Mette Kolpen
Guest researcher
Core Facility for Integrated Microscopy
Blegdamsvej 3B
2200 København N.
- Published
The consequences of being in an infectious biofilm – microenvironmental conditions governing antibiotic tolerance
Sønderholm, M., Bjarnsholt, Thomas, Alhede, M., Kolpen, Mette, Jensen, Peter Østrup, Kühl, Michael & Kragh, K. N., 2017, In: International Journal of Molecular Sciences. 18, 12, 14 p., 2688.Research output: Contribution to journal › Review › Research › peer-review
- Published
Tools for studying growth patterns and chemical dynamics of aggregated Pseudomonas aeruginosa exposed to different electron acceptors in an alginate bead model
Sønderholm, M., Koren, K., Wangpraseurt, D., Jensen, Peter Østrup, Kolpen, Mette, Kragh, K. N., Bjarnsholt, Thomas & Kühl, Michael, 2018, In: npj Biofilms and Microbiomes. 4, 11 p., 3.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hyperbaric oxygen treatment increases killing of aggregating Pseudomonas aeruginosa isolates from cystic fibrosis patients
Møller, S. A., Jensen, Peter Østrup, Høiby, Niels, Ciofu, Oana, Kragh, K. N., Bjarnsholt, Thomas & Kolpen, Mette, 2019, In: Journal of Cystic Fibrosis. 18, 5, p. 657–664Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biofilms and host response - helpful or harmful
Moser, Claus Ernst, Pedersen, H. T., Lerche, C. J., Kolpen, Mette, Line, L., Thomsen, K., Høiby, Niels & Jensen, Peter Østrup, Apr 2017, In: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 125, 4, p. 320-338 19 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Synergy between Mecillinam and Ceftazidime/Avibactam or Avibactam against Multi-Drug-Resistant Carbapenemase-Producing Escherichia coli and Klebsiella pneumoniae
List, K. K., Kolpen, Mette, Kragh, K. N., Charbon, Godefroid, Radmer, S., Hansen, F., Løbner-Olesen, Anders, Frimodt-Møller, N. & Hertz, F. B., 2022, In: Antibiotics. 11, 10, 13 p., 1280.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Physiological levels of nitrate support anoxic growth by denitrification of Pseudomonas aeruginosa at growth rates reported in cystic fibrosis lungs and sputum
Line, L., Alhede, M., Kolpen, Mette, Kühl, Michael, Ciofu, Oana, Bjarnsholt, Thomas, Moser, Claus Ernst, Toyofuku, M., Nomura, N., Høiby, Niels & Jensen, Peter Østrup, 2014, In: Frontiers in Microbiology. 5, 11 p., 554.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The structure-function relationship of Pseudomonas aeruginosa in infections and its influence on the microenvironment
Lichtenberg, Mads, Jakobsen, Tim Holm, Kühl, Michael, Kolpen, Mette, Jensen, Peter Østrup & Bjarnsholt, Thomas, 2022, In: FEMS Microbiology Reviews. 46, 5, 13 p., fuac018.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Nitric-oxide-driven oxygen release in anoxic Pseudomonas aeruginosa
Lichtenberg, Mads, Line, L., Schrameyer, V., Jakobsen, Tim Holm, Rybtke, Morten Levin, Toyofuku, M., Nomura, N., Kolpen, Mette, Tolker-Nielsen, Tim, Kühl, Michael, Bjarnsholt, Thomas & Jensen, Peter Østrup, 2021, In: iScience. 24, 12, 103404.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hyperbaric oxygen treatment augments tobramycin efficacy in experimental staphylococcus aureus endocarditis
Lerche, C. J., Christophersen, L. J., Kolpen, Mette, Nielsen, P. R., Trøstrup, H., Thomsen, K., Hyldegaard, Ole, Bundgård, Henning, Jensen, Peter Østrup, Høiby, Niels & Moser, Claus Ernst, 2017, In: International Journal of Antimicrobial Agents. 50, 3, p. 406-412Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hyperbaric oxygen therapy augments ciprofloxacin effect against Pseudomonas aeruginosa biofilm infected chronic wounds in a mouse model
Laulund, A. S., Schwartz, F. A., Christophersen, L., Kolpen, Mette, Jensen, Peter Østrup, Calum, Henrik Pierre, Høiby, Niels, Thomsen, K. & Moser, Claus Ernst, 2023, In: Biofilm. 5, 100100.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Oxygen restriction generates difficult-to-culture p. Aeruginosa
Kvich, Lasse Andersson, Fritz, Blaine Gabriel, Crone, S., Kragh, K. N., Kolpen, Mette, Sønderholm, M., Andersson, M., Koch, A., Jensen, Peter Østrup & Bjarnsholt, Thomas, 2019, In: Frontiers in Microbiology. 10, AUG, 15 p., 1992.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Reinforcement of the bactericidal effect of ciprofloxacin on Pseudomonas aeruginosa biofilm by hyperbaric oxygen treatment
Kolpen, Mette, Mousavi, N., Sams, T., Bjarnsholt, Thomas, Ciofu, Oana, Moser, Claus Ernst, Kühl, Michael, Høiby, Niels & Jensen, Peter Østrup, 2016, In: International Journal of Antimicrobial Agents. 47, 2, p. 163–167 5 p.Research output: Contribution to journal › Letter › Research › peer-review
- Published
Hyperbaric oxygen sensitizes anoxic Pseudomonas aeruginosa biofilm to ciprofloxacin
Kolpen, Mette, Lerche, C. J., Kragh, K. N., Sams, T., Koren, K., Jensen, A. S., Line, L., Bjarnsholt, Thomas, Ciofu, Oana, Moser, Claus Ernst, Kühl, Michael, Høiby, Niels & Jensen, Peter Østrup, Nov 2017, In: Antimicrobial Agents and Chemotherapy. 61, 11, 9 p., e01024-17.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Nitric oxide production by polymorphonuclear leukocytes in sputum from cystic fibrosis patients with chronic lung infection
Kolpen, Mette, Bjarnsholt, Thomas, Moser, C., Hansen, C. R., Kühl, Michael, Høiby, Niels & Jensen, P. Ø., 2010, In: Journal of Cystic Fibrosis. Supplement 1, p. S49 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Nitric oxide production by polymorphonuclear leukocytes in infected cystic fibrosis sputum consumes oxygen
Kolpen, Mette, Bjarnsholt, Thomas, Moser, Claus Ernst, Hansen, C. R., Rickelt, L. F., Kühl, Michael, Hempel, C., Pressler, T., Høiby, Niels & Jensen, Peter Østrup, 2014, In: Clinical and Experimental Immunology. 177, 1, p. 310–319 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Denitrification by cystic fibrosis pathogens - Stenotrophomonas maltophilia is dormant in sputum
Kolpen, Mette, Kragh, K. N., Bjarnsholt, Thomas, Line, L., Hansen, C. R., Dalbøge, C. S., Hansen, N., Kühl, Michael, Høiby, Niels & Jensen, Peter Østrup, 2015, In: International Journal of Medical Microbiology. 305, 1, p. 1-10 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Nitrous oxide production in sputum from cystic fibrosis patients with chronic Pseudomonas aeruginosa lung infection
Kolpen, Mette, Kühl, Michael, Bjarnsholt, Thomas, Moser, Claus Ernst, Hansen, C. R., Liengaard, L., Kharazmi, A., Pressler, T., Høiby, Niels & Jensen, Peter Østrup, 2014, In: PLOS ONE. 9, 1, p. e84353 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Polymorphonuclear leucocytes consume oxygen in sputum from chronic Pseudomonas aeruginosa pneumonia in cystic fibrosis
Kolpen, Mette, Hansen, C. R., Bjarnsholt, Thomas, Moser, C., Hultqvist, Louise Dahl, van Gennip, M., Ciofu, Oana, Mandsberg, L., Kharazmi, A., Döring, G., Givskov, Michael, Høiby, Niels & Jensen, Peter Østrup, 1 Jan 2010, In: Thorax. 65, 1, p. 57-62 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biofilms of mycobacterium abscessus complex can be sensitized to antibiotics by disaggregation and oxygenation
Kolpen, Mette, Jensen, Peter Østrup, Qvist, T., Kragh, K. N., Ravnholt, C., Fritz, Blaine Gabriel, Johansen, U. R., Bjarnsholt, Thomas & Høiby, Niels, 2020, In: Antimicrobial Agents and Chemotherapy. 64, 2, e01212.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Increased bactericidal activity of colistin on Pseudomonas aeruginosa biofilms in anaerobic conditions
Kolpen, Mette, Appeldorff, C. F., Brandt, S., Mousavi, N., Kragh, K. N., Aydogan, S., Uppal, H. A., Bjarnsholt, Thomas, Ciofu, Oana, Høiby, Niels & Jensen, Peter Østrup, Feb 2016, In: Pathogens and Disease. 74, 1, 7 p., ftv086.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bacterial biofilms predominate in both acute and chronic human lung infections
Kolpen, Mette, Kragh, K. N., Enciso, J. B., Faurholt-Jepsen, D., Lindegaard, Birgitte, Egelund, G. B., Jensen, A. V., Ravn, P., Mathiesen, I. H. M., Gheorghe, Alexandra Gabriella, Hertz, Frederik Boëtius, Qvist, T., Whiteley, M., Jensen, Peter Østrup & Bjarnsholt, Thomas, 2022, In: European Respiratory Journal. Supplement. 60, Suppl. 66, 4.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
RE-SENSITIZATION OF ANOXIC PSEUDOMONAS AERUGINOSA BIOFILMS WITH RE-OXYGENATION USING HYPERBARIC OXYGEN TREATMENT
Kolpen, Mette, Mousavi, N., Sams, T., Kragh, K. N., Bjarnsholt, Thomas, Ciofu, Oana, Høiby, Niels & Jensen, P. O., Oct 2015, In: Pediatric Pulmonology. 50, S41, p. 312-312 1 p., 322.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Exhaled nitric oxide in intubated ICU patients on mechanical ventilation—a feasibility study
Kofoed, A., Hindborg, M., Hjembæk-Brandt, J., Sørensen, C. D., Kolpen, Mette & Bestle, Morten Heiberg, 2023, In: Journal of Breath Research. 17, 4, 6 p., 046014.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antimicrobial resistance of Pseudomonas aeruginosa in a cystic fibrosis population after introduction of a novel cephalosporin/β-lactamase inhibitor combination
Katzenstein, T. L., Faurholt-Jepsen, D., Qvist, T., Jensen, Peter Østrup, Pressler, T., Johansen, Helle Krogh & Kolpen, Mette, 2023, In: APMIS. 131, 8, p. 419-425Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Increased sputum lactate during oral glucose tolerance test in cystic fibrosis
Jensen, Peter Østrup, Nielsen, B. U., Kolpen, Mette, Pressler, T., Faurholt-Jepsen, D. & Mathiesen, I. H. M., 2022, In: APMIS. 130, 8, p. 535-539Research output: Contribution to journal › Journal article › Research › peer-review
- E-pub ahead of print
Bacterial aerobic respiration is a major consumer of oxygen in sputum from patients with acute lower respiratory tract infection
Jensen, Peter Østrup, Olsen, P., Dungu, A. M., Egelund, G. B., Jensen, A. V., Ravn, P., Lindegaard, Birgitte, Hertz, Frederik Boëtius, Bjarnsholt, Thomas, Faurholt-Jepsen, D. & Kolpen, Mette, 2024, (E-pub ahead of print) In: APMIS.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Formation of hydroxyl radicals contributes to the bactericidal activity of ciprofloxacin against Pseudomonas aeruginosa biofilms
Jensen, Peter Østrup, Briales, A., Brochmann, R. P., Wang, H., Kragh, K. N., Kolpen, Mette, Hempel, C., Bjarnsholt, Thomas, Høiby, Niels & Ciofu, Oana, 2014, In: Pathogens and Disease. 70, 3, p. 440-443 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hyperbaric Oxygen Treatment May Advance the Outcome of Antibiotic Treatment of Biofilm Infections
Jensen, Peter Østrup, Møller, S. A., Stjernekilde, S., Olsen, P., Moser, Claus Ernst, Schwartz, F. A., Lerche, C. J., Høiby, Niels, Hyldegaard, Ole, Faurholt-jepsen, D. & Kolpen, Mette, 2022, Antibiofilm Strategies: Current and Future Applications to Prevent, Control and Eradicate Biofilms. Springer, p. 201-223 (Antibiofilm Strategies, Vol. 11).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Microenvironmental characteristics and physiology of biofilms in chronic infections of CF patients are strongly affected by the host immune response
Jensen, Peter Østrup, Kolpen, Mette, Kragh, K. N. & Kühl, Michael, 2017, In: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 125, 4, p. 276–288 13 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Improving antibiotic treatment of bacterial biofilm by hyperbaric oxygen therapy: Not just hot air
Jensen, Peter Østrup, Møller, S. A., Lerche, C. J., Moser, Claus Ernst, Bjarnsholt, Thomas, Ciofu, Oana, Faurholt-Jepsen, Daniel, Høiby, Niels & Kolpen, Mette, 2019, In: Biofilm. 1, 4 p., 100008.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Complete genome sequence of the cystic fibrosis pathogen Achromobacter xylosoxidans NH44784-1996 complies with important pathogenic phenotypes
Jakobsen, T. H., Hansen, M. A., Jensen, P. Ø., Hansen, L., Riber, L., Cockburn, A. P. I., Kolpen, M., Hansen, C. R., Ridderberg, W., Eickhardt-Sørensen, S. R., Hansen, M., Kerpedjiev, P., Alhede, M., Qvortrup, K., Burmølle, M., Moser, C. E., Kühl, M., Ciofu, O., Givskov, M., Sørensen, S. J. & 2 others, , 2013, In: P L o S One. 8, 7, 17 p., e68484.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Diagnosis of biofilm infections in cystic fibrosis patients
Høiby, Niels, Bjarnsholt, Thomas, Moser, Claus Ernst, Jensen, Peter Østrup, Kolpen, Mette, Qvist, T., Aanæs, Kasper, Pressler, T., Skov, M. & Ciofu, Oana, Apr 2017, In: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 125, 4, p. 339-343 5 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Pseudomonas aeruginosa Biofilms in the Lungs of Cystic Fibrosis Patients
Høiby, Niels, Johansen, Helle Krogh, Moser, Claus Ernst, Ciofu, Oana, Jensen, Peter Østrup, Kolpen, Mette, Mandsberg, L., Givskov, Michael, Molin, S. & Bjarnsholt, Thomas, 2011, Biofilm Infections. Springer, p. 167-184 18 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Modelling of ciprofloxacin killing enhanced by hyperbaric oxygen treatment in Pseudomonas aeruginosa PAO1 biofilms
Gade, P. A. V., Olsen, T. B., Jensen, Peter Østrup, Kolpen, Mette, Høiby, Niels, Henneberg, K. Å. & Sams, T., 2018, In: PLoS ONE. 13, 6, 16 p., e0198909.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The inflamed sputum in lower respiratory tract infection: l-lactate levels are correlated to neutrophil accumulation
Fredman, G., Kolpen, Mette, Hertz, F. B., Petersen, P. T., Jensen, A. V., Baunbæk-Egelund, G., Ravn, Pernille, Jensen, Peter Østrup & Faurholt-Jepsen, Daniel, 2019, In: APMIS. 127, 2, p. 72-79Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Diffusion retardation by binding of tobramycin in an alginate biofilm model
Cao, B., Christophersen, L., Kolpen, Mette, Jensen, Peter Østrup, Sneppen, Kim, Høiby, Niels, Moser, Claus Ernst & Sams, T., 21 Apr 2016, In: P L o S One. 11, 4, 11 p., e0153616.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bactericidal effect of colistin on planktonic Pseudomonas aeruginosa is independent of hydroxyl radical formation
Brochmann, R. P., Toft, A., Ciofu, Oana, Briales, A., Kolpen, Mette, Hempel, C., Bjarnsholt, Thomas, Høiby, Niels & Jensen, Peter Østrup, 2014, In: International Journal of Antimicrobial Agents. 43, 2, p. 140-147 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Adaptation of Pseudomonas aeruginosa biofilms to tobramycin and the quorum sensing inhibitor C-30 during experimental evolution requires multiple genotypic and phenotypic changes
Bové, M., Kolpen, Mette, Lichtenberg, Mads, Bjarnsholt, Thomas & Coenye, T., 2023, In: Microbiology (United Kingdom). 169, 1, 001278.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 17579642
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2988
downloads
Physiological levels of nitrate support anoxic growth by denitrification of Pseudomonas aeruginosa at growth rates reported in cystic fibrosis lungs and sputum
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
2839
downloads
Complete genome sequence of the cystic fibrosis pathogen Achromobacter xylosoxidans NH44784-1996 complies with important pathogenic phenotypes
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
1921
downloads
Nitrous oxide production in sputum from cystic fibrosis patients with chronic Pseudomonas aeruginosa lung infection
Research output: Contribution to journal › Journal article › Research › peer-review
Published