Pathophysiology and management of diabetic gastroenteropathy

Research output: Contribution to journalReviewResearchpeer-review


  • Theresa Meldgaard
  • Jutta Keller
  • Anne Estrup Olesen
  • Søren Schou Olesen
  • Klaus Krogh
  • Mette Borre
  • Adam Farmer
  • Brock, Birgitte
  • Christina Brock
  • Asbjørn Mohr Drewes

Polyneuropathy is a common complication to diabetes. Neuropathies within the enteric nervous system are associated with gastroenteropathy and marked symptoms that severely reduce quality of life. Symptoms are pleomorphic but include nausea, vomiting, dysphagia, dyspepsia, pain, bloating, diarrhoea, constipation and faecal incontinence. The aims of this review are fourfold. First, to provide a summary of the pathophysiology underlying diabetic gastroenteropathy. Secondly to give an overview of the diagnostic methods. Thirdly, to provide clinicians with a focussed overview of current and future methods for pharmacological and nonpharmacological treatment modalities. Pharmacological management is categorised according to symptoms arising from the upper or lower gut as well as sensory dysfunctions. Dietary management is central to improvement of symptoms and is discussed in detail, and neuromodulatory treatment modalities and other emerging management strategies for diabetic gastroenteropathy are discussed. Finally, we propose a diagnostic/investigation algorithm that can be used to support multidisciplinary management.

Original languageEnglish
JournalTherapeutic Advances in Gastroenterology
Pages (from-to)1-17
Publication statusPublished - Jun 2019

    Research areas

  • complications, diabetes mellitus, diabetic neuropathies, enteric nervous system, enteropathy, gastrointestinal motility, gastrointestinal transit, pharmacology

Number of downloads are based on statistics from Google Scholar and

No data available

ID: 241104014