Pharmaceutical Physical and Analytical Chemistry
Universitetsparken 2, 2100 København Ø
Primary fields of research
Scientific Focus area
Of particular interest is the possible utilization of colloidal aqueous dispersions of lipids with confined inner nanostructures (such as cubosomes, hexosomes, and micellar cubosomes) as safe and efficient drug nanocarriers. The optimal utilization of these dispersions requires studying the impact of loading drugs on their internal nanostructures, and fully comprehending the interaction of these drug-loaded dispersed particles with the biological environment to ensure the efficient transportation of the solubilized drugs. In addition, it is of our interest to address the challenges of enhancing the stability of the dispersed particles under different conditions, and of modulating their nanostructure in order to optimize their loading of different drugs.
- Cubosomes and hexosomes as drug nanocarriers
- Formation and characterization of drug nanocarriers
- Characterization of stimuli-responsive self-assembled drug nanocarriers.
- Hierarchically organized aqueous dispersions of self-assembled lipid phases: cubosomes, hexosomes, and emulsified microemulsions.
- Formulation and characterization of O/W and W/O microemulsions.
Fields of interest
Design and characterization of nanomedicines, liquid crystalline phases, cubosomes, hexosomes, safe and efficient self-assembled drug nanocarriers
Lipid-based nano-structured drug delivery systems:
Cubosomes and hexosomes as drug nanocarriers
In situ characterization of drug formulations based on liquid crystalline phases
Dr. Sana Ghayas: pH-responsive nano-self-assemblies for treatment of biofilm infections. The project is financed by the Higher Education Commission of Pakistan (HEC).
Current PhD students:
Chenyang Wu: Versatile cubosomal and hexosomal nanocarriers for colorectal cancer therapy. The project is financed by the China Scholarship Council (CSC). Primiary co-supervisor Associate Prof. Huiling Mu.
Habibullah Jan: Cubosomes and hexosomes as versatile nanocarriers for prevention and treatment of biofilm infections. The project is financed by the Higher Education Commission of Pakistan (HEC). Primiary co-supervisor Prof. Oana Ciofu (Department of Immunology and Microbiology, University of Copenhagen).
Ibrahim Abdulbaqi (co-supervision, Main supervisor: Prof. H. Wahab (Universiti Sains Malaysia(USM), Malaysia)
Current Master students:
Nasir Mahmood Ahmad
Former Postdocs and students:
Maha Diab (Master student)
Angelina Le (Master student)
Amy Mirzai Nielsen (Master student)
Gizem Bor (PhD student): BRAIN-PENNANO project: BRAIN PENetrating cubosomal and hexosomal NANOcarriers for glioma-targeting delivery. The project is financed by the Danish Council for Independent Research | Technology and Production Sciences (FTP).
William Schmidt Nannerup (Master student)
Wenyao Song (co-supervision, Danish co-supervisor, the Sino-Danish program, main supervisor: Prof. Guanglu Ge)
Shen Helvig (PhD student): NANOLYMPH: NANO-engineered LYMphotropic Cubosomes and Hexosomes. The project is financed by the Danish Council for Independent Research | Technology and Production Sciences. MAX4ESSFUN grant: Co-financing 6 months SAXS experiments by the Interreg project ESS & MAX IV Cross Border Science and Society
Samim Aryan (Master student: co-supervision)
Laura Amedovski (Master student: co-supervision)
Aria Aria Rahbar Barkadehi (Master student)
Balsam Altemimei (Master student)
Mikail Atsiz (Master student)
Ghulam Rasool Sadat (Master student)
Evrim Sahin (Master student)
Begüm Nur Ödevci (Master student)
Sarah Ariabod (Master student)
Raghib Ghazal (Master student)
Xianrong Shao (Master student)
Rama Prajapati (Master student)
Sabah Al-Hosayni (Master student)
Boi Vi Tran (Master student)
Umar Asghar (Master student)
Wael Alhalaq (Master student)
Firas Alturk (Master student)
Hasan Ammar Akram (Master student)
Christa Nilsson (PhD student): Cuboosmes and hexosomes as theranostic nanocarriers
Intan Diana Mat Azmi (Postdoc & PhD student):
Postdoc Project: NANO-engineered LYMphotropic Cubosomes and Hexosomes
PhD Project: Safe Cubosome and Hexosome Nanocarrier Design for Drug Delivery
The project was supported by the Staff Tranining Program (University of Puta Malaysia, UPM)
Aghiad Ghazal (Phd student): Formulation of soft self-assembled nano-pharmaceuticals (CONEXT project with Prof. Kell Mortensen)
Helene Andersen (Postdoc):NANO-engineered LYMphotropic Cubosomes and Hexosomes
Kirstin Khaliqi (Master student)
Mohammed-Jawad Tahir (Master student)
Erdal Avci (Master student)
Simon Pham (Master student)
Tadeusz Induszewski (Research assistant and Master student)
Ali Kazem (Master student)
Ömer Faruk Özdemir (Master student)
Sophie Schulha (Master student)
Selma Keceli (Master student)
Gültekin Caliskan (Master student)
Mark Gontsarik (Master student)
Sofie Fogh Hedegaard (Master student): Lipidic nanostructured aqueous dispersions as novel drug nanocarriers
Exchange/Guest and BA students:
Somayeh Khanmohammadi (November 2019-May 2020)
Esra Ilhan Ayisigi (November 2019-December 2019)
Jesper Sand Mortensen
1. MICNANO project (2023-2026, 2.926.972 DKK): Microfluidic synthesis and online characterization of cubosomal and hexosomal NANOcarriers for colorectal cancer therapy. It is financed by awarded grant from Novo Nordisk Foundation. Collaboration with Prof. Winnie Edith Svendsen and Dr. Maria Dimaki (DTU Bioengineering: Department of Biotechnology and Biomedicine).
2. INP project 2019 & 2020 (Microfluidic Platforms for Drug Delivery Applications): 217.179 kr. Co-applicant: Associate Prof. Ozlem Yesil Celiktas (Bioengineering Department, Ege University, Izmir, Turkey). A grant from the Danish Agency for Science and Higher Education for initiating and exploring new networking and collaboration opportunities between Danish and Turkish research institutions
3. BRAIN-PENNANO project 2017-2021: 2.591.817 kr. The project is financed by the Danish Council for Independent Research | Technology and Production Sciences (FTP).
4. NANOLYMPH project 2013-2017: 5.432.056 DKK. The project is financed by the Danish Council for Independent Research | Technology and Production Sciences (Det Frie Forskningsråd for Teknologi og Produktion (FTP))
5. CoNEXT PhD project: PhD student Aghiad Ghazal
Project related to the UCPH Excellence Research Program with Kell Mortensen (Niels Bohr Institiute, Science), Susan Weng Larsen and Camilla Foged (Department of Pharmacy, Faculty of Health and Medical Sciences)
6. Danscatt: Annual financial support for SAXS experiments
7. Financial support for 2013-2016: 130000 DKK/year from the Ministry of Higher Education Malaysia (Intan's PhD project).
Articles with open access
Molecules | Free Full-Text | Microfluidic Nanomaterial Synthesis and In Situ SAXS, WAXS, or SANS Characterization: Manipulation of Size Characteristics and Online Elucidation of Dynamic Structural Transitions (mdpi.com)
Cell medium-dependent dynamic modulation of size and structural transformations of binary phospholipid/ω-3 fatty acid liquid crystalline nano-self-assemblies: Implications in interpretation of cell uptake studies - ScienceDirect
A structurally diverse library of glycerol monooleate/oleic acid non-lamellar liquid crystalline nanodispersions stabilized with nonionic methoxypoly(ethylene glycol) (mPEG)-lipids showing variable complement activation properties - ScienceDirect
Nanomaterials | Free Full-Text | Continuous Microfluidic Production of Citrem-Phosphatidylcholine Nano-Self-Assemblies for Thymoquinone Delivery (mdpi.com)
Molecules | Free Full-Text | Non-Lamellar Liquid Crystalline Nanocarriers for Thymoquinone Encapsulation (mdpi.com)
Physical Chemistry, Lectures and class teaching
Physical Chemistry, Laboratory Course
Academic Awards and Honors
Årets Underviser 2011: the teacher of the Year 2011 award from the Faculty of Health and Medical Sciecnes (KU).
Lise-Meitner Fellowship (2003 & 2004) from FWF (the Austrian Science Funds).