Maiken Nedergaard
Professor
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A SPECT-based method for dynamic imaging of the glymphatic system in rats
Sigurdsson, B., Hauglund, Natalie Linea, Lilius, T. O., Mogensen, F. L. H., Mortensen, K. N., Beschorner, Natalie, Klinger, L., Bærentzen, S. L., Rosenholm, Marko, Shalgunov, Vladimir, Herth, Matthias Manfred, Mori, Yuki & Nedergaard, Maiken, 2023, In: Journal of Cerebral Blood Flow and Metabolism. 43, 7, 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A mesothelium divides the subarachnoid space into functional compartments
Møllgård, Kjeld, Beinlich, Felix Ralf Michael, Kusk, P., Miyakoshi, L. M., Delle, Christine, Pla Requena, Virginia Teresa, Hauglund, Natalie Linea, Esmail, Tina, Rasmussen, Martin Kaag, Gomolka, Ryszard Stefan, Mori, Yuki & Nedergaard, Maiken, 2023, In: Science. 379, 6627, p. 84-885Research output: Contribution to journal › Journal article › Research › peer-review
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A sensitive and specific genetically-encoded potassium ion biosensor for in vivo applications across the tree of life
Wu, S-Y., Wen, Y., Serre, N. B. C., Laursen, C. C. H., Dietz, A. G., Taylor, B. R., Drobizhev, M., Molina, R. S., Aggarwal, A., Rancic, V., Becker, M., Ballanyi, K., Podgorski, K., Hirase, H., Nedergaard, M., Fendrych, M., Lemieux, M. J., Eberl, D. F., Kay, A. R., Campbell, R. E. & 1 others, , 2023, In: PLOS Biology. 20, 9, 23 p., e3001772.Research output: Contribution to journal › Journal article › Research › peer-review
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Age- and glaucoma-induced changes to the ocular glymphatic system
Wang, X., Delle, Christine, Peng, W., Pla Requena, Virginia Teresa, Giannetto, M., Kusk, P., Sigurdsson, B., Sakurai, S., Sweeney, A., Sun, Q., Du, Ting, Libby, R. T. & Nedergaard, Maiken, 2023, In: Neurobiology of Disease. 188, 9 p., 106322.Research output: Contribution to journal › Journal article › Research › peer-review
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Air pollution, glymphatic impairment, and Alzheimer's disease
Hussain, R., Graham, U., Elder, A. & Nedergaard, Maiken, 2023, In: Trends in Neurosciences. 46, 11, p. 901-911 11 p.Research output: Contribution to journal › Review › Research › peer-review
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Astrocyte endfeet may theoretically act as valves to convert pressure oscillations to glymphatic flow
Bork, Peter Aleksander Rousing, Ladrón-De-Guevara, A., Christensen, A. H., Jensen, K. H., Nedergaard, Maiken & Bohr, T., 2023, In: Journal of the Royal Society Interface. 20, 204, 5 p., 20230050.Research output: Contribution to journal › Journal article › Research › peer-review
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Astrocytic GPCR-Induced Ca2+ Signaling Is Not Causally Related to Local Cerebral Blood Flow Changes
Ozawa, K., Nagao, Masaki, Konno, A., Iwai, Y., Vittani, Marta, Kusk, P., Mishima, Tsuneko, Hirai, H., Nedergaard, Maiken & Hirase, Hajime, 2023, In: International Journal of Molecular Sciences. 24, 17, 12 p., 13590.Research output: Contribution to journal › Journal article › Research › peer-review
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Astrocytic chloride is brain state dependent and modulates inhibitory neurotransmission in mice
Untiet, Verena, Beinlich, Felix Ralf Michael, Kusk, P., Kang, N., Ladrón-de-Guevara, A., Song, W., Kjærby, Celia, Andersen, Mie, Hauglund, Natalie Linea, Bojarowska, Zuzanna, Sigurdsson, B., Deng, S., Hirase, Hajime, Petersen, Nicolas Caesar, Verkhratsky, A. & Nedergaard, Maiken, 2023, In: Nature Communications. 14, 1, 14 p., 1871.Research output: Contribution to journal › Journal article › Research › peer-review
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Blood–brain barrier permeable β-blockers linked to lower risk of Alzheimer’s disease in hypertension
Beaman, Emily Eufaula, Bonde, A. N., Larsen, S. M. U., Ozenne, Brice Maxime Hugues, Lohela, T. J., Nedergaard, Maiken, Gislason, Gunnar Hilmar, Knudsen, Gitte Moos & Holst, S. C., 2023, In: Brain. 146, 3, p. 1141–1151 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Delivery of gene therapy through a cerebrospinal fluid conduit to rescue hearing in adult mice
Mathiesen, B. K., Miyakoshi, L. M., Cederroth, C. R., Tserga, E., Versteegh, C., Bork, Peter Aleksander Rousing, Hauglund, Natalie Linea, Gomolka, Ryszard Stefan, Mori, Yuki, Edvall, N. K., Rouse, S., Møllgård, Kjeld, Holt, J. R., Nedergaard, Maiken & Canlon, B., 2023, In: Science Translational Medicine. 15, 702, 13 p., eabq3916.Research output: Contribution to journal › Journal article › Research › peer-review
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Development of 11C-labeled CRANAD-102 for positron emission tomography imaging of soluble Aβ-species
Staudt, Markus, Shalgunov, Vladimir, Nedergaard, Maiken & Herth, Matthias Manfred, 2023, In: Journal of Labelled Compounds and Radiopharmaceuticals. 66, 12, p. 393-399Research output: Contribution to journal › Journal article › Research › peer-review
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Early impairments of visually-driven neuronal ensemble dynamics in the rTg4510 tauopathy mouse model
Parka, A., Degel, C., Dreyer, J., Richter, U., Hall, B., Bastlund, J. F., Laursen, B., Nedergaard, Maiken, Sotty, F. & Botta, P., 2023, In: Neurobiology of Disease. 178, 13 p., 106012.Research output: Contribution to journal › Journal article › Research › peer-review
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Effect of sleep deprivation and NREM sleep stage on physiological brain pulsations
Helakari, H., Järvelä, M., Väyrynen, T., Tuunanen, J., Piispala, J., Kallio, M., Ebrahimi, S. M., Poltojainen, V., Kananen, J., Elabasy, A., Huotari, N., Raitamaa, L., Tuovinen, T., Korhonen, V., Nedergaard, Maiken & Kiviniemi, V., 2023, In: Frontiers in Neuroscience. 17, 17 p., 1275184.Research output: Contribution to journal › Journal article › Research › peer-review
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Glymphatic influx and clearance are accelerated by neurovascular coupling: [Inkl. Correction]
Holstein-Rønsbo, Stephanie, Gan, Y., Giannetto, M. J., Rasmussen, Martin Kaag, Sigurdsson, B., Beinlich, Felix Ralf Michael, Rose, Laura, Untiet, Verena, Hablitz, L. M., Kelley, D. H. & Nedergaard, Maiken, 2023, In: Nature Neuroscience. 26, p. 1042–1053Research output: Contribution to journal › Journal article › Research › peer-review
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Glymphatic-assisted perivascular brain delivery of intrathecal small gold nanoparticles
Lilius, T. O., Mortensen, K. N., Deville, C., Lohela, T. J., Stæger, Frederik Filip Vinggaard, Sigurdsson, B., Fiordaliso, E. M., Rosenholm, Marko, Kamphuis, C., Beekman, F. J., Jensen, A. I. & Nedergaard, Maiken, 2023, In: Journal of Controlled Release. 355, p. 135-148 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Lactate biosensors for spectrally and spatially multiplexed fluorescence imaging
Nasu, Y., Aggarwal, A., Le, G. N. T., Vo, C. T., Kambe, Y., Wang, X., Beinlich, F. R. M., Lee, A. B., Ram, T. R., Wang, F., Gorzo, K. A., Kamijo, Y., Boisvert, M., Nishinami, S., Kawamura, G., Ozawa, T., Toda, H., Gordon, G. R., Ge, S., Hirase, H. & 5 others, , 2023, In: Nature Communications. 14, 1, 17 p., 6598.Research output: Contribution to journal › Journal article › Research › peer-review
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Local extracellular K+ in cortex regulates norepinephrine levels, network state, and behavioral output
Dietz, Andrea Grostøl, Weikop, Pia, Hauglund, Natalie Linea, Andersen, Mie, Petersen, Nicolas Caesar, Rose, Laura, Hirase, Hajime & Nedergaard, Maiken, 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 40, 9 p., e2305071120.Research output: Contribution to journal › Journal article › Research › peer-review
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Locomotion Induces Fundamentally Different Patterns of Ca2+Signaling in Astrocytes and Neurons
Hirase, Hajime & Nedergaard, Maiken, 2023, In: Function. 4, 4, 2 p., zqad028.Research output: Contribution to journal › Comment/debate › Research › peer-review
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Long-term high-fat diet increases glymphatic activity in the hypothalamus in mice
Delle, Christine, Cankar, Neza, Digebjerg Holgersson, C., Hvorup Knudsen, H., Nielsen, Elise Schiøler, Kjærby, Celia, Mori, Yuki, Nedergaard, Maiken & Weikop, Pia, 2023, In: Scientific Reports. 13, 1, 11 p., 4137.Research output: Contribution to journal › Journal article › Research › peer-review
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Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation
Gomolka, Ryszard Stefan, Hablitz, L. M., Mestre, H., Giannetto, M., Du, Ting, Hauglund, Natalie Linea, Xie, L., Peng, W., Martinez, P. M., Nedergaard, Maiken & Mori, Yuki, 2023, In: eLife. 12, 36 p., e82232.Research output: Contribution to journal › Journal article › Research › peer-review
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Perivascular pumping of cerebrospinal fluid in the brain with a valve mechanism
Gan, Y., Holstein-Rønsbo, Stephanie, Nedergaard, Maiken, Boster, K. A. S., Thomas, J. H. & Kelley, D. H., 2023, In: Journal of the Royal Society, Interface. 20, 206, 17 p., 20230288.Research output: Contribution to journal › Journal article › Research › peer-review
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Potentiating glymphatic drainage minimizes post-traumatic cerebral oedema
Hussain, R., Tithof, J., Wang, W., Cheetham-West, A., Song, W., Peng, W., Sigurdsson, B., Kim, D., Sun, Q., Peng, S., Pla Requena, Virginia Teresa, Kelley, D. H., Hirase, Hajime, Castorena-Gonzalez, J. A., Weikop, Pia, Goldman, Steven Alan, Davis, M. J. & Nedergaard, Maiken, 2023, In: Nature. 623, p. 992–1000 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Protocol to study molecule exchange between venous blood and CSF in live mice using transcranial bioluminescence imaging
Esmail, Tina, Nedergaard, Maiken & Beinlich, Felix Ralf Michael, 2023, In: STAR Protocols. 4, 4, 18 p., 102652.Research output: Contribution to journal › Journal article › Research › peer-review
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Reply to: 'Do all norepinephrine surges disrupt sleep?'
Kjærby, Celia, Andersen, Mie, Hauglund, Natalie Linea, Untiet, Verena, Dall, C., Ding, F., Hirase, Hajime & Nedergaard, Maiken, 2023, In: Nature Neuroscience. 26, 3 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
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SDREAMER: Self-distilled Mixture-of-Modality-Experts Transformer for Automatic Sleep Staging
Chen, J., Yao, Y., Anderson, M., Hauglund, Natalie Linea, Kjærby, Celia, Untiet, Verena, Nedergaard, Maiken & Luo, J., 2023, p. 131-142. 12 p.Research output: Contribution to conference › Paper › Research › peer-review
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Structural characterization of SLYM—a 4th meningeal membrane
Pla Requena, Virginia Teresa, Bitsika, S., Giannetto, M. J., Ladron-de-Guevara, A., Gahn-Martinez, D., Mori, Yuki, Nedergaard, Maiken & Møllgård, Kjeld, 2023, In: Fluids and Barriers of the CNS. 20, 1, 18 p., 93.Research output: Contribution to journal › Journal article › Research › peer-review
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The Alzheimer's disease 5xFAD mouse model is best suited to investigate pretargeted imaging approaches beyond the blood-brain barrier
Lopes van den Broek, S. I., Sehlin, D., Andersen, Jens Velde, Aldana, Blanca, Beschorner, Natalie, Nedergaard, Maiken, Knudsen, Gitte Moos, Syvanen, S. & Herth, Matthias Manfred, 2023, In: Frontiers in Nuclear Medicine. 2, 7 p., 1001722.Research output: Contribution to journal › Journal article › Research › peer-review
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The state of brain activity modulates cerebrospinal fluid transport
Miyakoshi, L. M., Stæger, Frederik Filip Vinggaard, Li, Q., Pan, C., Xie, L., Kang, H., Pavan, C., Dang, J., Sun, Q., Ertürk, A. & Nedergaard, Maiken, 2023, In: Progress in Neurobiology. 229, 11 p., 102512.Research output: Contribution to journal › Journal article › Research › peer-review
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Using Fiber Photometry in Mice to Estimate Fluorescent Biosensor Levels During Sleep
Andersen, Mie, Tsopanidou, Anastasia, Radovanovic, Tessa, Compere, V. N., Hauglund, Natalie Linea, Nedergaard, Maiken & Kjærby, Celia, 2023, In: Bio-protocol. 13, 15, 17 p., e4734.Research output: Contribution to journal › Journal article › Research › peer-review
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Visual Evoked Potentials as an Early-Stage Biomarker in the rTg4510 Tauopathy Mouse Model
Parka, A., Volbracht, C., Hall, B., Bastlund, J. F., Nedergaard, Maiken, Laursen, B., Botta, P. & Sotty, F., 2023, In: Journal of Alzheimer's Disease. 93, 1, p. 247-262 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 101366876
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580
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SPECT imaging of the glymphatic pathway with In-111-labeled ovalbumin in the rat brain
Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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472
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In Vivo Imaging of Cerebrospinal Fluid Transport through the Intact Mouse Skull using Fluorescence Macroscopy
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
339
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Understanding the functions and relationships of the glymphatic system and meningeal lymphatics
Research output: Contribution to journal › Review › Research › peer-review
Published