Birgitte Brock

Birgitte Brock

Clinical Associate Professor

Member of:

  • No speciality


  1. Published

    Altered functional connectivity between brain structures in adults with type 1 diabetes and polyneuropathy

    Croosu, S. S., Hansen, T. M., Brock, Birgitte, Mohr Drewes, A., Brock, C. & Frøkjær, J. B., 2022, In: Brain Research. 1784, 8 p., 147882.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    At the centennial of Michaelis and Menten, competing Michaelis-Menten steps explain effect of GLP-1 on blood-brain transfer and metabolism of glucose

    Gejl, M., Rungby, J., Brock, Birgitte & Gjedde, Albert, Aug 2014, In: Basic & Clinical Pharmacology & Toxicology. 115, 2, p. 162-71 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Blood-Brain Glucose Transfer in Alzheimer's disease: Effect of GLP-1 Analog Treatment

    Gejl, M., Brock, Birgitte, Egefjord, L., Vang, K., Rungby, Jørgen & Gjedde, Albert, Dec 2017, In: Scientific Reports. 7, 1, 10 p., 17490.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Brain spectroscopy reveals that N-acetylaspartate is associated to peripheral sensorimotor neuropathy in type 1 diabetes

    Hansen, T. M., Brock, Birgitte, Juhl, A., Drewes, A. M., Vorum, H., Andersen, C. U., Jakobsen, P. E., Karmisholt, J., Frokjaer, J. B. & Brock, C., Apr 2019, In: Journal of Diabetes and its Complications. 33, 4, p. 323-328

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Cardiac vagal tone as a novel screening tool to recognize asymptomatic cardiovascular autonomic neuropathy: Aspects of utility in type 1 diabetes

    Wegeberg, A. M., Lunde, E. D., Riahi, S., Ejskjaer, N., Drewes, A. M., Brock, Birgitte, Pop-Busui, R. & Brock, C., 2020, In: Diabetes Research and Clinical Practice. 170, 108517.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Cardiac vagal tone, a non-invasive measure of parasympathetic tone, is a clinically relevant tool in Type 1 diabetes mellitus

    Brock, C., Jessen, N., Brock, Birgitte, Jakobsen, P. E., Hansen, T. K., Rantanen, Jukka, Riahi, S., Dimitrova, Y. K., Dons-Jensen, A., Aziz, Q., Drewes, A. M. & Farmer, A. D., Oct 2017, In: Diabetic Medicine. 34, 10, p. 1428-1434 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Circulating Inflammatory Markers Are Inversely Associated with Heart Rate Variability Measures in Type 1 Diabetes

    Wegeberg, A. L., Okdahl, T., Fløyel, T., Brock, C., Ejskjaer, N., Riahi, S., Pociot, Flemming, Størling, Joachim & Brock, Birgitte, 2020, In: Mediators of Inflammation. 2020, 10 p., 3590389.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Contemporary prevalence of diabetic neuropathies in individuals with type 1 and type 2 diabetes in a Danish tertiary outpatient clinic

    Mizrak, H. I., Kufaishi, H., Hecquet, S. K., Hansen, Tine Willum, Pop-Busui, R., Rossing, Peter, Brock, Birgitte & Hansen, C. S., 2024, In: Journal of Diabetes and its Complications. 38, 6, 9 p., 108761.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Diabetes

    Felding, P., Jensen, I., Manford, G., Linnet, Kristian, Stahl, M., Jørgensen, L. G. M., Hyltoft Petersen, P., Brandslund, I., Olivarius de Fine, N., Borch-Johnsen, K., Ivanov, A., Zemtsovskaja, G., Nerhus, K., Kristensen, G., Sandberg, S., Brock, Birgitte, Gregersen, S. & Hermansen, K., 1 Jan 2000, In: Scandinavian Journal of Clinical and Laboratory Investigation, Supplement. 60, 232, p. 96-98 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Diabetic Neuropathy Influences Control of Spinal Mechanisms

    Nedergaard, R. B., Nissen, T. D., Mørch, C. D., Meldgaard, T., Juhl, A. H., Jakobsen, P. E., Karmisholt, J., Brock, Birgitte, Drewes, A. M. & Brock, C., 2021, In: Journal of Clinical Neurophysiology. 38, 4, p. 299-305 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Discontinuation of diabetes medication in the 10 years before death in Denmark: a register-based study

    Kosjerina, V., Carstensen, Bendix, Jørgensen, M. E., Brock, Birgitte, Christensen, H. R., Rungby, Jørgen & Andersen, G. S., 1 Sep 2021, In: The Lancet Healthy Longevity. 2, 9, p. e561-e570 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Disrupted white matter integrity in the brain of type 1 diabetes is associated with peripheral neuropathy and abnormal brain metabolites

    Muthulingam, J. A., Brock, C., Hansen, T. M., Drewes, A. M., Brock, Birgitte & Frøkjær, J. B., 2022, In: Journal of Diabetes and its Complications. 36, 9, 8 p., 108267.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Effects of hypoglycaemia on working memory and regional cerebral blood flow in type 1 diabetes: a randomised, crossover trial

    Gejl, M., Gjedde, Albert, Brock, Birgitte, Møller, A., van Duinkerken, E., Haahr, H. L., Hansen, C. T., Chu, P. L., Stender-Petersen, K. L. & Rungby, Jørgen, Mar 2018, In: Diabetologia. 61, 3, p. 551–561

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Effects of liraglutide on neurodegeneration, blood flow and cognition in Alzheimer´s disease - protocol for a controlled, randomized double-blinded trial

    Egefjord, L., Gejl, M., Møller, P. A., Brændgaard, H., Gottrup, H., Antropova, O., Møller, N., Poulsen, Henrik Enghusen, Gjedde, Albert, Brock, Birgitte & Rungby, J., Oct 2012, In: Danish Medical Bulletin (Online). 59, 10, p. A4519

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Elevated levels of interleukin-12/23p40 may serve as a potential indicator of dysfunctional heart rate variability in type 2 diabetes

    Wegeberg, A. M., Okdahl, T., Riahi, S., Ejskjaer, N., Pociot, Flemming, Størling, Joachim, Brock, Birgitte & Brock, C., 2022, In: Cardiovascular Diabetology. 21, 1, 10 p., 5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Features characterising cardiac autonomic neuropathy in diabetes using ensembled classification

    Nedergaard, R. B., Scott, M., Wegeberg, A., Okdahl, T., Størling, Joachim, Brock, Birgitte, Drewes, A. M. & Brock, C., 2023, In: Clinical Neurophysiology. 154, p. 200-208

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Gastrointestinal function in diabetes is affected regardless of asymptomatic appearance

    Wegeberg, A. M., Bertoli, D., Ejskjaer, N., Brock, Birgitte, Drewes, A. M. & Brock, C., 2022, In: Journal of Internal Medicine. 291, 4, p. 505-512 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Gastrointestinal symptom burden in diabetic autonomic and peripheral neuropathy – A Danes cohort study

    Kufaishi, H., Mizrak, H. I., Brock, Birgitte, Hansen, T. W., Rossing, Peter & Hansen, C. S., 2024, In: Journal of Diabetes and its Complications. 38, 5, 7 p., 108745.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Gastrointestinal symptoms and cardiac vagal tone in type 1 diabetes correlates with gut transit times and motility index

    Wegeberg, A. L., Brock, C., Ejskjaer, N., Karmisholt, J. S., Jakobsen, P., Drewes, A. M., Brock, Birgitte & Farmer, A. D., 1 Jan 2021, In: Neurogastroenterology and Motility. 33, 1, 10 p., e13885.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Glucagon-like peptide-1 (GLP-1) raises blood-brain glucose transfer capacity and hexokinase activity in human brain

    Gejl, M., Lerche, S., Egefjord, L., Brock, Birgitte, Møller, N., Vang, K., Rodell, A., Bibby, B. M., Holst, Jens Juul, Rungby, J. & Gjedde, Albert, 2013, In: Frontiers in Neuroenergetics. 5, p. 1-9 10 p., 2.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Impact of glucagon-like peptide-1 on myocardial glucose metabolism revisited

    Hansen, J., Brock, Birgitte, Bøtker, H. E., Gjedde, Albert, Rungby, J. & Gejl, M., Sep 2014, In: Reviews in Endocrine and Metabolic Disorders. 15, 3, p. 219-31 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    In Alzheimer's disease, 6-month treatment with GLP-1 analog prevents decline of brain glucose metabolism: Randomized, placebo-controlled, double-blind clinical trial

    Gejl, M., Gjedde, Albert, Egefjord, L., Møller, A., Hansen, S. B., Vang, K., Rodell, A., Brændgaard, H., Gottrup, H., Schacht, A. C., Møller, N., Brock, Birgitte & Rungby, Jørgen, 2016, In: Frontiers in Aging Neuroscience. 8, 10 p., 108.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    In Alzheimer's disease, amyloid beta accumulation is a protective mechanism that ultimately fails

    Rischel, E. B., Gejl, M., Brock, Birgitte, Rungby, Jørgen & Gjedde, Albert, 2023, In: Alzheimer's and Dementia. 19, 3, p. 771–783 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Increased levels of inflammatory factors are associated with severity of polyneuropathy in type 1 diabetes

    Okdahl, T., Brock, C., Floyel, T., Wegeberg, A. L., Jakobsen, P. E., Ejskjaer, N., Pociot, Flemming, Brock, Birgitte & Størling, Joachim, 2020, In: Clinical Endocrinology. 93, 4, p. 419-428

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Influence of GLP-1 on myocardial glucose metabolism in healthy men during normo- or hypoglycemia

    Gejl, M., Lerche, S., Mengel, A., Møller, N., Bibby, B. M., Smidt, K., Brock, Birgitte, Søndergaard, H., Bøtker, H. E., Gjedde, Albert, Holst, Jens Juul, Hansen, S. B. & Rungby, J., 2014, In: PLOS ONE. 9, 1, p. 1-10 10 p., e83758.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Liraglutide Treatment Does Not Induce Changes in the Peripapillary Retinal Nerve Fiber Layer Thickness in Patients with Diabetic Retinopathy

    Arendt Nielsen, T., Sega, R., Uggerhøj Andersen, C., Vorum, H., Drewes, A. M., Jakobsen, P. E., Brock, Birgitte & Brock, C., 2022, In: Journal of Ocular Pharmacology and Therapeutics. 38, 1, p. 114-121 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Liraglutide accelerates colonic transit in people with type 1 diabetes and polyneuropathy: A randomised, double-blind, placebo-controlled trial

    Wegeberg, A. L., Hansen, C. S., Farmer, A. D., Karmisholt, J. S., Drewes, A. M., Jakobsen, P. E., Brock, Birgitte & Brock, C., 2020, In: United European Gastroenterology Journal. 8, 6, p. 695-704 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Liraglutide treatment reduced interleukin-6 in adults with type 1 diabetes but did not improve established autonomic or polyneuropathy

    Brock, C., Hansen, C. S., Karmisholt, J., Møller, H. J., Juhl, A., Farmer, A. D., Drewes, A. M., Riahi, S., Lervang, H. H., Jakobsen, P. E. & Brock, Birgitte, 2019, In: British Journal of Clinical Pharmacology. 85, 11, p. 2512-2523 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Low-grade inflammation in type 2 diabetes: A cross-sectional study from a Danish diabetes outpatient clinic

    Okdahl, T., Wegeberg, A. M., Pociot, Flemming, Brock, Birgitte, Størling, Joachim & Brock, C., 2022, In: BMJ Open. 12, 12, 10 p., e062188.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    MRI-Based Quantification of Pan-Alimentary Function and Motility in Subjects with Diabetes and Gastrointestinal Symptoms

    Bertoli, D., Mark, E. B., Liao, D., Okdahl, T., Nauser, S., Daugberg, L. H., Brock, C., Brock, Birgitte, Knop, Filip Krag, Krogh, K., Brøndum Frøkjær, J. & Drewes, A. M., 2023, In: Journal of Clinical Medicine. 12, 18, 16 p., 5968.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Oral administration of sitagliptin activates CREB and is neuroprotective in murine model of brain trauma

    Della Valle, B. W., Brix, G. S., Brock, Birgitte, Geji, M., Rungby, J. & Larsen, A., 1 Dec 2016, In: Frontiers in Pharmacology. 7, 8 p., 450.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Palpebral Fissure Response to Phenylephrine Indicates Autonomic Dysfunction in Patients with Type 1 Diabetes and Polyneuropathy

    Nielsen, T. A., Andersen, C. U., Vorum, H., Riahi, S., Sega, R., Drewes, A. M., Karmisholt, J., Jakobsen, P. E., Brock, Birgitte & Brock, C., 2022, In: Investigative Ophthalmology and Visual Science. 63, 9, 21.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Pan-alimentary assessment of motility, luminal content, and structures: an MRI-based framework

    Bertoli, D., Mark, E. B., Liao, D., Brock, C., Brock, Birgitte, Knop, Filip Krag, Krogh, K., Frøkjær, J. B. & Drewes, A. M., 2023, In: Scandinavian Journal of Gastroenterology. 58, 12, p. 1378–1390 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Pathophysiology and management of diabetic gastroenteropathy

    Meldgaard, T., Keller, J., Olesen, A. E., Olesen, S. S., Krogh, K., Borre, M., Farmer, A., Brock, Birgitte, Brock, C. & Drewes, A. M., Jun 2019, In: Therapeutic Advances in Gastroenterology. 12, p. 1-17

    Research output: Contribution to journalReviewResearchpeer-review

  35. Published

    Peripheral, synaptic and central neuronal transmission is affected in type 1 diabetes

    Nissen, T. D., Meldgaard, T., Nedergaard, R. W., Juhl, A. H., Jakobsen, P. E., Karmisholt, J., Drewes, A. M., Brock, Birgitte & Brock, C., 2020, In: Journal of Diabetes and its Complications. 34, 9, 107614.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Plasma glycerol levels in men with hypertriglyceridemia

    Lebeck, J. & Brock, Birgitte, 2021, In: Scandinavian Journal of Clinical and Laboratory Investigation. 81, 4, p. 298-302

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Population pharmacokinetics of piperacillin in febrile children receiving cancer chemotherapy: the impact of body weight and target on an optimal dosing regimen

    Thorsted, A., Kristoffersson, A. N., Maarbjerg, S. F., Schrøder, H., Wang, M., Brock, Birgitte, Nielsen, E. I. & Friberg, L. E., 2019, In: The Journal of antimicrobial chemotherapy. 74, 10, p. 2984-2993 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Protective role of beta-amyloid revealed by PET of [C-11]PiB and [F-18]FDG in Alzheimer's disease

    Rischel, E., Gejl, M., Brock, Birgitte, Rungby, Jørgen & Gjedde, Albert, 2021, In: Journal of Cerebral Blood Flow and Metabolism. 41, Supplement 1, p. 188-189 2 p.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  39. Published

    Quantities of comorbidities affects physical, but not mental health related quality of life in type 1 diabetes with confirmed polyneuropathy

    Wegeberg, A. L., Meldgaard, T., Hyldahl, S., Jakobsen, P. E., Drewes, A. M., Brock, Birgitte & Brock, C., 2019, In: World Journal of Diabetes. 10, 2, p. 87-95

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Reduced Thalamic Volume and Metabolites in Type 1 Diabetes with Polyneuropathy

    Hansen, T. M., Frøkjær, J. B., Selvarajah, D., Muthulingam, J. A., Tesfaye, S., Juhl, A., Drewes, A. M., Jakobsen, P. E., Karmisholt, J., Brock, Birgitte & Brock, C., 2022, In: Experimental and Clinical Endocrinology and Diabetes. 130, 05, p. 327-334

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Reduced gray matter brain volume and cortical thickness in adults with type 1 diabetes and neuropathy

    Hansen, T. M., Muthulingam, J. A., Brock, Birgitte, Drewes, A. M., Juhl, A., Vorum, H., Jakobsen, P. E., Karmisholt, J., Brock, C. & Frøkjær, J. B., Mar 2022, In: Neuroscience Research. 176, p. 66-72 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Reduced prescription of TNF-inhibitors in chronic arthritis based on therapeutic drug monitoring: A randomized controlled trial

    Pfeiffer-Jensen, M., Liao, D., Tarp, U., Deleuran, B., Stengaard-Pedersen, K., Venborg, J., Brock, Birgitte & Brock, C., 2023, In: Scandinavian Journal of Rheumatology. 52, 5, p. 468-480

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Short-term transcutaneous non-invasive vagus nerve stimulation may reduce disease activity and pro-inflammatory cytokines in rheumatoid arthritis: results of a pilot study

    Drewes, A., Brock, C., Rasmussen, S., Møller, H., Brock, Birgitte, Deleuran, B., Farmer, A. & Pfeiffer-jensen, M., 2 Jan 2021, In: Scandinavian Journal of Rheumatology. 50, 1, p. 20-27 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published
  45. Published

    Subcutaneous adipose tissue composition and function are unaffected by liraglutide-induced weight loss in adults with type 1 diabetes

    Wegeberg, A. M., Meldgaard, T., Bæk, A., Drewes, A. M., Vyberg, M., Jessen, N., Brock, Birgitte & Brock, C., 2021, In: Basic and Clinical Pharmacology and Toxicology. 128, 6, p. 773-782 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Systemic Cytokine Expression in Diabetes Is Associated with Prolonged Gastrointestinal Transit Times and Cardinal Gastroparesis Symptoms

    Okdahl, T., Wegeberg, A., Jensen, A. B. H., Jensen, S. T., Andersen, H. R. P., Størling, Joachim, Brock, Birgitte & Brock, C., 2023, In: Biomedicines. 11, 4, 11 p., 1027.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    The effect of transcutaneous vagus nerve stimulation in patients with polymyalgia rheumatica

    Venborg, J., Wegeberg, A. M., Kristensen, S., Brock, Birgitte, Brock, C. & Pfeiffer-Jensen, M., 2021, In: Pharmaceuticals. 14, 11, 1166.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    The effects of incretin hormones on cerebral glucose metabolism in health and disease

    Nilsson, M., Gjedde, Albert, Brock, Birgitte, Gejl, M. & Rungby, Jørgen, 2018, In: Neuropharmacology. 136, Part B, p. 243-250 8 p.

    Research output: Contribution to journalReviewResearchpeer-review

  49. Published

    The zinc transporter Zip14 (SLC39a14) affects Beta-cell Function: Proteomics, Gene expression, and Insulin secretion studies in INS-1E cells

    Maxel, T., Smidt, K., Petersen, C. C., Honoré, B., Christensen, A. K., Jeppesen, P. B., Brock, Birgitte, Rungby, Jørgen, Palmfeldt, J. & Larsen, A., 2019, In: Scientific Reports. 9, 1, 15 p., 8589.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Transcutaneous vagal nerve stimulation for treating gastrointestinal symptoms in individuals with diabetes: a randomised, double-blind, sham-controlled, multicentre trial

    Kornum, D. S., Bertoli, D., Kufaishi, H., Wegeberg, A., Okdahl, T., Mark, E. B., Høyer, K. L., Frøkjær, J. B., Brock, Birgitte, Krogh, K., Hansen, C. S., Knop, Filip Krag, Brock, C. & Drewes, A. M., 2024, In: Diabetologia. 67, 6, p. 1122-1137

    Research output: Contribution to journalJournal articleResearchpeer-review

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