Arne Schousboe
Professor, emeritus
Molecular and Cellular Pharmacology
Jagtvej 160
2100 København Ø
- 2024
- E-pub ahead of print
Preface: Special issue: 14th International Conference on Brain Energy Metabolism: Energy substrates and microbiome govern brain bioenergetics and cognitive function with aging
McKenna, M. C., Choi, I. & Schousboe, Arne, 2024, (E-pub ahead of print) In: Journal of Neurochemistry.Research output: Contribution to journal › Review › Research › peer-review
- 2023
- Accepted/In press
A tribute to Leif Hertz: The historical context of his pioneering studies of the roles of astrocytes in brain energy metabolism, neurotransmission, cognitive functions, and pharmacology identifies important, unresolved topics for future studies
Dienel, G. A., Schousboe, Arne, McKenna, M. C. & Rothman, D. L., 2023, (Accepted/In press) In: Journal of Neurochemistry.Research output: Contribution to journal › Review › Research › peer-review
- Published
Astrocytes regulate inhibitory neurotransmission through GABA uptake, metabolism, and recycling
Andersen, Jens Velde, Schousboe, Arne & Wellendorph, Petrine, 2023, In: Essays in Biochemistry. 67, 1, p. 77-91Research output: Contribution to journal › Journal article › Research › peer-review
- Accepted/In press
Deletion of CaMKIIα disrupts glucose metabolism, glutamate uptake, and synaptic energetics in the cerebral cortex
Andersen, Jens Velde, Westi, Emil Winther, Griem-Krey, Nane, Skotte, Niels Henning, Schousboe, Arne, Aldana, Blanca & Wellendorph, Petrine, 2023, (Accepted/In press) In: Journal of Neurochemistry.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glial Glutamine Homeostasis in Health and Disease
Andersen, J. V. & Schousboe, Arne, 2023, In: Neurochemical Research. 48, p. 1100–1128Research output: Contribution to journal › Review › Research › peer-review
- Published
Glutamate Neurotoxicity Related to Energy Failure
Schousboe, Arne, 2023, Handbook of Neurotoxicity. 2 ed. Springer, p. 803-815 13 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Milestone Review: Metabolic dynamics of glutamate and GABA mediated neurotransmission — The essential roles of astrocytes
Andersen, Jens Velde & Schousboe, Arne, 2023, In: Journal of Neurochemistry. 166, 2, p. 109-137Research output: Contribution to journal › Review › Research › peer-review
- Published
The history of Danish neuroscience
Paulson, Olaf B., Schousboe, Arne & Hultborn, Hans, 2023, In: European Journal of Neuroscience. 58, 4, p. 2893-2960Research output: Contribution to journal › Editorial › Research › peer-review
- 2022
- Published
Astrocyte energy and neurotransmitter metabolism in Alzheimer's disease: Integration of the glutamate/GABA-glutamine cycle
Andersen, Jens Velde, Schousboe, Arne & Verkhratsky, A., 2022, In: Progress in Neurobiology. 217, 24 p., 102331.Research output: Contribution to journal › Review › Research › peer-review
- Published
Low cerebral energy metabolism in hepatic encephalopathy reflects low neuronal energy demand. Role of ammonia-induced increased GABAergic tone
Sorensen, M., Walls, Anne Byriel, Dam, G., Bak, Lasse Kristoffer, Andersen, Jens Velde, Ott, P., Vilstrup, H. & Schousboe, Arne, 2022, In: Analytical Biochemistry. 654, 4 p., 114766.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
Amino acids: Glutamate dehydrogenase: An anaplerotic enzyme in neurons and an energy producing enzyme in astrocytes
Schousboe, Arne & Aldana, Blanca, 29 Jul 2021, Encyclopedia of Biological Chemistry: Third Edition. Elsevier, Vol. 1. p. 51-55 5 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Deficient astrocyte metabolism impairs glutamine synthesis and neurotransmitter homeostasis in a mouse model of Alzheimer's disease
Andersen, Jens Velde, Christensen, S. K., Westi, Emil Winther, Diaz-delcastillo, M., Tanila, H., Schousboe, Arne, Aldana, Blanca & Waagepetersen, Helle S., 2021, In: Neurobiology of Disease. 148, 13 p., 105198.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Downregulation of GABA Transporter 3 (GAT3) is Associated with Deficient Oxidative GABA Metabolism in Human Induced Pluripotent Stem Cell-Derived Astrocytes in Alzheimer's Disease
Salcedo, C., Wagner, A., Andersen, Jens Velde, Vinten, K. T., Waagepetersen, Helle S., Schousboe, Arne, Freude, Kristine & Aldana, Blanca, 2021, In: Neurochemical Research. 46, p. 2676–2686Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glutamate Dehydrogenase Is Important for Ammonia Fixation and Amino Acid Homeostasis in Brain During Hyperammonemia
Voss, C. M., Arildsen, L., Nissen, J. D., Waagepetersen, Helle S., Schousboe, Arne, Maechler, P., Ott, P., Vilstrup, H. & Walls, Anne Byriel, 2021, In: Frontiers in Neuroscience. 15, 18 p., 646291.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glutamate metabolism and recycling at the excitatory synapse in health and neurodegeneration
Andersen, Jens Velde, Markussen, K. H., Jakobsen, Emil, Schousboe, Arne, Waagepetersen, Helle S., Rosenberg, P. A. & Aldana, Blanca, 2021, In: Neuropharmacology. 196, 14 p., 108719.Research output: Contribution to journal › Review › Research › peer-review
- Published
Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer's disease
Andersen, Jens Velde, Skotte, Niels Henning, Christensen, S. K., Polli, F. S., Shabani, M., Markussen, K. H., Haukedal, H., Westi, Emil Winther, Diaz-delCastillo, M., Sun, R. C., Kohlmeier, Kristi Anne, Schousboe, Arne, Gentry, M. S., Tanila, H., Freude, Kristine, Aldana, Blanca, Mann, Matthias & Waagepetersen, Helle S., 2021, In: Cell Death & Disease. 12, 11, 13 p., 954 .Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Preface for the Vladimir Parpura Honorary Issue of Neurochemical Research
Verkhratsky, A., Schousboe, Arne & Zorec, R., 2021, In: Neurochemical Research. 46, 10, p. 2507-2511Research output: Contribution to journal › Editorial › Research
- Published
Two Metabolic Fuels, Glucose and Lactate, Differentially Modulate Exocytotic Glutamate Release from Cultured Astrocytes
Montana, V., Flint, D., Waagepetersen, Helle S., Schousboe, Arne & Parpura, V., 2021, In: Neurochemical Research. 46, p. 2551–2579Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
Astrocytic Metabolism Focusing on Glutamate Homeostasis: A Short Review Dedicated to Vittorio Gallo
Schousboe, Arne, 2020, In: Neurochemical Research. 45, 3, p. 522-525Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Extensive astrocyte metabolism of γ-aminobutyric acid (GABA) sustains glutamine synthesis in the mammalian cerebral cortex
Andersen, Jens Velde, Jakobsen, Emil, Westi, Emil Winther, Lie, M. E. K., Voss, C. M., Aldana, Blanca, Schousboe, Arne, Wellendorph, Petrine, Bak, Lasse Kristoffer, Pinborg, Lars Hageman & Waagepetersen, Helle S., 2020, In: Glia. 68, 12, p. 2601-2612Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pharmacological Characterization of a Betaine/GABA Transporter 1 (BGT1) Inhibitor Displaying an Unusual Biphasic Inhibition Profile and Anti-seizure Effects
Lie, M. E. K., Kickinger, S., Skovgaard-Petersen, J., Ecker, G. F., Clausen, Rasmus Prætorius, Schousboe, Arne, White, H. S. & Wellendorph, Petrine, 2020, In: Neurochemical Research. 45, p. 1551–1565Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Preface for the Vittorio Gallo Honorary Issue of Neurochemical Research
Schousboe, Arne, 2020, In: Neurochemical Research. 45, 3, p. 519-521Research output: Contribution to journal › Editorial › Research › peer-review
- 2019
- Published
Astrocytic pyruvate carboxylation: Status after 35 years
Schousboe, Arne, Waagepetersen, Helle S. & Sonnewald, U., 1 Jan 2019, In: Journal of Neuroscience Research. 97, p. 890-896Research output: Contribution to journal › Review › Research › peer-review
- Published
Metabolic signaling in the brain and the role of astrocytes in control of glutamate and GABA neurotransmission
Schousboe, Arne, 2019, In: Neuroscience Letters. 689, p. 11-13 3 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Preface: Special issue on neurotransmitter transporters
Chaudhry, F. A., Loland, Claus Juul, Ortega, A. & Schousboe, Arne, 2019, In: Neuropharmacology. 161, 1 p., 107859.Research output: Contribution to journal › Editorial › Research › peer-review
- Published
Special Issue in Honor of Dr. Elias K. Michaelis
Choi, I. & Schousboe, Arne, 2019, In: Neurochemical Research. 44, 1, p. 1-4Research output: Contribution to journal › Journal article › Research › peer-review
- Published
State-Dependent Changes in Brain Glycogen Metabolism
DiNuzzo, M., Walls, Anne Byriel, Öz, G., Seaquist, E. R., Waagepetersen, Helle S., Bak, Lasse Kristoffer, Nedergaard, Maiken & Schousboe, Arne, 2019, Brain Glycogen Metabolism. DiNuzzo, M. & Schousboe, A. (eds.). Springer, p. 269-309 41 p. (Advances in Neurobiology, Vol. 23).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Structural and molecular aspects of betaine-GABA transporter 1 (BGT1) and its relation to brain function
Kickinger, S., Hellsberg, E., Frølund, Bente, Schousboe, Arne, Ecker, G. F. & Wellendorph, Petrine, 2019, In: Neuropharmacology. 161, 14 p., 107644.Research output: Contribution to journal › Review › Research › peer-review
- Published
The 13th International Conference on Brain Energy Metabolism: "How Metabolism Dictates Neurotransmission, Function and Behavior"
Barros, L. F., Schousboe, Arne & McKenna, M. C., 2019, In: Journal of Neuroscience Research. 97, 8, p. 849-853 5 p.Research output: Contribution to journal › Journal article › Research
- 2018
- Published
Astrocytic glycogen metabolism in the healthy and diseased brain
Bak, Lasse Kristoffer, Walls, Anne Byriel, Schousboe, Arne & Waagepetersen, Helle S., 11 May 2018, In: The Journal of Biological Chemistry. 293, 19, p. 7108-7116 9 p.Research output: Contribution to journal › Review › Research › peer-review
- 2017
- Published
Misconceptions regarding basic thermodynamics and enzyme kinetics have led to erroneous conclusions regarding the metabolic importance of lactate dehydrogenase isoenzyme expression
Bak, Lasse Kristoffer & Schousboe, Arne, Nov 2017, In: Journal of Neuroscience Research. 95, 11, p. 2098-2102 5 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
The 12th International Conference on Brain Energy Metabolism (ICBEM): "Energy Metabolism and Neuron-Glia Interactions in Brain: From Molecular Mechanisms to Novel Therapeutic Approaches"
Yu, A. C. H., Schousboe, Arne & McKenna, M. C., Nov 2017, In: Journal of Neuroscience Research. 95, 11, p. 2095-2097 3 p.Research output: Contribution to journal › Journal article › Communication
- Published
The novel anticonvulsant neuropeptide and galanin analogue, NAX-5055, does not alter energy and amino acid metabolism in cultured brain cells
Aldana, Blanca, Waagepetersen, Helle S., Schousboe, Arne, White, H. S., Bulaj, G. & Walls, Anne Byriel, Nov 2017, In: Journal of Neuroscience Research. 95, 11, p. 2286-2296 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure-Activity Relationship, Pharmacological Characterization, and Molecular Modeling of Noncompetitive Inhibitors of the Betaine/γ-Aminobutyric Acid Transporter 1 (BGT1)
Jørgensen, L., Al-Khawaja, A., Kickinger, S., Vogensen, S. B., Skovgaard-Petersen, J., Rosenthal, E., Borkar, N., Löffler, R., Madsen, K. K., Bräuner, Hans, Schousboe, Arne, Ecker, G. F., Wellendorph, Petrine & Clausen, Rasmus Prætorius, 9 Oct 2017, In: Journal of Medicinal Chemistry. 60, 21, p. 8834-8846Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glycogen Shunt Activity and Glycolytic Supercompensation in Astrocytes May Be Distinctly Mediated via the Muscle Form of Glycogen Phosphorylase
Jakobsen, Emil, Bak, Lasse Kristoffer, Walls, Anne Byriel, Christiansen, Ann-Kathrin Lindahl, Schousboe, Arne & Waagepetersen, Helle S., Sep 2017, In: Neurochemical Research. 42, 9, p. 2490-2494 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Delineation of the Role of Astroglial GABA Transporters in Seizure Control
Schousboe, Arne & Madsen, K. K., Jul 2017, In: Neurochemical Research. 42, 7, p. 2019-2023Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Citrate, a Ubiquitous Key Metabolite with Regulatory Function in the CNS
Westergaard, N., Waagepetersen, Helle S., Belhage, B. & Schousboe, Arne, Jun 2017, In: Neurochemical Research. 42, 6, p. 1583-1588 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A Tribute to Mary C. McKenna: Glutamate as Energy Substrate and Neurotransmitter-Functional Interaction Between Neurons and Astrocytes
Schousboe, Arne, Jan 2017, In: Neurochemical Research. 42, 1, p. 4-9 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Astrocytic GABA Transporters: Pharmacological Properties and Targets for Antiepileptic Drugs
Schousboe, Arne, Wellendorph, Petrine, Frølund, Bente, Clausen, Rasmus Prætorius & Krogsgaard-Larsen, Povl, 2017, Glial Amino Acid Transporters. Springer, Vol. 16. p. 283-296 14 p. (Advances in Neurobiology).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication
- Published
Expression of the human isoform of glutamate dehydrogenase, hGDH2, augments TCA cycle capacity and oxidative metabolism of glutamate during glucose deprivation in astrocytes
Nissen, J. D., Lykke, K., Bryk, J., Stridh, M. H., Zaganas, I., Jensen, Dorte Skytt, Schousboe, Arne, Bak, Lasse Kristoffer, Enard, W., Pääbo, S. & Waagepetersen, Helle S., 2017, In: Glia. 65, 3, p. 474–488Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glial GABA Transporters as Modulators of Inhibitory Signalling in Epilepsy and Stroke
Lie, M. E. K., Al-Khawaja, A., Damgaard, M., Haugaard, A. S., Schousboe, Arne, Clarkson, A. N. & Wellendorph, Petrine, 2017, Advances in Neurobiology. Vol. 16. p. 137-167 31 p. (Advances in Neurobiology).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Glutamate and ATP at the Interface Between Signaling and Metabolism in Astroglia: Examples from Pathology
Parpura, V., Fisher, E. S., Lechleiter, J. D., Schousboe, Arne, Waagepetersen, Helle S., Brunet, S., Baltan, S. & Verkhratsky, A., 2017, In: Neurochemical Research. 42, 1, p. 19-34 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Metabolic Characterization of Acutely Isolated Hippocampal and Cerebral Cortical Slices Using [U-(13)C]Glucose and [1,2-(13)C]Acetate as Substrates
McNair, Laura M., Kornfelt, R., Walls, Anne Byriel, Andersen, Jens Velde, Aldana, B. I., Nissen, J. D., Schousboe, Arne & Waagepetersen, Helle S., 2017, In: Neurochemical Research. 42, 3, p. 810-826 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Preface for the Mary C. McKenna Honorary Issue of Neurochemical Research
Schousboe, Arne, 2017, In: Neurochemical Research. 42, 1, 1-3.Research output: Contribution to journal › Editorial › Research
- Published
Preface for the Ursula Sonnewald Honorary Issue of Neurochemical Research
Schousboe, Arne, 2017, In: Neurochemical Research. 42, 6, p. 1581-1582 2 p.Research output: Contribution to journal › Editorial › Research
- Published
Specificity of exogenous acetate and glutamate as astrocyte substrates examined in acute brain slices from female mice using methionine sulfoximine (MSO) to inhibit glutamine synthesis
Andersen, Jens Velde, McNair, Laura M., Schousboe, Arne & Waagepetersen, Helle S., 2017, In: Journal of Neuroscience Research. 95, 11, p. 2207-2216Research output: Contribution to journal › Journal article › Research › peer-review
- Published
gamma-Aminobutyric Acid and Glycine Neurotransmitter Transporters
Wellendorph, Petrine, Jacobsen, Julie, Skovgaard-Petersen, J., Jurik, A., Vogensen, S. B., Ecker, G., Schousboe, Arne, Krogsgaard-Larsen, Povl & Clausen, Rasmus Prætorius, 2017, Transporters As Drug Targets.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- 2016
- Published
Glutamate oxidation in astrocytes: Roles of glutamate dehydrogenase and aminotransferases
McKenna, M. C., Stridh, M. H., McNair, Laura M., Sonnewald, U., Waagepetersen, Helle S. & Schousboe, Arne, 15 Sep 2016, In: Journal of Neuroscience Research. 94, 12, p. 1561-1571 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The anticonvulsant action of the galanin receptor agonist NAX-5055 involves modulation of both excitatory- and inhibitory neurotransmission
Walls, Anne Byriel, Flynn, S. P., West, P. J., Müller, M. S., Bak, Lasse Kristoffer, Bulaj, G., Schousboe, Arne & White, H. S., Mar 2016, In: Epilepsy Research. 121, p. 55-63 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neuronal Cell Death Induced by Mechanical Percussion Trauma in Cultured Neurons is not Preceded by Alterations in Glucose, Lactate and Glutamine Metabolism
Jayakumar, A. R., Bak, Lasse Kristoffer, Rama Rao, K. V., Waagepetersen, Helle S., Schousboe, Arne & Norenberg, M. D., Feb 2016, In: Neurochemical Research. 41, 1, p. 307-15 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 1300836
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221
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Astrocytic pyruvate carboxylation: Status after 35 years
Research output: Contribution to journal › Review › Research › peer-review
Published -
115
downloads
Deficient astrocyte metabolism impairs glutamine synthesis and neurotransmitter homeostasis in a mouse model of Alzheimer's disease
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
112
downloads
The 13th International Conference on Brain Energy Metabolism: "How Metabolism Dictates Neurotransmission, Function and Behavior"
Research output: Contribution to journal › Journal article › Research
Published