Ulrik Gether

Ulrik Gether

Head of Department, Professor

ORCID: 0000-0002-0020-3807

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  1. Published

    Structural and functional probing of the biogenic amine transporters by fluorescence spectroscopy

    Rasmussen, Søren Gøgsig Faarup, Adkins, E. M., Carroll, F. I., Maresch, M. J. & Gether, Ulrik, 31 Oct 2003, In: European Journal of Pharmacology. 479, 1-3, p. 13-22 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Steric hindrance mutagenesis in the conserved extracellular vestibule impedes allosteric binding of antidepressants to the serotonin transporter

    Plenge, P., Shi, L., Beuming, T., Te, J., Newman, A. H., Weinstein, H., Gether, Ulrik & Loland, Claus Juul, 16 Nov 2012, In: The Journal of Biological Chemistry. 287, 47, p. 39316-26 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Serotonin-induced down-regulation of cell surface serotonin transporter

    Jørgensen, T. N., Christensen, P. M. & Gether, Ulrik, Jul 2014, In: Neurochemistry International. 73, p. 107-12 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Serine 77 in the PDZ domain of PICK1 is a protein kinase Cα phosphorylation site regulated by lipid membrane binding

    Ammendrup-Johnsen, I., Thorsen, T. S., Gether, Ulrik & Madsen, Kenneth Lindegaard, 17 Jan 2012, In: Biochemistry. 51, 2, p. 586-96 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    SLC6 Neurotransmitter Transporters: Structure, Function, and Regulation

    Kristensen, Anders Skov, Andersen, J., Jørgensen, T. N., Sørensen, L., Eriksen, J., Loland, Claus Juul, Strømgaard, Kristian & Gether, Ulrik, 1 Sep 2011, In: Pharmacological Reviews. 63, 3, p. 585-640 56 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Role of dopamine neurons in familiarity

    Fleury, S., Kolaric, R., Espera, J., Ha, Q., Tomaio, J., Gether, Ulrik, Sørensen, Andreas Toft & Mingote, S., 2024, In: European Journal of Neuroscience. 59, 10, p. 2522-2534 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Rhodamine-labeled 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)tropane analogues as high-affinity fluorescent probes for the dopamine transporter

    Cha, J. H., Zou, M., Adkins, E. M., Rasmussen, Søren Gøgsig Faarup, Loland, Claus Juul, Schoenenberger, B., Gether, Ulrik & Newman, A. H., 1 Dec 2005, In: Journal of Medicinal Chemistry. 48, 24, p. 7513-6 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Residues in the extracellular loop 4 are critical for maintaining the conformational equilibrium of the gamma-aminobutyric acid transporter-1.

    MacAulay, Nanna, Meinild, A., Zeuthen, Thomas & Gether, Ulrik, 2003, In: Journal of Biological Chemistry. 278, 31, p. 28771-7 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Reply to Wilkinson et al. Concerning the use of pHluorin-tagged GluA2 as a reporter for NMDA-induced AMPA receptor recycling

    Rathje, Mette, Fang, H., Bachman, J. L., Gether, Ulrik, Huganir, R. L. & Madsen, Kenneth Lindegaard, 21 Jan 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 3, p. E305 1 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Reliability of clinical ICD-10 diagnoses among electroconvulsive therapy patients with chronic affective disorders

    Jakobsen, K. D., Hansen, T. F., Dam, H., Larsen, E. B., Gether, Ulrik & Werge, Thomas, 2008, In: European Journal of Psychiatry. 22, 3, p. 161-172 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Relationship between conformational changes in the dopamine transporter and cocaine-like subjective effects of uptake inhibitors.

    Loland, Claus Juul, Desai, R. I., Zou, M., Cao, J., Grundt, P., Gerstbrein, K., Sitte, H. H., Newman, A. H., Katz, J. L. & Gether, Ulrik, 2007, In: Molecular Pharmacology. 73, 3, p. 813-23 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Regulation of dopamine transporter trafficking by intracellular amphetamine.

    Kahlig, K. M., Lute, B. J., Wei, Y., Loland, Claus Juul, Gether, Ulrik, Javitch, J. A. & Galli, A., 2006, In: Molecular Pharmacology. 70, 2, p. 542-8 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Regulation of dopamine transporter function by protein-protein interactions: new discoveries and methodological challenges

    Eriksen, J., Jørgensen, T. N. & Gether, Ulrik, 2010, In: Journal of Neurochemistry. 113, 1, p. 27-41 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Recruitment of beta-arrestin2 to the dopamine D2 receptor: insights into anti-psychotic and anti-parkinsonian drug receptor signaling

    Klewe, I. V., Nielsen, S. M., Tarpø, L., Urizar, E., Dipace, C., Javitch, J. A., Gether, Ulrik, Egebjerg, J. & Christensen, K. V., 2008, In: Neuropharmacology. 54, 8, p. 1215-1222 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Rationale and design of the participant, investigator, observer, and data-analyst-blinded randomized AGENDA trial on associations between gene-polymorphisms, endophenotypes for depression and antidepressive intervention: the effect of escitalopram versus placebo on the combined dexamethasone-corticotrophine releasing hormone test and other potential endophenotypes in healthy first-degree relatives of persons with depression

    Knorr, Ulla Benedichte Søsted, Vinberg, Maj, Klose, M., Feldt-Rasmussen, Ulla, Hilsted, Linda, Gade, A., Haastrup, E., Paulson, Olaf B., Wetterslev, J., Gluud, C., Gether, Ulrik & Kessing, Lars Vedel, 2009, In: Trials. 10, p. 66

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Rare autism-associated variants implicate syntaxin 1 (STX1 R26Q) phosphorylation and the dopamine transporter (hDAT R51W) in dopamine neurotransmission and behaviors

    Cartier, E., Hamilton, P. J., Belovich, A. N., Shekar, A., Campbell, N. G., Saunders, C., Andreassen, T. F., Gether, Ulrik, Veenstra-Vanderweele, J., Sutcliffe, J. S., Ulery-Reynolds, P. G., Erreger, K., Matthies, H. J. G. & Galli, A., Feb 2015, In: EBioMedicine. 2, 2, p. 135-146 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Rab2 drives axonal transport of dense core vesicles and lysosomal organelles

    Lund, Viktor Karlovich, Lycas, M. D., Schack, A., Andersen, Rita Chan, Gether, Ulrik & Kjærulff, Ole, 2021, In: Cell Reports. 35, 2, 26 p., 108973.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Purification and fluorescent labeling of the human serotonin transporter

    Rasmussen, Søren Gøgsig Faarup & Gether, Ulrik, 8 Mar 2005, In: Biochemistry. 44, 9, p. 3494-505 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Protein interacting with C-kinase 1 (PICK1) binding promiscuity relies on unconventional PSD-95/Discs-Large/ZO-1 homology (PDZ) binding modes for nonclass II PDZ ligands

    qrc243, qrc243, Rathje, Mette, Heiðarsson, P. O., Poulsen, F. M., Madsen, Kenneth Lindegaard, Teilum, Kaare & Gether, Ulrik, 2014, In: Journal of Biological Chemistry. 289, 36, p. 25327-25340 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Protein interacting with C kinase 1 (PICK1) reduces reinsertion rates of interaction partners sorted to Rab11-dependent slow recycling pathway

    Madsen, Kenneth Lindegaard, Thorsen, T. S., Rahbek-Clemmensen, T., Eriksen, J. M. & Gether, Ulrik, 6 Apr 2012, In: The Journal of Biological Chemistry. 287, 15, p. 12293-308 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Probing dopamine transporter structure and function y Zn2+ site engineering

    Loland, Claus Juul, Nørgaard-Nielsen, K. & Gether, Ulrik, 2003, In: European Journal of Pharmacology. Vol. 479, no 1-3, p. 187-97

    Research output: Contribution to journal › Review › Research › peer-review

  22. Published

    Probing dopamine transporter structure and function by Zn2+-site engineering

    Loland, Claus Juul, Norgaard-Nielsen, K. & Gether, Ulrik, 31 Oct 2003, In: European Journal of Pharmacology. 479, 1-3, p. 187-97 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Preserved dopaminergic homeostasis and dopamine-related behaviour in hemizygous TH-Cre mice

    Thomsen, A. H. R., Jensen, Kathrine Louise, Fitzpatrick, C. M., Dencker, D., Weikop, Pia, Gether, Ulrik & Rickhag, Karl Mattias, Jan 2017, In: European Journal of Neuroscience. 45, 1, p. 121-128

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Postendocytic sorting of constitutively internalized dopamine transporter in cell lines and dopaminergic neurons

    Eriksen, J., Bjørn-Yoshimoto, Walden, Jørgensen, T. N., Newman, A. H. & Gether, Ulrik, 2010, In: Journal of Biological Chemistry. 285, 35, p. 27289-301 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Phosphorylation of the norepinephrine transporter at threonine 258 and serine 259 is linked to protein kinase C-mediated transporter internalization

    Jayanthi, L. D., Annamalai, B., Samuvel, D. J., Gether, Ulrik & Ramamoorthy, S., 2006, In: Journal of Biological Chemistry. 281, 33, p. 23326-40 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Passive water and urea permeability of a human Na(+)-glutamate cotransporter expressed in Xenopus oocytes

    MacAulay, Nanna, Gether, Ulrik, Klærke, Dan Arne & Zeuthen, Thomas, 2002, In: Journal of Physiology. 542, 3, p. 817-828 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Partial Unwinding of Transmembrane Helices Facilitates Alternating Access in the Neurotransmitter: Sodium Symporter LeuT

    Merkle, P. S., Gotfryd, K., Cuendet, M. A., Leth-Espensen, K. Z., Gether, Ulrik, Loland, Claus Juul & Rand, Kasper Dyrberg, 28 Jun 2017

    Research output: Other contribution › Research

  28. Published

    PICK1-Deficient Mice Exhibit Impaired Response to Cocaine and Dysregulated Dopamine Homeostasis

    Jensen, Kathrine Louise, Sørensen, G., Dencker, D., Owens, W. A., Rahbek-Clemmensen, T., Brett Lever, M., Runegaard, A. H., Riis Christensen, N., Weikop, Pia, Wörtwein, Gitta, Fink-Jensen, Anders, Madsen, Kenneth Lindegaard, Daws, L., Gether, Ulrik & Rickhag, Karl Mattias, 2018, In: eNeuro. 5, 3

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    PICK1 expression in the Drosophila central nervous system primarily occurs in the neuroendocrine system

    Jansen, A. M., Nässel, D. R., Madsen, Kenneth Lindegaard, Jung, A. G., Gether, Ulrik & Kjærulff, Ole, 2009, In: Journal of Comparative Neurology. 517, 3, p. 313-32 19 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance

    Holst, Birgitte, Madsen, Kenneth Lindegaard, Jansen, A. M., Jin, C., Rickhag, Karl Mattias, Lund, Viktor Karlovich, Jensen, M., Bhatia, V., Sørensen, G., Madsen, A. N., Xue, Z., Møller, S. K., Woldbye, David Paul Drucker, Qvortrup, Klaus, Huganir, R., Stamou, Dimitrios, Kjærulff, Ole & Gether, Ulrik, Apr 2013, In: P L o S Biology (Online). 11, 4, p. 1-25 25 p., e1001542.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Optogenetik bringer neurale mekanismer frem i lyset og kan blive en ny terapiform

    Axelsen, T. M., Navntoft, C. A. E., Christiansen, S. H., Dreyer, J. K., Sørensen, Jakob Balslev, Gether, Ulrik & Woldbye, David Paul Drucker, 17 Aug 2015, In: Ugeskrift for Laeger. 177, 34, p. 2-5 4 p., V06150501.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Obituary

    Brøsen, K., Simonsen, U. & Gether, Ulrik, 2018, In: Basic & clinical pharmacology & toxicology. 123, 5, p. 521-522 2 p.

    Research output: Contribution to journal › Comment/debate › Communication

  33. Published

    Novel and high affinity fluorescent ligands for the serotonin transporter based on (s)-citalopram

    Kumar, V., Rahbek-Clemmensen, T., Billesbølle, C. B., Jorgensen, T. N., Gether, Ulrik & Newman, A. H., 12 Jun 2014, In: A C S Medicinal Chemistry Letters. 5, 6, p. 696-9 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Novel Tripod Amphiphiles for Membrane Protein Analysis

    Chae, P. S., Kruse, A. C., Gotfryd, K., Rana, R. R., Cho, K. H., Rasmussen, Søren Gøgsig Faarup, Bae, H. E., Chandra, R., Gether, Ulrik, Guan, L., Kobilka, B. K., Loland, Claus Juul, Byrne, B. & Gellman, S. H., 2 Oct 2013, In: Chemistry: A European Journal. 19, 46

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Novel Fluorescent Ligands Enable Single-Molecule Localization Microscopy of the Dopamine Transporter

    Guthrie, D. A., Klein Herenbrink, Carmen, Lycas, M. D., Ku, T., Bonifazi, A., Devree, B. T., Mathiasen, Signe, Javitch, J. A., Grimm, J. B., Lavis, L., Gether, Ulrik & Newman, A. H., 2020, In: ACS Chemical Neuroscience. 11, 20, p. 3288-3300 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    No interactions between genetic polymorphisms and stressful life events on outcome of antidepressant treatment

    Bukh, Jens Otto Drachmann, Bock, C., Vinberg, Maj, Werge, Thomas, Gether, Ulrik, Kessing, Lars Vedel, Bukh, J. D., Bock, C., Vinberg, Maj, Werge, Thomas, Gether, U. & Kessing, Lars Vedel, 2009, In: European Neuropsychopharmacology.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    No effect of escitalopram versus placebo on brain-derived neurotrophic factor in healthy individuals: a randomised trial

    Knorr, Ulla Benedichte Søsted, Koefoed, P., Soendergaard, M. H. G., Vinberg, Maj, Gether, Ulrik, Gluud, C., Wetterslev, J., Winkel, P. & Kessing, Lars Vedel, Apr 2016, In: Acta Neuropsychiatrica. 28, 2, p. 101-109 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Neurotransmitter transporters: structure and function

    Loland, Claus Juul & Gether, Ulrik, 2009, Texbook of Drug Design and Discovery. Madsen, U., Krogsgaard-Larsen, P. & Stromgaard, K. (eds.). 4 ed. Taylor & Francis

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education

  39. Published

    Neurotransmitter transporters: molecular function of important drug targets

    Gether, Ulrik, Andersen, P. H., Larsson, O. M. & Schousboe, A., 2006, In: Trends in Pharmacological Sciences. 27, 7, p. 375-383 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Neurotransmitter transporters: molecular function of important drug targets

    Gether, Ulrik, Andersen, P. H., Larsson, O. M. & Schousboe, Arne, Jul 2006, In: Trends in Pharmacological Sciences. 27, 7, p. 375-83 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Neurotransmitter Transporters: Structure, Function, and Drug Binding

    Loland, Claus Juul & Gether, Ulrik, 2017, Textbook of Drug Design and Discovery. Stromgaard, K., Krogsgaard-Larsen, P. & Madsen, U. (eds.). 5 ed. Boca Raton: CRC Press, p. 233-248 16 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education

  42. Published

    Neuropsychiatric disease-associated genetic variants of the dopamine transporter display heterogeneous molecular phenotypes

    Herborg, Freja, Andreassen, T. F., Berlin, F., Loland, Claus Juul & Gether, Ulrik, 2018, In: The Journal of Biological Chemistry. 293, 19, p. 7250-7262 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Nanoscopic dopamine transporter distribution and conformation are inversely regulated by excitatory drive and D2 autoreceptor activity

    Lycas, M. D., Ejdrup, Aske Lykke, Sørensen, Andreas Toft, Haahr, N. O., Jørgensen, Søren Heide, Guthrie, D. A., Støier, J. F., Werner, C., Newman, A. H., Sauer, M., Herborg, Freja & Gether, Ulrik, 2022, In: Cell Reports. 40, 13, 27 p., 111431.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    N-terminal truncation of the dopamine transporter abolishes phorbol ester- and substance P receptor-stimulated phosphorylation without impairing transporter internalization

    Granas, C., Ferrer, J., Loland, Claus Juul, Javitch, J. A. & Gether, Ulrik, 14 Feb 2003, In: The Journal of Biological Chemistry. 278, 7, p. 4990-5000 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    N-terminal truncation of the dopamine transporter abolishes phorbol ester- and substance P receptor-stimulated phosphorylation without impairing transporter interanalization

    Granas, C., Ferrer, J., Loland, Claus Juul, Javitch, J. A. & Gether, Ulrik, 2003, In: Journal of Biological Chemistry. Vol. 278 (7), p. 4990-5000

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Mutation of a conserved aspartic acid in the Beta2 adrenergic recptor: constitutive activation, structural instability, and conformational rearrangement of transmembrane segment VI

    Rasmussen, Søren Gøgsig Faarup, Dam Jensen, A., Ghanouni, P., Liapakis, G., Javitch, J. & Gether, Ulrik, 1999, In: Molecular Pharmacology. 56, p. 175-184

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Multimodal detection of dopamine by sniffer cells expressing genetically encoded fluorescent sensors

    Klein Herenbrink, Carmen, Støier, J. F., Reith, W. D., Dagra, A., Gregorek, M. A. C., Cola, R. B., Patriarchi, T., Li, Y., Tian, L., Gether, Ulrik & Herborg, Freja, 2022, In: Communications Biology . 5, 1, 578.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Molecular mechanisms of GPCR activation

    Rasmussen, Søren Gøgsig Faarup & Gether, Ulrik, 2006, G Protein-Coupled Receptors as Drug Targets: Analysis of Activation and Constitutive ActivityG Protein-Coupled Receptors as Drug Targets: Analysis of Activation and Constitutive Activity. 2006: Wiley, Vol. 24. p. 27-42 16 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication

  49. Published

    Molecular mechanism of action of non-peptide ligands for peptide receptors

    Schwartz, Thue W., Gether, Ulrik, Schambye, H. T. & Hjorth, Siv Annegrethe, Oct 1995, In: Current Pharmaceutical Design. 1, 3, p. 325-342 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Molecular determinants for the complex binding specifity of the PDZ domain in PICK1

    Madsen, K. L., Beuming, T., Niv, M. Y., Chang, C. W., Dev, K. K., Weinstein, H. & Gether, Ulrik, 2005, In: Journal of Biological Chemistry. Vol. 280, no. 21, p. 20539-48

    Research output: Contribution to journal › Journal article › Research › peer-review

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