In: Journal of General Virology. 92, Pt 2, p. 233-46 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    89. 2010
    90. Published

      Challenge pools of hepatitis C virus genotypes 1-6 prototype strains: replication fitness and pathogenicity in chimpanzees and human liver-chimeric mouse models

      Bukh, Jens, Meuleman, P., Tellier, R., Engle, R. E., Feinstone, S. M., Eder, G., Satterfield, W. C., Govindarajan, S., Krawczynski, K., Miller, R. H., Leroux-Roels, G. & Purcell, R. H., 1 May 2010, In: Journal of Infectious Diseases. 201, 9, p. 1381-9 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    91. Published

      Molecular and epidemiological profiles of hepatitis C virus genotype 4 in Denmark

      Eriksen, M. B., Jørgensen, L. B., Krarup, H., Laursen, A. L., Christensen, P. B., Møller, A., Schlichting, P., Kuiken, C., Bukh, Jens, Weis, N. & DANHEP Group, D. G., 2010, In: Journal of Medical Virology. 82, 11, p. 1869-1877 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    92. Published

      Novel infectious cDNA clones of hepatitis C virus genotype 3a (strain S52) and 4a (strain ED43): genetic analyses and in vivo pathogenesis studies

      Gottwein, Judith Margarete, Scheel, Troels Kasper Høyer, Callendret, B., Li, Y., Eccleston, H. B., Engle, R. E., Govindarajan, S., Satterfield, W., Purcell, R. H., Walker, C. M. & Bukh, Jens, 2010, In: Journal of Virology. 84, 10, p. 5277-93 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    93. Published

      Molecular evolution of GB virus B hepatitis virus during acute resolving and persistent infections in experimentally infected tamarins

      Takikawa, S., Engle, R. E., Faulk, K. N., Emerson, S. U., Purcell, R. H. & Bukh, Jens, 2010, In: Journal of General Virology. 91, Pt 3, p. 727-33 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    94. 2009
    95. Published

      MONOCISTRONIC HEPATITIS C REPORTER VIRUS RECOMBINANTS OF ALL MAJOR GENOTYPES EXPRESSING ENHANCED GREEN FLUORESCENT PROTEIN TAGGED NS5A PROTEIN

      Gottwein, Judith Margarete, Lademann, J. B., Scheel, Troels Kasper Høyer, Jensen, T. B., Prentø, Jannick & Bukh, Jens, 2009, In: Journal of Hepatology. 50, p. S33-S33

      Research output: Contribution to journal › Journal article › Research › peer-review

    96. Published

      Development and characterization of hepatitis C virus genotype 1-7 cell culture systems: role of CD81 and scavenger receptor class B type I and effect of antiviral drugs

      Gottwein, Judith Margarete, Scheel, Troels Kasper Høyer, Jensen, T. B., Lademann, J. B., Prentø, Jannick, Knudsen, M. L., Hoegh, A. M. & Bukh, Jens, 2009, In: Hepatology. 49, 2, p. 364-77 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    97. Published

      Predictors of antiviral treatment initiation in hepatitis C virus-infected patients: a Danish cohort study

      Hansen, N., Obel, N., Christensen, P. B., Krarup, H., Laursen, A. L., Clausen, M. R., Lunding, S., Møller, A., Schlichting, P., Kromann-Andersen, H., Bukh, J., Weis, N., Hansen, N., Obel, N., Christensen, P. B., Krarup, H., Laursen, A. L., Clausen, M. R., Lunding, S., Møller, A. & 4 others, Schlichting, P., Kromann-Andersen, H., Bukh, J. & Weis, Nina, 2009, In: Journal of Viral Hepatitis. 16, 9, p. 659-65 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    98. Published

      DELETION OF HYPERVARIABLE REGION 1 (HVR1) OF E2 FROM HCV GENOTYPES 1-6 HAS DIFFERENTIAL EFFECT ON INFECTIVITY IN VITRO AND CAUSES INCREASED SUSCEPTIBILITY TO NEUTRALIZATION

      Prentø, Jannick, Gottwein, Judith Margarete, Scheel, Troels Kasper Høyer, Jensen, T. B., Serre, S. & Bukh, Jens, 2009, In: Journal of Hepatology. 50, p. S34-S34

      Research output: Contribution to journal › Journal article › Research › peer-review

    99. Published

      Mutational analysis of the hepatitis C virus E1 glycoprotein in retroviral pseudoparticles and cell-culture-derived H77/JFH1 chimeric infectious virus particles

      Russell, R. S., Kawaguchi, K., Meunier, J., Takikawa, S., Faulk, K., Bukh, Jens, Purcell, R. H. & Emerson, S. U., 2009, In: Journal of Viral Hepatitis. 16, 9, p. 621-32 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    100. 2008
    101. Published

      Hepatitis C: the virus and studies of its lifecycle in cell culture systems

      Bukh, Jens, Gottwein, J. M., Scheel, T. K. & Forns, X., 2008, 100 Key Questions on Hepatitis C. Forns, X. (ed.). 1 ed. Barcelona, Spain: Permanyer Publications, Vol. 1. p. 1-15 14 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    102. Published

      Immunity against the GBV-B hepatitis virus in tamarins can prevent productive infection following rechallenge and is long-lived

      Bukh, Jens, Engle, R. E., Govindarajan, S. & Purcell, R. H., 2008, In: Journal of Medical Virology. 80, 1, p. 87-94 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    103. Published

      Previously infected chimpanzees are not consistently protected against reinfection or persistent infection after reexposure to the identical hepatitis C virus strain.

      Bukh, Jens, Thimme, R., Meunier, J., Faulk, K., Spangenberg, H. C., Chang, K., Satterfield, W., Chisari, F. V. & Purcell, R. H., 2008, In: Journal of Virology. 82, 16, p. 8183-95 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    104. Published

      Development of a TaqMan assay for the six major genotypes of hepatitis C virus: Comparison with commercial assays

      Engle, R. E., Russell, R. S., Purcell, R. H. & Bukh, Jens, 2008, In: Journal of Medical Virology. 80, 1, p. 72-9 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    105. Published

      Cutting the gordian knot-development and biological relevance of hepatitis C virus cell culture systems.

      Gottwein, Judith Margarete & Bukh, Jens, 2008, In: Advances in Virus Research. 71, p. 51-133 82 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    106. Published

      Highly Efficient JFH1-Based Cell-Culture System for Hepatitis C Virus Genotype 5a: Failure of Homologous Neutralizing-Antibody Treatment to Control Infection

      Jensen, T. B., Gottwein, Judith Margarete, Scheel, Troels Kasper Høyer, Høgh, A. M., Eugen-Olsen, J. & Bukh, Jens, 2008, In: Journal of Infectious Diseases. 198, 12, p. 1756-1765 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    107. Published

      Intragenotypic JFH1 based recombinant hepatitis C virus produces high levels of infectious particles but causes increased cell death.

      Mateu, G., Donis, R. O., Wakita, T., Bukh, Jens & Grakoui, A., 2008, In: Virology. 376, 2, p. 397-407 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    108. Published

      Isolation and characterization of broadly neutralizing human monoclonal antibodies to the e1 glycoprotein of hepatitis C virus

      Meunier, J., Russell, R. S., Goossens, V., Priem, S., Walther, H., Depla, E., Union, A., Faulk, K. N., Bukh, Jens, Emerson, S. U. & Purcell, R. E., 2008, In: Journal of Virology. 82, 2, p. 966-73 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    109. Published

      Advantages of a single-cycle production assay to study cell culture-adaptive mutations of hepatitis C virus

      Russell, R. S., Meunier, J., Takikawa, S., Faulk, K., Engle, R. E., Bukh, Jens, Purcell, R. H. & Emerson, S. U., 18 Mar 2008, In: PNAS Early Edition. 105, 11, p. 4370-5 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    110. Published

      Development of JFH1-based cell culture systems for hepatitis C virus genotype 4a and evidence for cross-genotype neutralization

      Scheel, Troels Kasper Høyer, Gottwein, Judith Margarete, Jensen, T. B., Prentø, Jannick, Høegh, A. M., Alter, H. J., Eugen-Olsen, J. & Bukh, Jens, 2008, In: Proceedings of the National Academy of Science of the United States of America. 105, 3, p. 997-1002 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    111. Published

      Polyclonal immunoglobulins from a chronic hepatitis C virus patient protect human liver-chimeric mice from infection with a homologous hepatitis C virus strain.

      Vanwolleghem, T., Bukh, Jens, Meuleman, P., Desombere, I., Meunier, J., Alter, H., Purcell, R. H. & Leroux-Roels, G., 2008, In: Hepatology. 47, 6, p. 1846-1855 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    Previous 1 2 3 Next

    ID: 12437