Jens Lykkesfeldt

Jens Lykkesfeldt

Professor

Member of:

  • Lifepharm

ORCID: 0000-0002-6514-8407

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  1. Published

    High dietary fat and cholesterol exacerbates chronic vitamin C deficiency in guinea pigs

    Frikke-Schmidt, H. R., Tveden-Nyborg, Pernille, Birck, M. M. & Lykkesfeldt, Jens, 2011, In: British Journal of Nutrition. 105, 1, p. 54-61 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Heterozygous mutations in GTP-cyclohydrolase-1 reduce BH4 biosynthesis but not pain sensitivity

    Nasser, A., Møller, A. T., Hellmund, V., Thorborg, S. S., Jespersgaard, C., Bjerrum, Ole Jannik, Dupontd, E., Nachman, G., Lykkesfeldt, Jens, Jensen, T. S. & Møller, L. B., 2018, In: Pain. 159, 6, p. 1012-1024 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. E-pub ahead of print

    Hemostatic Effects of Exercise-Related Hypoglycemia in Male Persons With Type 1 Diabetes

    Hagelqvist, P. G., Andersen, A., Maytham, K., Andreasen, C. R., Engberg, S., Pedersen-Bjergaard, Ulrik, Forman, Julie Lyng, Jo­hans­son, Pär In­ge­mar , Lykkesfeldt, Jens, Knop, Filip Krag & Vilsbøll, Tina, 2024, (E-pub ahead of print) In: The Journal of clinical endocrinology and metabolism.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Göttingen minipig model of diet-induced atherosclerosis: influence of mild streptozotocin-induced diabetes on lesion severity and markers of inflammation evaluated in obese, obese and diabetic, and lean control animals

    Ludvigsen, Trine Pagh, Kirk, R. K., Christoffersen, B. Ø., Pedersen, H. D., Martinussen, Torben, Kildegaard, J., Heegaard, P. M. H., Lykkesfeldt, Jens & Olsen, Lisbeth Høier, 2015, In: Journal of Translational Medicine. 13, 12 p., 312.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Guinea pig ascorbate status predicts tetrahydrobiopterin plasma concentration and oxidation ratio in vivo

    Mortensen, A., Andersen, S. H., Tveden-Nyborg, Pernille & Lykkesfeldt, Jens, 2013, In: Nutrition Research. 33, 10, p. 859-867 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Glycemic control during pregnancy — A predictor of vitamin C status at labor in type 1 diabeticwomen?

    Juhl, B., Lauszus, F. F. & Lykkesfeldt, Jens, 2019, In: Antioxidants. 8, 6, 153.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Generic immune complex assay for detection of murine anti-drug-antibodies in complex with human IgG

    Boysen, L., Sprinkel, A. M. E., Lauritzen, B., Breinholt, J., Lykkesfeldt, Jens, Viuff, B. M. & Landsy, L. H., 2019, In: Biologicals. 60, p. 42-48 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Gamma-tocopherol supplementation inhibits protein nitration and ascorbate oxidation in rats with inflammation

    Jiang, Q., Lykkesfeldt, Jens, Shigenaga, M. K., Shigeno, E. T., Christen, S. & Ames, B. N., 2002, In: Free Radical Biology & Medicine. 33, 11, p. 1534-1542 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Functional network analysis of obese and lean Göttingen minipigs elucidates changes in oxidative and inflammatory networks in obese pigs

    Boonen, H. C. M., Moesgaard, S. G., Birck, M. M., Christoffersen, B. Ø., Cirera, Susanna, Heegaard, P. M. H., Højbøge, T. R., Jensen, Lars Jørn, Mortensen, A., Olsen, Lisbeth Høier, Sheykhzade, Majid, Tang, J. & Lykkesfeldt, Jens, 2014, In: Pflügers ARchiv (European Journal of Physiology). 466, 12, p. 2167-2176 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Formation and glomerular deposition of immune complexes in mice administered bovine serum albumin: Evaluation of dose, frequency, and biomarkers

    Boysen, L., Viuff, B. M., Landsy, L. H., Price, S. A., Raymond, J. T., Lykkesfeldt, Jens & Lauritzen, B., 2019, In: Journal of Immunotoxicology. 16, 1, p. 191-200 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Formation and Glomerular Deposition of Immune Complexes in Mice Administered Human Antibodies: Evaluation of Dose, Frequency, and Biomarkers

    Boysen, L., Viuff, B. M., Landsy, L. H., Lykkesfeldt, Jens, Raymond, J. T., Price, S. A., Pelzer, H. & Lauritzen, B., 2020, In: Toxicologic Pathology. 48, 4, p. 570-585 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Food intake rather than blood glucose levels affects the pharmacokinetic profile of insulin aspart in pigs

    Gradel, Anna Katrina Jógvansdóttir, Kildegaard, J., Porsgaard, T., Lykkesfeldt, Jens & Refsgaard, H. H. F., 2021, In: Basic & Clinical Pharmacology & Toxicology. 128, 6, p. 783-794

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Fluctuating hyperglycaemia increases oxidative stress response in lean rats compared to sustained hyperglycaemia despite lower glycaemic exposure

    Rakipovski, G., Raun, K. & Lykkesfeldt, Jens, 2011, In: Diabetes and Vascular Disease Research. 8, 4, p. 295-298 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress

    Hagen, T. M., Liu, J., Lykkesfeldt, Jens, Wehr, C. M., Ingersoll, R. T., Vinarsky, V., Bartholomew, J. C. & Ames, B. N., 2002, In: Proceedings of the National Academy of Science of the United States of America. 99, 4, p. 1870-1875 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Factors Affecting the Vitamin C Dose-Concentration Relationship: Implications for Global Vitamin C Dietary Recommendations

    Carr, A. C. & Lykkesfeldt, Jens, 2023, In: Nutrients. 15, 7, 19 p., 1657.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Factors Affecting the Absorption of Subcutaneously Administered Insulin: Effect on Variability

    Gradel, Anna Katrina Jógvansdóttir, Porsgaard, T., Lykkesfeldt, Jens, Seested, T., Gram-Nielsen, S., Kristensen, N. R. & Refsgaard, H., 2018, In: Journal of Diabetes Research. 2018, 17 p., 1205121.

    Research output: Contribution to journal › Review › Research › peer-review

  17. Published

    Expression of endothelin type B receptors in uterine artery smooth muscle cells from pregnant Guinea pigs

    Skovsted, Gry Freja, Tveden-Nyborg, Pernille & Lykkesfeldt, Jens, 2019, In: Placenta. 77, p. 8-15 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Expression of endothelin type B receptors (EDNRB) on smooth muscle cells is controlled by ternary complex factors and the actin cytoskeleton

    Krawczyk, K. K., Skovsted, Gry Freja, Perisic, L., Rippe, C., Dreier, R., Berg, J. O., Lykkesfeldt, Jens, Hedin, U. & Sward, K., Apr 2018.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  19. Published

    Evaluation of a single dose versus a divided dose regimen of danofloxacin in treatment of Actinobacillus pleuropneumoniae infection in pigs

    Lauritzen, B., Lykkesfeldt, Jens & Friis, C., 2003, In: Research in Veterinary Science. 74, 3, p. 271-277 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Evaluation of a single dose versus a divided dose regimen of amoxycillin in treatment of Actinobacillus pleuropneumoniae infection in pigs

    Lauritzen, B., Lykkesfeldt, Jens & Friis, C., 2005, In: Research in Veterinary Science. 79, 1, p. 61-67 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Evaluation of a single dose and a split-dose regimen of danofloxacin against Actinobacillus pleuropneumoniae infection in pigs

    Lauritzen, B., Lykkesfeldt, Jens & Friis, C., 2002.

    Research output: Contribution to conference › Paper › Research

  22. Published

    Estimation of Vitamin C Intake Requirements Based on Body Weight: Implications for Obesity

    Carr, A. C., Block, G. & Lykkesfeldt, Jens, 2022, In: Nutrients. 14, 7, 8 p., 1460.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Endothelial dysfunction in the early postoperative period after major colon cancer surgery.

    Ekeløf, S., Larsen, M. H., Schou-Pedersen, A. M. V., Lykkesfeldt, Jens, Rosenberg, Jacob & Gögenur, Ismail, Feb 2017, In: British Journal of Anaesthesia. 118, 2, p. 200-206

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Endothelial dysfunction and myocardial injury after major emergency abdominal surgery: a prospective cohort study

    Ekeloef, S., Oreskov, J. O., Falkenberg, A., Burcharth, J., Schou-Pedersen, A. M. V., Lykkesfeldt, Jens & Gögenur, Ismail, 2020, In: BMC Anesthesiology. 20, 9 p., 67.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Elimination of ascorbic acid after high-dose infusion in prostate cancer patients: a pharmacokinetic evaluation

    Nielsen, Torben Kjær, Højgaard, M., Andersen, J. T. T., Poulsen, Henrik Enghusen, Lykkesfeldt, Jens & Mikines, K. J., 2015, In: Basic & Clinical Pharmacology & Toxicology. 116, 4, p. 343-348 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Electroencephalographic changes after pediatric cardiac surgery with cardiopulmonary bypass: is slow wave activity unfavorable?

    Schmitt, B., Finckh, B., Christen, S., Lykkesfeldt, Jens, Schmid, E. R., Bauersfeld, U., Critelli, H., Hajnal, B. L., Gessler, P. & Molinari, L., 2005, In: Pediatric Research. 58, 4, p. 771-778 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Efficacy of fibroblast growth factor 21 in non-alcoholic fatty liver disease in guinea pigs

    Klaebel, J. H., Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2022, In: Basic & Clinical Pharmacology & Toxicology. 130, 3, p. 385-393

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Effects of two- and twelve-weeks sodium-glucose cotransporter 2 inhibition on DNA and RNA oxidation: two randomized, placebo-controlled trials

    Larsen, E. L., Andersen, A., Kjær, L. K., Eickhoff, M. K., Frimodt-Møller, M., Persson, F., Rossing, Peter, Lykkesfeldt, Jens, Knop, Filip Krag, Vilsbøll, Tina, Rungby, Jørgen & Poulsen, Henrik Enghusen, 2023, In: Free Radical Research. 57, 2, p. 140-151

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Effects of heparin-binding protein (CAP37/azurocidin) in a porcine model of Actinobacillus pleuropneumoniae-induced pneumonia

    Lauritzen, B., Lykkesfeldt, Jens, Djurup, R., Flodgaard, H. & Svendsen, O., 2005, In: Pharmacological Research. 51, 6, p. 509-514 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Effect of vitamin C and iron chelation on diesel exhaust particle and carbon black induced oxidative damage and cell adhesion molecule expression in human endothelial cells

    Frikke-Schmidt, H. R., Roursgaard, Martin, Lykkesfeldt, Jens, Loft, Steffen, Nøjgaard, J. K. & Møller, Peter, 2011, In: Toxicology Letters. 203, 3, p. 181-189 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Effect of smoking on erythorbic acid pharmacokinetics

    Lykkesfeldt, Jens, Bolbjerg, M. L. & Poulsen, H. E., 2003, In: British Journal of Nutrition. 89, 5, p. 667-671 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Effect of smoking cessation on plasma ascorbic acid concentration

    Lykkesfeldt, Jens, Priemé, H., Loft, Steffen & Poulsen, Henrik Enghusen, 13 Jul 1996, In: B M J (Clinical Research Edition). 313, 7049, p. 91

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Effect of melatonin on human nighttime endotoxaemia: randomized, double-blinded, cross-over study

    Alamili, M., Bendtzen, K., Lykkesfeldt, Jens, Rosenberg, Jacob & Gögenur, Ismail, 2014, In: In Vivo. 28, 6, p. 1057-1063 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Effect of maternal hypoglycaemia during gestation on materno-foetal nutrient transfer and embryo-foetal development: Evidence from experimental studies focused primarily on the rat

    Jensen, Vivi Flou Hjorth, Mølck, A. M., Lykkesfeldt, Jens & Bøgh, I. B., Apr 2018, In: Reproductive Toxicology. 77, p. 1-24 24 p.

    Research output: Contribution to journal › Review › Research › peer-review

  35. Published

    Effect of insulin-induced hypoglycaemia on the peripheral nervous system: focus on adaptive mechanisms, pathogenesis and histopathological changes

    Jensen, Vivi Flou Hjorth, Mølck, A., Bøgh, I. B. & Lykkesfeldt, Jens, 2014, In: Journal of Neuroendocrinology. 26, 8, p. 482-496 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Effect of insulin-induced hypoglycaemia on the central nervous system: evidence from experimental studies

    Jensen, Vivi Flou Hjorth, Bøgh, I. B. & Lykkesfeldt, Jens, 2014, In: Journal of Neuroendocrinology. 26, 3, p. 123-150 28 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Effect of antioxidant supplementation on insulin sensitivity in response to endurance exercise training

    Yfanti, C., Nielsen, A. R., Åkerström, T., Nielsen, S., Rose, A. J., Richter, Erik A., Lykkesfeldt, Jens, Fischer, C. P. & Pedersen, Bente Klarlund, 2011, In: American Journal of Physiology: Endocrinology and Metabolism. 300, 5, p. E761-E770 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Effect of Remote Ischaemic Preconditioning on Perioperative Endothelial Dysfunction in Non-Cardiac Surgery: A Randomised Clinical Trial

    Wahlstrøm, K. L., Hansen, H. F., Kvist, M., Burcharth, Jakob, Lykkesfeldt, Jens, Gögenur, Ismail & Ekeloef, S., 2023, In: Cells. 12, 6, 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Effect of High Inspiratory Oxygen Fraction on Endothelial Dysfunction in Healthy Volunteers: A Randomized Controlled Cross-over Pilot Study

    Larsen, M. H. H., Ekeløf, S., Kokotovic, D., Schou-Pedersen, A. M. V., Lykkesfeldt, Jens & Gögenur, I., 2017, In: Anesthesia and Analgesia. 125, 5, p. 1793–1796

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Early life vitamin C deficiency does not alter morphology of hippocampal CA1 pyramidal neurons or markers of synaptic plasticity in a Guinea pig model

    Hansen, S. N., Jørgensen, J. M. B., Nyengaard, J. R., Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2018, In: Nutrients. 10, 6, 749.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Dyslipidemia: Obese or Not Obese-That Is Not the Question

    Ipsen, David Højland, Tveden-Nyborg, Pernille & Lykkesfeldt, Jens, Dec 2016, In: Current Obesity Reports. 5, 4, p. 405-412

    Research output: Contribution to journal › Review › Research › peer-review

  42. Published

    Does vitamin C matter? A quest for in vivo effects of vitamin C deficiency

    Lykkesfeldt, Jens, 2008, In: Free Radical Research. 42, S1, p. s23 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research

  43. Published

    Does vitamin C enhance nitric oxide bioavailability in a tetrahydrobiopterin-dependent manner? In vitro, in vivo and clinical studies

    Mortensen, A. & Lykkesfeldt, Jens, 2014, In: Nitric Oxide: Biology and Chemistry. 36, p. 51-57 7 p.

    Research output: Contribution to journal › Review › Research › peer-review

  44. Published

    Does vitamin C deficiency result in impaired brain development in infants?

    Tveden-Nyborg, Pernille & Lykkesfeldt, Jens, 2009, In: Redox Report. 14, 1, p. 2-6 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Does vitamin C deficiency promote fatty liver disease development?

    Ipsen, David Højland, Tveden-Nyborg, Pernille & Lykkesfeldt, Jens, 2014, In: Nutrients. 6, 12, p. 5473-5499 27 p.

    Research output: Contribution to journal › Review › Research › peer-review

  46. Published

    Does vitamin C deficiency increase lifestyle-associated vascular disease progression? evidence based on experimental and clinical studies

    Tveden-Nyborg, Pernille & Lykkesfeldt, Jens, 2013, In: Antioxidants & Redox Signaling. 19, 17, p. 2084-2104 21 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Does vitamin C deficiency affect cognitive development and function?

    Hansen, S. N., Tveden-Nyborg, Pernille & Lykkesfeldt, Jens, 2014, In: Nutrients. 6, 9, p. 3818-3846 29 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Does Glucagon-like Peptide-1 Ameliorate Oxidative Stress in Diabetes? Evidence Based on Experimental and Clinical Studies

    Petersen, Karen Ekkelund, Rakipovski, G., Raun, K. & Lykkesfeldt, Jens, 2016, In: Current Diabetes Reviews. 12, 4, p. 331-358 28 p.

    Research output: Contribution to journal › Review › Research › peer-review

  49. Published

    Does Aging Affect Vitamin C Status Relative to Intake? Findings from NHANES 2017-2018

    Carr, A. C. & Lykkesfeldt, Jens, 2023, In: Nutrients. 15, 4, 10 p., 892.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Distribution of vitamin C is tissue specific with early saturation of the brain and adrenal glands following differential oral dose regimens in guinea pigs

    Andersen, S. H., Tveden-Nyborg, Pernille & Lykkesfeldt, Jens, 2015, In: British Journal of Nutrition. 113, 10, p. 1539-1549 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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