Arne Schousboe
Professor, emeritus
Molecular and Cellular Pharmacology
Jagtvej 160
2100 København Ø
- 2012
- Published
Brain glycogen: new perspectives on its metabolic function and regulation at the subcellular level
Obel, L. L. F., Müller, M. S., Walls, Anne Byriel, Sickmann, H. M., Bak, Lasse Kristoffer, Waagepetersen, Helle S. & Schousboe, Arne, 2 Mar 2012, In: Frontiers in Neuroenergetics. 4, 15 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Effects of adrenergic agents on intracellular ca(2+) homeostasis and metabolism of glucose in astrocytes with an emphasis on pyruvate carboxylation, oxidative decarboxylation and recycling: implications for glutamate neurotransmission and excitotoxicity
Obel, L. L. F., Andersen, K. M. H., Bak, Lasse Kristoffer, Schousboe, Arne & Waagepetersen, Helle S., 2012, In: Neurotoxicity Research. 21, 4, p. 405-17 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
(1S, 3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a potent gamma-aminobutyric acid aminotransferase inactivator for the treatment of cocaine addiction
Pan, Y., Gerasimov, M. R., Kvist, T., Wellendorph, Petrine, Madsen, K. K., Pera, E., Lee, H., Schousboe, Arne, Chebib, M., Bräuner, Hans, Craft, C. M., Brodie, J. D., Schiffer, W. K., Dewey, S. L., Miller, S. R. & Silverman, R. B., 1 Jan 2012, In: Journal of Medicinal Chemistry. 55, 1, p. 357-366Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glial cells in (patho)physiology
Parpura, V., Heneka, M. T., Montana, V., Oliet, S. H. R., Schousboe, Arne, Haydon, P. G., Stout Jr., R. F., Spray, D. C., Andreas, R., Pannicke, T., Pekny, M., Pekna, M., Zorec, R. & Verkhratsky, A., 2012, In: Journal of Neurochemistry. 121, 1, p. 4-27 24 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Studies of brain metabolism: a historical perspective
Schousboe, Arne, 2012, Neural metabolism in vivo. Choi, I-Y. & Gruetter, R. (eds.). New York: Springer Publishing Company, p. 909-920 12 p. (Advances in Neurobiology, Vol. 4).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Brain glycogen and its role in supporting glutamate and GABA homeostasis in a type 2 diabetes rat model
Sickmann, H. M., Waagepetersen, Helle S., Schousboe, Arne, Benie, A. J. & Bouman, S. D., 2012, In: Neurochemistry International. 60, 3, p. 267-75 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
siRNA knock down of glutamate dehydrogenase in astrocytes affects glutamate metabolism leading to extensive accumulation of the neuroactive amino acids glutamate and aspartate
Jensen, Dorte Skytt, Klawonn, A. M., Strid, M. H., Pajecka, K., Patruss, Y., Quintana-Cabrera, R., Bolanos, J. P., Schousboe, Arne & Waagepetersen, Helle S., 2012, In: Neurochemistry International. 61, 4, p. 490-497Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
- Published
Brain energy and ammonia metabolism
Bak, Lasse Kristoffer, Waagepetersen, Helle S. & Schousboe, Arne, 2011, Functional molecular imaging in hepatology. Bussum, The Netherlands: Bentham Science Publishers, p. 129-144Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Glutamate and glutamine in brain disorders
Bak, Lasse Kristoffer, Schousboe, Arne & Waagepetersen, Helle S., 2011, Neurochemical mechanisms in diseases. Blass, J. P. (ed.). New York: Springer Publishing Company, Vol. 1. p. 195-212 (Advances in Neurobiology).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Inhibition of glutamine synthesis induces glutamate dehydrogenase-dependent ammonia fixation into alanine in co-cultures of astrocytes and neurons
Dadsetan, S., Bak, Lasse Kristoffer, Sørensen, M., Keiding, S., Vilstrup, H., Ott, P., Leke, R., Schousboe, Arne & Waagepetersen, Helle S., 1 Sep 2011, In: Neurochemistry International. 59, 4, p. 482-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Branched-chain amino acids increase arterial blood ammonia in spite of enhanced intrinsic muscle ammonia metabolism in patients with cirrhosis and healthy subjects
Dam, G., Keiding, S., Munk, O. L., Ott, P., Buhl, M., Vilstrup, H., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Schousboe, Arne, Møller, N. & Sørensen, M., 1 Aug 2011, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 301, 2, p. G269-77Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mechanism of Ca2+/calmodulin-dependent kinase II regulation of AMPA receptor gating
Kristensen, Anders Skov, Jenkins, M. A., Banke, T. G., Schousboe, Arne, Makino, Y., Johnson, R. C., Huganir, R. & Traynelis, S. F., 1 Jun 2011, In: Nature Neuroscience. 14, 6, p. 727-735Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Deletion of the betaine-GABA transporter (BGT1; slc6a12) gene does not affect seizure thresholds of adult mice
Lehre, A. C., Rowley, N. M., Zhou, Y., Holmseth, S., Guo, C., Holen, T., Hua, R., Laake, P., Olofsson, A. M., Poblete-Naredo, I., Rusakov, D. A., Madsen, K. K., Clausen, Rasmus Prætorius, Schousboe, Arne, White, H. S. & Danbolt, N. C., 1 Jun 2011, In: Epilepsy Research. 95, 1-2, p. 70-81Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Detoxification of ammonia in mouse cortical GABAergic cell cultures increases neuronal oxidative metabolism and reveals an emerging role for release of glucose-derived alanine
Leke, R., Bak, Lasse Kristoffer, Anker, M., Melø, T. M., Sørensen, M., Keiding, S., Vilstrup, H., Ott, P., Portela, L. V., Sonnewald, U., Schousboe, Arne & Waagepetersen, Helle S., 1 Apr 2011, In: Neurotoxicity Research. 19, 3, p. 496-510 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis of neurotransmitter GABA via the neuronal tricarboxylic acid cycle is elevated in rats with liver cirrhosis consistent with a high GABAergic tone in chronic hepatic encephalopathy
Leke, R., Bak, Lasse Kristoffer, Iversen, P., Sørensen, M., Keiding, S., Vilstrup, H., Ott, P., Portela, L. V., Schousboe, Arne & Waagepetersen, Helle S., 1 Jun 2011, In: Journal of Neurochemistry. 117, 5, p. 824-32 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Selective GABA transporter inhibitors tiagabine and EF1502 exhibit mechanistic differences in their ability to modulate the ataxia and anticonvulsant action of the extrasynaptic GABA(A) receptor agonist gaboxadol
Madsen, K. K., Ebert, B., Clausen, Rasmus Prætorius, Krogsgaard-Larsen, Povl, Schousboe, Arne & White, H. S., 1 Jul 2011, In: Journal of Pharmacology and Experimental Therapeutics. 338, 1, p. 214-219Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hippocampal betaine/GABA transporter mRNA expression is not regulated by inflammation or dehydration post-status epilepticus
Rowley, N. M., Smith, M. D., Lamb, J. G., Schousboe, Arne & White, H. S., 2011, In: Journal of Neurochemistry. 117, 1, p. 82-90Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neuron-glia interactions in glutamatergic neurotransmission: roles of oxidative and glycolytic adenosine triphosphate as energy source
Schousboe, Arne, Sickmann, H. M., Bak, Lasse Kristoffer, Schousboe, I., Jajo, F. S., Faek, S. A. A. & Waagepetersen, Helle S., 1 Dec 2011, In: Journal of Neuroscience Research. 89, 12, p. 1926-34 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GABA transport inhibitors and seizure protection: the past and future
Schousboe, Arne, Madsen, K. K. & White, S., 2011, In: Future Medicinal Chemistry. 3, 2, p. 183-187 5 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Simple cellemodeller for kommunikation i hjernen
Schousboe, Arne, Madsen, K. K. & Pickering, Darryl S, 2011, Bioteknologi - en temabog. Gasbjerg, P., Jensen, G. & Sørensen, A. (eds.). Aarhus Danmark: Systime Academic, p. 98-107 10 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education
- Published
13C NMR spectroscopy and mass spectrometry analysis of intermediary metabolism in cultured neural cells
Sonnewald, U., Schousboe, Arne & Waagepetersen, Helle S., 18 Mar 2011, Cell Culture Techniques. Aschner, M., Sunol, C. & Bal-Price, A. (eds.). p. 403-415 13 p. (Neuromethods, Vol. 56).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Knockout of GAD65 has major impact on synaptic GABA synthesized from astrocyte-derived glutamine
Walls, Anne Byriel, Eyjolfsson, E. M., Smeland, O. B., Nilsen, L. H., Schousboe, I., Schousboe, Arne, Sonnewald, U. & Waagepetersen, Helle S., 2011, In: Journal of Cerebral Blood Flow and Metabolism. 31, 2, p. 494-503 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
- Published
Neuronal and non-neuronal GABA transporters as targets for antiepileptic drugs
Madsen, K. K., White, H. S. & Schousboe, Arne, 2010, In: Pharmacology & Therapeutics. 125, 3, p. 394-401Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A functioning glycolysis is important for maintenance of glutamate transport in cultured astrocytes
Schousboe, Arne, Sickmann, H. M., Bak, Lasse Kristoffer, Schousboe, I., Bouman, S. D. & Waagepetersen, Helle S., 2010, In: Journal of Neurochemistry. s1, p. 288-289Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Functional importance of the astrocytic glycogen-shunt and glycolysis for maintenance of an intact intra/extracellular glutamate gradient
Schousboe, Arne, Sickmann, H. M., Walls, Anne Byriel, Bak, Lasse Kristoffer & Waagepetersen, Helle S., 2010, In: Neurotoxicity Research. 18, 1, p. 94-9 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glial cell biology: neuronal-glial interaction in nutrition and amino-acid-mediated neurotransmission
Schousboe, Arne & Waagepetersen, Helle S., 2010, The newborn brain: Neuroscience and clinical applications. Lagercrantz, H., Hanson, M. A., Ment, L. R. & Peebles, D. M. (eds.). 2 ed. Cambridge: Cambridge University Press, p. 121-128Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Obesity and type 2 diabetes in rats are associated with altered brain glycogen and amino-acid homeostasis
Sickmann, H. M., Waagepetersen, Helle S., Schousboe, Arne, Benie, A. J. & Bouman, S. D., 2010, In: Journal of Cerebral Blood Flow and Metabolism. 30, 8, p. 1527-37 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of primary and secondary cultures of astrocytes prepared from mouse cerebral cortex
Jensen, Dorte Skytt, Madsen, K. K., Pajecka, K., Schousboe, Arne & Waagepetersen, Helle S., 2010, In: Neurochemical Research. 35, 12, p. 2043-2052 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A possible role of the non-GAT1 GABA transporters in transfer of GABA from GABAergic to glutamatergic neurons in mouse cerebellar neuronal cultures
Suñol, C., Babot, Z., Cristòfol, R., Sonnewald, U., Waagepetersen, Helle S. & Schousboe, Arne, Sep 2010, In: Neurochemical Research. 35, 9, p. 1384-1390 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GAD65 is essential for synthesis of GABA destined for tonic inhibition regulating epileptiform activity
Walls, Anne Byriel, Nilsen, L. H., Eyjolfsson, E. M., Vestergaard, H. T., Hansen, S. L., Schousboe, Arne, Sonnewald, U. & Waagepetersen, Helle S., 2010, In: Journal of Neurochemistry. 115, 6, p. 1398–1408Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GABA-syntese - en vigtig brik for kontrol af epilepsi
Walls, Anne Byriel, Schousboe, Arne & Waagepetersen, Helle S., 2010, In: Lægemiddelforskning. 2010, p. 31-33Research output: Contribution to journal › Journal article › Communication
- 2009
- Published
Prenatal stress effect on glutamate metabolism, evaluated with mass espectroscopy-liquid cromatography
Adrover, E., Katunar, M. R., Waagepetersen, Helle S., Schousboe, Arne & Antonelli, M. C., 2009, In: Journal of Neurochemistry. Suppl. 2, p. 172-172Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Neuronal glucose but not lactate utilization is positively correlated with NMDA-induced neurotransmission and fluctuations in cytosolic Ca2+ levels
Bak, Lasse Kristoffer, Walls, Anne Byriel, Schousboe, Arne, Ring, A., Sonnewald, U. & Waagepetersen, Helle S., 2009, In: Journal of Neurochemistry. 109, Suppl. 1, p. 87-93 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Metabolic fate of isoleucine in a rat model of hepatic encephalopathy and in cultured neural cells exposed to ammonia
Bak, Lasse Kristoffer, Iversen, P., Sørensen, M., Keiding, S., Vilstrup, H., Ott, P., Waagepetersen, Helle S. & Schousboe, Arne, 2009, In: Metabolic Brain Disease. 24, 1, p. 135-145Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glutamate uptake triggers transporter-mediated GABA release from astrocytes
Héja, L., Barabás, P., Nyitrai, G., Kékesi, K. A., Lasztóczi, B., Toke, O., Tárkányi, G., Madsen, K. K., Schousboe, Arne, Dobolyi, Á., Palkovits, M. & Kardos, J., 2009, In: PLoS ONE. 4, 9, p. e7153-e7153Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Low Cerebral Oxygen Consumption and Blood Flow in Patients With Cirrhosis and an Acute Episode of Hepatic Encephalopathy
Iversen, P., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Vafaee, M. S., Borghammer, P., Mouridsen, K., Jensen, S. B., Vilstrup, H., Schousboe, Arne, Ott, P., Gjedde, Albert & Keiding, S., 2009, In: Gastroenterology. 136, 3, p. 863-871Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Reduced cerebral blood flow and oxygen consumption in cirrhosis patients with acute hepatic encephalopathy
Keiding, S., Iversen, P., Sørensen, M., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Gjedde, A., Schousboe, Arne & Vilstrup, H., 2009, In: Journal of Neurochemistry. s1, p. 269-270Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Knockdown of GDH indicates its potential impact in sustaining glutamate homeostasis and neurotransmission
Klawonn, A. M., Bolanos, J. P., Waagepetersen, Helle S. & Schousboe, Arne, 2009, In: Journal of Neurochemistry. s2, p. 105Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Erratum: Demonstration of neuron-glia transfer of precursors for gaba biosynthesis in a co-culture system of dissociated mouse cerebral cortex (Neurochem Res (2008) 33:26292635;DOI 10.1007/s11064-008-9814-6)
Leke, R., Bak, Lasse Kristoffer, Schousboe, Arne & Waagepetersen, Helle S., 1 Dec 2009, In: Neurochemical Research. 34, 12, 1 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
Aspartate-glutamate homeostasis in cerebellar neurons changes when shifting from glucose to beta-hydroxybutyrate as substrate
Lund, Trine Meldgaard, Clausen, M., Risa, Ø., Sonnewald, U., Schousboe, Arne & Waagepetersen, Helle S., 2009, In: Journal of Neurochemistry. s1, p. 291-291Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Availability of neurotransmitter glutamate is diminished when beta-hydroxybutyrate replaces glucose in cultured neurons
Lund, Trine Meldgaard, Risa, Ø., Sonnewald, U., Schousboe, Arne & Waagepetersen, Helle S., 2009, In: Journal of Neurochemistry. 110, 1, p. 80-91 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GABA synthesis from ß-hydroxybutyrate and glucose is differentially affected by neuronal activity in cultured GABAergic neurons
Lund, Trine Meldgaard, Risa, O., Sonnewald, U., Schousboe, Arne & Waagepetersen, Helle S., 2009, In: Journal of Neurochemistry. s2, p. 95Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Synaptic and extrasynaptic GABA transporters as targets for anti-epileptic drugs
Madsen, K. K., Clausen, Rasmus Prætorius, Larsson, O. M., Krogsgaard-Larsen, Povl, Schousboe, Arne & White, H. S., 2009, In: Journal of Neurochemistry. 109, Suppl. 1, p. 139-44Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Gamma-aminobutyric acid (GABA)
Schousboe, Arne & Waagepetersen, Helle S., 2009, Encyclopedia of neuroscience. Squire, L. R. (ed.). Academic Press, Vol. 4. p. 511-515Research output: Chapter in Book/Report/Conference proceeding › Encyclopedia chapter › Research
- Published
Glial modulation of excitability via glutamate and GABA transporters
Schousboe, Arne & White, H. S., 2009, Encyclopedia of basic epilepsy research. Schwartzkroin, P. A. (ed.). Academic Press, Vol. 1. p. 397-401Research output: Chapter in Book/Report/Conference proceeding › Encyclopedia chapter › Research
- Published
Functional significance of brain glycogen in sustaining glutamatergic neurotransmission
Sickmann, H. M., Walls, Anne Byriel, Schousboe, Arne, Bouman, S. D. & Waagepetersen, Helle S., 2009, In: Journal of Neurochemistry. 109, Suppl. 1, p. 80-86 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Metabolic profiles of the brains of Zucker Diabetic Fatty, Zucker Obese and Sprague-Dawley rats and the involvement of glycogen metabolism
Sickmann, H. M., Bouman, S. D., Schousboe, Arne, Tracey, W. R. & Waagepetersen, Helle S., 2009, In: Journal of Neurochemistry. s1, p. 293-293Research output: Contribution to journal › Conference abstract in journal › Research
- Published
GAD65 is essential for the maintenance of GABA homeostasis
Smeland, O., Walls, A. B., Eyolfsson, E. M., Schousboe, Arne, Waagepetersen, Helle S. & Sonnewald, U., 2009, In: Journal of Neurochemistry. p. 51-51Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Impact of the malate-aspartate shuttle in glutamate neurotransmission
Waagepetersen, Helle S., Bak, Lasse Kristoffer, Lund, Trine Meldgaard, Walls, A. B., Sonnewald, U. & Schousboe, Arne, 2009, In: Journal of Neurochemistry. s1, p. 9Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Glial glutamate and GABA metabolism
Waagepetersen, Helle S. & Schousboe, Arne, 2009, Encyclopedia of neuroscience. Squire, L. R. (ed.). Academic Press, Vol. 4. p. 789-792Research output: Chapter in Book/Report/Conference proceeding › Encyclopedia chapter › Research
- Published
GAD65 is essential for the maintenance of GABA homeostasis
Walls, A. B., Eyolfsson, E. M., Sonnewald, U., Vestergaard, H. T., Hansen, S. L., Schousboe, I. E., Schousboe, Arne & Waagepetersen, Helle S., 2009, In: Journal of Neurochemistry. s1, p. 292-292Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Neuronal metabolism in GAD65 knockout mice is compromised and not susceptible to kainic acid
Walls, A. B., Eyjolfsson, E. M., Sonnewald, U., Waagepetersen, Helle S. & Schousboe, Arne, 2009, In: Journal of Neurochemistry. Suppl. 2, p. 123Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Robust glycogen shunt activity in astrocytes: Effects of glutamatergic and adrenergic agents
Walls, Anne Byriel, Heimbürger, C., Bouman, S., Schousboe, Arne & Waagepetersen, Helle S., 2009, In: Neuroscience. 158, 1, p. 284-292Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
- Published
Metabolism of [U-13C]glutamine and [U-13C]glutamate in isolated rat brain mitochondria suggests functional phosphate-activated glutaminase activity in matrix
Bak, Lasse Kristoffer, Zieminska, E., Waagepetersen, Helle S., Schousboe, Arne & Albrecht, J., 2008, In: Neurochemical Research. 33, 2, p. 273-278Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structures of the ligand-binding core of iGluR2 in complex with the agonists (R)- and (S)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propionic acid explain their unusual equipotency
Beich-Frandsen, M., Pickering, Darryl S, Mirza, Osman Asghar, Johansen, Tommy Nørskov, Greenwood, J., Vestergaard, Bente, Schousboe, Arne, Gajhede, Michael, Liljefors, T. & Kastrup, Jette Sandholm Jensen, 2008, In: Journal of Medicinal Chemistry. 51, 5, p. 1459-63Research output: Contribution to journal › Journal article › Research › peer-review
- Published
1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. Structure-activity relationships and identification of potent and selective iGluR5 modulators
Butini, S., Pickering, Darryl S, Morelli, E., Coccone, S. S., Trotta, F., De Angelis, M., Guarino, E., Fiorini, I., Campiani, G., Novellino, E., Schousboe, Arne, Christensen, J. K. & Gemma, S., 2008, In: Journal of Medicinal Chemistry. 51, 20, p. 6614-8Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Demonstration of neuron-glia transfer of precursors for Gaba biosynthesis in a co-culture system of dissociated mouse cerebral cortex
Leke, R., Bak, Lasse Kristoffer, Schousboe, Arne & Waagepetersen, Helle S., 2008, In: Neurochemical Research. 33, 12, p. 2629-2635Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GABA-transportører: håb om bedre epilepsibehandling
Madsen, K. K., Clausen, Rasmus Prætorius, Larsson, O. M. & Schousboe, Arne, 2008, In: Lægemiddelforskning. p. 22-24Research output: Contribution to journal › Journal article › Communication
- Published
Pharmacological manipulation of extrasynaptic GABA transporters: implications for epilepsy management
Madsen, K. K., Ebert, B., Larsson, O. M., Clausen, Rasmus Prætorius, Schousboe, Arne & White, H. S., 2008, In: Epilepsia. Suppl. 7, p. 347Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Regulation of excitation by GABA neurotransmission: Focus on metabolism and transport
Madsen, K. K., Larsson, O. M. & Schousboe, Arne, 2008, In: Results and Problems in Cell Differentiation. 44, p. 201-221Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The micro-architecture of the cerebral cortex: Functional neuroimaging models and metabolism
Riera, J. J., Schousboe, Arne, Waagepetersen, Helle S., Howarth, C. & Hyder, F., 2008, In: NeuroImage. 40, 4, p. 1436-1459Research output: Contribution to journal › Review › Research
- Published
GABA Neurotransmission: An overview
Schousboe, Arne & Waagepetersen, Helle S., 2008, Handbook of Neurochemistry and Molecular Neurobiology: Neurotransmitter Systems. Vizi, E. S. (ed.). The Netherlands: Springer Publishing Company, p. 213-226Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Inhibition of the betaine-GABA transporter (mGAT2/BGT-1) modulates spontaneous electrographic bursting in the medial entorhinal cortex (mEC)
Smith, M. D., Saunders, G. W., Clausen, Rasmus Prætorius, Frølund, Bente, Krogsgaard-Larsen, Povl, Larsson, O. M., Schousboe, Arne, Wilcox, K. S. & White, H. S., 2008, In: Epilepsy Research. 79, 1, p. 6-13Research output: Contribution to journal › Journal article › Research › peer-review
- Published
- Published
Metabolism of [1,6-13C]glucose and [U-13C]glutamine and depolarization induced GABA release in superfused mouse cerebral cortical mini-slices
Waagepetersen, Helle S., Døring, S. & Schousboe, Arne, 2008, In: Neurochemical Research. 33, 8, p. 1610-1617Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of 1,4-dideoxy-1,4-imino-d-arabinitol (DAB) as an inhibitor of brain glycogen shunt activity
Walls, Anne Byriel, Sickmann, H. M., Brown, A., Bouman, S. D., Ransom, B., Schousboe, Arne & Waagepetersen, Helle S., 2008, In: Journal of Neurochemistry. 105, p. 1462-1470Research output: Contribution to journal › Journal article › Research › peer-review
- 2007
- Published
Glutamine in the central nervous system: function and dysfunction
Albrecht, J., Sonnewald, U., Waagepetersen, Helle S. & Schousboe, Arne, 2007, In: Frontiers in Bioscience. 12, p. 332-343Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Among the branched-chain amino acids, only valine metabolism is up-regulated in astrocytes during glutamate exposure
Bak, Lasse Kristoffer, Johansen, M. L., Schousboe, Arne & Waagepetersen, Helle S., 2007, In: Journal of Neuroscience Research. 86, p. 3465-3470Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Complex glutamate labeling from [U-13C]glucose or [U-13C]lactate in co-cultures of cerebellar neurons and astrocytes
Bak, Lasse Kristoffer, Waagepetersen, Helle S., Melø, T. M., Schousboe, Arne & Sonnewald, U., 2007, In: Neurochemical Research. 32, p. 671-680Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Partial agonism and antagonism of the ionotropic glutamate receptor iGLuR5: Structures of the ligand-bining core in complex with domoic acid and 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid
Hald, H., Naur, P., Pickering, Darryl S, Sprogøe, D., Madsen, Ulf, Timmermann, D. B., Ahring, P. K., Liljefors, T., Schousboe, Arne, Egebjerg, J., Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 2007, In: Journal of Biological Chemistry. 282, 35, p. 25726-25736Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The metabolic role of isoleucine in detoxification of ammonia in cultured mouse neurons and astrocytes
Johansen, M. L., Bak, Lasse Kristoffer, Schousboe, Arne, Iversen, P., Sørensen, M., Keiding, S., Vilstrup, H., Gjedde, A., Ott, P. & Waagepetersen, Helle S., 2007, In: Neurochemistry International. 50, p. 1042-1051Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evidence of Oatp and Mdr1 in cryopreserved rat hepatocytes
Jørgensen, L., van Beek, J., Lund, S., Schousboe, Arne & Badolo, L., 2007, In: European Journal of Pharmaceutical Sciences. 30, 2, p. 181-189Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The transcriptome and metabolic gene signature of protoplasmic astrocytes in the adult murine cortex
Lovatt, D., Sonnewald, U., Waagepetersen, Helle S., Schousboe, Arne, He, W., Lin, J. H., Han, X., Takano, T., Wang, S., Sim, F. J., Goldman, S. A. & Nedergaard, M., 2007, In: Journal of Neuroscience. 27, 45, p. 12255-12266Research output: Contribution to journal › Journal article › Research › peer-review
- Published
ß-hydroxybutyrate and glucose metabolism is differently affected by neuronal activity
Lund, Trine Meldgaard, Clausen, M., Risa, O., Sonnewald, U., Schousboe, Arne & Waagepetersen, Helle S., 2007, In: Journal of Neurochemistry. 102, s1, p. 116Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Functional and pharmacological aspects of GABA transporters
Madsen, K., White, H. S., Clausen, Rasmus Prætorius, Frølund, Bente, Larsson, O. M., Krogsgaard-Larsen, Povl & Schousboe, Arne, 2007, Handbook of nerochemistry and molecular neurobiology: Neural membranes and transport. Lajtha, A. & Reith, M. E. A. (eds.). 3rd. ed. Berlin: Springer, Vol. 3. p. 285-304Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
GABA transporter localization to lipid raft membrane microdomains in neurons and astrocytes
Madsen, K. K., Pickering, Darryl S, Hansen, G. H., Danielsen, E. M., Larsson, O. M. & Schousboe, Arne, 2007, In: Journal of Neurochemistry. 102, s1, p. 46Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Energy substrates to support glutamatergic and GABAergic synaptic function: role of glycogen, glucose and lactate
Schousboe, Arne, Bak, Lasse Kristoffer, Sickmann, H. M., Sonnewald, U. & Waagepetersen, Helle S., Dec 2007, In: Neurotoxicity Research. 12, 4, p. 263-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Energy substrates to support glutamatergic and GABAergic synaptic function: Role of glycogen, glucose and lactate
Schousboe, Arne, Bak, Lasse Kristoffer, Sickmann, H. M., Sonnewald, U. & Waagepetersen, Helle S., 2007, In: Neurotoxicity Research. 12, 4, p. 263-268Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GABA: Homeostatic and pharmacological aspects
Schousboe, Arne & Waagepetersen, Helle S., 2007, In: Progress in Brain Research. 160, p. 9-19Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Actions of toxins on cerebral metabolism at cellular level
Sonnewald, U., Syversen, T., Schousboe, Arne, Waagepetersen, Helle S. & Aschner, M., 2007, Handbook of Neurochemistry and Molecular Neurobiology: Brain Energetics. Integration of Molecular and Cellular Processes. Lajtha, A., Gibson, G. E. & Dienel, G. A. (eds.). 3rd. ed. ed. Berlin: Springer, Vol. 3. p. 569-585Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Glutamine, glutamate and GABA: metabolic aspects
Waagepetersen, Helle S., Sonnerwald, U. & Schousboe, Arne, 2007, Handbook of neurochemistry and molecular neurobiology: amino acids and peptides in the nervous system. Lajtha, A., Oja, S. S., Schousboe, A. & Saransaari, P. (eds.). 3rd. ed. Berlin: Springer, p. 1-21Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
One third of glycolytic activity in astrocytes depends on the operation of the glycogen shunt
Walls, Anne Byriel, Heimbürger, C. M., Sickmann, H. M., Bouman, S. D., Schousboe, Arne & Waagepetersen, Helle S., 2007, In: Journal of Neurochemistry. 102, s1, p. 119Research output: Contribution to journal › Conference abstract in journal › Research
- 2006
- Published
Glucose is necessary to maintain neurotransmitter homeostasis during synaptic activity in cultured glutamatergic neurons
Bak, Lasse Kristoffer, Schousboe, Arne, Sonnewald, U. & Waagepetersen, Helle S., Oct 2006, In: Journal of Cerebral Blood Flow and Metabolism. 26, 10, p. 1285-97 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer
Bak, Lasse Kristoffer, Schousboe, Arne & Waagepetersen, Helle S., Aug 2006, In: Journal of Neurochemistry. 98, 3, p. 641-53 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure-Activity Relationship and Pharmacology of γ-Aminobutyric Acid (GABA) Transport Inhibitors
Clausen, Rasmus Prætorius, Madsen, K., Larsson, O. M., Frølund, Bente, Krogsgaard-Larsen, Povl & Schousboe, Arne, 1 Dec 2006, GABA. Enna, S. J. (ed.). p. 265-284 20 p. (Advances in Pharmacology, Vol. 54).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Structure–Activity Relationship and Pharmacology of γ‐Aminobutyric Acid Transport Inhibitor
Clausen, Rasmus Prætorius, Madsen, K., Larsson, O. M., Frølund, Bente, Krogsgaard-Larsen, Povl & Schousboe, Arne, 2006, GABA. Enna, S. (ed.). Vol. 54. p. 265–284 (Advances in Pharmacology).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
A novel selective γ-aminobutyric acid transport inhibitor demonstrates a functional role for GABA transporter subtype GAT2/BGT-1 in the CNS
Frølund, Bente, Clausen, Rasmus Prætorius, Larsson, O. M., Schousboe, Arne, Krogsgaard-Larsen, Povl & White, H. S., 2006, In: Neurochemistry International. 48, p. 637–642Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neurotransmitter transporters: molecular function of important drug targets
Gether, Ulrik, Andersen, P. H., Larsson, O. M. & Schousboe, Arne, Jul 2006, In: Trends in Pharmacological Sciences. 27, 7, p. 375-83 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure-Activity Relationships of Selective GABA Uptake Inhibitors
Høg, S., Greenwood, J., Madsen, K. B., Larsson, O. M., Frølund, Bente, Schousboe, Arne, Krogsgaard-Larsen, Povl & Clausen, Rasmus Prætorius, 2006, In: Current Topics in Medicinal Chemistry. 6, 17, p. 1861–1882Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The structure of a mixed GluR2 ligand-binding core dimer in complex with (S)-glutamate and the antagonist (S)-NS1209
Kasper, C., Pickering, Darryl S, Mirza, Osman Asghar, Olsen, L., Kristensen, Anders Skov, Greenwood, J. R., Liljefors, T., Schousboe, Arne, Wätjen, F., Gajhede, Michael, Sigurskjold, B. W. & Kastrup, Jette Sandholm Jensen, 2006, In: Journal of Molecular Biology. 357, 4, p. 1184-201 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional and Pharmacological Aspects of GABA Transporters
Madsen, K., White, S. H., Clausen, Rasmus Prætorius, Larsson, O. M., Frølund, Bente, Krogsgaard-Larsen, Povl & Schousboe, Arne, 2006, Handbook of Neurochemistry and Molecular neurobiology. p. 1-17Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Effect of topiramate and dBcAMP on expression of the glutamate transporters GLAST and GLT-1 in astrocytes cultured separately, or together with neurons
Poulsen, C. F., Schousboe, E. I., Sarup, A., White, H. S. & Schousboe, Arne, 2006, In: Neurochemistry International. 48, Sp. Iss. SI 6-7, p. 657-661 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Demonstration of extensive GABA synthesis in the small population of GAD positive neurons in cerebellar cultures by the use of pharmacological tools
Sonnewald, U., Kortner, T. M., Qu, H., Olstad, E., Suñol, C., Bak, Lasse Kristoffer, Schousboe, Arne & Waagepetersen, Helle S., 7 Mar 2006, In: Neurochemistry International. 48, 6-7, p. 572-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2005
- Published
Astrocyte glycogen metabolism is required for neural activity during aglycemia or intense stimulation in mouse white matter
Brown, A. M., Sickmann, H. M., Fosgerau, K., Lund, Trine Meldgaard, Schousboe, Arne, Waagepetersen, Helle S. & Ransom, B. R., 2005, In: Journal of Neuroscience Research. 79, 1-2, p. 74-80 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Design, synthesis, and characterisation of selective GABA transport inhibitors
Clausen, Rasmus Prætorius, Moltzen, E., Perregaard, J., Lenz, S., Sanchez, S., Frølund, Bente, Bolvig, T., Sarup, A., Larsson, O., White, H., Schousboe, Arne & Krogsgaard-Larsen, Povl, Aug 2005, In: Journal of Neurochemistry. 94, p. 150-150Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Selective inhibitors of GABA uptake: synthesis and molecular pharmacology of 4-N-methylamino- 4,5,6,7-tetrahydrobenzo[d]isoxazol-3-ol analogues
Clausen, Rasmus Prætorius, Moltzen, E. K., Perregaard, J., Lenz, S., Sanchez, C., Falch, E., Frølund, Bente, Bolvig, T., Sarup, A., Larsson, O. M., Schousboe, Arne & Krogsgaard-Larsen, Povl, 2005, In: Bioorganic & Medicinal Chemistry. 13, p. 895–908Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lipid raft localization of GABA A receptor and Na+, K+-ATPase in discrete microdomain clusters in rat cerebellar granule cells
Dalskov, S., Immerdal, L., Niels-Christiansen, L. W., Hansen, Gert Helge, Schousboe, Arne & Danielsen, E. M., 2005, In: Neurochemistry International. 46, 6, p. 489-99 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Tyr702 is an important determinant of agonist binding and domain closure of the ligand-binding core of GluR2
Frandsen, A., Pickering, Darryl S, Vestergaard, Bente, Kasper, C., Nielsen, B. B., Greenwood, J. R., Campiani, G., Fattorusso, C., Gajhede, Michael, Schousboe, Arne & Kastrup, Jette Sandholm Jensen, 2005, In: Molecular Pharmacology. 67, 3, p. 703-13 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Exploring the GluR2 ligand-binding core in complex with the bicyclical AMPA analogue (S)-4-AHCP
Nielsen, B. B., Pickering, Darryl S, Greenwood, J. R., Brehm, L., Gajhede, Michael, Schousboe, Arne & Kastrup, Jette Sandholm Jensen, 2005, In: FEBS Journal. 272, 7, p. 1639-48 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Differential effects of two GABA transport inhibitors, tiagabine and EF-1502, on phenytoin-resistant spontaneous bursting in the entorhinal cortex of slices from kainic acid treated rats
Smith-Yockman, M., Saunders, G., Wilcox, K., Clausen, Rasmus Prætorius, Frølund, Bente, Larsson, O., Schousboe, Arne & White, H., 2005, In: Epilepsia. 46, p. 188-188Research output: Contribution to journal › Conference abstract in journal › Research
ID: 1300836
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Astrocytic pyruvate carboxylation: Status after 35 years
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Deficient astrocyte metabolism impairs glutamine synthesis and neurotransmitter homeostasis in a mouse model of Alzheimer's disease
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The 13th International Conference on Brain Energy Metabolism: "How Metabolism Dictates Neurotransmission, Function and Behavior"
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